iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Oga-088167

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

E3 ubiquitin-protein ligase

Genbank Nucleotide ID

AAQR03054281

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSOGAG00000016792.2	ENSOGAT00000016802.2	ENSOGAP00000015038.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	4.60e-136	453.6	520	852

Active Site

Position(s)	Description	Evidence
821	Glycyl thioester intermediate	{ECO:0000256\|PIRSR:PIRSR001569-1, ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 2    ksdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldl 90
           ++dl++rl+v f gEegld+gGv+re+++lls+e+ np+++lf+y  +d+++lq+np+s++ np+hlk+F+f+Gr++++al++g+++d+
   Q: 520  PQDLRRRLWVIFPGEEGLDYGGVAREWFFLLSHEVLNPMYCLFEYAGKDNYCLQINPASYI-NPDHLKYFRFIGRFIAMALFHGKFIDT 607
           689*********************************************************9.89************************* PP
   S: 91   plsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvve 179
            +s +fyk++l+k++ l+dle++dpe+y+sl ++ken   +iee+gl++ fsv++eilge+k+++Lk +G+ni Vt+eNkeeY++ v+e
   Q: 608  GFSLPFYKRILNKPVGLKDLESIDPEFYNSLIWVKEN---NIEECGLEMYFSVDKEILGEIKSHDLKHNGSNILVTEENKEEYIRMVAE 693
           ***********************************99...9************************************************ PP
   S: 180  yrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkafLqFv 268
           +rl +g++eq++af eGfne++p++ l++F+++ele+l+cG++eid++d+++++ y++ yt++s++i wFw++++e+++e+r ++LqFv
   Q: 694  WRLSRGVEEQTQAFFEGFNEILPQQYLQYFDAKELEVLLCGMQEIDLNDWQRHAIYRH-YTRTSKQIMWFWQFVKEIDNEKRMRLLQFV 781
           ********************************************************99.****************************** PP
   S: 269  TgssrlPlgGfaelk....prlfvirkdasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFel 335
           Tg++rlP+gGfa+l+    p++f+i+k +++++lP+s+TCfn+L+LP+Y+s+e+lkekLl+Aieet+gF++
   Q: 782  TGTCRLPVGGFADLMgsngPQKFCIEKVGKENWLPRSHTCFNRLDLPPYKSYEQLKEKLLFAIEETEGFGQ 852
           *********************************************************************96 PP

Organism

Otolemur garnettii

Protein Sequence
(Fasta)

IQVMSELKLI VLSAKLKENK KNWFGPSPYV EVTVDGQSKK TEKCNNTNSP KWKQPLTVIV 60
TPVSKLHFRV WSHQTLKSDV LLGTAALDIY ETLKSNNMKL EEVVVTLQLV GDKEPTETMG 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATTCAGGTCA TGAGTGAGTT AAAATTAGTA AATATTTTAA AGCAAAACTG CTTATCTGAA 60
TAAAAGTAAT CTCCCTAATC TTTGTGAAAT TAGATTGATT TGAAAAAGAA ATGACATCTC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000008--C2_dom
IPR024928--E3_ub_ligase_SMURF1
IPR000569--HECT_dom
IPR001202--WW_dom

PROSITE

PS50004--C2
PS50237--HECT
PS01159--WW_DOMAIN_1
PS50020--WW_DOMAIN_2

Pfam

PF00168--C2
PF00632--HECT
PF00397--WW

SMART

SM00239--C2
SM00119--HECTc
SM00456--WW

Gene Ontology

GO:0005938--C:cell cortex
GO:0031410--C:cytoplasmic vesicle
GO:0070062--C:extracellular exosome
GO:0005654--C:nucleoplasm
GO:0005886--C:plasma membrane
GO:0016874--F:ligase activity
GO:0043021--F:ribonucleoprotein complex binding
GO:0061630--F:ubiquitin protein ligase activity
GO:0046642--P:negative regulation of alpha-beta T cell proliferation
GO:0043066--P:negative regulation of apoptotic process
GO:0050687--P:negative regulation of defense response to virus
GO:0046329--P:negative regulation of JNK cascade
GO:0032088--P:negative regulation of NF-kappaB transcription factor activity
GO:0045732--P:positive regulation of protein catabolic process
GO:0002669--P:positive regulation of T cell anergy
GO:0035519--P:protein K29-linked ubiquitination
GO:0070936--P:protein K48-linked ubiquitination
GO:0070534--P:protein K63-linked ubiquitination
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0090085--P:regulation of protein deubiquitination

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002302	Ailuropoda melanoleuca	90.36	0.00e+00	1481.00
IUUC-Apl-003752	Anas platyrhynchos	77.65	0.00e+00	1321.00
IUUC-Aca-005338	Anolis carolinensis	76.40	0.00e+00	1307.00
IUUC-Ame-011081	Astyanax mexicanus	62.84	0.00e+00	1082.00
IUUC-Bta-012782	Bos taurus	89.82	0.00e+00	1429.00
IUUC-Cja-018899	Callithrix jacchus	87.26	0.00e+00	1440.00
IUUC-Cfa-020648	Canis familiaris	89.11	0.00e+00	1445.00
IUUC-Cpo-022073	Cavia porcellus	90.29	0.00e+00	1484.00
IUUC-Csa-023252	Chlorocebus sabaeus	89.82	0.00e+00	1478.00
IUUC-Cho-024695	Choloepus hoffmanni	83.73	0.00e+00	1461.00
IUUC-Dre-028451	Danio rerio	71.45	0.00e+00	1194.00
IUUC-Dno-029884	Dasypus novemcinctus	89.24	0.00e+00	1499.00
IUUC-Eca-033793	Equus caballus	90.06	0.00e+00	1478.00
IUUC-Eeu-034716	Erinaceus europaeus	92.79	0.00e+00	882.00
IUUC-Fca-035605	Felis catus	90.60	0.00e+00	1516.00
IUUC-Fal-037126	Ficedula albicollis	77.92	0.00e+00	1320.00
IUUC-Gmo-038596	Gadus morhua	73.59	0.00e+00	912.00
IUUC-Gga-040832	Gallus gallus	77.23	0.00e+00	1331.00
IUUC-Gac-041658	Gasterosteus aculeatus	79.76	0.00e+00	1020.00
IUUC-Ggo-044535	Gorilla gorilla	86.90	0.00e+00	1442.00
IUUC-Hsa-046564	Homo sapiens	87.21	0.00e+00	1479.00
IUUC-Itr-048918	Ictidomys tridecemlineatus	90.25	0.00e+00	1428.00
IUUC-Lch-050454	Latimeria chalumnae	72.47	0.00e+00	1269.00
IUUC-Loc-052647	Lepisosteus oculatus	70.23	0.00e+00	1243.00
IUUC-Laf-054383	Loxodonta africana	90.53	0.00e+00	1487.00
IUUC-Mcc-055532	Macaca mulatta	89.82	0.00e+00	1479.00
IUUC-Mga-059661	Meleagris gallopavo	77.40	0.00e+00	1323.00
IUUC-Mmr-061135	Microcebus murinus	91.09	0.00e+00	1524.00
IUUC-Mdo-062505	Monodelphis domestica	81.27	0.00e+00	1382.00
IUUC-Mmu-063375	Mus musculus	88.21	0.00e+00	1438.00
IUUC-Mpu-066203	Mustela putorius furo	90.72	0.00e+00	1485.00
IUUC-Mlu-067837	Myotis lucifugus	89.82	0.00e+00	1478.00
IUUC-Nle-069244	Nomascus leucogenys	89.15	0.00e+00	1463.00
IUUC-Opr-070585	Ochotona princeps	84.74	0.00e+00	1438.00
IUUC-Ont-071798	Oreochromis niloticus	80.69	0.00e+00	1038.00
IUUC-Oan-073679	Ornithorhynchus anatinus	64.87	0.00e+00	942.00
IUUC-Ocu-074298	Oryctolagus cuniculus	89.96	0.00e+00	1476.00
IUUC-Ola-086526	Oryzias latipes	78.64	0.00e+00	1012.00
IUUC-Oar-090316	Ovis aries	74.36	0.00e+00	1075.00
IUUC-Ptr-090819	Pan troglodytes	86.40	0.00e+00	1440.00
IUUC-Pan-092454	Papio anubis	89.82	0.00e+00	1479.00
IUUC-Psi-093319	Pelodiscus sinensis	76.00	0.00e+00	1308.00
IUUC-Pfo-097346	Poecilia formosa	77.63	0.00e+00	1001.00
IUUC-Pab-097580	Pongo abelii	85.52	0.00e+00	1435.00
IUUC-Pca-100923	Procavia capensis	76.66	0.00e+00	1213.00
IUUC-Pva-103209	Pteropus vampyrus	89.01	0.00e+00	1430.00
IUUC-Rno-104924	Rattus norvegicus	88.56	0.00e+00	1451.00
IUUC-Sha-107175	Sarcophilus harrisii	82.10	0.00e+00	1373.00
IUUC-Sar-113761	Sorex araneus	80.91	0.00e+00	1366.00
IUUC-Tgu-116632	Taeniopygia guttata	77.33	0.00e+00	1283.00
IUUC-Tru-118442	Takifugu rubripes	82.04	0.00e+00	1021.00
IUUC-Tsy-119198	Tarsius syrichta	83.39	0.00e+00	1362.00
IUUC-Tni-120168	Tetraodon nigroviridis	79.12	0.00e+00	955.00
IUUC-Tbe-127756	Tupaia belangeri	87.76	0.00e+00	867.00
IUUC-Ttr-128504	Tursiops truncatus	81.74	0.00e+00	1024.00
IUUC-Vpa-130103	Vicugna pacos	76.01	0.00e+00	1239.00
IUUC-Xtr-132885	Xenopus tropicalis	71.91	0.00e+00	1254.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence