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Tag Content
UUCD2 ID IUUC-Mlu-067623
UUCD1 version UUC-MyL-00277
Ensembl Protein ID ENSMLUP00000004942.2
UniProt Accession G1P4Q1; G1P4Q1_MYOLU
Genbank Protein ID ENSMLUP00000004942
Protein Name E3 ubiquitin-protein ligase
Genbank Nucleotide ID AAPE02023028
Gene Name WWP2
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMLUG00000005409.2 ENSMLUT00000005414.2 ENSMLUP00000004942.2
Status Unreviewed
Classification
Family E-Value Score Start End
E3 activity/HECT 5.70e-123 410.6 536 860
Active Site
Position(s) Description Evidence
829 Glycyl thioester intermediate {ECO:0000256|PIRSR:PIRSR001569-1,
ECO:0000256|PROSITE-ProRule:PRU00104}
Domain Profile

   E3 activity/HECT
   S: 2    ksdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldl 90
           ++dl++rl++ ++gEegld+gG++re+++lls+e+ np+++lf+y  +++++lq+np+s + np+hl +F+f+Gr++++al++g+++d+
   Q: 536  PYDLRRRLYIIMRGEEGLDYGGIAREWFFLLSHEVLNPMYCLFEYAGKNNYCLQINPASSI-NPDHLTYFRFIGRFIAMALYHGKFIDT 623
           6799********************************************************9.89************************* PP
   S: 91   plsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvve 179
            ++ +fyk++l+k+          p++   l +   + e+++ee+gl+l f ++ eilg+++++eLk+gGe+i+Vt+eNkeeY+ l+++
   Q: 624  GFTLPFYKRMLNKR----------PKMSSLLCSRAPR-ENNLEECGLELYFIQDMEILGKVTTHELKEGGESIRVTEENKEEYIMLLTD 701
           *************7..........5555555555544.6799*********************************************** PP
   S: 180  yrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkafLqFv 268
           +r+++g++eq++af +Gfnev ple+l++F+e+elel++cG++eid++d++k+t y++ yt++s++iqwFw+v++e+++e+  ++LqFv
   Q: 702  WRFTRGVEEQTKAFLDGFNEVAPLEWLRYFDEKELELMLCGMQEIDMNDWQKNTIYRH-YTKNSKQIQWFWQVVKEMDNEKSIRLLQFV 789
           ********************************************************99.****************************** PP
   S: 269  TgssrlPlgGfaelk....prlfvirkdasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFel 335
           Tg++rlP+gGfael     p++f+i k +++++lP+s+TCfn+L+LP+Y+s+e+lkekLlyAieet+gF++
   Q: 790  TGTCRLPVGGFAELIgsngPQKFCIDKVGKETWLPRSHTCFNRLDLPPYKSYEQLKEKLLYAIEETEGFGQ 860
           *********************************************************************96 PP
   
Organism Myotis lucifugus
Protein Sequence
(Fasta)
MASASASRTG VALPFEKSQL TLKVVSAKPK VHNRQHRINS FVEVAVDGLP SETKKTGKRI 60
GSSELLWNEI IILNVTAQSH LDLKVWSCHT LRNELLGTAS VNLSNVLKNN GGKMENTQLT 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Mlu-067623|E3,HECT|Myotis lucifugus
Please wait for a moment...
Nucleotide Sequence
(Fasta)
ATGGCATCTG CCAGCGCCAG CCGGACAGGA GTGGCCCTGC CTTTTGAGAA GTCTCAGCTT 60
ACTTTGAAGG GTGAGTGGCA CTGTGTGGAG TGTTTGTTAG TCATTTGAGG TCCAGCCCAG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Mlu-067623|E3,HECT|Myotis lucifugus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway
Interpro

IPR000008--C2_dom
IPR024928--E3_ub_ligase_SMURF1
IPR000569--HECT_dom
IPR001202--WW_dom
PROSITE

