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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Hsa-046827
Ensembl Protein ID ENSP00000296328.4
UniProt Accession O94888; D3DXB3; Q6ZP77; Q86X20; Q8N327; UBXN7_HUMAN
Genbank Protein ID BAA34514.1; BAC85247.1; EAW53652.1; EAW53654.1; AAH28986.1
Protein Name UBX domain-containing protein 7
Genbank Nucleotide ID AB018337; AK129880; CH471191; CH471191; BC028986
Gene Name UBXN7; KIAA0794; UBXD7
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000163960.11 ENST00000296328.8 ENSP00000296328.4
ENSG00000163960.11 ENST00000429160.1 ENSP00000397238.1
ENSG00000163960.11 ENST00000381887.7 ENSP00000371311.3
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbAREsitecircBasecircRNADb
CircNetmiRTarBasemicroRNATRANSFAC
TargetScanRepTarSomamiRmiRcode
RAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
MenthaInWeb_IM
Protein 3D Structure
PDBMMDB
Disease-associated Information
GWASdbOMIM
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
HPRDPhospho.ELMUniProtBioGRID
mUbiSiDa
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
UBD/Alpha-Helix/UBA UBA 22537386
UBD/Alpha-Helix/UIM UIM 22466964; 22537386
ULD/UDP/UFD/UBX UBX 22537386
Classification
Family E-value Score Start End
UBD/Alpha-Helix/UIM 0.18 13.7 285 301
UBD/Alpha-Helix/UBA 5.90e-06 27.9 13 52
ULD/UDP/UFD/UBX 3.50e-19 70.8 411 485
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   UBD/Alpha-Helix/UIM
   S: 1    dEdeeLqlAlalSlqEe 17
           +Ed++L+ A++ SlqE 
   Q: 285  SEDSQLEAAIRASLQET 301
           7**************96 PP
   

   UBD/Alpha-Helix/UBA
   S: 3    dedkleqlve.MGFdreealqaLraa.nnnleaAveyLldg 41
           ++ +++q++  +G   e + +++++a nnnle+Av+++ldg
   Q: 13   LKGLIQQFTTiTG-ASESVGKHMLEAcNNNLEMAVTMFLDG 52
           6789*********.9999*******99************97 PP
   

   ULD/UDP/UFD/UBX
   S: 4    eqatlqiRlpdGkrlvrkFpssttleqiyqfveyllvessdpFeLvspfPrrtlkpeehmstlqeagLvpsgsllv 79
           ++a+l +R+pdGkr + ++p++++l +++++v+ ++++++++FeL+++fPrr+l++ +++ tlqeagL+p+++++v
   Q: 411  PKAQLMLRYPDGKREQITLPEQAKLLALVKHVQ-SKGYPNERFELLTNFPRRKLSHLDYDITLQEAGLCPQETVFV 485
           59*******************************.****************************************98 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Ubiquitin-binding adapter that links a subset of NEDD8-associated cullin ring ligases (CRLs) to the segregase VCP/p97, to regulate turnover of their ubiquitination substrates.
 Ubiquitin-binding adapter that links a subset of NEDD8-associated cullin ring ligases (CRLs) to the segregase VCP/p97, to regulate turnover of their ubiquitination substrates.
Protein Sequence
(Fasta)
MAAHGGSAAS SALKGLIQQF TTITGASESV GKHMLEACNN NLEMAVTMFL DGGGIAEEPS 60
TSSASVSTVR PHTEEEVRAP IPQKQEILVE PEPLFGAPKR RRPARSIFDG FRDFQTETIR 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-046827|UBD,UBA;UBD,UIM;ULD,UBX|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
ACACCGCACG GCGAAGTGGG GGAGGGCAGT CCGTGTGTGT CTGTGTTGTT GTTCGGCGGC 60
GGCGGCGGCG GTAAGATGGC TGCCCACGGG GGCTCCGCGG CGTCCTCGGC GCTGAAGGGG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046827|UBD,UBA;UBD,UIM;ULD,UBX|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0007--Acetylation
KW-0181--Complete proteome
KW-1017--Isopeptide bond
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0832--Ubl conjugation
Interpro

IPR012336--Thioredoxin-like_fold
IPR006577--UAS
IPR009060--UBA-like
IPR029071--Ubiquitin-rel_dom
IPR017346--UBX_7/2
IPR001012--UBX_dom
PROSITE

PS50033--UBX
Pfam

PF00789--UBX
SMART

SM00594--UAS
SM00166--UBX
Gene Ontology

GO:0016604--C:nuclear body
GO:0005654--C:nucleoplasm
GO:0034098--C:VCP-NPL4-UFD1 AAA ATPase complex
GO:0008134--F:transcription factor binding
GO:0043130--F:ubiquitin binding
GO:0031625--F:ubiquitin protein ligase binding
KEGG hsa:26043
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000182 Aegilops tauschii 36.60 5.00e-36 145.00
IUUC-Aml-001944 Ailuropoda melanoleuca 97.87 0.00e+00 895.00
IUUC-Atr-002562 Amborella trichopoda 36.84 6.00e-37 148.00
IUUC-Apl-003869 Anas platyrhynchos 87.91 0.00e+00 821.00
IUUC-Aca-004442 Anolis carolinensis 87.84 0.00e+00 804.00
IUUC-Aly-006399 Arabidopsis lyrata 28.81 2.00e-30 127.00
IUUC-Ath-006586 Arabidopsis thaliana 29.66 5.00e-33 135.00
IUUC-Ago-007718 Ashbya gossypii 40.72 3.00e-28 119.00
IUUC-Acl-008032 Aspergillus clavatus 30.41 4.00e-25 109.00
IUUC-Afl-008654 Aspergillus flavus 30.41 1.00e-25 111.00
IUUC-Afu-008821 Aspergillus fumigatus 31.78 9.00e-26 111.00
IUUC-Ani-009458 Aspergillus nidulans 33.80 3.00e-27 116.00
IUUC-Ang-009569 Aspergillus niger 32.26 1.00e-27 118.00
IUUC-Aor-010044 Aspergillus oryzae 30.41 1.00e-25 111.00
IUUC-Ate-010483 Aspergillus terreus 31.05 8.00e-27 115.00
IUUC-Bgr-012199 Blumeria graminis 34.43 7.00e-28 119.00
IUUC-Bta-012363 Bos taurus 96.62 0.00e+00 898.00
IUUC-Bci-013929 Botrytis cinerea 35.59 3.00e-28 120.00
IUUC-Bdi-014936 Brachypodium distachyon 33.21 4.00e-36 145.00
IUUC-Bol-016354 Brassica oleracea 31.70 8.00e-35 141.00
IUUC-Bra-016632 Brassica rapa 32.03 8.00e-35 141.00
IUUC-Cja-019055 Callithrix jacchus 94.02 0.00e+00 839.00
IUUC-Cfa-020168 Canis familiaris 98.32 0.00e+00 917.00
IUUC-Cpo-021430 Cavia porcellus 96.65 0.00e+00 890.00
IUUC-Cre-022974 Chlamydomonas reinhardtii 29.87 2.00e-25 110.00
IUUC-Csa-023976 Chlorocebus sabaeus 99.16 0.00e+00 914.00
IUUC-Cho-025035 Choloepus hoffmanni 89.88 0.00e+00 723.00
IUUC-Cin-025322 Ciona intestinalis 43.25 1.00e-64 240.00
IUUC-Csv-025965 Ciona savignyi 47.67 3.00e-70 259.00
IUUC-Dre-027359 Danio rerio 72.44 0.00e+00 700.00
IUUC-Dno-029627 Dasypus novemcinctus 97.37 0.00e+00 871.00
IUUC-Dor-031133 Dipodomys ordii 85.78 0.00e+00 678.00
IUUC-Dse-031560 Dothistroma septosporum 39.86 3.00e-28 119.00
IUUC-Dme-031981 Drosophila melanogaster 30.00 1.00e-36 147.00
IUUC-Ete-033025 Echinops telfairi 91.88 1.00e-175 608.00
IUUC-Eca-034228 Equus caballus 98.11 0.00e+00 916.00
IUUC-Eeu-034469 Erinaceus europaeus 87.07 0.00e+00 766.00
IUUC-Fca-036404 Felis catus 98.52 0.00e+00 911.00
IUUC-Fal-036686 Ficedula albicollis 84.13 0.00e+00 761.00
IUUC-Fox-037758 Fusarium oxysporum 35.43 3.00e-29 123.00
IUUC-Fso-038081 Fusarium solani 36.57 5.00e-30 125.00
IUUC-Gmo-038652 Gadus morhua 82.52 1.00e-145 509.00
IUUC-Ggr-039845 Gaeumannomyces graminis 28.16 7.00e-28 119.00
IUUC-Gga-040734 Gallus gallus 86.85 2.00e-156 544.00
IUUC-Gac-041490 Gasterosteus aculeatus 65.42 5.00e-178 617.00
IUUC-Gma-042709 Glycine max 39.79 1.00e-35 144.00
IUUC-Ggo-044872 Gorilla gorilla 91.49 0.00e+00 812.00
IUUC-Hvu-047400 Hordeum vulgare 36.71 4.00e-37 148.00
IUUC-Itr-048785 Ictidomys tridecemlineatus 97.96 0.00e+00 842.00
IUUC-Kpa-049161 Komagataella pastoris 31.46 6.00e-35 141.00
IUUC-Lch-049556 Latimeria chalumnae 70.10 0.00e+00 650.00
IUUC-Lpe-051673 Leersia perrieri 38.30 4.00e-34 139.00
IUUC-Loc-051741 Lepisosteus oculatus 85.16 3.00e-151 528.00
IUUC-Lma-053009 Leptosphaeria maculans 34.85 3.00e-31 129.00
IUUC-Laf-054106 Loxodonta africana 94.49 0.00e+00 901.00
IUUC-Mcc-054866 Macaca mulatta 98.96 0.00e+00 922.00
IUUC-Meu-056868 Macropus eugenii 85.95 3.00e-178 618.00
IUUC-Mor-057056 Magnaporthe oryzae 32.00 3.00e-25 110.00
IUUC-Mpo-057332 Magnaporthe poae 30.89 1.00e-26 114.00
IUUC-Mtr-058153 Medicago truncatula 43.43 8.00e-38 151.00
IUUC-Mla-059046 Melampsora laricipopulina 31.82 1.30e-01 30.00
IUUC-Mga-059940 Meleagris gallopavo 88.65 0.00e+00 792.00
IUUC-Mmr-060737 Microcebus murinus 97.69 0.00e+00 914.00
IUUC-Mdo-062970 Monodelphis domestica 93.63 0.00e+00 764.00
IUUC-Mmu-063481 Mus musculus 97.69 0.00e+00 914.00
IUUC-Mac-065522 Musa acuminata 35.85 9.00e-38 151.00
IUUC-Mpu-065853 Mustela putorius furo 98.31 0.00e+00 908.00
IUUC-Mlu-068056 Myotis lucifugus 96.17 0.00e+00 846.00
IUUC-Nfi-068479 Neosartorya fischeri 31.06 2.00e-25 110.00
IUUC-Ncr-068638 Neurospora crassa 28.41 1.00e-27 118.00
IUUC-Nle-070140 Nomascus leucogenys 94.15 0.00e+00 855.00
IUUC-Opr-071163 Ochotona princeps 84.71 0.00e+00 644.00
IUUC-Ont-071318 Oreochromis niloticus 83.12 1.00e-145 509.00
IUUC-Oan-072847 Ornithorhynchus anatinus 84.83 7.00e-79 286.00
IUUC-Ocu-074018 Oryctolagus cuniculus 98.31 0.00e+00 910.00
IUUC-Oba-074980 Oryza barthii 34.57 1.00e-35 144.00
IUUC-Obr-076741 Oryza brachyantha 38.83 2.00e-34 139.00
IUUC-Ogl-077363 Oryza glaberrima 34.27 1.00e-35 144.00
IUUC-Ogu-078011 Oryza glumaepatula 34.57 1.00e-35 144.00
IUUC-Oin-079454 Oryza indica 34.57 1.00e-35 144.00
IUUC-Olo-080898 Oryza longistaminata 35.86 1.00e-31 130.00
IUUC-Ome-081479 Oryza meridionalis 34.27 1.00e-35 144.00
IUUC-Oni-082128 Oryza nivara 36.36 1.00e-32 134.00
IUUC-Opu-083967 Oryza punctata 38.18 2.00e-19 92.00
IUUC-Oru-084233 Oryza rufipogon 34.27 9.00e-36 144.00
IUUC-Osa-085483 Oryza sativa 34.57 1.00e-35 144.00
IUUC-Ola-087217 Oryzias latipes 67.95 5.00e-180 624.00
IUUC-Oga-088688 Otolemur garnettii 97.69 0.00e+00 914.00
IUUC-Oar-090133 Ovis aries 97.69 0.00e+00 914.00
IUUC-Pan-092026 Papio anubis 89.69 0.00e+00 889.00
IUUC-Psi-093468 Pelodiscus sinensis 90.56 0.00e+00 631.00
IUUC-Pma-094180 Petromyzon marinus 52.04 1.00e-126 446.00
IUUC-Pno-095137 Phaeosphaeria nodorum 32.21 3.00e-32 133.00
IUUC-Ppa-095977 Physcomitrella patens 38.67 1.00e-32 134.00
IUUC-Pfo-097017 Poecilia formosa 66.98 0.00e+00 635.00
IUUC-Pab-098140 Pongo abelii 100.00 0.00e+00 930.00
IUUC-Pop-098981 Populus trichocarpa 32.13 3.00e-37 149.00
IUUC-Pca-100856 Procavia capensis 85.89 0.00e+00 817.00
IUUC-Ppe-101162 Prunus persica 43.90 9.00e-30 124.00
IUUC-Pva-103250 Pteropus vampyrus 88.89 0.00e+00 808.00
IUUC-Pte-104178 Pyrenophora teres 31.82 2.00e-31 130.00
IUUC-Pyt-104744 Pyrenophora triticirepentis 31.94 2.00e-31 130.00
IUUC-Rno-105201 Rattus norvegicus 97.69 0.00e+00 915.00
IUUC-Sce-106451 Saccharomyces cerevisiae 38.32 1.00e-24 107.00
IUUC-Sha-107343 Sarcophilus harrisii 93.62 0.00e+00 848.00
IUUC-Sja-107754 Schizosaccharomyces japonicus 32.67 5.00e-34 139.00
IUUC-Spo-108295 Schizosaccharomyces pombe 31.17 3.00e-36 145.00
IUUC-Sit-109720 Setaria italica 34.32 9.00e-35 141.00
IUUC-Sly-111080 Solanum lycopersicum 33.81 2.00e-39 156.00
IUUC-Stu-112704 Solanum tuberosum 40.31 3.00e-39 156.00
IUUC-Sar-113160 Sorex araneus 96.13 1.00e-150 526.00
IUUC-Sbi-114212 Sorghum bicolor 34.60 2.00e-33 136.00
IUUC-Ssc-116258 Sus scrofa 97.06 0.00e+00 902.00
IUUC-Tgu-116707 Taeniopygia guttata 89.08 0.00e+00 796.00
IUUC-Tru-118460 Takifugu rubripes 66.23 7.00e-176 610.00
IUUC-Tsy-119242 Tarsius syrichta 91.42 0.00e+00 816.00
IUUC-Tni-120184 Tetraodon nigroviridis 68.90 1.00e-155 542.00
IUUC-Tca-121697 Theobroma cacao 30.22 3.00e-36 146.00
IUUC-Tre-122170 Trichoderma reesei 32.11 5.00e-31 129.00
IUUC-Tvi-122652 Trichoderma virens 33.73 1.00e-32 134.00
IUUC-Tae-124106 Triticum aestivum 37.18 2.00e-36 147.00
IUUC-Tur-126601 Triticum urartu 36.71 8.00e-36 144.00
IUUC-Tme-126975 Tuber melanosporum 28.19 7.00e-24 105.00
IUUC-Tbe-128096 Tupaia belangeri 83.75 2.00e-127 449.00
IUUC-Ttr-128699 Tursiops truncatus 95.81 0.00e+00 885.00
IUUC-Vda-129909 Verticillium dahliae 46.43 2.00e-19 90.10
IUUC-Vpa-130207 Vicugna pacos 99.66 1.00e-173 602.00
IUUC-Vvi-130875 Vitis vinifera 33.08 4.00e-36 145.00
IUUC-Xtr-132737 Xenopus tropicalis 79.57 0.00e+00 696.00
IUUC-Xma-133046 Xiphophorus maculatus 68.18 0.00e+00 636.00
IUUC-Yli-134393 Yarrowia lipolytica 38.59 1.00e-33 137.00
IUUC-Zma-135572 Zea mays 33.89 4.00e-33 135.00
Created Date 25-Jun-2017

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