iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Mdo-062005

UUCD1 version

UUC-MoD-00867

Ensembl Protein ID

ENSMODP00000008018.3

UniProt Accession

F7FGS3; F7FGS3_MONDO

Protein Name

Uncharacterized protein

Gene Name

FBXW11

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMODG00000006464.3	ENSMODT00000008181.3	ENSMODP00000008018.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	1.80e-58	192.0	409	443
UBD/Beta-Prp	6.30e-69	232.6	323	487

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclafsd.tllvsGsdDgtikvWDlrtgvl 35
           gH++ v+c++f d +++vsG++Dg+ikvWDl    +
   Q: 409  GHEELVRCIRF-DnKRIVSGAYDGKIKVWDLQAALD 443
           8**********.44****************977665 PP

UBD/Beta-Prp

   S: 44   llrslsgheaevtavkfspdgkilvtgseDrtikvwdlstgkcvhtlkghedsvlslsfspsgdklvsGshdrtirvwdletgqcleet 132
           l r l gh a+v+ v+f+++  ++v++s Drtikvw+ st++ v+tl+gh++ + +l++      +vsGs+d+tir+wd+e g cl+ +
   Q: 323  LRRVLVGHRAAVNVVDFDDK--YIVSASGDRTIKVWSTSTCEFVRTLNGHKRGIACLQYRD--RLVVSGSSDNTIRLWDIECGACLR-V 406
           445579*************9..8**************************************..************************.* PP
   S: 133  lsghdgvvncvvvhpdgnllvsGslDrtvrlWdl.........ktgkllrtltgghtdsvyslsfdsngkelvsgsldgtvklwdl 209
           l+gh+++v+c++++   + +vsG++D+++++Wdl         ++  +lrtl + h ++v  l+fd+  ++++s s+d t+ +wd+
   Q: 407  LEGHEELVRCIRFDN--KRIVSGAYDGKIKVWDLqaaldprapASTLCLRTLVE-HSGRVFRLQFDE--FQIISSSHDDTILIWDF 487
           **************9..***********************************99.************..99**************7 PP

Organism

Monodelphis domestica

Protein Sequence
(Fasta)

MEDQNEDESP KKNTLWQISN GTSSVIVSRK RPSEGNYQKE KDLCIKYFDQ WSESDQVEFV 60
EHLISRMCHY QHGHINSYLK PMLQRDFITA LPEQGLDHIA ENILSYLDAR SLCAAELVCK 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AATGGAAAAA TTCAGTATAA TCAAAATAAC CTTTTTCTCC CTTAGAACAC ATCAGTTATG 60
GAGGATCAGA ATGAAGATGA GTCCCCAAAG AAAAATACAC TATGGCAGGT AGGAGCAATG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0853--WD repeat

Interpro

IPR021977--Beta-TrCP_D
IPR001810--F-box_dom
IPR020472--G-protein_beta_WD-40_rep
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS50181--FBOX
PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF12125--Beta-TrCP_D
PF12937--F-box-like
PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM01028--Beta-TrCP_D
SM00256--FBOX
SM00320--WD40

Gene Ontology

GO:0005813--C:centrosome
GO:0005829--C:cytosol
GO:0005634--C:nucleus
GO:0019005--C:SCF ubiquitin ligase complex
GO:0061630--F:ubiquitin protein ligase activity
GO:0042347--P:negative regulation of NF-kappaB import into nucleus
GO:0045892--P:negative regulation of transcription, DNA-templated
GO:0042753--P:positive regulation of circadian rhythm
GO:0045862--P:positive regulation of proteolysis
GO:0045893--P:positive regulation of transcription, DNA-templated
GO:0006470--P:protein dephosphorylation
GO:0031648--P:protein destabilization
GO:0000209--P:protein polyubiquitination
GO:0031146--P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001397	Ailuropoda melanoleuca	99.39	0.00e+00	1016.00
IUUC-Apl-003449	Anas platyrhynchos	99.22	0.00e+00	1048.00
IUUC-Aca-004341	Anolis carolinensis	98.87	0.00e+00	913.00
IUUC-Ame-011393	Astyanax mexicanus	90.59	0.00e+00	958.00
IUUC-Bta-012920	Bos taurus	99.22	0.00e+00	1050.00
IUUC-Cja-018879	Callithrix jacchus	99.39	0.00e+00	1016.00
IUUC-Cfa-020021	Canis familiaris	99.39	0.00e+00	1016.00
IUUC-Cpo-022151	Cavia porcellus	99.02	0.00e+00	1043.00
IUUC-Csa-024095	Chlorocebus sabaeus	99.41	0.00e+00	1051.00
IUUC-Cho-024658	Choloepus hoffmanni	99.07	7.00e-126	444.00
IUUC-Dre-028160	Danio rerio	90.50	0.00e+00	960.00
IUUC-Dno-029485	Dasypus novemcinctus	88.72	0.00e+00	920.00
IUUC-Dor-030498	Dipodomys ordii	98.99	0.00e+00	1011.00
IUUC-Eca-033804	Equus caballus	99.39	0.00e+00	1015.00
IUUC-Fca-035887	Felis catus	99.41	0.00e+00	1053.00
IUUC-Fal-036783	Ficedula albicollis	99.41	0.00e+00	1053.00
IUUC-Gmo-038590	Gadus morhua	91.70	0.00e+00	933.00
IUUC-Gga-040628	Gallus gallus	99.22	0.00e+00	1050.00
IUUC-Gac-041305	Gasterosteus aculeatus	91.30	0.00e+00	935.00
IUUC-Ggo-044604	Gorilla gorilla	99.39	0.00e+00	1016.00
IUUC-Hsa-046139	Homo sapiens	99.39	0.00e+00	1016.00
IUUC-Lch-050460	Latimeria chalumnae	96.67	0.00e+00	1028.00
IUUC-Laf-053968	Loxodonta africana	99.41	0.00e+00	1052.00
IUUC-Mcc-055822	Macaca mulatta	96.19	0.00e+00	1040.00
IUUC-Mga-059225	Meleagris gallopavo	99.02	0.00e+00	1043.00
IUUC-Mvi-060284	Microbotryum violaceum	44.65	5.00e-69	256.00
IUUC-Mmr-060746	Microcebus murinus	99.39	0.00e+00	1016.00
IUUC-Mmu-063851	Mus musculus	98.63	0.00e+00	1045.00
IUUC-Mpu-065716	Mustela putorius furo	99.41	0.00e+00	1052.00
IUUC-Mlu-067001	Myotis lucifugus	99.41	0.00e+00	1051.00
IUUC-Nle-069788	Nomascus leucogenys	99.39	0.00e+00	1015.00
IUUC-Opr-071229	Ochotona princeps	99.19	0.00e+00	1015.00
IUUC-Ont-071792	Oreochromis niloticus	91.90	0.00e+00	943.00
IUUC-Oan-072782	Ornithorhynchus anatinus	99.41	0.00e+00	1053.00
IUUC-Ocu-074894	Oryctolagus cuniculus	99.41	0.00e+00	1052.00
IUUC-Ola-086985	Oryzias latipes	90.62	0.00e+00	959.00
IUUC-Oga-088604	Otolemur garnettii	93.54	0.00e+00	1034.00
IUUC-Oar-090412	Ovis aries	99.41	0.00e+00	1052.00
IUUC-Ptr-091039	Pan troglodytes	99.19	0.00e+00	1015.00
IUUC-Pan-092770	Papio anubis	99.39	0.00e+00	1004.00
IUUC-Psi-093887	Pelodiscus sinensis	99.02	0.00e+00	1044.00
IUUC-Pno-094808	Phaeosphaeria nodorum	29.05	2.00e-44	174.00
IUUC-Pfo-096783	Poecilia formosa	90.62	0.00e+00	961.00
IUUC-Pva-102547	Pteropus vampyrus	99.19	0.00e+00	1010.00
IUUC-Rno-105246	Rattus norvegicus	98.63	0.00e+00	1046.00
IUUC-Sha-107339	Sarcophilus harrisii	100.00	0.00e+00	1056.00
IUUC-Sja-107743	Schizosaccharomyces japonicus	34.97	1.00e-73	270.00
IUUC-Spo-108200	Schizosaccharomyces pombe	32.22	2.00e-67	249.00
IUUC-Tgu-116541	Taeniopygia guttata	99.22	0.00e+00	1048.00
IUUC-Tru-117671	Takifugu rubripes	90.04	0.00e+00	952.00
IUUC-Tni-120359	Tetraodon nigroviridis	90.43	0.00e+00	950.00
IUUC-Tbe-127418	Tupaia belangeri	92.71	0.00e+00	931.00
IUUC-Ttr-129131	Tursiops truncatus	99.39	0.00e+00	1016.00
IUUC-Vpa-130668	Vicugna pacos	99.39	0.00e+00	1016.00
IUUC-Xma-133187	Xiphophorus maculatus	95.36	9.00e-159	552.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence