iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Mpu-065983

Ensembl Protein ID

ENSMPUP00000009924.1

UniProt Accession

M3YF17; M3YF17_MUSPF

Genbank Protein ID

ENSMPUP00000009924

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AEYP01028357

Gene Name

UBR1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMPUG00000009999.1	ENSMPUT00000010084.1	ENSMPUP00000009924.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/RING	1.50e-08	35.0	1101	1204
E3 activity/N-recognin/N-domain	1.50e-40	137.2	226	302
E3 activity/N-recognin/UBR-box	1.50e-30	105.6	97	167

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 1    CaiCledf...............kd..............................gplvlpCgHvfhadClqkw............. 29
           C++C+e+                ++                              g+++++CgHv+ha C+qk+             
   Q: 1101 CILCQEEQevkiennamvlsacvQKstaltqnrgkpielsgeivdplfmdpdlayGTYTGSCGHVMHAVCWQKYfeavqlssqqrih 1187
           78885555444433333333333003333333333333333333333333333337999**************************** PP
   S: 30   pglknssskefrCPlCr 46
           ++l +++s+e +CPlC+
   Q: 1188 VDLFDLESGEYLCPLCK 1204
           ****************7 PP

E3 activity/N-recognin/N-domain

   S: 1    YylvLfNDEkHsyeqviyslqkAleleqkeakkfatiidkeGRravkaGdyavceeakkeilknseklaqipLkVev 77
           Yy+vLfNDE+Hsy++viyslq+Al++e++ea++++t+idkeGRravkaG++a+c+eak++i+++se+++q+pL+Vev
   Q: 226  YYCVLFNDEHHSYDHVIYSLQRALDCELAEAQLHTTAIDKEGRRAVKAGAFAACQEAKEDIKSHSENVSQHPLHVEV 302
           9**************************************************************************97 PP

E3 activity/N-recognin/UBR-box

   S: 1    slCgrvfkvgetiyeCrtCsvdetlvlCteCfakvvHkdHeyklkksggggfCdCGdteAwedgskCkkll 71
           +lCg+vfk+get+y+Cr+C++d+t+vlC++Cf+++vHk+H+yk+++s+gggfCdCGdteAw++g++C++++
   Q: 97   QLCGKVFKSGETTYSCRDCAIDPTCVLCMDCFQNSVHKNHRYKMHTSTGGGFCDCGDTEAWKTGPFCVSHE 167
           68*****************************************************************9986 PP

Organism

Mustela putorius furo

Protein Sequence
(Fasta)

MADEEAGGAE RMEVSTELPQ TPQLLASWWD QQVDFYTTFL HYLAQLVPEI YSAEMDPDLE 60
KQEESIQMSI FTPLEWYLFG EDPDICLEKL KHSGAFQLCG KVFKSGETTY SCRDCAIDPT 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGCGGACG AGGAGGCCGG GGGTGCGGAG AGGATGGAAG TCAGTACGGA GTTGCCGCAG 60
ACCCCTCAGC TCCTGGCATC TGTAAGTCCT TGTAGGCAAG TTCCTTTTGT CCCCCCCAGT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR003769--ClpS_core
IPR014719--Ribosomal_L7/12_C/ClpS-like
IPR011991--WHTH_DNA-bd_dom
IPR013083--Znf_RING/FYVE/PHD
IPR003126--Znf_UBR

PROSITE

PS51157--ZF_UBR

Pfam

PF02617--ClpS
PF02207--zf-UBR

SMART

SM00396--ZnF_UBR1

Gene Ontology

GO:0000502--C:proteasome complex
GO:0000151--C:ubiquitin ligase complex
GO:0070728--F:leucine binding
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0071233--P:cellular response to leucine
GO:0032007--P:negative regulation of TOR signaling
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001354	Ailuropoda melanoleuca	97.32	0.00e+00	3429.00
IUUC-Apl-004160	Anas platyrhynchos	78.45	0.00e+00	2758.00
IUUC-Aca-004982	Anolis carolinensis	75.43	0.00e+00	2659.00
IUUC-Acl-008055	Aspergillus clavatus	22.15	7.00e-48	187.00
IUUC-Ate-010550	Aspergillus terreus	22.80	2.00e-47	185.00
IUUC-Ame-011231	Astyanax mexicanus	56.95	0.00e+00	1882.00
IUUC-Bgr-011999	Blumeria graminis	23.11	2.00e-47	186.00
IUUC-Bta-012347	Bos taurus	95.58	0.00e+00	3369.00
IUUC-Cja-018911	Callithrix jacchus	90.74	0.00e+00	3190.00
IUUC-Cfa-020991	Canis familiaris	97.95	0.00e+00	3445.00
IUUC-Cpo-021448	Cavia porcellus	91.73	0.00e+00	3246.00
IUUC-Cre-022930	Chlamydomonas reinhardtii	46.15	2.40e-02	30.80
IUUC-Csa-024255	Chlorocebus sabaeus	95.23	0.00e+00	2783.00
IUUC-Cho-024550	Choloepus hoffmanni	73.53	0.00e+00	2477.00
IUUC-Dno-029427	Dasypus novemcinctus	93.19	0.00e+00	3207.00
IUUC-Dor-031073	Dipodomys ordii	79.98	0.00e+00	1395.00
IUUC-Ete-032318	Echinops telfairi	76.45	0.00e+00	1271.00
IUUC-Eca-033348	Equus caballus	95.81	0.00e+00	3131.00
IUUC-Eeu-034664	Erinaceus europaeus	86.29	0.00e+00	3024.00
IUUC-Fca-035604	Felis catus	90.77	0.00e+00	3108.00
IUUC-Fal-037333	Ficedula albicollis	78.11	0.00e+00	2717.00
IUUC-Gmo-039363	Gadus morhua	55.97	0.00e+00	1649.00
IUUC-Gga-040486	Gallus gallus	77.52	0.00e+00	2678.00
IUUC-Gac-041985	Gasterosteus aculeatus	56.30	0.00e+00	1725.00
IUUC-Ggo-044704	Gorilla gorilla	87.92	0.00e+00	2591.00
IUUC-Hsa-046753	Homo sapiens	95.27	0.00e+00	3376.00
IUUC-Itr-048410	Ictidomys tridecemlineatus	95.45	0.00e+00	3350.00
IUUC-Lch-049904	Latimeria chalumnae	61.88	0.00e+00	2125.00
IUUC-Loc-052624	Lepisosteus oculatus	60.87	0.00e+00	2055.00
IUUC-Laf-053857	Loxodonta africana	91.65	0.00e+00	3214.00
IUUC-Mcc-054873	Macaca mulatta	95.38	0.00e+00	3336.00
IUUC-Meu-056858	Macropus eugenii	67.04	0.00e+00	1037.00
IUUC-Mga-059917	Meleagris gallopavo	78.01	0.00e+00	2796.00
IUUC-Mmr-061128	Microcebus murinus	92.01	0.00e+00	3188.00
IUUC-Mdo-062306	Monodelphis domestica	81.14	0.00e+00	2847.00
IUUC-Mmu-063389	Mus musculus	91.80	0.00e+00	3276.00
IUUC-Mlu-068013	Myotis lucifugus	92.31	0.00e+00	3265.00
IUUC-Nle-070031	Nomascus leucogenys	95.61	0.00e+00	3386.00
IUUC-Opr-070551	Ochotona princeps	71.27	0.00e+00	1384.00
IUUC-Ont-072035	Oreochromis niloticus	57.62	0.00e+00	1969.00
IUUC-Ocu-074930	Oryctolagus cuniculus	90.32	0.00e+00	3159.00
IUUC-Oba-075295	Oryza barthii	38.54	5.00e-14	74.70
IUUC-Oin-079343	Oryza indica	38.54	5.00e-14	74.70
IUUC-Oni-083099	Oryza nivara	38.54	5.00e-14	74.30
IUUC-Oru-084471	Oryza rufipogon	38.54	5.00e-14	74.70
IUUC-Osa-086106	Oryza sativa	35.29	2.00e-13	71.20
IUUC-Ola-086683	Oryzias latipes	57.30	0.00e+00	1908.00
IUUC-Oga-088017	Otolemur garnettii	90.23	0.00e+00	3163.00
IUUC-Oar-089557	Ovis aries	94.92	0.00e+00	3353.00
IUUC-Ptr-091366	Pan troglodytes	94.07	0.00e+00	3346.00
IUUC-Pan-092184	Papio anubis	95.27	0.00e+00	3335.00
IUUC-Psi-093720	Pelodiscus sinensis	78.71	0.00e+00	2707.00
IUUC-Pfo-097124	Poecilia formosa	57.05	0.00e+00	1922.00
IUUC-Pab-098586	Pongo abelii	95.49	0.00e+00	3378.00
IUUC-Pop-099184	Populus trichocarpa	44.21	1.00e-13	70.90
IUUC-Pca-100673	Procavia capensis	85.07	0.00e+00	1739.00
IUUC-Pva-102724	Pteropus vampyrus	89.96	0.00e+00	3125.00
IUUC-Pte-104174	Pyrenophora teres	23.36	4.00e-49	191.00
IUUC-Pyt-104431	Pyrenophora triticirepentis	23.41	1.00e-47	186.00
IUUC-Rno-105474	Rattus norvegicus	88.95	0.00e+00	2355.00
IUUC-Sha-106993	Sarcophilus harrisii	81.48	0.00e+00	2926.00
IUUC-Sar-113447	Sorex araneus	89.33	0.00e+00	2198.00
IUUC-Ssc-115768	Sus scrofa	91.69	0.00e+00	3002.00
IUUC-Tgu-116949	Taeniopygia guttata	73.18	0.00e+00	2500.00
IUUC-Tru-117782	Takifugu rubripes	56.66	0.00e+00	1939.00
IUUC-Tsy-119177	Tarsius syrichta	83.50	0.00e+00	2264.00
IUUC-Tni-120884	Tetraodon nigroviridis	53.13	0.00e+00	1763.00
IUUC-Tbe-128088	Tupaia belangeri	83.51	0.00e+00	1291.00
IUUC-Ttr-129062	Tursiops truncatus	89.91	0.00e+00	3134.00
IUUC-Vpa-130578	Vicugna pacos	87.79	0.00e+00	3025.00
IUUC-Xtr-132244	Xenopus tropicalis	61.08	0.00e+00	2115.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence