iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Laf-053397

UUCD1 version

UUC-LoA-00588

Ensembl Protein ID

ENSLAFP00000014271.2

UniProt Accession

G3TI24; G3TI24_LOXAF

Protein Name

Nitric oxide synthase-interacting protein

Gene Name

NOSIP

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSLAFG00000017025.2	ENSLAFT00000017024.2	ENSLAFP00000014271.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/U-box	6.30e-16	58.6	40	79

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/U-box

   S: 2    vpeeflCpIslelMrdPvvlpsGitydrssIekwlasggk 41
           v ++ +C +sl++ +dPvv+p+G+ y+r++I +++ +++k
   Q: 40   VKDFDCCCLSLQPCHDPVVTPDGYLYEREAILEYILHQKK 79
           567789*****************************98887 PP

Organism

Loxodonta africana

Functional Description
(View)

Negatively regulates nitric oxide production by inducing NOS1 and NOS3 translocation to actin cytoskeleton and inhibiting their enzymatic activity.

Protein Sequence
(Fasta)

MTRHGKNCTA GAVYTYHEKK KDTAASGYGT QNIRLSRDAV KDFDCCCLSL QPCHDPVVTP 60
DGYLYEREAI LEYILHQKKE IARQMKAYEK QRGARREEQK ELQRAAAQDQ VRGFLEKEAA 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGACACGAC ATGGCAAGAA CTGCACGGCA GGTGCTGTCT ACACCTACCA CGAGAAGAAG 60
AAGGACACAG GTACTGAGCA GGGGCCTCCA GGGAGCCACT GGGGACAGGA AGGGCGAATG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0539--Nucleus
KW-1185--Reference proteome

Interpro

IPR016818--Nitric_oxide_synth-interacting
IPR031790--Znf-NOSIP
IPR013083--Znf_RING/FYVE/PHD

Pfam

PF15906--zf-NOSIP

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005634--C:nucleus
GO:0003723--F:RNA binding
GO:0051001--P:negative regulation of nitric-oxide synthase activity

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000769	Aegilops tauschii	46.51	1.00e-16	81.30
IUUC-Aml-002069	Ailuropoda melanoleuca	91.14	1.00e-163	568.00
IUUC-Atr-002661	Amborella trichopoda	32.99	2.00e-31	129.00
IUUC-Aca-004630	Anolis carolinensis	75.58	5.00e-136	476.00
IUUC-Aly-006316	Arabidopsis lyrata	30.42	5.00e-30	124.00
IUUC-Ath-007000	Arabidopsis thaliana	30.29	2.00e-29	122.00
IUUC-Acl-008175	Aspergillus clavatus	34.51	2.00e-06	47.00
IUUC-Afl-008440	Aspergillus flavus	34.75	1.00e-06	47.40
IUUC-Afu-009012	Aspergillus fumigatus	35.65	5.00e-07	48.90
IUUC-Ani-009153	Aspergillus nidulans	30.40	2.00e-03	36.60
IUUC-Ang-009556	Aspergillus niger	34.75	1.00e-06	47.80
IUUC-Aor-009892	Aspergillus oryzae	34.75	1.00e-06	47.40
IUUC-Ate-010473	Aspergillus terreus	30.43	7.00e-05	42.70
IUUC-Ame-011874	Astyanax mexicanus	64.29	4.00e-109	387.00
IUUC-Bgr-012090	Blumeria graminis	26.62	4.00e-07	48.50
IUUC-Bta-012956	Bos taurus	95.39	4.00e-169	586.00
IUUC-Bci-013897	Botrytis cinerea	42.50	7.00e-10	58.20
IUUC-Bdi-014968	Brachypodium distachyon	30.64	2.00e-34	139.00
IUUC-Bol-015578	Brassica oleracea	30.62	6.00e-34	137.00
IUUC-Bra-017234	Brassica rapa	30.62	6.00e-34	137.00
IUUC-Cel-018637	Caenorhabditis elegans	40.80	1.00e-57	216.00
IUUC-Cja-019632	Callithrix jacchus	93.07	5.00e-167	579.00
IUUC-Cfa-020192	Canis familiaris	93.73	4.00e-167	580.00
IUUC-Cpo-021939	Cavia porcellus	88.78	3.00e-155	540.00
IUUC-Cre-023005	Chlamydomonas reinhardtii	35.90	9.00e-44	170.00
IUUC-Csa-023802	Chlorocebus sabaeus	93.40	5.00e-167	579.00
IUUC-Cho-024637	Choloepus hoffmanni	78.34	3.00e-85	307.00
IUUC-Cin-025180	Ciona intestinalis	51.15	2.00e-83	301.00
IUUC-Csv-026206	Ciona savignyi	53.74	4.00e-42	163.00
IUUC-Cgl-026696	Colletotrichum gloeosporioides	25.21	2.00e-13	69.70
IUUC-Cne-026827	Cryptococcus neoformans	29.00	6.00e-08	51.60
IUUC-Dre-028092	Danio rerio	64.80	8.00e-116	409.00
IUUC-Dno-029501	Dasypus novemcinctus	88.82	1.00e-142	499.00
IUUC-Dor-030542	Dipodomys ordii	91.42	2.00e-164	571.00
IUUC-Dse-031188	Dothistroma septosporum	24.44	9.00e-14	70.90
IUUC-Dme-031734	Drosophila melanogaster	48.43	5.00e-80	290.00
IUUC-Eca-033577	Equus caballus	96.37	1.00e-172	598.00
IUUC-Fca-035761	Felis catus	95.05	5.00e-169	586.00
IUUC-Fox-037703	Fusarium oxysporum	26.29	5.00e-14	71.60
IUUC-Fso-038208	Fusarium solani	27.53	1.00e-14	73.60
IUUC-Gmo-038523	Gadus morhua	61.14	5.00e-62	229.00
IUUC-Ggr-040087	Gaeumannomyces graminis	41.03	6.00e-10	58.20
IUUC-Gac-042621	Gasterosteus aculeatus	61.01	3.00e-108	384.00
IUUC-Gma-042698	Glycine max	31.40	6.00e-33	134.00
IUUC-Ggo-045357	Gorilla gorilla	94.06	4.00e-168	583.00
IUUC-Hsa-046195	Homo sapiens	94.06	4.00e-168	583.00
IUUC-Hvu-047174	Hordeum vulgare	30.98	3.00e-35	141.00
IUUC-Itr-048487	Ictidomys tridecemlineatus	93.40	5.00e-161	559.00
IUUC-Lch-050569	Latimeria chalumnae	65.81	2.00e-112	398.00
IUUC-Lpe-050992	Leersia perrieri	35.44	9.00e-24	104.00
IUUC-Loc-052522	Lepisosteus oculatus	69.87	2.00e-115	408.00
IUUC-Lma-053254	Leptosphaeria maculans	39.24	1.00e-09	57.40
IUUC-Mcc-054681	Macaca mulatta	93.40	3.00e-167	580.00
IUUC-Meu-056723	Macropus eugenii	83.50	4.00e-151	526.00
IUUC-Mor-056961	Magnaporthe oryzae	37.27	3.00e-10	59.30
IUUC-Mpo-057359	Magnaporthe poae	23.78	1.00e-07	50.10
IUUC-Mtr-058063	Medicago truncatula	32.31	2.00e-34	139.00
IUUC-Mla-059004	Melampsora laricipopulina	30.25	2.00e-26	112.00
IUUC-Mvi-060460	Microbotryum violaceum	29.46	2.00e-26	112.00
IUUC-Mmr-060847	Microcebus murinus	94.72	1.00e-168	585.00
IUUC-Mdo-062480	Monodelphis domestica	84.49	5.00e-153	533.00
IUUC-Mmu-063809	Mus musculus	91.42	1.00e-162	565.00
IUUC-Mac-064870	Musa acuminata	31.74	4.00e-34	138.00
