iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Bta-013024

Ensembl Protein ID

ENSBTAP00000004279.3

UniProt Accession

O77774; Q5E9R8; NCF1_BOVIN

Genbank Protein ID

AAC82462.1; AAX08869.1; AAX31363.1; AAI03146.1

Protein Name

Neutrophil cytosol factor 1; 47 kDa neutrophil oxidase factor; NCF-47K; Neutrophil NADPH oxidase factor 1; p47-phox

Genbank Nucleotide ID

AF079302; BT020852; BT021181; BC103145

Gene Name

NCF1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSBTAG00000003305.3	ENSBTAT00000004279.3	ENSBTAP00000004279.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/SH3	9.30e-17	60.9	161	214

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 6    vqvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvekle 63
            +++ dye  ++  + l  Gdvv+v+  e+++ gW+ +  + ++krG +P+ + e l+
   Q: 161  YRAIADYEKGSSSQMALATGDVVDVV--EKNESGWWFC--QMKTKRGWVPASYLEPLD 214
           678889********************..999*******..7************99886 PP

Organism

Bos taurus

Functional Description
(View)

NCF2, NCF1, and a membrane bound cytochrome b558 are required for activation of the latent NADPH oxidase (necessary for superoxide production).

Protein Sequence
(Fasta)

MGDHFIRHIA LLGFEKRFVP SQHYVYMFLV KWQDLSEKVV YRRFTEIYEF HKILKEMFPI 60
EAGDINPENR IIPHLPAPRW YDGQRVAESR QGTLTEYCST LMSLPVKISR CPHLLNFFKV 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TGGAGGAGAG GGTGCCGTGT GCAGCCGAGC CATGGGGGAC CACTTCATCC GCCACATTGC 60
CCTCCTGGGC TTCGAGAAGC GCTTCGTCCC CAGCCAGCAC TACGTGAGTA CCTGCCGGCT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0446--Lipid-binding
KW-0472--Membrane
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0728--SH3 domain

Interpro

IPR015039--NADPH_oxidase_p47Phox_C
IPR032136--NECFESHC
IPR001655--P47PHOX
IPR001683--Phox
IPR001452--SH3_domain

PROSITE

PS50195--PX
PS50002--SH3

Pfam

PF16621--NECFESHC
PF08944--p47_phox_C
PF00787--PX
PF00018--SH3_1

PRINTS

PR00498--P47PHOX
PR00452--SH3DOMAIN

SMART

SM00312--PX
SM00326--SH3

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0019898--C:extrinsic component of membrane
GO:0016020--C:membrane
GO:0043020--C:NADPH oxidase complex
GO:0002102--C:podosome
GO:0035091--F:phosphatidylinositol binding
GO:0043325--F:phosphatidylinositol-3,4-bisphosphate binding
GO:0016176--F:superoxide-generating NADPH oxidase activator activity
GO:0016175--F:superoxide-generating NADPH oxidase activity
GO:0055114--P:oxidation-reduction process
GO:0071800--P:podosome assembly
GO:0006612--P:protein targeting to membrane
GO:0042554--P:superoxide anion generation
GO:0006801--P:superoxide metabolic process

KEGG

bta:281345

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001307	Ailuropoda melanoleuca	85.71	0.00e+00	662.00
IUUC-Apl-003633	Anas platyrhynchos	68.03	2.00e-160	558.00
IUUC-Ame-011567	Astyanax mexicanus	57.83	1.00e-128	452.00
IUUC-Cja-019026	Callithrix jacchus	84.26	0.00e+00	677.00
IUUC-Cfa-020704	Canis familiaris	86.73	0.00e+00	664.00
IUUC-Cpo-021794	Cavia porcellus	81.17	0.00e+00	672.00
IUUC-Csa-023617	Chlorocebus sabaeus	84.44	0.00e+00	681.00
IUUC-Dre-027789	Danio rerio	53.58	3.00e-124	438.00
IUUC-Dno-029091	Dasypus novemcinctus	65.17	3.00e-95	341.00
IUUC-Dor-030695	Dipodomys ordii	73.03	3.00e-87	315.00
IUUC-Dse-031169	Dothistroma septosporum	43.10	4.00e-08	55.10
IUUC-Eeu-035337	Erinaceus europaeus	78.36	1.00e-147	515.00
IUUC-Fca-035712	Felis catus	74.60	6.00e-160	556.00
IUUC-Fal-036697	Ficedula albicollis	68.37	4.00e-171	593.00
IUUC-Gmo-039060	Gadus morhua	48.61	6.00e-90	324.00
IUUC-Gga-040325	Gallus gallus	67.78	7.00e-166	576.00
IUUC-Gac-042580	Gasterosteus aculeatus	54.55	1.00e-115	409.00
IUUC-Hsa-046017	Homo sapiens	85.24	0.00e+00	683.00
IUUC-Itr-048254	Ictidomys tridecemlineatus	85.24	0.00e+00	704.00
IUUC-Lch-050575	Latimeria chalumnae	58.71	3.00e-136	478.00
IUUC-Loc-052607	Lepisosteus oculatus	48.93	6.00e-123	434.00
IUUC-Mcc-054644	Macaca mulatta	84.69	0.00e+00	683.00
IUUC-Mga-059367	Meleagris gallopavo	67.86	5.00e-168	583.00
IUUC-Mmr-061698	Microcebus murinus	85.28	0.00e+00	654.00
IUUC-Mdo-061949	Monodelphis domestica	75.13	1.00e-176	612.00
IUUC-Mmu-063793	Mus musculus	80.45	0.00e+00	681.00
IUUC-Mpu-066081	Mustela putorius furo	79.13	0.00e+00	630.00
IUUC-Ont-072602	Oreochromis niloticus	55.83	2.00e-131	461.00
IUUC-Ocu-073838	Oryctolagus cuniculus	61.60	6.00e-119	420.00
IUUC-Ola-086427	Oryzias latipes	52.97	1.00e-116	413.00
IUUC-Oga-088639	Otolemur garnettii	88.55	0.00e+00	685.00
IUUC-Oar-089376	Ovis aries	92.66	0.00e+00	681.00
IUUC-Ptr-090689	Pan troglodytes	85.50	0.00e+00	685.00
IUUC-Pan-092800	Papio anubis	84.69	0.00e+00	683.00
IUUC-Psi-093746	Pelodiscus sinensis	69.64	6.00e-174	603.00
IUUC-Pfo-096204	Poecilia formosa	52.62	4.00e-115	408.00
IUUC-Pab-098062	Pongo abelii	83.92	0.00e+00	639.00
IUUC-Pca-100793	Procavia capensis	85.03	0.00e+00	686.00
IUUC-Pva-102363	Pteropus vampyrus	81.93	1.00e-176	612.00
IUUC-Pgr-103429	Puccinia graminis	32.22	3.00e-06	47.40
IUUC-Ptt-103749	Puccinia triticina	32.22	2.00e-06	48.10
IUUC-Rno-105704	Rattus norvegicus	83.42	0.00e+00	683.00
IUUC-Sha-107450	Sarcophilus harrisii	74.20	0.00e+00	631.00
IUUC-Ssc-115354	Sus scrofa	86.48	0.00e+00	684.00
IUUC-Tgu-117439	Taeniopygia guttata	72.55	4.00e-139	487.00
IUUC-Tru-118215	Takifugu rubripes	53.58	8.00e-127	446.00
IUUC-Tni-120011	Tetraodon nigroviridis	55.31	7.00e-131	460.00
IUUC-Ttr-128852	Tursiops truncatus	76.54	3.00e-144	504.00
IUUC-Xtr-132894	Xenopus tropicalis	61.44	2.00e-147	515.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence