iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMMUG00000015097.3	ENSMMUT00000021155.3	ENSMMUP00000019781.2
ENSMMUG00000015097.3	ENSMMUT00000059423.1	ENSMMUP00000059924.1
ENSMMUG00000015097.3	ENSMMUT00000065441.1	ENSMMUP00000049086.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/RING	4.90e-08	34.5	11	54
E3 activity/RING/U-box	1.60e-06	29.2	6	75

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 1    CaiCledfkdgplvlpCgHvfhadCl.qkwpglknssskefrCPlCr 46
           C+iCl+ ++d p++l+C H f++ C+ ++w+ +   ++++  CP Cr
   Q: 11   CSICLSIYQD-PVSLGCEHYFCRRCItEHWVRQE--AQGARDCPECR 54
           **********.*******************5555..**********8 PP

E3 activity/RING/U-box

   S: 3    peeflCpIslelMrdPvvlpsGitydrssIekwl....asggktcPvtrqplteedlvPnltlrrliqaw 68
            +e+lC+I l + +dPv l + + + r++I ++     a+g + cP +r++++e  l P+l l ++++++
   Q: 6    KDELLCSICLSIYQDPVSLGCEHYFCRRCITEHWvrqeAQGARDCPECRRTFAEPALAPSLKLANIVERY 75
           689***************************9888455444444*******************99999887 PP

Organism

Macaca mulatta

Protein Sequence
(Fasta)

MACSLKDELL CSICLSIYQD PVSLGCEHYF CRRCITEHWV RQEAQGARDC PECRRTFAEP 60
ALAPSLKLAN IVERYSAFPL DAILNARRAA RPCQAHDKVK LFCLTDRALL CFFCDEPALH 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GGCTGGTTCC GGGTTGAGAG GCTGCGCTGG ACCGAAGCGG TGGCTGCTAA GCCCGCGGGG 60
GTAAGGGTCC GCGCTGGGCC AGGGTTTGGG GCCGGGATCC GGCAGCTGAG CGGGCCGGCA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001870--B30.2/SPRY
IPR003879--Butyrophylin
IPR013320--ConA-like_dom
IPR006574--PRY
IPR003877--SPRY_dom
IPR000315--Znf_B-box
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS

PROSITE

PS50188--B302_SPRY
PS50119--ZF_BBOX
PS00518--ZF_RING_1
PS50089--ZF_RING_2

Pfam

PF13765--PRY
PF00622--SPRY
PF00643--zf-B_box

PRINTS

PR01407--BUTYPHLNCDUF

SMART

SM00589--PRY
SM00184--RING
SM00449--SPRY

Gene Ontology

GO:0005737--C:cytoplasm
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0045087--P:innate immune response
GO:0010719--P:negative regulation of epithelial to mesenchymal transition
GO:0032897--P:negative regulation of viral transcription
GO:0043123--P:positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0051092--P:positive regulation of NF-kappaB transcription factor activity
GO:0046596--P:regulation of viral entry into host cell
GO:1902186--P:regulation of viral release from host cell

KEGG

mcc:709927

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002199	Ailuropoda melanoleuca	100.00	0.00e+00	956.00
IUUC-Apl-003767	Anas platyrhynchos	88.26	0.00e+00	801.00
IUUC-Aca-004412	Anolis carolinensis	84.31	0.00e+00	819.00
IUUC-Ame-010927	Astyanax mexicanus	83.16	0.00e+00	852.00
IUUC-Bta-012927	Bos taurus	99.79	0.00e+00	955.00
IUUC-Cja-019317	Callithrix jacchus	93.47	0.00e+00	866.00
IUUC-Cfa-020292	Canis familiaris	99.71	0.00e+00	702.00
IUUC-Cpo-022274	Cavia porcellus	99.71	0.00e+00	706.00
IUUC-Csa-023042	Chlorocebus sabaeus	100.00	0.00e+00	956.00
IUUC-Dre-028493	Danio rerio	81.89	0.00e+00	843.00
IUUC-Dno-030029	Dasypus novemcinctus	95.37	0.00e+00	896.00
IUUC-Dor-031051	Dipodomys ordii	97.14	0.00e+00	905.00
IUUC-Ete-032752	Echinops telfairi	98.35	1.00e-108	386.00
IUUC-Eca-033898	Equus caballus	79.33	0.00e+00	827.00
IUUC-Eeu-034659	Erinaceus europaeus	100.00	1.00e-84	305.00
IUUC-Fca-035492	Felis catus	91.19	0.00e+00	888.00
IUUC-Fal-036867	Ficedula albicollis	88.15	0.00e+00	854.00
IUUC-Gmo-038916	Gadus morhua	82.53	0.00e+00	820.00
IUUC-Gga-040360	Gallus gallus	90.53	0.00e+00	879.00
IUUC-Gac-041871	Gasterosteus aculeatus	83.16	0.00e+00	853.00
IUUC-Ggo-044411	Gorilla gorilla	93.08	0.00e+00	880.00
IUUC-Hsa-047025	Homo sapiens	99.37	0.00e+00	984.00
IUUC-Itr-047905	Ictidomys tridecemlineatus	100.00	0.00e+00	956.00
IUUC-Loc-052114	Lepisosteus oculatus	84.63	0.00e+00	865.00
IUUC-Laf-054359	Loxodonta africana	94.16	0.00e+00	676.00
IUUC-Meu-056027	Macropus eugenii	75.79	0.00e+00	724.00
IUUC-Mga-060146	Meleagris gallopavo	84.30	4.00e-75	273.00
IUUC-Mmr-060822	Microcebus murinus	99.79	0.00e+00	954.00
IUUC-Mdo-062117	Monodelphis domestica	78.71	0.00e+00	645.00
IUUC-Mmu-064086	Mus musculus	99.79	0.00e+00	955.00
IUUC-Mpu-066378	Mustela putorius furo	100.00	0.00e+00	956.00
IUUC-Mlu-067155	Myotis lucifugus	98.94	0.00e+00	967.00
IUUC-Nle-069464	Nomascus leucogenys	99.58	0.00e+00	953.00
IUUC-Opr-071058	Ochotona princeps	98.64	2.00e-133	469.00
IUUC-Ont-071253	Oreochromis niloticus	74.48	0.00e+00	730.00
IUUC-Oan-073614	Ornithorhynchus anatinus	93.67	1.00e-94	337.00
IUUC-Ola-086794	Oryzias latipes	83.37	0.00e+00	848.00
IUUC-Oga-088889	Otolemur garnettii	99.37	0.00e+00	952.00
IUUC-Oar-089203	Ovis aries	96.02	0.00e+00	844.00
IUUC-Ptr-090795	Pan troglodytes	99.58	0.00e+00	986.00
IUUC-Pfo-096942	Poecilia formosa	82.74	0.00e+00	842.00
IUUC-Pab-097936	Pongo abelii	86.35	0.00e+00	634.00
IUUC-Pca-100397	Procavia capensis	98.53	0.00e+00	944.00
IUUC-Ppe-101916	Prunus persica	30.97	3.00e-10	61.20
IUUC-Pva-102293	Pteropus vampyrus	99.41	0.00e+00	689.00
IUUC-Rno-105551	Rattus norvegicus	99.58	0.00e+00	951.00
IUUC-Sre-115193	Sporisorium reilianum	45.83	4.00e-07	50.40
IUUC-Ssc-115983	Sus scrofa	100.00	0.00e+00	956.00
IUUC-Tgu-117279	Taeniopygia guttata	75.06	0.00e+00	655.00
IUUC-Tru-118238	Takifugu rubripes	82.95	0.00e+00	847.00
IUUC-Tni-119788	Tetraodon nigroviridis	61.12	5.00e-158	550.00
IUUC-Uma-129518	Ustilago maydis	45.83	4.00e-07	50.40
IUUC-Xtr-132768	Xenopus tropicalis	75.25	0.00e+00	731.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence