iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Details
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

iUUCD ID

IUUC-Hsa-046664

UUCD1 version

UUC-HoS-01196

Ensembl Protein ID

ENSP00000272930.4

UniProt Accession

Q969M7; A8K1Z8; B4DDT9; B4DFI1; B4DMK3; B4DZU2; B8ZZG2; C9J212; H9KVB9; UBE2F_HUMAN

Genbank Protein ID

AAL26792.1; BAF82752.1; BAG56850.1; BAG57442.1; BAG59915.1; BAG64204.1; AAY24220.1; EAW71129.1; EAW71132.1; AAH10549.1

Protein Name

NEDD8-conjugating enzyme UBE2F; NEDD8 carrier protein UBE2F; NEDD8 protein ligase UBE2F; NEDD8-conjugating enzyme 2; RING-type E3 NEDD8 transferase UBE2F; Ubiquitin-conjugating enzyme E2 F

Genbank Nucleotide ID

AF310723; AK290063; AK293334; AK294107; AK297502; AK303094; AC016776; CH471063; CH471063; BC010549

Gene Name

UBE2F; NCE2

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000184182.18	ENST00000440223.5	ENSP00000412965.1
ENSG00000184182.18	ENST00000441728.6	ENSP00000409749.2
ENSG00000184182.18	ENST00000272930.8	ENSP00000272930.4
ENSG00000184182.18	ENST00000433568.5	ENSP00000410867.1
ENSG00000184182.18	ENST00000448502.5	ENSP00000396003.1
ENSG00000184182.18	ENST00000409633.5	ENSP00000387299.1
ENSG00000184182.18	ENST00000455999.5	ENSP00000389685.1
ENSG00000184182.18	ENST00000417231.5	ENSP00000408823.1
ENSG00000184182.18	ENST00000445676.5	ENSP00000396296.1
ENSG00000184182.18	ENST00000439338.5	ENSP00000410345.1
ENSG00000184182.18	ENST00000439780.5	ENSP00000396630.1
ENSG00000184182.18	ENST00000433241.5	ENSP00000393515.1
ENSG00000184182.18	ENST00000409953.5	ENSP00000386680.1
ENSG00000184182.18	ENST00000409332.5	ENSP00000387060.1
ENSG00000184182.18	ENST00000434137.2	ENSP00000414619.2
ENSG00000184182.18	ENST00000414443.5	ENSP00000399183.1

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	AREsite	circBase	circRNADb
CircNet	miRTarBase	microRNA	TRANSFAC
miRWalk	TargetScan	RepTar	miRNAMap
miRcode	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha	InWeb_IM
Protein 3D Structure
PDB	MMDB
Disease-associated Information
GWASdb
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
HPRD	UniProt	PHOSIDA	BioGRID
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E2/UBC	E2_UBC	19940261

Classification

Family	E-value	Score	Start	End
E2/UBC	8.50e-37	127.7	37	177

Active Site

Position(s)	Description	Evidence
116	Glycyl thioester intermediate	{ECO:0000255\|PROSITE-ProRule:PRU00388, ECO:0000255\|PROSITE-ProRule:PRU10133}

Domain Profile

E2/UBC

   S: 2    lkkelkelekdppegisakpvdesdltewevlilGpedtpYeggvFkleiefpedYPfkPPkvkfltkifhPnvyenGkvClsilk....ee 89
           l ke++ele++ p ++++++ d ++l+ ++++++ p++ +Y+gg+F++e e+p+ Y++ PPkvk+ltki+hPn++e+G++Cls+l+    + 
   Q: 37   LVKEVAELEANLPCTCKVHFPDPNKLHCFQLTVT-PDEGYYQGGKFQFETEVPDAYNMVPPKVKCLTKIWHPNITETGEICLSLLRehsiDG 127
           679********************99*********.**************************************************7778889 PP
   S: 90   ekWspalsvesvllsiqsllae.pnpesplneeaaellkknreeykkkvr 138
           + W p+ ++++v+++++sl+++  n+++pln eaae++ +++e++++kv+
   Q: 128  TGWAPTRTLKDVVWGLNSLFTDlLNFDDPLNIEAAEHHLRDKEDFRNKVD 177
           9*******************8879***********************995 PP

Organism

Homo sapiens

Functional Description
(View)

Accepts the ubiquitin-like protein NEDD8 from the UBA3-NAE1 E1 complex and catalyzes its covalent attachment to other proteins. The specific interaction with the E3 ubiquitin ligase RBX2, but not RBX1, suggests that the RBX2-UBE2F complex neddylates specific target proteins, such as CUL5.

Protein Sequence
(Fasta)

MLTLASKLKR DDGLKGSRTA ATASDSTRRV SVRDKLLVKE VAELEANLPC TCKVHFPDPN 60
KLHCFQLTVT PDEGYYQGGK FQFETEVPDA YNMVPPKVKC LTKIWHPNIT ETGEICLSLL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TGGCCGCGCC CTCTGCCAAT GAGCGAGGTC CGAGAGGCCC GTCGCCCAGC CCAGTCCCGA 60
TCGGCGCACG CCGCTGTTCG CGTGTCTGGT TCCAAATAAA GTTTTTCGCG ACTTTGAATT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0007--Acetylation
KW-0025--Alternative splicing
KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000608--UBQ-conjugat_E2
IPR023313--UBQ-conjugating_AS
IPR016135--UBQ-conjugating_enzyme/RWD

PROSITE

PS00183--UBIQUITIN_CONJUGAT_1
PS50127--UBIQUITIN_CONJUGAT_2

Pfam

PF00179--UQ_con

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005524--F:ATP binding
GO:0019788--F:NEDD8 transferase activity
GO:0061630--F:ubiquitin protein ligase activity
GO:0031625--F:ubiquitin protein ligase binding
GO:0045116--P:protein neddylation

KEGG

hsa:140739

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001473	Ailuropoda melanoleuca	97.30	2.00e-93	334.00
IUUC-Apl-003569	Anas platyrhynchos	85.71	3.00e-48	182.00
IUUC-Aca-005152	Anolis carolinensis	90.81	2.00e-98	351.00
IUUC-Ame-011839	Astyanax mexicanus	80.00	4.00e-89	320.00
IUUC-Bta-013524	Bos taurus	97.30	7.00e-94	335.00
IUUC-Cel-018579	Caenorhabditis elegans	58.27	1.00e-35	142.00
IUUC-Cja-019211	Callithrix jacchus	99.46	4.00e-97	346.00
IUUC-Cfa-020014	Canis familiaris	97.30	2.00e-93	334.00
IUUC-Cpo-022479	Cavia porcellus	99.46	4.00e-97	346.00
IUUC-Cho-024583	Choloepus hoffmanni	67.57	5.00e-63	233.00
IUUC-Cin-025378	Ciona intestinalis	50.00	8.00e-53	199.00
IUUC-Csv-026195	Ciona savignyi	51.37	9.00e-51	192.00
IUUC-Dre-028671	Danio rerio	82.16	7.00e-91	326.00
IUUC-Dno-029004	Dasypus novemcinctus	98.92	2.00e-108	384.00
IUUC-Dor-030940	Dipodomys ordii	97.84	4.00e-96	343.00
IUUC-Eca-034345	Equus caballus	97.84	7.00e-94	335.00
IUUC-Fca-036125	Felis catus	97.30	2.00e-93	334.00
IUUC-Fal-036808	Ficedula albicollis	92.43	1.00e-101	361.00
IUUC-Gmo-039394	Gadus morhua	90.27	9.00e-61	224.00
IUUC-Gga-041269	Gallus gallus	88.17	2.00e-94	338.00
IUUC-Gac-041480	Gasterosteus aculeatus	82.70	2.00e-89	320.00
IUUC-Ggo-045010	Gorilla gorilla	100.00	4.00e-109	386.00
IUUC-Itr-048522	Ictidomys tridecemlineatus	97.30	8.00e-96	342.00
IUUC-Loc-052137	Lepisosteus oculatus	84.32	3.00e-92	330.00
IUUC-Laf-053694	Loxodonta africana	95.68	4.00e-97	347.00
IUUC-Mcc-055638	Macaca mulatta	100.00	4.00e-109	386.00
IUUC-Meu-056568	Macropus eugenii	77.84	7.00e-81	292.00
IUUC-Mga-059437	Meleagris gallopavo	93.51	6.00e-102	362.00
IUUC-Mmr-060651	Microcebus murinus	95.00	1.00e-90	325.00
IUUC-Mdo-061993	Monodelphis domestica	93.51	1.00e-101	362.00
IUUC-Mmu-064372	Mus musculus	96.76	9.00e-96	342.00
IUUC-Mpu-066423	Mustela putorius furo	96.76	3.00e-93	333.00
IUUC-Mlu-067910	Myotis lucifugus	96.76	3.00e-93	333.00
IUUC-Nle-069032	Nomascus leucogenys	99.46	4.00e-97	346.00
IUUC-Opr-070798	Ochotona princeps	98.38	2.00e-107	380.00
IUUC-Ont-071232	Oreochromis niloticus	83.24	4.00e-90	323.00
IUUC-Oan-072779	Ornithorhynchus anatinus	92.56	5.00e-66	242.00
IUUC-Ocu-074366	Oryctolagus cuniculus	94.05	3.00e-104	370.00
IUUC-Ola-087548	Oryzias latipes	88.14	1.00e-61	228.00
IUUC-Oga-089149	Otolemur garnettii	99.46	3.00e-99	353.00
IUUC-Oar-089662	Ovis aries	97.30	7.00e-94	335.00
IUUC-Ptr-090895	Pan troglodytes	100.00	4.00e-109	386.00
IUUC-Pan-092771	Papio anubis	99.46	1.00e-107	381.00
IUUC-Psi-093582	Pelodiscus sinensis	92.43	2.00e-101	360.00
IUUC-Pma-094321	Petromyzon marinus	84.96	3.00e-67	246.00
IUUC-Pfo-096040	Poecilia formosa	84.32	2.00e-91	327.00
IUUC-Pab-097931	Pongo abelii	100.00	4.00e-109	386.00
IUUC-Pca-100697	Procavia capensis	96.55	3.00e-84	303.00
IUUC-Pva-102609	Pteropus vampyrus	96.22	2.00e-94	337.00
IUUC-Rno-105622	Rattus norvegicus	96.22	9.00e-96	342.00
IUUC-Sha-107614	Sarcophilus harrisii	92.47	2.00e-100	357.00
IUUC-Ssc-115597	Sus scrofa	95.14	2.00e-95	341.00
IUUC-Tgu-117397	Taeniopygia guttata	92.97	4.00e-102	363.00
IUUC-Tru-118496	Takifugu rubripes	81.62	5.00e-88	316.00
IUUC-Tsy-119592	Tarsius syrichta	98.92	7.00e-99	352.00
IUUC-Tni-119759	Tetraodon nigroviridis	81.62	3.00e-88	317.00
IUUC-Tbe-128085	Tupaia belangeri	81.48	1.00e-61	228.00
IUUC-Ttr-129228	Tursiops truncatus	96.22	5.00e-93	333.00
IUUC-Xtr-131773	Xenopus tropicalis	90.51	6.00e-62	229.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence