iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Cja-019588

UUCD1 version

UUC-CaJ-01128

Ensembl Protein ID

ENSCJAP00000043049.1

UniProt Accession

F7HWE7; F7HWE7_CALJA

Genbank Protein ID

JAB11593.1; JAB18564.1; JAB26058.1; JAB37830.1; JAB46512.1

Protein Name

Ubiquitin carboxyl-terminal hydrolase 1

Genbank Nucleotide ID

ACFV01020121; GAMS01004572; GAMR01007874; GAMQ01004021; GAMP01006243

Gene Name

USP1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSCJAG00000016287.2	ENSCJAT00000061509.1	ENSCJAP00000043049.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	7.80e-86	289.3	81	782

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrellle......kkkeklneenpkepkg..........ellkslqklfeel.......w..... 61
           +Gl+NlgNtCY+NS+LQ+L+++p +++ +++      +kke+l++e+++++kg          el++slq+l+ ++       +     
   Q: 81   VGLNNLGNTCYLNSILQVLYFCPGFKSGVKHlfniisRKKEALKDEANQKDKGnckedslasyELICSLQSLIISVeqlqasfLlnpek 169
           6************************************999999999999999999999*****99999999999995555555144555 PP
   S: 62   kskkkavsprellkalkkeaeefsgyeqqDaqEflaflldqleeelkk.................eknkpkeeeeeedkselsde.... 129
           ++++ a++pr+ll++l++++++++gy q+DaqE+l+++l +++e+++                  e  ++kee+++        +    
   Q: 170  YTDELATQPRRLLNTLRELNPMYEGYLQHDAQEVLQCILGNIQETCQLlkkeevknvaelstkveEIPHQKEEMSG--------Insme 250
           88888*****************************************545555555555555555444444455555........05555 PP
   S: 130  ......................................................................................... 129
                                                                                                    
   Q: 251  mdsmrhsedfkeklpkgngkrksdtefgsmkkkvkvskehqsleenqrqtrskrkatsdtleippkvipkyisenesarasqkksrvki 339
           5555************************************************************************************* PP
   S: 130  ...................................................................aeekkkkknk.....slisdlF 146
                                                                              +e k+ +k++     +l+++lF
   Q: 340  nwlksankqpsilskfcslgkittnqgakgqskeneydpeedlgkcesdntanglespentvipvnvNEVKPINKGEeqigfELVEKLF 428
           *****************************************************************99555555555556666******* PP
   S: 147  qgqlksqikclecdnvssreepfldlslpvpgkeetkke..............slqdcLesftkeeelegenkyycekckkkqeaekkl 221
           qgql  +++clec++ ++r+e+f+d+s+pv+++e +k e              +l++++++f++ e++ ge+ky+ce+c++++eae++l
   Q: 429  QGQLVLRTRCLECESLTERREDFQDISVPVQEDELSKVEesseispepktemkTLRWAISQFASVERIVGEDKYFCENCHHYTEAERSL 517
           **********************************99998************************************************** PP
   S: 222  klkklPevLilhLkRf.....sfseeqksrekinkkvefpleLdlspfctspeekqkekkkYeLiavvvHsG.slssGHYvayvkn... 301
            ++k+Pev+++hLk+f     +f+++++  +kin+ + +pl+L+l+++ t+p+     +++Y L+avv+HsG ++ssGHY+a vk    
   Q: 518  LFDKMPEVITIHLKCFaasglEFDCYGGGLSKINTPLLTPLKLSLEEWSTKPT-----NDSYGLFAVVMHSGiTISSGHYTASVKVtdl 601
           ***************************************************99.....678**************************** PP
   S: 302  ......................................................................................... 301
                                                                                                    
   Q: 602  nsleldkgnfvvdqmceigkpeplneeeargvvenyddeevsirvggntqpskvlnkknveaigllggqkskadyelynkasnpdkvas 690
           ***************************************************************************************** PP
   S: 302  ..................................................ekgkWllfdDskVtevkeeevleetg......staYvlf 334
                                                              +gkWllfdDs+V++++e+++l++ +      st+Y+lf
   Q: 691  tafaenrnsetndangthesdrnkessdqtginisgfenkisyvvqslkeYEGKWLLFDDSEVKVTEEKDFLNSLSpstsptSTPYLLF 779
           **************9999999999999999999999988888888877766999*******************888************* PP
   S: 335  Ykr 337
           Yk+
   Q: 780  YKK 782
           *97 PP

Organism

Callithrix jacchus

Protein Sequence
(Fasta)

MPGVIPSESN GLSRGSPSKK NRLSLKFFQK KETKRALDFT NSQENEEKVS EYRASEIDQV 60
VPAAQSSPIN CEKRENLLPF VGLNNLGNTC YLNSILQVLY FCPGFKSGVK HLFNIISRKK 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GGGGCTTGCC GCGAGGGCCT CGCTCCGGAA GCCGCACCCT CCGCGGCGTC CCACCGTCGA 60
AGATTAACAA AACGCCAAAC AAGATTTTAA CAGTCGGAAG CGAAAGCGCG CACTCGAGCG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0378--Hydrolase
KW-1185--Reference proteome

Interpro

IPR001394--Peptidase_C19_UCH
IPR033815--USP1
IPR018200--USP_CS
IPR028889--USP_dom

PROSITE

PS00972--USP_1
PS00973--USP_2
PS50235--USP_3

Pfam

PF00443--UCH

Gene Ontology

GO:0005654--C:nucleoplasm
GO:0004197--F:cysteine-type endopeptidase activity
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0035520--P:monoubiquitinated protein deubiquitination
GO:0006282--P:regulation of DNA repair
GO:0009411--P:response to UV
GO:0001501--P:skeletal system development
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

cjc:100411303

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001939	Ailuropoda melanoleuca	93.77	0.00e+00	1409.00
IUUC-Apl-004204	Anas platyrhynchos	72.60	0.00e+00	919.00
IUUC-Aca-004637	Anolis carolinensis	66.50	0.00e+00	922.00
IUUC-Ame-011718	Astyanax mexicanus	48.21	5.00e-174	604.00
IUUC-Bta-012552	Bos taurus	91.97	0.00e+00	1383.00
IUUC-Cfa-020211	Canis familiaris	94.27	0.00e+00	1420.00
IUUC-Cpo-021551	Cavia porcellus	84.55	0.00e+00	1256.00
IUUC-Csa-024186	Chlorocebus sabaeus	97.20	0.00e+00	1496.00
IUUC-Cho-024739	Choloepus hoffmanni	82.11	0.00e+00	723.00
IUUC-Dre-028184	Danio rerio	49.63	1.00e-176	613.00
IUUC-Dno-029669	Dasypus novemcinctus	90.48	0.00e+00	1384.00
IUUC-Dor-030168	Dipodomys ordii	86.28	0.00e+00	1238.00
IUUC-Dme-031732	Drosophila melanogaster	28.77	4.00e-18	87.40
IUUC-Ete-032825	Echinops telfairi	86.81	0.00e+00	942.00
IUUC-Eca-033595	Equus caballus	93.82	0.00e+00	1330.00
IUUC-Eeu-034877	Erinaceus europaeus	81.06	7.00e-154	537.00
IUUC-Fca-035381	Felis catus	92.98	0.00e+00	989.00
IUUC-Fal-037592	Ficedula albicollis	69.30	0.00e+00	947.00
IUUC-Gmo-039680	Gadus morhua	45.40	2.00e-152	533.00
IUUC-Gga-041196	Gallus gallus	72.41	0.00e+00	1043.00
IUUC-Gac-042292	Gasterosteus aculeatus	48.64	1.00e-144	506.00
IUUC-Ggo-044671	Gorilla gorilla	97.20	0.00e+00	1503.00
IUUC-Hsa-047020	Homo sapiens	96.94	0.00e+00	1496.00
IUUC-Itr-048800	Ictidomys tridecemlineatus	85.24	0.00e+00	1248.00
IUUC-Lch-050543	Latimeria chalumnae	57.24	0.00e+00	702.00
IUUC-Loc-052338	Lepisosteus oculatus	53.45	0.00e+00	707.00
IUUC-Laf-053707	Loxodonta africana	90.62	0.00e+00	1394.00
IUUC-Mcc-055885	Macaca mulatta	97.20	0.00e+00	1497.00
IUUC-Meu-056573	Macropus eugenii	66.41	0.00e+00	931.00
IUUC-Mga-059346	Meleagris gallopavo	72.76	0.00e+00	993.00
IUUC-Mmr-061612	Microcebus murinus	93.76	0.00e+00	1392.00
IUUC-Mdo-062887	Monodelphis domestica	72.37	0.00e+00	1035.00
IUUC-Mmu-064044	Mus musculus	88.03	0.00e+00	1349.00
IUUC-Mpu-066847	Mustela putorius furo	94.90	0.00e+00	1427.00
IUUC-Mlu-067684	Myotis lucifugus	91.49	0.00e+00	1401.00
IUUC-Nle-070057	Nomascus leucogenys	97.20	0.00e+00	1503.00
IUUC-Opr-070463	Ochotona princeps	83.80	0.00e+00	1231.00
IUUC-Ont-071975	Oreochromis niloticus	46.31	3.00e-152	532.00
IUUC-Oan-073062	Ornithorhynchus anatinus	85.71	3.00e-46	177.00
IUUC-Ocu-074840	Oryctolagus cuniculus	93.12	0.00e+00	1410.00
IUUC-Ola-087088	Oryzias latipes	46.76	2.00e-172	599.00
IUUC-Oga-088472	Otolemur garnettii	92.99	0.00e+00	1424.00
IUUC-Oar-089498	Ovis aries	92.36	0.00e+00	1393.00
IUUC-Ptr-091395	Pan troglodytes	97.32	0.00e+00	1501.00
IUUC-Pan-092462	Papio anubis	97.32	0.00e+00	1498.00
IUUC-Psi-093583	Pelodiscus sinensis	72.58	0.00e+00	899.00
IUUC-Pma-094644	Petromyzon marinus	36.36	3.00e-28	118.00
IUUC-Pfo-096314	Poecilia formosa	46.56	4.00e-169	588.00
IUUC-Pab-098568	Pongo abelii	97.71	0.00e+00	1508.00
IUUC-Pca-100948	Procavia capensis	81.96	0.00e+00	1228.00
IUUC-Pva-102853	Pteropus vampyrus	92.71	0.00e+00	1408.00
IUUC-Rno-105573	Rattus norvegicus	88.03	0.00e+00	1326.00
IUUC-Sha-107495	Sarcophilus harrisii	72.53	0.00e+00	879.00
IUUC-Sar-113545	Sorex araneus	77.04	0.00e+00	1090.00
IUUC-Ssc-115962	Sus scrofa	93.92	0.00e+00	1437.00
IUUC-Tgu-116731	Taeniopygia guttata	69.61	0.00e+00	963.00
IUUC-Tru-117893	Takifugu rubripes	46.77	2.00e-158	553.00
IUUC-Tsy-119644	Tarsius syrichta	84.31	0.00e+00	1239.00
IUUC-Tni-119819	Tetraodon nigroviridis	45.14	3.00e-168	585.00
IUUC-Tbe-127272	Tupaia belangeri	89.44	0.00e+00	1243.00
IUUC-Ttr-128404	Tursiops truncatus	94.01	0.00e+00	1432.00
IUUC-Vpa-130205	Vicugna pacos	93.75	0.00e+00	1427.00
IUUC-Xtr-132613	Xenopus tropicalis	56.05	0.00e+00	734.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence