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Tag Content
iUUCD ID IUUC-Mga-059576
Ensembl Protein ID ENSMGAP00000013772.1
UniProt Accession G1NK54; G1NK54_MELGA
Protein Name Histone-lysine N-methyltransferase
Gene Name WHSC1
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMGAG00000013051.1 ENSMGAT00000014687.1 ENSMGAP00000013772.1
Status Unreviewed
Classification
Family E-Value Score Start End
E3 activity/RING/PHD 1.30e-15 57.0 838 879
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 activity/RING/PHD
   S: 3    vClvCgeggedekslveCekCrewfHpaClklsveeelpnsekwiCpkCr 52
           +C vC ++g    sl++Ce C  +fHp+Cl+++    +p+ + w+C++Cr
   Q: 838  WCFVCSKEGG---SLLCCESCPAAFHPDCLNIE----MPDGS-WYCNDCR 879
           8*******99...5*******************....9***8.******8 PP
   
Organism Meleagris gallopavo
Protein Sequence
(Fasta)
MDFSIKRSSQ LLTRKINYLK MKQVPEILGN TNGKTQNCEV NRECSVYLGK AQLSATLQEG 60
VMQKYNGHDA LPFIPADKLK DLTSRVFNGE SGAQDAKLRF EPQEIKGVGT PPNTTPIKNG 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Mga-059576|E3,PHD|Meleagris gallopavo
Please wait for a moment...
Nucleotide Sequence
(Fasta)
ATAGCAGTGT AAGACTGGAA ACATCTGGGC TGGATGGACT TTAGCATCAA AAGAAGTTCT 60
CAACTTTTAA CTCGAAAAAT TAACTACTTA AAAATGAAGC AAGTACCAGA GATCCTTGGA 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Mga-059576|E3,PHD|Meleagris gallopavo
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0181--Complete proteome
KW-0238--DNA-binding
KW-0479--Metal-binding
KW-0489--Methyltransferase
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0949--S-adenosyl-L-methionine
KW-0808--Transferase
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR006560--AWS_dom
IPR009071--HMG_box_dom
IPR003616--Post-SET_dom
IPR000313--PWWP_dom
IPR001214--SET_dom
IPR019786--Zinc_finger_PHD-type_CS
IPR011011--Znf_FYVE_PHD
IPR001965--Znf_PHD
IPR019787--Znf_PHD-finger
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
PROSITE

PS51215--AWS
PS50118--HMG_BOX_2
PS50868--POST_SET
PS50812--PWWP
PS50280--SET
PS01359--ZF_PHD_1
PS50016--ZF_PHD_2
PS50089--ZF_RING_2
Pfam

PF00505--HMG_box
PF00855--PWWP
PF00856--SET
SMART

SM00570--AWS
SM00398--HMG
SM00249--PHD
SM00508--PostSET
SM00293--PWWP
SM00184--RING
SM00317--SET
Gene Ontology

