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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Spo-108197
Ensembl Protein ID SPCC1183.03c.1:pep
UniProt Accession O74831; FRDA_SCHPO
Genbank Protein ID CAA21083.1
Protein Name Frataxin homolog, mitochondrial
Genbank Nucleotide ID CU329672
Gene Name fxn1; SPCC1183.03c
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
SPCC1183.03c SPCC1183.03c.1 SPCC1183.03c.1:pep
Annotation
mRNA Expression
GEO
Protein Expression/Proteomics
Status Unreviewed
Classification
Family Identity E-Value Score Source Orthology
UBD/Other/Other 42.28 2.00e-20 95.90 IUUC-Hsa-046921
Active Site
Position(s) Description Evidence
N/A N/A N/A
Organism Schizosaccharomyces pombe
Functional Description
(View)

Functional Description


     Promotes the biosynthesis of heme as well as the assembly and repair of iron-sulfur clusters by delivering Fe(2+) to proteins involved in these pathways. May play a role in the protection against iron-catalyzed oxidative stress through its ability to catalyze the oxidation of Fe(2+) to Fe(3+). May be able to store large amounts of the metal in the form of a ferrihydrite mineral by oligomerization (By similarity).
 Promotes the biosynthesis of heme as well as the assembly and repair of iron-sulfur clusters by delivering Fe(2+) to proteins involved in these pathways. May play a role in the protection against iron-catalyzed oxidative stress through its ability to catalyze the oxidation of Fe(2+) to Fe(3+). May be able to store large amounts of the metal in the form of a ferrihydrite mineral by oligomerization (By similarity).
Protein Sequence
(Fasta)
MQSLRAAFRR RTPIFLKPYE FSTNVFGLRC RYYSQVRHNG ALTDLEYHRV ADDTLDVLND 60
TFEDLLEEVG KKDYDIQYAN GVITLMLGEK GTYVINKQPP AHQIWLSSPV SGPKHYEYSL 120
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Protein Fasta Sequence


>IUUC-Spo-108197|UBD,UBD/Other/Other|Schizosaccharomyces pombe
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Nucleotide Sequence
(Fasta)
GTCGTTCTGT ACAGCATATT TCCCAAAACC CAGAATTCCT TCTTTATGTA AATTCACTTC 60
TTGAGTTTGC GACCGTAATT TGATCCAAGT GCGAACACAC GAATTATCCG CTAACTACTC 120
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Nucleotide Fasta Sequence


>IUUC-Spo-108197|UBD,UBD/Other/Other|Schizosaccharomyces pombe
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0181--Complete proteome
KW-0350--Heme biosynthesis
KW-0406--Ion transport
KW-0408--Iron
KW-0409--Iron storage
KW-0410--Iron transport
KW-0496--Mitochondrion
KW-0560--Oxidoreductase
KW-1185--Reference proteome
KW-0809--Transit peptide
KW-0813--Transport
Interpro

IPR017789--Frataxin
IPR002908--Frataxin/CyaY
IPR020895--Frataxin_CS
PROSITE

PS01344--FRATAXIN_1
PS50810--FRATAXIN_2
Pfam

PF01491--Frataxin_Cyay
PRINTS

PR00904--FRATAXIN
SMART

SM01219--Frataxin_Cyay
Gene Ontology

GO:0005759--C:mitochondrial matrix
GO:0005739--C:mitochondrion
GO:0051537--F:2 iron, 2 sulfur cluster binding
GO:0008199--F:ferric iron binding
GO:0008198--F:ferrous iron binding
GO:0004322--F:ferroxidase activity
GO:0034986--F:iron chaperone activity
GO:0005506--F:iron ion binding
GO:0006879--P:cellular iron ion homeostasis
GO:0034599--P:cellular response to oxidative stress
GO:0006783--P:heme biosynthetic process
GO:0006811--P:ion transport
GO:0018283--P:iron incorporation into metallo-sulfur cluster
GO:0016226--P:iron-sulfur cluster assembly
GO:0007005--P:mitochondrion organization
KEGG spo:SPCC1183.03c
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-002122 Ailuropoda melanoleuca 40.34 4.00e-19 85.90
IUUC-Apl-003853 Anas platyrhynchos 46.67 6.00e-21 90.50
IUUC-Aca-005026 Anolis carolinensis 35.86 3.00e-20 89.00
IUUC-Aly-006200 Arabidopsis lyrata 40.62 2.00e-18 83.60
IUUC-Ath-007033 Arabidopsis thaliana 40.62 3.00e-18 82.80
IUUC-Ago-007707 Ashbya gossypii 46.30 5.00e-21 90.90
IUUC-Acl-008146 Aspergillus clavatus 35.00 3.00e-17 79.70
IUUC-Afl-008501 Aspergillus flavus 43.27 1.00e-17 80.90
IUUC-Afu-008851 Aspergillus fumigatus 34.64 7.00e-19 85.10
IUUC-Ani-009129 Aspergillus nidulans 30.08 1.00e-14 70.90
IUUC-Ang-009557 Aspergillus niger 33.79 4.00e-18 82.40
IUUC-Ate-010486 Aspergillus terreus 37.14 1.00e-17 80.90
IUUC-Bgr-012108 Blumeria graminis 40.19 9.00e-16 74.30
IUUC-Bta-013437 Bos taurus 45.00 5.00e-19 85.50
IUUC-Bci-013810 Botrytis cinerea 53.57 1.00e-12 63.90
IUUC-Bdi-014226 Brachypodium distachyon 37.61 5.00e-22 95.10
IUUC-Bol-015092 Brassica oleracea 40.43 7.00e-18 81.60
IUUC-Bra-017945 Brassica rapa 37.90 2.00e-19 86.30
IUUC-Cel-018466 Caenorhabditis elegans 42.57 2.00e-16 75.90
IUUC-Cja-019306 Callithrix jacchus 44.04 8.00e-20 88.20
IUUC-Cfa-020063 Canis familiaris 40.94 1.00e-21 94.00
IUUC-Cpo-021325 Cavia porcellus 38.93 4.00e-21 92.40
IUUC-Cre-022889 Chlamydomonas reinhardtii 48.89 2.00e-20 90.50
IUUC-Csa-023739 Chlorocebus sabaeus 40.46 1.00e-22 97.40
IUUC-Cho-024324 Choloepus hoffmanni 48.39 1.00e-17 81.30
IUUC-Cgl-026402 Colletotrichum gloeosporioides 39.42 3.00e-17 79.70
IUUC-Cne-027094 Cryptococcus neoformans 47.95 4.00e-18 82.40
IUUC-Cme-027112 Cyanidioschyzon merolae 37.76 6.00e-16 74.30
IUUC-Dre-028813 Danio rerio 45.00 5.00e-23 98.60
IUUC-Dno-029949 Dasypus novemcinctus 46.88 6.00e-19 84.30
IUUC-Dse-031482 Dothistroma septosporum 33.04 6.00e-16 75.10
IUUC-Dme-031608 Drosophila melanogaster 43.93 7.00e-20 88.20
IUUC-Ete-032937 Echinops telfairi 67.74 3.00e-06 42.40
IUUC-Eca-033899 Equus caballus 43.81 4.00e-19 85.50
IUUC-Fca-036579 Felis catus 51.76 1.00e-18 84.30
IUUC-Fox-037940 Fusarium oxysporum 37.40 1.00e-19 87.80
IUUC-Fso-038465 Fusarium solani 48.00 2.00e-21 93.60
IUUC-Ggr-040089 Gaeumannomyces graminis 37.50 1.00e-18 84.30
IUUC-Gga-040910 Gallus gallus 41.94 3.00e-22 95.50
IUUC-Gma-044349 Glycine max 40.17 6.00e-24 101.00
IUUC-Ggo-044854 Gorilla gorilla 43.36 3.00e-20 89.70
IUUC-Hsa-046921 Homo sapiens 43.36 2.00e-20 90.10
IUUC-Hvu-047142 Hordeum vulgare 36.97 3.00e-20 89.70
IUUC-Kpa-049187 Komagataella pastoris 37.29 5.00e-19 85.10
IUUC-Lch-050614 Latimeria chalumnae 48.48 6.00e-21 91.70
IUUC-Lpe-051184 Leersia perrieri 38.66 2.00e-22 96.70
IUUC-Loc-052083 Lepisosteus oculatus 40.68 1.00e-20 89.70
IUUC-Lma-053209 Leptosphaeria maculans 37.39 7.00e-13 64.70
IUUC-Laf-054090 Loxodonta africana 47.17 5.00e-21 92.00
IUUC-Meu-056814 Macropus eugenii 42.02 5.00e-20 88.20
IUUC-Mor-057169 Magnaporthe oryzae 46.02 1.00e-21 94.40
IUUC-Mpo-057483 Magnaporthe poae 37.19 1.00e-18 84.00
IUUC-Mtr-058166 Medicago truncatula 40.87 9.00e-20 87.80
IUUC-Mla-059015 Melampsora laricipopulina 45.00 5.00e-24 101.00
IUUC-Mvi-060356 Microbotryum violaceum 48.91 3.00e-20 89.40
IUUC-Mdo-062658 Monodelphis domestica 40.71 4.00e-21 92.80
IUUC-Mmu-063470 Mus musculus 42.11 4.00e-20 89.00
IUUC-Mac-065327 Musa acuminata 40.83 7.00e-24 101.00
IUUC-Mpu-065761 Mustela putorius furo 42.48 9.00e-19 84.00
IUUC-Mlu-067175 Myotis lucifugus 39.69 8.00e-22 94.70
IUUC-Nfi-068535 Neosartorya fischeri 34.64 1.00e-18 84.30
IUUC-Ncr-068966 Neurospora crassa 40.16 1.00e-19 87.80
IUUC-Opr-070533 Ochotona princeps 44.23 6.00e-06 41.60
IUUC-Oan-073024 Ornithorhynchus anatinus 41.90 9.00e-19 84.30
IUUC-Ocu-074451 Oryctolagus cuniculus 48.45 2.00e-19 87.40
IUUC-Oba-075540 Oryza barthii 40.00 2.00e-22 97.10
IUUC-Obr-076285 Oryza brachyantha 38.66 7.00e-22 95.10
IUUC-Ogl-077827 Oryza glaberrima 40.00 2.00e-22 97.10
IUUC-Ogu-078491 Oryza glumaepatula 40.00 2.00e-22 97.10
IUUC-Oin-080149 Oryza indica 40.54 9.00e-22 94.40
IUUC-Olo-080318 Oryza longistaminata 36.89 2.00e-19 85.90
IUUC-Oni-083037 Oryza nivara 40.00 2.00e-22 96.70
IUUC-Opu-083448 Oryza punctata 40.34 3.00e-23 99.40
IUUC-Oru-084793 Oryza rufipogon 40.00 2.00e-22 96.70
IUUC-Osa-086032 Oryza sativa 40.00 2.00e-22 96.70
IUUC-Ola-086956 Oryzias latipes 45.13 1.00e-20 90.90
IUUC-Olu-087806 Ostreococcus lucimarinus 40.57 2.00e-17 79.30
IUUC-Oga-089029 Otolemur garnettii 43.75 5.00e-20 89.00
IUUC-Oar-089471 Ovis aries 45.00 2.00e-19 87.00
IUUC-Pan-092091 Papio anubis 40.46 1.00e-22 97.40
IUUC-Psi-093193 Pelodiscus sinensis 41.09 2.00e-21 92.80
IUUC-Pma-094540 Petromyzon marinus 43.86 6.00e-21 90.50
IUUC-Pno-094873 Phaeosphaeria nodorum 36.13 1.00e-12 64.70
IUUC-Ppa-095343 Physcomitrella patens 44.94 1.00e-20 90.90
IUUC-Pfo-097093 Poecilia formosa 46.15 7.00e-23 98.20
IUUC-Pab-098781 Pongo abelii 52.54 3.00e-11 58.50
IUUC-Pop-098983 Populus trichocarpa 39.50 1.00e-23 100.00
IUUC-Pca-100872 Procavia capensis 46.99 4.00e-15 72.40
IUUC-Ppe-101711 Prunus persica 40.62 9.00e-19 84.30
IUUC-Pva-102256 Pteropus vampyrus 42.28 3.00e-20 89.40
IUUC-Pgr-103607 Puccinia graminis 42.62 8.00e-23 97.80
IUUC-Pte-104220 Pyrenophora teres 34.23 2.00e-11 59.30
IUUC-Pyt-104562 Pyrenophora triticirepentis 35.45 2.00e-11 60.10
IUUC-Rno-105021 Rattus norvegicus 38.60 6.00e-18 82.00
IUUC-Sce-106182 Saccharomyces cerevisiae 45.95 3.00e-14 69.30
IUUC-Sha-107279 Sarcophilus harrisii 41.46 1.00e-19 87.40
IUUC-Sja-107819 Schizosaccharomyces japonicus 52.27 2.00e-40 155.00
IUUC-Smo-108810 Selaginella moellendorffii 47.95 4.00e-17 77.80
IUUC-Sit-110256 Setaria italica 39.25 4.00e-21 92.80
IUUC-Sly-111448 Solanum lycopersicum 38.66 9.00e-21 90.90
IUUC-Stu-112702 Solanum tuberosum 38.66 9.00e-21 90.90
IUUC-Sbi-113956 Sorghum bicolor 39.50 8.00e-23 98.20
IUUC-Sre-115024 Sporisorium reilianum 38.41 6.00e-20 88.60
IUUC-Ssc-116034 Sus scrofa 41.53 4.00e-20 89.00
IUUC-Tgu-117503 Taeniopygia guttata 47.47 1.00e-19 86.70
IUUC-Tsy-119166 Tarsius syrichta 39.02 6.00e-03 31.60
IUUC-Tni-120703 Tetraodon nigroviridis 35.90 1.00e-09 54.30
IUUC-Tca-121473 Theobroma cacao 39.58 1.00e-18 84.00
IUUC-Tre-122241 Trichoderma reesei 41.07 2.00e-19 85.50
IUUC-Tvi-122347 Trichoderma virens 44.21 7.00e-18 81.30
IUUC-Tae-124560 Triticum aestivum 39.66 3.00e-20 89.40
IUUC-Tur-126452 Triticum urartu 34.23 9.00e-21 90.90
IUUC-Tme-127205 Tuber melanosporum 45.83 1.00e-18 82.40
IUUC-Ttr-128186 Tursiops truncatus 40.16 1.00e-18 84.00
IUUC-Uma-129523 Ustilago maydis 32.74 3.00e-19 86.30
IUUC-Vda-129793 Verticillium dahliae 43.59 6.00e-22 95.10
IUUC-Vpa-130040 Vicugna pacos 38.93 1.00e-19 86.70
IUUC-Vvi-131588 Vitis vinifera 42.71 1.00e-19 87.40
IUUC-Yli-134631 Yarrowia lipolytica 45.88 2.00e-17 80.10
IUUC-Zma-135478 Zea mays 39.50 1.00e-22 97.10
Created Date 25-Jun-2017

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