PS50237--HECT
PS01159--WW_DOMAIN_1
PS50020--WW_DOMAIN_2
Pfam

PF00632--HECT
PF00397--WW
SMART

SM00239--C2
SM00119--HECTc
SM00456--WW
Gene Ontology

GO:0005737--C:cytoplasm
GO:0070062--C:extracellular exosome
GO:0016020--C:membrane
GO:0005634--C:nucleus
GO:0001190--F:transcriptional activator activity, RNA polymerase II transcription factor binding
GO:0061630--F:ubiquitin protein ligase activity
GO:0051224--P:negative regulation of protein transport
GO:0043433--P:negative regulation of sequence-specific DNA binding transcription factor activity
GO:0032410--P:negative regulation of transporter activity
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0051865--P:protein autoubiquitination
GO:0070534--P:protein K63-linked ubiquitination
GO:0042391--P:regulation of membrane potential
GO:1901016--P:regulation of potassium ion transmembrane transporter activity
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001575 Ailuropoda melanoleuca 92.90 0.00e+00 1576.00
IUUC-Apl-003912 Anas platyrhynchos 74.97 0.00e+00 1191.00
IUUC-Aca-004291 Anolis carolinensis 77.99 0.00e+00 1372.00
IUUC-Bta-013231 Bos taurus 91.04 0.00e+00 1545.00
IUUC-Cel-018299 Caenorhabditis elegans 65.11 0.00e+00 795.00
IUUC-Cja-019455 Callithrix jacchus 92.88 0.00e+00 1619.00
IUUC-Cfa-021017 Canis familiaris 93.69 0.00e+00 1577.00
IUUC-Cpo-021988 Cavia porcellus 92.77 0.00e+00 1594.00
IUUC-Csa-023549 Chlorocebus sabaeus 92.54 0.00e+00 1618.00
IUUC-Cin-025212 Ciona intestinalis 70.24 0.00e+00 837.00
IUUC-Csv-026256 Ciona savignyi 69.55 0.00e+00 829.00
IUUC-Dre-028513 Danio rerio 89.16 0.00e+00 1090.00
IUUC-Dno-028976 Dasypus novemcinctus 93.35 0.00e+00 1625.00
IUUC-Dor-030176 Dipodomys ordii 89.48 0.00e+00 1445.00
IUUC-Dme-032041 Drosophila melanogaster 66.39 0.00e+00 823.00
IUUC-Eca-033949 Equus caballus 94.03 0.00e+00 1602.00
IUUC-Eeu-034529 Erinaceus europaeus 85.66 0.00e+00 1311.00
IUUC-Fca-036236 Felis catus 93.57 0.00e+00 1617.00
IUUC-Fal-036948 Ficedula albicollis 76.34 0.00e+00 1283.00
IUUC-Gmo-038842 Gadus morhua 86.27 0.00e+00 1018.00
IUUC-Gga-040617 Gallus gallus 78.71 0.00e+00 1393.00
IUUC-Gac-041338 Gasterosteus aculeatus 68.35 0.00e+00 1201.00
IUUC-Ggo-045278 Gorilla gorilla 92.88 0.00e+00 1619.00
IUUC-Hsa-046148 Homo sapiens 92.88 0.00e+00 1620.00
IUUC-Itr-047945 Ictidomys tridecemlineatus 94.40 0.00e+00 1069.00
IUUC-Lch-050663 Latimeria chalumnae 76.02 0.00e+00 1332.00
IUUC-Loc-052604 Lepisosteus oculatus 75.34 0.00e+00 1270.00
IUUC-Laf-053944 Loxodonta africana 92.88 0.00e+00 1598.00
IUUC-Mcc-055655 Macaca mulatta 92.64 0.00e+00 1620.00
IUUC-Meu-055953 Macropus eugenii 77.32 0.00e+00 1327.00
IUUC-Mga-060190 Meleagris gallopavo 79.28 0.00e+00 1394.00
IUUC-Mmr-060896 Microcebus murinus 93.06 0.00e+00 1569.00
IUUC-Mdo-062536 Monodelphis domestica 87.97 0.00e+00 1551.00
IUUC-Mmu-064017 Mus musculus 92.08 0.00e+00 1580.00
IUUC-Mpu-066608 Mustela putorius furo 92.43 0.00e+00 1576.00
IUUC-Nle-069496 Nomascus leucogenys 90.83 0.00e+00 1572.00
IUUC-Opr-071054 Ochotona princeps 81.53 0.00e+00 1364.00
IUUC-Ont-071279 Oreochromis niloticus 72.10 0.00e+00 1237.00
IUUC-Oan-073512 Ornithorhynchus anatinus 84.61 0.00e+00 1434.00
IUUC-Ocu-074271 Oryctolagus cuniculus 92.19 0.00e+00 1554.00
IUUC-Ola-087237 Oryzias latipes 68.28 0.00e+00 1178.00
IUUC-Oga-088164 Otolemur garnettii 93.23 0.00e+00 1617.00
IUUC-Oar-089698 Ovis aries 91.39 0.00e+00 1556.00
IUUC-Ptr-091306 Pan troglodytes 91.62 0.00e+00 1589.00
IUUC-Pan-092814 Papio anubis 88.99 0.00e+00 1528.00
IUUC-Pfo-096709 Poecilia formosa 70.36 0.00e+00 1225.00
IUUC-Pab-098494 Pongo abelii 87.89 0.00e+00 1530.00
IUUC-Pca-100596 Procavia capensis 81.23 0.00e+00 1313.00
IUUC-Pva-103154 Pteropus vampyrus 88.72 0.00e+00 1511.00
IUUC-Rno-104954 Rattus norvegicus 90.63 0.00e+00 1355.00
IUUC-Sha-106781 Sarcophilus harrisii 89.12 0.00e+00 1592.00
IUUC-Ssc-116307 Sus scrofa 85.08 0.00e+00 1436.00
IUUC-Tgu-116530 Taeniopygia guttata 73.68 0.00e+00 1137.00
IUUC-Tru-118287 Takifugu rubripes 67.78 0.00e+00 1186.00
IUUC-Tsy-119097 Tarsius syrichta 80.05 0.00e+00 1160.00
IUUC-Tni-120801 Tetraodon nigroviridis 68.47 0.00e+00 1134.00
IUUC-Tbe-127793 Tupaia belangeri 81.63 0.00e+00 1382.00
IUUC-Ttr-128275 Tursiops truncatus 88.86 0.00e+00 1503.00
IUUC-Xtr-132866 Xenopus tropicalis 81.08 0.00e+00 1108.00
Created Date 25-Jun-2017

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