GO:0005634--C:nucleus
GO:0003682--F:chromatin binding
GO:0018024--F:histone-lysine N-methyltransferase activity
GO:0043565--F:sequence-specific DNA binding
GO:0008270--F:zinc ion binding
GO:0003289--P:atrial septum primum morphogenesis
GO:0003290--P:atrial septum secundum morphogenesis
GO:0060348--P:bone development
GO:0010452--P:histone H3-K36 methylation
GO:0034770--P:histone H4-K20 methylation
GO:0003149--P:membranous septum morphogenesis
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0048298--P:positive regulation of isotype switching to IgA isotypes
GO:2001032--P:regulation of double-strand break repair via nonhomologous end joining
GO:0070201--P:regulation of establishment of protein localization
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-002181 Ailuropoda melanoleuca 80.56 0.00e+00 2089.00
IUUC-Apl-003677 Anas platyrhynchos 95.19 0.00e+00 2504.00
IUUC-Aca-004278 Anolis carolinensis 77.57 0.00e+00 1473.00
IUUC-Ame-011932 Astyanax mexicanus 70.63 0.00e+00 1063.00
IUUC-Bta-012522 Bos taurus 76.07 0.00e+00 1964.00
IUUC-Cja-018908 Callithrix jacchus 79.20 0.00e+00 2054.00
IUUC-Cfa-020894 Canis familiaris 79.76 0.00e+00 2110.00
IUUC-Cpo-021982 Cavia porcellus 78.51 0.00e+00 2070.00
IUUC-Csa-023807 Chlorocebus sabaeus 80.13 0.00e+00 2086.00
IUUC-Cho-024405 Choloepus hoffmanni 59.54 3.00e-174 604.00
IUUC-Dre-027492 Danio rerio 73.49 0.00e+00 1110.00
IUUC-Dno-030020 Dasypus novemcinctus 76.90 0.00e+00 1801.00
IUUC-Dor-031103 Dipodomys ordii 72.53 0.00e+00 1846.00
IUUC-Ete-032488 Echinops telfairi 74.90 0.00e+00 1899.00
IUUC-Eca-034066 Equus caballus 81.44 0.00e+00 2151.00
IUUC-Eeu-035199 Erinaceus europaeus 62.08 0.00e+00 629.00
IUUC-Fca-035434 Felis catus 75.99 0.00e+00 1719.00
IUUC-Fal-037113 Ficedula albicollis 91.76 0.00e+00 2536.00
IUUC-Gmo-039686 Gadus morhua 68.38 0.00e+00 1029.00
IUUC-Gga-040273 Gallus gallus 95.56 0.00e+00 2528.00
IUUC-Gac-042123 Gasterosteus aculeatus 50.30 0.00e+00 1244.00
IUUC-Ggo-044643 Gorilla gorilla 79.84 0.00e+00 2095.00
IUUC-Hsa-046380 Homo sapiens 80.09 0.00e+00 2076.00
IUUC-Itr-048658 Ictidomys tridecemlineatus 84.72 0.00e+00 1314.00
IUUC-Lch-050217 Latimeria chalumnae 67.49 0.00e+00 1768.00
IUUC-Lpe-051201 Leersia perrieri 26.24 2.00e-11 63.90
IUUC-Loc-052766 Lepisosteus oculatus 70.20 0.00e+00 1158.00
IUUC-Laf-053780 Loxodonta africana 80.12 0.00e+00 2140.00
IUUC-Mcc-054928 Macaca mulatta 80.21 0.00e+00 2112.00
IUUC-Meu-056184 Macropus eugenii 77.58 0.00e+00 800.00
IUUC-Mla-058986 Melampsora laricipopulina 28.57 2.60e+00 26.20
IUUC-Mmr-061045 Microcebus murinus 80.33 0.00e+00 2138.00
IUUC-Mdo-062576 Monodelphis domestica 83.38 0.00e+00 2202.00
IUUC-Mmu-063640 Mus musculus 78.34 0.00e+00 2048.00
IUUC-Mac-065303 Musa acuminata 28.57 9.00e-11 61.60
IUUC-Mpu-066512 Mustela putorius furo 80.56 0.00e+00 2090.00
IUUC-Mlu-067280 Myotis lucifugus 75.39 0.00e+00 1038.00
IUUC-Nle-069896 Nomascus leucogenys 80.33 0.00e+00 2005.00
IUUC-Ont-072197 Oreochromis niloticus 73.89 0.00e+00 1048.00
IUUC-Oan-072724 Ornithorhynchus anatinus 79.42 0.00e+00 1344.00
IUUC-Ocu-074758 Oryctolagus cuniculus 77.49 0.00e+00 2008.00
IUUC-Obr-076122 Oryza brachyantha 24.64 3.00e-11 61.60
IUUC-Ogl-077641 Oryza glaberrima 25.00 9.00e-11 60.50
IUUC-Ogu-078030 Oryza glumaepatula 28.43 3.00e-13 68.90
IUUC-Oin-079557 Oryza indica 25.00 7.00e-11 60.80
IUUC-Olo-080702 Oryza longistaminata 41.01 8.00e-44 172.00
IUUC-Opu-083371 Oryza punctata 44.22 5.00e-45 176.00
IUUC-Osa-085353 Oryza sativa 25.49 8.00e-11 60.80
IUUC-Oga-088702 Otolemur garnettii 80.86 0.00e+00 1863.00
IUUC-Oar-089736 Ovis aries 70.73 0.00e+00 1739.00
IUUC-Ptr-091055 Pan troglodytes 80.01 0.00e+00 2076.00
IUUC-Pan-092752 Papio anubis 87.57 0.00e+00 1310.00
IUUC-Psi-093620 Pelodiscus sinensis 89.86 0.00e+00 2415.00
IUUC-Ppa-095277 Physcomitrella patens 28.90 4.00e-11 62.80
IUUC-Pfo-097464 Poecilia formosa 61.57 0.00e+00 1060.00
IUUC-Pab-098051 Pongo abelii 80.16 0.00e+00 2107.00
IUUC-Pop-099927 Populus trichocarpa 28.27 3.00e-11 63.90
IUUC-Pca-100273 Procavia capensis 79.14 0.00e+00 2093.00
IUUC-Ppe-101635 Prunus persica 27.47 6.00e-11 62.80
IUUC-Pva-102473 Pteropus vampyrus 70.34 0.00e+00 1750.00
IUUC-Rno-105056 Rattus norvegicus 78.77 0.00e+00 2070.00
IUUC-Sha-107494 Sarcophilus harrisii 83.64 0.00e+00 2176.00
IUUC-Sit-110333 Setaria italica 27.81 8.00e-10 58.50
IUUC-Sar-113310 Sorex araneus 79.61 0.00e+00 1627.00
IUUC-Sbi-114581 Sorghum bicolor 30.56 1.00e-08 53.10
IUUC-Ssc-116344 Sus scrofa 74.31 0.00e+00 1952.00
IUUC-Tgu-116786 Taeniopygia guttata 93.85 0.00e+00 2476.00
IUUC-Tru-117638 Takifugu rubripes 51.05 0.00e+00 1238.00
IUUC-Tsy-118937 Tarsius syrichta 84.33 0.00e+00 1380.00
IUUC-Tni-120452 Tetraodon nigroviridis 69.28 0.00e+00 1065.00
IUUC-Tae-125237 Triticum aestivum 31.54 1.00e-06 46.60
IUUC-Tbe-127291 Tupaia belangeri 77.23 0.00e+00 1335.00
IUUC-Ttr-129017 Tursiops truncatus 71.77 0.00e+00 1507.00
IUUC-Xtr-132673 Xenopus tropicalis 67.59 0.00e+00 1776.00
IUUC-Xma-133695 Xiphophorus maculatus 73.80 0.00e+00 1016.00
Created Date 25-Jun-2017

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