iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

   S: 2    ksdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldl 90
           ++dl++rl++ ++gEegld+gG++re+++lls+e+ np+++lf+y  +++++lq+np+s + np+hl +F+f+Gr++++al++g+++d+
   Q: 425  PYDLRRRLYIIMRGEEGLDYGGIAREWFFLLSHEVLNPMYCLFEYAGKNNYCLQINPASSI-NPDHLTYFRFIGRFIAMALYHGKFIDT 512
           6799********************************************************9.89************************* PP
   S: 91   plsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvve 179
            ++ +fyk++l+k+ +l dle++dpe+y+s+ +iken   +++e+gl+l f ++ eilg+++++eLk+gGeni+Vt+eNkeeY+ l+++
   Q: 513  GFTLPFYKRMLNKRPTLRDLESIDPEFYNSIIWIKEN---NLDECGLELFFIQDMEILGKVTTHELKEGGENIRVTEENKEEYIMLLTD 598
           ***********************************99...9************************************************ PP
   S: 180  yrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkafLqFv 268
           +r+++g++eq++af +Gfnev ple+l++F+e+elel++cG++eid++d++k++ y++ yt++s++iqwFw+v++e+++e+r ++LqFv
   Q: 599  WRFTRGVEEQTKAFLDGFNEVAPLEWLRYFDEKELELMLCGMQEIDMSDWQKNAIYRH-YTKSSKQIQWFWQVVKEMDNEKRIRLLQFV 686
           ********************************************************99.****************************** PP
   S: 269  TgssrlPlgGfaelk....prlfvirkdasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFel 335
           Tg++rlP+gGfael     p++f+i + +++++lP+s+TCfn+L+LP+Y+s+e+lkekLlyAieet+gF++
   Q: 687  TGTCRLPVGGFAELIgsngPQKFCIDRVGKETWLPRSHTCFNRLDLPPYKSYEQLKEKLLYAIEETEGFGQ 757
           *********************************************************************96 PP

Organism

Rattus norvegicus

Protein Sequence
(Fasta)

TVENTQLTLN LQTENKGSVV SGGELTIFLD GPTVDLGSVP NGSAVTDGSQ PPSRESSGTA 60
LAPETRHQPP STNCFGGRSR THRHSGGSAR TATATGEQSP GARNRHRQPV KNPSSSGLAN 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ACAGTGGAGA ACACGCAACT GACCCTGAAC CTGCAGACAG AGAACAAAGG CAGCGTTGTC 60
TCAGGAGGAG AGCTGACAAT TTTCCTGGAT GGGCCAACTG TTGATCTGGG CAGTGTGCCT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR024928--E3_ub_ligase_SMURF1
IPR000569--HECT_dom
IPR001202--WW_dom

PROSITE

PS50237--HECT
PS01159--WW_DOMAIN_1
PS50020--WW_DOMAIN_2

Pfam

PF00632--HECT
PF00397--WW

SMART

SM00119--HECTc
SM00456--WW

Gene Ontology

GO:0005737--C:cytoplasm
GO:0070062--C:extracellular exosome
GO:0016020--C:membrane
GO:0005634--C:nucleus
GO:0001190--F:transcriptional activator activity, RNA polymerase II transcription factor binding
GO:0061630--F:ubiquitin protein ligase activity
GO:0051224--P:negative regulation of protein transport
GO:0043433--P:negative regulation of sequence-specific DNA binding transcription factor activity
GO:0032410--P:negative regulation of transporter activity
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0051865--P:protein autoubiquitination
GO:0070534--P:protein K63-linked ubiquitination
GO:0042391--P:regulation of membrane potential
GO:1901016--P:regulation of potassium ion transmembrane transporter activity

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001575	Ailuropoda melanoleuca	94.20	0.00e+00	1407.00
IUUC-Apl-003912	Anas platyrhynchos	78.93	0.00e+00	1210.00
IUUC-Aca-004291	Anolis carolinensis	82.44	0.00e+00	1294.00
IUUC-Bta-013231	Bos taurus	94.06	0.00e+00	1374.00
IUUC-Cja-019455	Callithrix jacchus	94.98	0.00e+00	1453.00
IUUC-Cfa-021017	Canis familiaris	94.98	0.00e+00	1402.00
IUUC-Cpo-021988	Cavia porcellus	94.72	0.00e+00	1438.00
IUUC-Csa-023549	Chlorocebus sabaeus	95.11	0.00e+00	1466.00
IUUC-Dre-028513	Danio rerio	91.07	0.00e+00	1126.00
IUUC-Dno-028976	Dasypus novemcinctus	94.33	0.00e+00	1439.00
IUUC-Dor-030176	Dipodomys ordii	91.81	0.00e+00	1325.00
IUUC-Eca-033949	Equus caballus	94.72	0.00e+00	1415.00
IUUC-Eeu-034529	Erinaceus europaeus	92.27	0.00e+00	1161.00
IUUC-Fca-036236	Felis catus	94.72	0.00e+00	1446.00
IUUC-Fal-036948	Ficedula albicollis	78.42	0.00e+00	1229.00
IUUC-Gmo-038842	Gadus morhua	88.36	0.00e+00	1057.00
IUUC-Gga-040617	Gallus gallus	79.31	0.00e+00	1287.00
IUUC-Gac-041338	Gasterosteus aculeatus	69.96	0.00e+00	1108.00
IUUC-Ggo-045278	Gorilla gorilla	95.38	0.00e+00	1465.00
IUUC-Hsa-046148	Homo sapiens	95.38	0.00e+00	1466.00
IUUC-Itr-047945	Ictidomys tridecemlineatus	97.20	0.00e+00	1111.00
IUUC-Lch-050663	Latimeria chalumnae	79.22	0.00e+00	1230.00
IUUC-Loc-052604	Lepisosteus oculatus	77.03	0.00e+00	1184.00
IUUC-Laf-053944	Loxodonta africana	94.98	0.00e+00	1442.00
IUUC-Mcc-055655	Macaca mulatta	95.24	0.00e+00	1467.00
IUUC-Meu-055953	Macropus eugenii	76.55	0.00e+00	1157.00
IUUC-Mga-060190	Meleagris gallopavo	79.78	0.00e+00	1292.00
IUUC-Mmr-060896	Microcebus murinus	95.51	0.00e+00	1418.00
IUUC-Mdo-062536	Monodelphis domestica	89.20	0.00e+00	1378.00
IUUC-Mmu-064017	Mus musculus	97.49	0.00e+00	1451.00
IUUC-Mpu-066608	Mustela putorius furo	92.36	0.00e+00	1359.00
IUUC-Mlu-067623	Myotis lucifugus	91.69	0.00e+00	1370.00
IUUC-Nle-069496	Nomascus leucogenys	93.14	0.00e+00	1419.00
IUUC-Opr-071054	Ochotona princeps	87.24	0.00e+00	1258.00
IUUC-Ont-071279	Oreochromis niloticus	75.00	0.00e+00	1135.00
IUUC-Oan-073512	Ornithorhynchus anatinus	86.22	0.00e+00	1286.00
IUUC-Ocu-074271	Oryctolagus cuniculus	94.72	0.00e+00	1422.00
IUUC-Ola-087237	Oryzias latipes	84.97	0.00e+00	1038.00
IUUC-Oga-088164	Otolemur garnettii	95.38	0.00e+00	1451.00
IUUC-Oar-089698	Ovis aries	94.19	0.00e+00	1383.00
IUUC-Ptr-091306	Pan troglodytes	93.92	0.00e+00	1435.00
IUUC-Pan-092814	Papio anubis	90.91	0.00e+00	1372.00
IUUC-Pfo-096709	Poecilia formosa	73.43	0.00e+00	1137.00
IUUC-Pab-098494	Pongo abelii	89.61	0.00e+00	1390.00
IUUC-Pca-100596	Procavia capensis	82.56	0.00e+00	1238.00
IUUC-Pva-103154	Pteropus vampyrus	89.56	0.00e+00	1342.00
IUUC-Sha-106781	Sarcophilus harrisii	89.59	0.00e+00	1424.00
IUUC-Ssc-116307	Sus scrofa	83.62	0.00e+00	1288.00
IUUC-Tgu-116530	Taeniopygia guttata	75.59	0.00e+00	1177.00
IUUC-Tru-118287	Takifugu rubripes	89.10	0.00e+00	1058.00
IUUC-Tsy-119097	Tarsius syrichta	79.64	0.00e+00	998.00
IUUC-Tni-120801	Tetraodon nigroviridis	70.20	0.00e+00	1107.00
IUUC-Tbe-127793	Tupaia belangeri	85.92	0.00e+00	1213.00
IUUC-Ttr-128275	Tursiops truncatus	89.70	0.00e+00	1322.00
IUUC-Xtr-132866	Xenopus tropicalis	82.24	0.00e+00	1127.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence