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Tag Content
UUCD2 ID IUUC-Ocu-074544
UUCD1 version UUC-OrC-00969
Ensembl Protein ID ENSOCUP00000007237.2
UniProt Accession G1SV13; G1SV13_RABIT
Genbank Protein ID ENSOCUP00000007237
Protein Name Ubiquitin-like modifier-activating enzyme 1
Genbank Nucleotide ID AAGW02040303
Gene Name UBA1
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSOCUG00000008376.3 ENSOCUT00000008378.3 ENSOCUP00000007237.2
Status Unreviewed
Classification
Family E-Value Score Start End
E1 3.10e-238 790.8 451 931
Active Site
Position(s) Description Evidence
632 Glycyl thioester intermediate {ECO:0000256|PROSITE-ProRule:PRU10132}
Domain Profile

   E1
   S: 1    YDRQirlwGeeaqeklksakvllvGagglGcEllKnLvlaGv.....gsitvvDmdtvevsnlnrqFLfraedvgksKAevaaealkel 84
           YD+Q++++G++ qekl+++k++lvGag++GcEllKn++++G+     g+i v+Dmdt+e+snlnrqFLfr++dv k K+++aa+a++++
   Q: 451  YDGQVAVFGSDLQEKLGRQKYFLVGAGAIGCELLKNFAMIGLgcgenGEIIVTDMDTIEKSNLNRQFLFRPWDVTKLKSDTAAAAVHQM 539
           ***************************************************************************************** PP
   S: 85   npdvnveaheesiteleeeiv...FfkkfdvVvlaldnrearrkvnrlclnarvpliesgtlGllGqvrviikgltecyscsddppqkt 170
           np+++v++h++++ +++e+i+   Ff+++d+V++aldn++ar++++r+c+++r+pl+esgtlG++G+v+v+i+ lte+ys+s+dpp+k+
   Q: 540  NPHIRVTSHQNRVGPDTERIYdddFFQTLDGVANALDNVDARMYMDRRCVYYRKPLLESGTLGTKGNVQVVIPFLTESYSSSQDPPEKS 628
           ***************************************************************************************** PP
   S: 171  iPfctlketpnaaehtiewa............vlfnklleeeageeevlekldseekeegkdkvkselksedeenfeeaieiavkafak 247
           iP+ctlk++pna+eht++wa            + +n++l ++++++e++ +l+ ++++e++++v+++l+ ++++++++++++a++++++
   Q: 629  IPICTLKNFPNAIEHTLQWArdefeglfkqpaENVNQYL-TDPKFVERTLRLAGTQPLEVLEAVQRSLVLQRPQSWADCVTWACHHWHT 716
           ***************************************.999999******************************************* PP
   S: 248  ttinsikqllksfecdivtkskspfwv..........................................sfcsnaealqvp........ 286
           +++n+i+qll++f++d++t+s++pfw+                                           + ++ +++qvp        
   Q: 717  QYSNNIRQLLHNFPPDQLTSSGAPFWSgpkrcphpltfdvsnplhldyvmaaanlfaqtyglagsqdraAVATLLQSVQVPeftpksgv 805
           *****************************************************************999966666666666655555555 PP
   S: 287  ekvekdeevvkasap.....lylllralerfekkkgrkpgelsfekddds..avdlvtaaanlraeslgiepkldddlikeiagniipa 368
           + +++d+e ++a+a+     l+ l+++l + +k +g k++ ++fekddds  ++d++ aa+nlrae+++i+p +d+++ k iag+iipa
   Q: 806  KIHVSDQELQSANASvddsrLEELKATLPSPDKLPGFKMYPIDFEKDDDSnfHMDFIVAASNLRAENYDIPP-ADRHKSKLIAGKIIPA 893
           66666666666666688889****************************************************.**************** PP
   S: 369  iattnavvgGlaaqEviKvvsg..kfeplknfflfdae 404
           iatt+a+v Gl+++E++Kvv+g  + + +kn fl++a+
   Q: 894  IATTTAAVVGLVCLELYKVVQGhrHLDSYKNGFLNLAL 931
           **********************99999*******9875 PP
   
Organism Oryctolagus cuniculus
Protein Sequence
(Fasta)
MSSSPLSKKR RVSGPDPKPG SNCSPAQSVL PQVPSAPTNG MAKNGSEADI DEGLYSRQLY 60
VLGHEAMKRL QTSSVLVSGL RGLGVEIAKN IILGGVKAVT LHDQGTAQWA DLSSQFYLRE 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Ocu-074544|E1,E1_ThiF|Oryctolagus cuniculus
Please wait for a moment...
Nucleotide Sequence
(Fasta)
ATGTCCAGCT CGCCGCTGTC CAAGAAACGT CGCGTGTCCG GGCCTGATCC AAAGCCGGGT 60
TCTAACTGCT CCCCTGCCCA GTCCGTGTTG CCCCAAGTGC CCTCGGCGCC AACCAACGTG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Ocu-074544|E1,E1_ThiF|Oryctolagus cuniculus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0436--Ligase
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway
Interpro

IPR032420--E1_4HB
IPR032418--E1_FCCH
IPR016040--NAD(P)-bd_dom
IPR000594--ThiF_NAD_FAD-bd
IPR018965--Ub-activating_enz_E1_C
IPR019572--UBA_E1_Cys
IPR018075--UBQ-activ_enz_E1
IPR018074--UBQ-activ_enz_E1_CS
IPR033127--UBQ-activ_enz_E1_Cys_AS
IPR000011--UBQ/SUMO-activ_enz_E1-like
PROSITE

PS00536--UBIQUITIN_ACTIVAT_1
PS00865--UBIQUITIN_ACTIVAT_2
Pfam

PF16191--E1_4HB
PF16190--E1_FCCH
PF09358--E1_UFD
PF00899--ThiF
PF10585--UBA_e1_thiolCys
PRINTS

PR01849--UBIQUITINACT
SMART

SM00985--UBA_e1_C
Gene Ontology

GO:0005829--C:cytosol
GO:0030057--C:desmosome
GO:0010008--C:endosome membrane
GO:0070062--C:extracellular exosome
GO:0000792--C:heterochromatin
GO:0005765--C:lysosomal membrane
GO:0005739--C:mitochondrion
GO:0005654--C:nucleoplasm
GO:0030867--C:rough endoplasmic reticulum membrane
GO:0005524--F:ATP binding
GO:0003723--F:RNA binding
GO:0004839--F:ubiquitin activating enzyme activity
GO:0006974--P:cellular response to DNA damage stimulus
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000367 Aegilops tauschii 46.51 0.00e+00 872.00
IUUC-Aml-001311 Ailuropoda melanoleuca 95.29 0.00e+00 2073.00
IUUC-Atr-002684 Amborella trichopoda 45.54 0.00e+00 904.00
IUUC-Aca-004620 Anolis carolinensis 80.94 0.00e+00 1796.00
IUUC-Aly-005515 Arabidopsis lyrata 46.13 0.00e+00 922.00
IUUC-Ath-006891 Arabidopsis thaliana 46.62 0.00e+00 930.00
IUUC-Ago-007873 Ashbya gossypii 54.19 0.00e+00 1065.00
IUUC-Acl-008181 Aspergillus clavatus 54.40 0.00e+00 1081.00
IUUC-Afl-008455 Aspergillus flavus 54.23 0.00e+00 1042.00
IUUC-Afu-009065 Aspergillus fumigatus 54.15 0.00e+00 1098.00
IUUC-Ani-009371 Aspergillus nidulans 53.97 0.00e+00 1066.00
IUUC-Ang-009737 Aspergillus niger 54.42 0.00e+00 1083.00
IUUC-Aor-010007 Aspergillus oryzae 54.23 0.00e+00 1042.00
IUUC-Ate-010466 Aspergillus terreus 54.16 0.00e+00 1109.00
IUUC-Ame-010933 Astyanax mexicanus 79.04 0.00e+00 1695.00
IUUC-Bgr-012281 Blumeria graminis 53.92 0.00e+00 1091.00
IUUC-Bta-012767 Bos taurus 95.75 0.00e+00 2089.00
IUUC-Bci-013721 Botrytis cinerea 54.41 0.00e+00 1036.00
IUUC-Bdi-014843 Brachypodium distachyon 46.12 0.00e+00 884.00
IUUC-Bol-015665 Brassica oleracea 44.79 0.00e+00 911.00
IUUC-Bra-017252 Brassica rapa 44.81 0.00e+00 915.00
IUUC-Cel-018260 Caenorhabditis elegans 50.05 0.00e+00 962.00
IUUC-Cja-019152 Callithrix jacchus 96.41 0.00e+00 2099.00
IUUC-Cfa-020622 Canis familiaris 93.95 0.00e+00 2001.00
IUUC-Cpo-022526 Cavia porcellus 96.12 0.00e+00 2072.00
IUUC-Cre-022702 Chlamydomonas reinhardtii 45.50 0.00e+00 851.00
IUUC-Csa-023780 Chlorocebus sabaeus 96.50 0.00e+00 2097.00
IUUC-Cho-024896 Choloepus hoffmanni 85.77 1.00e-115 411.00
IUUC-Cin-025790 Ciona intestinalis 63.57 0.00e+00 1368.00
IUUC-Csv-026084 Ciona savignyi 60.87 0.00e+00 1346.00
IUUC-Cgl-026512 Colletotrichum gloeosporioides 54.02 0.00e+00 1106.00
IUUC-Cne-026960 Cryptococcus neoformans 56.23 0.00e+00 1131.00
IUUC-Cme-027290 Cyanidioschyzon merolae 44.40 0.00e+00 838.00
IUUC-Dre-028149 Danio rerio 79.04 0.00e+00 1724.00
IUUC-Dno-028884 Dasypus novemcinctus 95.65 0.00e+00 2090.00
IUUC-Dor-030229 Dipodomys ordii 91.12 0.00e+00 1972.00
IUUC-Dse-031524 Dothistroma septosporum 52.65 0.00e+00 1082.00
IUUC-Dme-032045 Drosophila melanogaster 61.02 0.00e+00 1284.00
IUUC-Ete-032544 Echinops telfairi 83.43 0.00e+00 868.00
IUUC-Eca-033330 Equus caballus 96.22 0.00e+00 2096.00
IUUC-Fca-036255 Felis catus 96.69 0.00e+00 2081.00
IUUC-Fal-037445 Ficedula albicollis 48.04 0.00e+00 902.00
IUUC-Fox-038007 Fusarium oxysporum 53.68 3.00e-167 582.00
IUUC-Fso-038339 Fusarium solani 54.05 0.00e+00 1065.00
IUUC-Gmo-039338 Gadus morhua 75.91 0.00e+00 1623.00
IUUC-Ggr-039823 Gaeumannomyces graminis 54.63 0.00e+00 1133.00
IUUC-Gga-040365 Gallus gallus 47.72 0.00e+00 824.00
IUUC-Gac-041773 Gasterosteus aculeatus 76.48 0.00e+00 1630.00
IUUC-Gma-043198 Glycine max 44.71 0.00e+00 888.00
IUUC-Ggo-045336 Gorilla gorilla 97.07 0.00e+00 2086.00
IUUC-Hsa-045982 Homo sapiens 96.88 0.00e+00 2081.00
IUUC-Hvu-047418 Hordeum vulgare 46.13 0.00e+00 889.00
IUUC-Itr-048460 Ictidomys tridecemlineatus 96.69 0.00e+00 2104.00
IUUC-Kpa-049112 Komagataella pastoris 51.33 0.00e+00 1016.00
IUUC-Lch-050371 Latimeria chalumnae 80.36 0.00e+00 1784.00
IUUC-Lpe-051299 Leersia perrieri 45.14 0.00e+00 904.00
IUUC-Loc-052936 Lepisosteus oculatus 80.64 0.00e+00 1763.00
IUUC-Lma-053315 Leptosphaeria maculans 53.43 0.00e+00 1105.00
IUUC-Laf-053948 Loxodonta africana 93.10 0.00e+00 2025.00
IUUC-Mcc-055843 Macaca mulatta 96.79 0.00e+00 2107.00
IUUC-Meu-056258 Macropus eugenii 87.52 0.00e+00 1917.00
IUUC-Mor-057269 Magnaporthe oryzae 54.58 0.00e+00 1109.00
IUUC-Mpo-057435 Magnaporthe poae 54.59 0.00e+00 1096.00
IUUC-Mtr-058572 Medicago truncatula 44.88 0.00e+00 874.00
IUUC-Mla-059176 Melampsora laricipopulina 56.14 0.00e+00 1109.00
IUUC-Mvi-060437 Microbotryum violaceum 53.97 0.00e+00 1081.00
IUUC-Mmr-061405 Microcebus murinus 94.33 0.00e+00 2038.00
IUUC-Mdo-062032 Monodelphis domestica 86.41 0.00e+00 1899.00
IUUC-Mmu-063280 Mus musculus 94.33 0.00e+00 2046.00
IUUC-Mac-065505 Musa acuminata 45.92 0.00e+00 890.00
IUUC-Mpu-066409 Mustela putorius furo 96.12 0.00e+00 2100.00
IUUC-Mlu-067217 Myotis lucifugus 94.14 0.00e+00 2054.00
IUUC-Nfi-068407 Neosartorya fischeri 54.45 0.00e+00 1076.00
IUUC-Ncr-068698 Neurospora crassa 55.35 0.00e+00 1118.00
IUUC-Nle-070072 Nomascus leucogenys 91.64 0.00e+00 1962.00
IUUC-Ont-071671 Oreochromis niloticus 78.68 0.00e+00 1701.00
IUUC-Oba-075120 Oryza barthii 46.09 0.00e+00 895.00
IUUC-Obr-076557 Oryza brachyantha 46.49 0.00e+00 886.00
IUUC-Ogl-077887 Oryza glaberrima 46.09 0.00e+00 897.00
IUUC-Ogu-078305 Oryza glumaepatula 44.90 0.00e+00 898.00
IUUC-Oin-080154 Oryza indica 44.90 0.00e+00 897.00
IUUC-Olo-081089 Oryza longistaminata 44.90 0.00e+00 897.00
IUUC-Ome-081942 Oryza meridionalis 46.09 0.00e+00 895.00
IUUC-Oni-082365 Oryza nivara 45.99 0.00e+00 897.00
IUUC-Opu-083977 Oryza punctata 46.31 0.00e+00 897.00
IUUC-Oru-084469 Oryza rufipogon 45.00 0.00e+00 901.00
IUUC-Osa-085949 Oryza sativa 46.29 0.00e+00 906.00
IUUC-Ola-087002 Oryzias latipes 78.39 0.00e+00 1698.00
IUUC-Olu-087687 Ostreococcus lucimarinus 44.21 0.00e+00 824.00
IUUC-Oga-088594 Otolemur garnettii 96.32 0.00e+00 2067.00
IUUC-Oar-090068 Ovis aries 95.56 0.00e+00 2084.00
IUUC-Pan-092114 Papio anubis 96.88 0.00e+00 2108.00
IUUC-Pma-094214 Petromyzon marinus 58.14 4.00e-53 200.00
IUUC-Pno-095154 Phaeosphaeria nodorum 53.64 0.00e+00 1106.00
IUUC-Ppa-095227 Physcomitrella patens 46.04 0.00e+00 914.00
IUUC-Pfo-097184 Poecilia formosa 78.30 0.00e+00 1692.00
IUUC-Pab-097861 Pongo abelii 96.79 0.00e+00 2070.00
IUUC-Pop-098934 Populus trichocarpa 45.37 0.00e+00 931.00
IUUC-Pca-100347 Procavia capensis 90.42 0.00e+00 1634.00
IUUC-Ppe-102012 Prunus persica 44.54 0.00e+00 906.00
IUUC-Pva-102584 Pteropus vampyrus 96.31 0.00e+00 2115.00
IUUC-Pgr-103336 Puccinia graminis 54.16 0.00e+00 1061.00
IUUC-Ptt-103939 Puccinia triticina 54.26 0.00e+00 1063.00
IUUC-Pte-104200 Pyrenophora teres 53.74 0.00e+00 1105.00
IUUC-Pyt-104441 Pyrenophora triticirepentis 52.63 0.00e+00 1093.00
IUUC-Rno-105462 Rattus norvegicus 95.37 0.00e+00 2047.00
IUUC-Sce-106245 Saccharomyces cerevisiae 51.55 0.00e+00 1083.00
IUUC-Sha-107142 Sarcophilus harrisii 87.43 0.00e+00 1934.00
IUUC-Sja-107841 Schizosaccharomyces japonicus 55.61 0.00e+00 1147.00
IUUC-Spo-108034 Schizosaccharomyces pombe 54.26 0.00e+00 1087.00
IUUC-Ssl-108497 Sclerotinia sclerotiorum 54.49 0.00e+00 1059.00
IUUC-Smo-109211 Selaginella moellendorffii 46.02 0.00e+00 896.00
IUUC-Sit-110281 Setaria italica 46.44 0.00e+00 911.00
IUUC-Sly-110914 Solanum lycopersicum 45.28 0.00e+00 915.00
IUUC-Stu-112109 Solanum tuberosum 45.29 0.00e+00 921.00
IUUC-Sar-113737 Sorex araneus 94.90 0.00e+00 2064.00
IUUC-Sbi-114089 Sorghum bicolor 45.24 0.00e+00 909.00
IUUC-Sre-115148 Sporisorium reilianum 55.11 0.00e+00 1102.00
IUUC-Ssc-115777 Sus scrofa 96.41 0.00e+00 2096.00
IUUC-Tru-118742 Takifugu rubripes 78.01 0.00e+00 1642.00
IUUC-Tni-120401 Tetraodon nigroviridis 77.82 0.00e+00 1636.00
IUUC-Tca-121672 Theobroma cacao 44.89 0.00e+00 911.00
IUUC-Tre-122009 Trichoderma reesei 54.02 0.00e+00 1056.00
IUUC-Tvi-122259 Trichoderma virens 53.20 0.00e+00 1040.00
IUUC-Tae-125113 Triticum aestivum 46.51 0.00e+00 872.00
IUUC-Tur-126189 Triticum urartu 46.37 0.00e+00 871.00
IUUC-Tme-127055 Tuber melanosporum 53.52 0.00e+00 1023.00
IUUC-Tbe-127487 Tupaia belangeri 94.96 0.00e+00 1037.00
IUUC-Ttr-128331 Tursiops truncatus 95.56 0.00e+00 2068.00
IUUC-Uma-129387 Ustilago maydis 55.19 0.00e+00 1099.00
IUUC-Vda-129977 Verticillium dahliae 53.67 0.00e+00 1016.00
IUUC-Vvi-130857 Vitis vinifera 45.42 0.00e+00 912.00
IUUC-Xtr-132026 Xenopus tropicalis 63.79 0.00e+00 1281.00
IUUC-Xma-133805 Xiphophorus maculatus 77.82 0.00e+00 1664.00
IUUC-Yli-134547 Yarrowia lipolytica 53.95 0.00e+00 1112.00
IUUC-Zma-135052 Zea mays 46.38 0.00e+00 916.00
Created Date 25-Jun-2017

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