IUUC-Mpu-066322	Mustela putorius furo	96.70	9.00e-174	602.00
IUUC-Mlu-067556	Myotis lucifugus	92.11	9.00e-159	552.00
IUUC-Nfi-068440	Neosartorya fischeri	35.65	4.00e-07	48.90
IUUC-Ncr-068898	Neurospora crassa	38.46	9.00e-08	51.20
IUUC-Nle-070049	Nomascus leucogenys	93.73	1.00e-167	582.00
IUUC-Opr-070972	Ochotona princeps	89.18	2.00e-155	541.00
IUUC-Ont-071682	Oreochromis niloticus	65.56	7.00e-115	406.00
IUUC-Oan-073296	Ornithorhynchus anatinus	98.31	1.00e-32	131.00
IUUC-Ocu-074218	Oryctolagus cuniculus	90.43	3.00e-133	467.00
IUUC-Oba-075284	Oryza barthii	31.86	1.00e-34	140.00
IUUC-Obr-076651	Oryza brachyantha	32.08	9.00e-37	147.00
IUUC-Ogl-077899	Oryza glaberrima	31.86	1.00e-34	140.00
IUUC-Ogu-078477	Oryza glumaepatula	32.54	2.00e-35	142.00
IUUC-Oin-080011	Oryza indica	31.86	1.00e-34	140.00
IUUC-Olo-080545	Oryza longistaminata	31.42	9.00e-28	117.00
IUUC-Ome-081543	Oryza meridionalis	31.86	1.00e-34	140.00
IUUC-Oni-082955	Oryza nivara	31.86	1.00e-34	140.00
IUUC-Opu-083565	Oryza punctata	31.86	1.00e-34	140.00
IUUC-Oru-084474	Oryza rufipogon	31.86	1.00e-34	140.00
IUUC-Osa-085913	Oryza sativa	31.86	1.00e-34	140.00
IUUC-Ola-086851	Oryzias latipes	65.68	3.00e-119	421.00
IUUC-Olu-087724	Ostreococcus lucimarinus	33.01	6.00e-12	64.70
IUUC-Oga-087970	Otolemur garnettii	92.43	4.00e-164	570.00
IUUC-Oar-089756	Ovis aries	91.80	3.00e-157	547.00
IUUC-Ptr-091485	Pan troglodytes	92.74	2.00e-164	570.00
IUUC-Pan-091832	Papio anubis	93.73	1.00e-167	582.00
IUUC-Pma-094551	Petromyzon marinus	63.19	4.00e-108	384.00
IUUC-Pno-094830	Phaeosphaeria nodorum	27.23	9.00e-09	53.90
IUUC-Ppa-095255	Physcomitrella patens	30.00	8.00e-32	130.00
IUUC-Pfo-096373	Poecilia formosa	65.36	7.00e-117	412.00
IUUC-Pab-098247	Pongo abelii	94.06	4.00e-168	583.00
IUUC-Pop-099186	Populus trichocarpa	31.19	2.00e-32	132.00
IUUC-Pca-100677	Procavia capensis	91.70	1.00e-141	494.00
IUUC-Ppe-101403	Prunus persica	30.61	1.00e-32	133.00
IUUC-Pva-103000	Pteropus vampyrus	95.38	7.00e-171	592.00
IUUC-Pgr-103663	Puccinia graminis	30.37	2.00e-30	126.00
IUUC-Ptt-103712	Puccinia triticina	40.00	5.00e-09	54.70
IUUC-Pte-104287	Pyrenophora teres	26.06	3.00e-17	82.40
IUUC-Pyt-104579	Pyrenophora triticirepentis	26.24	6.00e-10	58.20
IUUC-Rno-106069	Rattus norvegicus	91.75	2.00e-163	567.00
IUUC-Sha-106553	Sarcophilus harrisii	84.49	4.00e-154	536.00
IUUC-Smo-108874	Selaginella moellendorffii	32.24	3.00e-38	151.00
IUUC-Sit-110307	Setaria italica	31.86	2.00e-33	135.00
IUUC-Sly-111094	Solanum lycopersicum	32.88	2.00e-34	139.00
IUUC-Stu-112363	Solanum tuberosum	32.56	4.00e-34	138.00
IUUC-Sar-113480	Sorex araneus	92.41	6.00e-157	546.00
IUUC-Sbi-113939	Sorghum bicolor	31.86	3.00e-34	138.00
IUUC-Ssc-115644	Sus scrofa	96.04	2.00e-171	594.00
IUUC-Tru-118781	Takifugu rubripes	64.50	5.00e-118	417.00
IUUC-Tni-119672	Tetraodon nigroviridis	73.56	2.00e-34	136.00
IUUC-Tca-121795	Theobroma cacao	32.33	2.00e-36	145.00
IUUC-Tre-122037	Trichoderma reesei	36.36	2.00e-08	53.10
IUUC-Tvi-122524	Trichoderma virens	27.49	7.00e-17	81.30
IUUC-Tae-122828	Triticum aestivum	31.31	2.00e-35	142.00
IUUC-Tur-126387	Triticum urartu	31.27	9.00e-29	121.00
IUUC-Tme-127111	Tuber melanosporum	40.00	1.00e-09	57.00
IUUC-Ttr-128227	Tursiops truncatus	94.06	8.00e-167	578.00
IUUC-Vda-129924	Verticillium dahliae	27.50	3.00e-15	75.90
IUUC-Vpa-130802	Vicugna pacos	97.75	1.00e-45	176.00
IUUC-Vvi-131105	Vitis vinifera	33.11	3.00e-35	141.00
IUUC-Xtr-132830	Xenopus tropicalis	65.53	1.00e-123	435.00
IUUC-Xma-133618	Xiphophorus maculatus	65.79	3.00e-110	390.00
IUUC-Zma-135389	Zea mays	31.51	2.00e-33	136.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence