iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Csa-024177

Ensembl Protein ID

ENSCSAP00000006451.1

UniProt Accession

A0A0D9RCW2; A0A0D9RCW2_CHLSB

Genbank Protein ID

ENSCSAP00000006451

Protein Name

Ubiquitinyl hydrolase 1

Genbank Nucleotide ID

AQIB01143758

Gene Name

USP5

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSCSAG00000010215.1	ENSCSAT00000008299.1	ENSCSAP00000006451.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	6.70e-45	153.7	326	602
UBD/Alpha-Helix/UBA	9.10e-23	79.7	702	739

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeel....................wkskkkavs 69
           tG++NlgN+CY+NSv+Q+L++ip++++ + + k ek+ +++p++p+++++++++kl + l                    +k+ +  ++
   Q: 326  TGIQNLGNSCYLNSVVQVLFSIPDFQRKYVD-KLEKIFQNAPTDPTQDFSTQVAKLGHGLlsgeyskpvpesgdgervpeQKEVQDGIA 413
           7******************************.99999999********************67766666666666655443366666*** PP
   S: 70   prellkalkkeaeefsgyeqqDaqEflaflldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikcle 158
           pr++++ ++k ++efs+++qqDaqEf+ +l++ +e+++                             ++++  +++F++ ++++ikcl+
   Q: 414  PRMFKALIGKGHPEFSTNRQQDAQEFFLHLINMVERNC-----------------------------RSSENPNEVFRFLVEEKIKCLA 473
           **************************************.............................6788899*************** PP
   S: 159  cdnvssreepfldlslpvpgkeetkke...........................slqdcLesftkeeelegenkyycekckkkqeaekk 220
            ++v+ ++   + ++lpvp++   +ke                            +++cLe++ ++e++++   ++++  ++k+ a+k+
   Q: 474  TEKVKYTQRVDYIMQLPVPMDAALNKEelleyeekkrqaeeekmplpelvraqvPFSSCLEAYGAPEQVDD---FWSTALQAKSVAVKT 559
           **********************999989*****************************************97...*************** PP
   S: 221  lklkklPevLilhLkRfsfseeqksrekinkkvefpleLdlspf 264
           +++ ++P++L++++k+f+f  + ++++k++ ++e+p+eLd+s+ 
   Q: 560  TRFASFPDYLVIQIKKFTFGLD-WVPKKLDVSIEMPEELDISQL 602
           *******************997.******************975 PP

UBD/Alpha-Helix/UBA

   S: 4    edkleqlveMGFdreealqaLraannnleaAveyLldg 41
           ed +  +v+MGF+r++al+aLra+nn+le+Av++++++
   Q: 702  EDCVTTIVSMGFSRDQALKALRATNNSLERAVDWIFSH 739
           889999******************************97 PP

Organism

Chlorocebus sabaeus

Protein Sequence
(Fasta)

MAELSEEALL SVLPTIRVPK AGDRVHKDEC AFSFDTPESE GGLYICMNTF LGFGKQYVER 60
HFNKTGQRVY LHLRRTRRLK EEDPTTGTGD PPRKKPTRLA IGVEGGFDLS EEKFELDEDV 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AGCACCGGCA GGCAGGCTGT GTCCAACTGC CATTCTCGCG CGTCGTCCCC GCGGCGCATG 60
CCCCTAACGA GTGGCGCTCA TTGGACGGGA GGGACAGGGG AGGAGACTAG GAACGGTGGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001394--Peptidase_C19_UCH
IPR015940--UBA
IPR009060--UBA-like
IPR016652--Ubiquitinyl_hydrolase
IPR018200--USP_CS
IPR028889--USP_dom
IPR013083--Znf_RING/FYVE/PHD
IPR001607--Znf_UBP

PROSITE

PS50030--UBA
PS00972--USP_1
PS50235--USP_3
PS50271--ZF_UBP

Pfam

PF00627--UBA
PF00443--UCH
PF02148--zf-UBP

SMART

SM00165--UBA
SM00290--ZnF_UBP

Gene Ontology

GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0008270--F:zinc ion binding
GO:0032436--P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0071108--P:protein K48-linked deubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002104	Ailuropoda melanoleuca	94.68	0.00e+00	1446.00
IUUC-Apl-003774	Anas platyrhynchos	88.13	0.00e+00	1337.00
IUUC-Aca-005368	Anolis carolinensis	88.40	0.00e+00	1400.00
IUUC-Ath-006974	Arabidopsis thaliana	48.65	0.00e+00	655.00
IUUC-Ago-007890	Ashbya gossypii	29.16	4.00e-73	269.00
IUUC-Afl-008547	Aspergillus flavus	38.14	2.00e-108	386.00
IUUC-Afu-008805	Aspergillus fumigatus	35.46	9.00e-104	371.00
IUUC-Ani-009441	Aspergillus nidulans	33.67	2.00e-92	333.00
IUUC-Ang-009720	Aspergillus niger	34.48	4.00e-108	385.00
IUUC-Aor-010111	Aspergillus oryzae	35.09	2.00e-117	416.00
IUUC-Ame-011893	Astyanax mexicanus	67.49	0.00e+00	1009.00
IUUC-Bgr-012183	Blumeria graminis	35.28	1.00e-111	397.00
IUUC-Bta-013179	Bos taurus	94.92	0.00e+00	1453.00
IUUC-Bci-013858	Botrytis cinerea	36.04	7.00e-119	421.00
IUUC-Bdi-014904	Brachypodium distachyon	48.44	0.00e+00	632.00
IUUC-Bol-015536	Brassica oleracea	49.13	0.00e+00	669.00
IUUC-Bra-017939	Brassica rapa	49.26	0.00e+00	673.00
IUUC-Cel-018625	Caenorhabditis elegans	33.96	3.00e-117	416.00
IUUC-Cja-019063	Callithrix jacchus	94.82	0.00e+00	1443.00
IUUC-Cfa-020976	Canis familiaris	98.43	0.00e+00	1476.00
IUUC-Cpo-022265	Cavia porcellus	98.43	0.00e+00	1471.00
IUUC-Cho-024702	Choloepus hoffmanni	84.47	0.00e+00	872.00
IUUC-Cin-025411	Ciona intestinalis	48.06	0.00e+00	729.00
IUUC-Cgl-026667	Colletotrichum gloeosporioides	34.79	4.00e-105	375.00
IUUC-Cne-026831	Cryptococcus neoformans	36.07	4.00e-119	422.00
IUUC-Dre-027982	Danio rerio	65.43	0.00e+00	972.00
IUUC-Dno-029034	Dasypus novemcinctus	95.56	0.00e+00	1478.00
IUUC-Dor-030479	Dipodomys ordii	92.78	0.00e+00	666.00
IUUC-Dse-031467	Dothistroma septosporum	36.51	2.00e-121	429.00
IUUC-Dme-032075	Drosophila melanogaster	48.04	0.00e+00	720.00
IUUC-Ete-032865	Echinops telfairi	83.10	0.00e+00	1269.00
IUUC-Eca-034059	Equus caballus	95.36	0.00e+00	1468.00
IUUC-Eeu-035304	Erinaceus europaeus	88.96	0.00e+00	1306.00
IUUC-Fca-035515	Felis catus	95.30	0.00e+00	1458.00
IUUC-Fal-037271	Ficedula albicollis	90.00	0.00e+00	1310.00
IUUC-Fox-037745	Fusarium oxysporum	37.14	9.00e-122	431.00
IUUC-Fso-038158	Fusarium solani	36.60	2.00e-119	423.00
IUUC-Gmo-039071	Gadus morhua	64.38	0.00e+00	979.00
IUUC-Ggr-040098	Gaeumannomyces graminis	35.08	3.00e-112	399.00
IUUC-Gga-040635	Gallus gallus	87.73	0.00e+00	1404.00
IUUC-Gac-042528	Gasterosteus aculeatus	64.88	0.00e+00	981.00
IUUC-Ggo-044602	Gorilla gorilla	96.45	0.00e+00	1472.00
IUUC-Hsa-045959	Homo sapiens	96.45	0.00e+00	1472.00
IUUC-Itr-048712	Ictidomys tridecemlineatus	95.06	0.00e+00	1454.00
IUUC-Kpa-049156	Komagataella pastoris	34.01	1.00e-105	377.00
IUUC-Lch-049648	Latimeria chalumnae	83.27	0.00e+00	1260.00
IUUC-Lpe-051523	Leersia perrieri	47.54	0.00e+00	629.00
IUUC-Lma-053216	Leptosphaeria maculans	35.68	9.00e-105	375.00
IUUC-Laf-054327	Loxodonta africana	94.16	0.00e+00	1441.00
IUUC-Mcc-055443	Macaca mulatta	96.83	0.00e+00	1479.00
IUUC-Meu-056298	Macropus eugenii	93.06	0.00e+00	1062.00
IUUC-Mor-057106	Magnaporthe oryzae	36.21	2.00e-121	429.00
IUUC-Mpo-057589	Magnaporthe poae	35.91	2.00e-115	410.00
IUUC-Mla-058903	Melampsora laricipopulina	33.33	4.00e-113	402.00
IUUC-Mga-059669	Meleagris gallopavo	84.38	0.00e+00	1328.00
IUUC-Mmr-060575	Microcebus murinus	95.30	0.00e+00	1459.00
IUUC-Mdo-062183	Monodelphis domestica	91.65	0.00e+00	1401.00
IUUC-Mmu-063592	Mus musculus	95.18	0.00e+00	1455.00
IUUC-Mpu-066082	Mustela putorius furo	98.04	0.00e+00	1471.00
IUUC-Mlu-067345	Myotis lucifugus	93.05	0.00e+00	1422.00
IUUC-Nfi-068558	Neosartorya fischeri	36.65	3.00e-112	399.00
IUUC-Ncr-068960	Neurospora crassa	35.96	5.00e-110	392.00
IUUC-Nle-070173	Nomascus leucogenys	99.61	0.00e+00	1488.00
IUUC-Opr-070556	Ochotona princeps	94.16	0.00e+00	1446.00
IUUC-Ont-071502	Oreochromis niloticus	66.62	0.00e+00	1004.00
IUUC-Ocu-074861	Oryctolagus cuniculus	97.91	0.00e+00	1471.00
IUUC-Ogl-077065	Oryza glaberrima	49.12	0.00e+00	662.00
IUUC-Oin-080048	Oryza indica	48.85	0.00e+00	658.00
IUUC-Oru-085139	Oryza rufipogon	46.96	0.00e+00	632.00
IUUC-Osa-085713	Oryza sativa	49.26	0.00e+00	665.00
IUUC-Ola-086951	Oryzias latipes	63.81	0.00e+00	959.00
IUUC-Olu-087822	Ostreococcus lucimarinus	41.96	1.00e-157	550.00
IUUC-Oga-088625	Otolemur garnettii	94.80	0.00e+00	1447.00
IUUC-Oar-089995	Ovis aries	93.43	0.00e+00	1420.00
IUUC-Ptr-090640	Pan troglodytes	93.53	0.00e+00	1449.00
IUUC-Pan-091974	Papio anubis	95.83	0.00e+00	1461.00
IUUC-Psi-093957	Pelodiscus sinensis	86.89	0.00e+00	1412.00
IUUC-Pma-094242	Petromyzon marinus	71.92	6.00e-166	576.00
IUUC-Pno-094835	Phaeosphaeria nodorum	36.23	5.00e-96	345.00
IUUC-Ppa-095901	Physcomitrella patens	49.24	0.00e+00	699.00
IUUC-Pfo-097148	Poecilia formosa	67.28	0.00e+00	1008.00
IUUC-Pab-098068	Pongo abelii	88.20	0.00e+00	1290.00
IUUC-Pca-100738	Procavia capensis	93.17	0.00e+00	941.00
IUUC-Pva-102154	Pteropus vampyrus	93.91	0.00e+00	1436.00
IUUC-Pgr-103343	Puccinia graminis	34.33	1.00e-110	394.00
IUUC-Ptt-103928	Puccinia triticina	30.85	8.00e-95	341.00
IUUC-Pte-104306	Pyrenophora teres	33.33	1.00e-92	334.00
IUUC-Rno-105801	Rattus norvegicus	94.80	0.00e+00	1452.00
IUUC-Sce-106304	Saccharomyces cerevisiae	28.02	9.00e-64	238.00
IUUC-Sha-107635	Sarcophilus harrisii	94.12	0.00e+00	1426.00
IUUC-Sja-107678	Schizosaccharomyces japonicus	33.25	2.00e-102	367.00
IUUC-Smo-108848	Selaginella moellendorffii	49.73	0.00e+00	658.00
IUUC-Sit-110728	Setaria italica	49.66	0.00e+00	692.00
IUUC-Sbi-114419	Sorghum bicolor	49.19	0.00e+00	676.00
IUUC-Sre-115225	Sporisorium reilianum	36.00	3.00e-116	413.00
IUUC-Ssc-115686	Sus scrofa	93.92	0.00e+00	1443.00
IUUC-Tgu-117346	Taeniopygia guttata	87.25	0.00e+00	1372.00
IUUC-Tru-118350	Takifugu rubripes	62.76	0.00e+00	989.00
IUUC-Tni-120658	Tetraodon nigroviridis	63.85	0.00e+00	973.00
IUUC-Tca-121585	Theobroma cacao	49.46	0.00e+00	644.00
IUUC-Tre-122043	Trichoderma reesei	35.35	7.00e-110	391.00
IUUC-Tvi-122303	Trichoderma virens	35.29	3.00e-114	406.00
IUUC-Tme-126909	Tuber melanosporum	34.99	6.00e-108	385.00
IUUC-Tbe-127261	Tupaia belangeri	85.79	0.00e+00	843.00
IUUC-Uma-129599	Ustilago maydis	34.06	5.00e-117	415.00
IUUC-Vda-129688	Verticillium dahliae	35.08	9.00e-114	404.00
IUUC-Vvi-131116	Vitis vinifera	48.99	0.00e+00	634.00
IUUC-Xtr-131953	Xenopus tropicalis	75.85	0.00e+00	1173.00
IUUC-Xma-133837	Xiphophorus maculatus	67.41	0.00e+00	1011.00
IUUC-Yli-134510	Yarrowia lipolytica	36.18	1.00e-115	410.00
IUUC-Zma-135786	Zea mays	49.05	0.00e+00	644.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence