iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

UUCD2 ID

IUUC-Hsa-046183

UUCD1 version

UUC-HoS-01213

Ensembl Protein ID

ENSP00000346437.3

UniProt Accession

O95352; B4E170; E9PB95; Q7L8L0; Q9BWP2; Q9UFH4; ATG7_HUMAN

Genbank Protein ID

AAC69630.1; BAG64682.1; AAH00091.1; CAB59250.1

Protein Name

Ubiquitin-like modifier-activating enzyme ATG7; ATG12-activating enzyme E1 ATG7; Autophagy-related protein 7; Ubiquitin-activating enzyme E1-like protein

Genbank Nucleotide ID

AF094516; AK303694; AC020750; AL122075

Gene Name

ATG7; APG7L

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000197548.12	ENST00000418682.5	ENSP00000389012.1
ENSG00000197548.12	ENST00000446450.6	ENSP00000412580.2
ENSG00000197548.12	ENST00000354956.9	ENSP00000347042.5
ENSG00000197548.12	ENST00000354449.7	ENSP00000346437.3
ENSG00000197548.12	ENST00000424071.5	ENSP00000409844.1
ENSG00000197548.12	ENST00000414717.5	ENSP00000407340.1
ENSG00000197548.12	ENST00000427759.5	ENSP00000388295.1
ENSG00000197548.12	ENST00000446110.1	ENSP00000406398.1

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	AREsite	circBase	circRNADb
CircNet	miRTarBase	microRNA	TRANSFAC
miRWalk	TargetScan	RepTar	miRNAMap
SomamiR	miRcode	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha	InWeb_IM
Disease-associated Variation
ClinVar	GWASdb	OMIM
Drug and target
TTD
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
HPRD	UniProt	PHOSIDA	BioGRID
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
E1	36.96	3.00e-114	407.00	IUUC-Sce-106413

Active Site

Position(s)	Description	Evidence
572	Glycyl thioester intermediate	{ECO:0000250}

Organism

Homo sapiens

Functional Description
(View)

E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 as well as the ATG8 family proteins for their conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Required for autophagic death induced by caspase-8 inhibition. Required for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Modulates p53/TP53 activity to regulate cell cycle and survival during metabolic stress. Plays also a key role in the maintenance of axonal homeostasis, the prevention of axonal degeneration, the maintenance of hematopoietic stem cells, the formation of Paneth cell granules, as well as in adipose differentiation.

Protein Sequence
(Fasta)

MAAATGDPGL SKLQFAPFSS ALDVGFWHEL TQKKLNEYRL DEAPKDIKGY YYNGDSAGLP 60
ARLTLEFSAF DMSAPTPARC CPAIGTLYNT NTLESFKTAD KKLLLEQAAN EIWESIKSGT 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GGCATGCCTC TGCTCCTTTG CGCACGCGCG CCGCTTCCCA GTGGCAAGCG CGGGCAGGAC 60
CGCGTTGCGT CATCGGGGCG CGCGCCTCAG AGAGAGCTGT GGTTGCCGGA AGTTGAGCGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0007--Acetylation
KW-0025--Alternative splicing
KW-0072--Autophagy
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-0653--Protein transport
KW-1185--Reference proteome
KW-0813--Transport
KW-0833--Ubl conjugation pathway

Interpro

IPR006285--Atg7
IPR032197--Atg7_N
IPR016040--NAD(P)-bd_dom
IPR000594--ThiF_NAD_FAD-bd

Pfam

PF16420--ATG7_N
PF00899--ThiF

Gene Ontology

GO:0030424--C:axon
GO:0005930--C:axoneme
GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0005576--C:extracellular region
GO:1904813--C:ficolin-1-rich granule lumen
GO:0000407--C:pre-autophagosomal structure
GO:0034774--C:secretory granule lumen
GO:0019778--F:Atg12 activating enzyme activity
GO:0042803--F:protein homodimerization activity
GO:0008134--F:transcription factor binding
GO:0004839--F:ubiquitin activating enzyme activity
GO:0007568--P:aging
GO:0006914--P:autophagy
GO:0006464--P:cellular protein modification process
GO:0071455--P:cellular response to hyperoxia
GO:0071315--P:cellular response to morphine
GO:0009267--P:cellular response to starvation
GO:0051607--P:defense response to virus
GO:0016236--P:macroautophagy
GO:0061025--P:membrane fusion
GO:0000422--P:mitophagy
GO:0090298--P:negative regulation of mitochondrial DNA replication
GO:1903204--P:negative regulation of oxidative stress-induced neuron death
GO:0043312--P:neutrophil degranulation
GO:0043065--P:positive regulation of apoptotic process
GO:0010508--P:positive regulation of autophagy
GO:0045732--P:positive regulation of protein catabolic process
GO:0031401--P:positive regulation of protein modification process
GO:0006497--P:protein lipidation
GO:0015031--P:protein transport
GO:1902617--P:response to fluoride
GO:0009749--P:response to glucose
GO:0039521--P:suppression by virus of host autophagy

KEGG

hsa:10533

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000588	Aegilops tauschii	34.55	4.00e-102	366.00
IUUC-Aml-002316	Ailuropoda melanoleuca	95.18	0.00e+00	1209.00
IUUC-Atr-002579	Amborella trichopoda	46.07	3.00e-164	572.00
IUUC-Apl-003805	Anas platyrhynchos	84.19	0.00e+00	1215.00
IUUC-Aca-004618	Anolis carolinensis	84.80	0.00e+00	1028.00
IUUC-Aly-005670	Arabidopsis lyrata	45.24	1.00e-142	499.00
IUUC-Ath-007499	Arabidopsis thaliana	45.82	6.00e-146	511.00
IUUC-Ago-007838	Ashbya gossypii	39.04	1.00e-118	420.00
IUUC-Acl-008093	Aspergillus clavatus	41.88	5.00e-145	508.00
IUUC-Afl-008663	Aspergillus flavus	44.79	7.00e-140	491.00
IUUC-Afu-008926	Aspergillus fumigatus	39.72	2.00e-136	479.00
IUUC-Ani-009156	Aspergillus nidulans	42.62	4.00e-145	508.00
IUUC-Ang-009853	Aspergillus niger	46.47	1.00e-56	212.00
IUUC-Aor-010055	Aspergillus oryzae	41.66	6.00e-149	521.00
IUUC-Ate-010281	Aspergillus terreus	42.98	1.00e-106	380.00
IUUC-Ame-010939	Astyanax mexicanus	76.58	0.00e+00	1149.00
IUUC-Bgr-012006	Blumeria graminis	40.28	8.00e-141	494.00
IUUC-Bta-012336	Bos taurus	94.31	0.00e+00	1308.00
IUUC-Bci-013598	Botrytis cinerea	40.61	2.00e-140	493.00
IUUC-Bdi-014170	Brachypodium distachyon	35.72	1.00e-101	365.00
IUUC-Bol-015357	Brassica oleracea	45.98	1.00e-153	536.00
IUUC-Bra-016835	Brassica rapa	46.12	4.00e-154	538.00
IUUC-Cel-018172	Caenorhabditis elegans	40.35	8.00e-134	471.00
IUUC-Cja-019544	Callithrix jacchus	97.30	0.00e+00	1397.00
IUUC-Cfa-021043	Canis familiaris	95.02	0.00e+00	1367.00
IUUC-Cpo-022366	Cavia porcellus	92.59	0.00e+00	1338.00
IUUC-Cre-022945	Chlamydomonas reinhardtii	42.08	6.00e-112	398.00
IUUC-Csa-023373	Chlorocebus sabaeus	98.72	0.00e+00	1420.00
IUUC-Cho-024965	Choloepus hoffmanni	73.15	0.00e+00	648.00
IUUC-Cin-025710	Ciona intestinalis	50.07	0.00e+00	698.00
IUUC-Cgl-026542	Colletotrichum gloeosporioides	39.92	1.00e-140	493.00
IUUC-Cne-027083	Cryptococcus neoformans	41.88	7.00e-134	471.00
IUUC-Dre-028740	Danio rerio	70.85	0.00e+00	1001.00
IUUC-Dno-029637	Dasypus novemcinctus	95.09	0.00e+00	1239.00
IUUC-Dor-030492	Dipodomys ordii	95.29	0.00e+00	1373.00
IUUC-Dse-031267	Dothistroma septosporum	37.16	1.00e-135	477.00
IUUC-Dme-032084	Drosophila melanogaster	41.08	8.00e-142	497.00
IUUC-Ete-032616	Echinops telfairi	87.91	0.00e+00	1243.00
IUUC-Eca-033991	Equus caballus	95.02	0.00e+00	1360.00
IUUC-Eeu-035126	Erinaceus europaeus	90.72	2.00e-123	436.00
IUUC-Fca-035472	Felis catus	95.02	0.00e+00	1370.00
IUUC-Fal-037178	Ficedula albicollis	84.18	0.00e+00	1195.00
IUUC-Fox-037901	Fusarium oxysporum	41.44	2.00e-143	503.00
IUUC-Fso-038279	Fusarium solani	40.86	2.00e-143	502.00
IUUC-Gmo-039329	Gadus morhua	70.22	0.00e+00	978.00
IUUC-Ggr-040061	Gaeumannomyces graminis	42.42	3.00e-139	489.00
IUUC-Gga-040244	Gallus gallus	84.36	0.00e+00	1249.00
IUUC-Gac-041880	Gasterosteus aculeatus	66.80	0.00e+00	943.00
IUUC-Gma-043235	Glycine max	44.89	5.00e-157	548.00
IUUC-Ggo-045428	Gorilla gorilla	99.15	0.00e+00	1422.00
IUUC-Hvu-047509	Hordeum vulgare	35.23	5.00e-100	359.00
IUUC-Itr-048165	Ictidomys tridecemlineatus	95.85	0.00e+00	1281.00
IUUC-Kpa-049142	Komagataella pastoris	38.92	5.00e-127	448.00
IUUC-Lch-049601	Latimeria chalumnae	67.47	0.00e+00	835.00
IUUC-Lpe-051496	Leersia perrieri	34.56	4.00e-98	353.00
IUUC-Loc-051751	Lepisosteus oculatus	77.34	0.00e+00	1142.00
IUUC-Lma-053203	Leptosphaeria maculans	40.78	1.00e-117	416.00
IUUC-Laf-053424	Loxodonta africana	94.99	0.00e+00	1365.00
IUUC-Mcc-054633	Macaca mulatta	98.86	0.00e+00	1423.00
IUUC-Meu-056523	Macropus eugenii	81.79	0.00e+00	1134.00
IUUC-Mor-056983	Magnaporthe oryzae	42.39	6.00e-148	518.00
IUUC-Mpo-057615	Magnaporthe poae	43.07	6.00e-146	511.00
IUUC-Mtr-058366	Medicago truncatula	44.57	6.00e-151	528.00
IUUC-Mla-058826	Melampsora laricipopulina	44.34	2.00e-162	566.00
IUUC-Mga-059447	Meleagris gallopavo	84.51	0.00e+00	1252.00
IUUC-Mvi-060537	Microbotryum violaceum	43.61	8.00e-154	537.00
IUUC-Mmr-060676	Microcebus murinus	96.30	0.00e+00	1385.00
IUUC-Mdo-062967	Monodelphis domestica	89.86	0.00e+00	1273.00
IUUC-Mmu-063217	Mus musculus	93.00	0.00e+00	1335.00
IUUC-Mac-065527	Musa acuminata	41.41	9.00e-139	487.00
IUUC-Mpu-066417	Mustela putorius furo	94.23	0.00e+00	1337.00
IUUC-Mlu-067195	Myotis lucifugus	94.03	0.00e+00	1375.00
IUUC-Nfi-068576	Neosartorya fischeri	40.30	6.00e-145	508.00
IUUC-Ncr-068867	Neurospora crassa	41.45	6.00e-142	498.00
IUUC-Nle-069447	Nomascus leucogenys	98.90	0.00e+00	722.00
IUUC-Opr-070737	Ochotona princeps	80.94	0.00e+00	1166.00
IUUC-Ont-071260	Oreochromis niloticus	73.61	0.00e+00	1074.00
IUUC-Oan-073622	Ornithorhynchus anatinus	87.20	0.00e+00	889.00
IUUC-Ocu-074584	Oryctolagus cuniculus	94.03	0.00e+00	1382.00
IUUC-Oba-075483	Oryza barthii	34.61	9.00e-95	342.00
IUUC-Obr-076786	Oryza brachyantha	35.48	2.00e-102	367.00
IUUC-Ogl-077388	Oryza glaberrima	34.41	4.00e-93	336.00
IUUC-Ogu-078618	Oryza glumaepatula	34.76	1.00e-99	358.00
IUUC-Oin-080007	Oryza indica	34.76	7.00e-96	345.00
IUUC-Olo-080994	Oryza longistaminata	35.33	1.00e-91	331.00
IUUC-Ome-081735	Oryza meridionalis	34.61	4.00e-95	343.00
IUUC-Oni-082153	Oryza nivara	34.46	2.00e-95	343.00
IUUC-Opu-083146	Oryza punctata	34.84	6.00e-94	339.00
IUUC-Oru-084919	Oryza rufipogon	34.46	3.00e-95	343.00
IUUC-Osa-086182	Oryza sativa	34.71	8.00e-96	345.00
IUUC-Ola-086441	Oryzias latipes	74.89	0.00e+00	1087.00
IUUC-Olu-087664	Ostreococcus lucimarinus	42.86	7.00e-138	484.00
IUUC-Oga-089074	Otolemur garnettii	96.47	0.00e+00	1291.00
IUUC-Oar-090159	Ovis aries	94.38	0.00e+00	1291.00
IUUC-Ptr-091105	Pan troglodytes	98.99	0.00e+00	1194.00
IUUC-Pan-092446	Papio anubis	98.72	0.00e+00	1421.00
IUUC-Psi-093372	Pelodiscus sinensis	83.13	0.00e+00	1109.00
IUUC-Pma-094661	Petromyzon marinus	59.77	0.00e+00	712.00
IUUC-Pno-094813	Phaeosphaeria nodorum	38.65	2.00e-116	413.00
IUUC-Ppa-095224	Physcomitrella patens	43.71	2.00e-149	522.00
IUUC-Pfo-096565	Poecilia formosa	76.33	0.00e+00	1069.00
IUUC-Pop-099702	Populus trichocarpa	45.51	2.00e-167	582.00
IUUC-Pca-100324	Procavia capensis	72.01	0.00e+00	973.00
IUUC-Ppe-101416	Prunus persica	46.15	8.00e-163	567.00
IUUC-Pva-102589	Pteropus vampyrus	89.19	0.00e+00	1256.00
IUUC-Pgr-103497	Puccinia graminis	41.79	2.00e-156	546.00
IUUC-Ptt-103718	Puccinia triticina	42.72	2.00e-155	543.00
IUUC-Pte-104206	Pyrenophora teres	39.53	8.00e-110	390.00
IUUC-Pyt-104767	Pyrenophora triticirepentis	38.30	9.00e-121	427.00
IUUC-Rno-105911	Rattus norvegicus	93.27	0.00e+00	1338.00
IUUC-Sce-106413	Saccharomyces cerevisiae	37.68	2.00e-119	423.00
IUUC-Sha-106679	Sarcophilus harrisii	88.43	0.00e+00	1290.00
IUUC-Sja-107928	Schizosaccharomyces japonicus	36.57	5.00e-122	431.00
IUUC-Spo-108107	Schizosaccharomyces pombe	39.97	4.00e-124	438.00
IUUC-Ssl-108570	Sclerotinia sclerotiorum	41.82	2.00e-146	512.00
IUUC-Smo-109677	Selaginella moellendorffii	41.65	2.00e-136	479.00
IUUC-Sit-110319	Setaria italica	32.24	8.00e-82	298.00
IUUC-Sly-111215	Solanum lycopersicum	45.57	9.00e-156	544.00
IUUC-Stu-112442	Solanum tuberosum	45.92	7.00e-153	534.00
IUUC-Sar-113370	Sorex araneus	87.37	0.00e+00	685.00
IUUC-Sbi-114261	Sorghum bicolor	32.37	1.00e-88	322.00
IUUC-Sre-114997	Sporisorium reilianum	40.99	6.00e-150	524.00
IUUC-Ssc-115304	Sus scrofa	95.09	0.00e+00	1294.00
IUUC-Tgu-117235	Taeniopygia guttata	84.16	0.00e+00	1191.00
IUUC-Tru-118374	Takifugu rubripes	75.95	0.00e+00	1069.00
IUUC-Tsy-118966	Tarsius syrichta	85.43	0.00e+00	1159.00
IUUC-Tni-120269	Tetraodon nigroviridis	69.31	0.00e+00	905.00
IUUC-Tca-121245	Theobroma cacao	45.17	2.00e-161	563.00
IUUC-Tre-121966	Trichoderma reesei	41.18	7.00e-140	491.00
IUUC-Tvi-122360	Trichoderma virens	41.34	1.00e-137	483.00
IUUC-Tae-125251	Triticum aestivum	34.26	2.00e-101	363.00
IUUC-Tur-126294	Triticum urartu	34.26	1.00e-96	348.00
IUUC-Tme-127117	Tuber melanosporum	39.40	1.00e-136	480.00
IUUC-Tbe-127662	Tupaia belangeri	68.80	6.00e-144	504.00
IUUC-Ttr-129054	Tursiops truncatus	94.59	0.00e+00	1363.00
IUUC-Uma-129526	Ustilago maydis	40.73	2.00e-154	540.00
IUUC-Vda-129878	Verticillium dahliae	39.47	9.00e-138	484.00
IUUC-Vpa-130264	Vicugna pacos	74.75	0.00e+00	1028.00
IUUC-Vvi-131163	Vitis vinifera	45.43	3.00e-164	572.00
IUUC-Xtr-132328	Xenopus tropicalis	54.64	0.00e+00	673.00
IUUC-Xma-133015	Xiphophorus maculatus	73.59	0.00e+00	1033.00
IUUC-Yli-134468	Yarrowia lipolytica	37.81	8.00e-119	421.00
IUUC-Zma-134871	Zea mays	32.76	9.00e-98	352.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence