iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

mRNA Expression
GEO	FFGED
DNA & RNA Element
TRANSFAC
Protein-protein Interaction
IID	iRefIndex	HINT	Mentha
Protein 3D Structure
PDB	MMDB
Post-translational Modifications (PTMs)
dbPAF	BioGRID
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	1.10e-38	128.0	527	560
UBD/Beta-Prp	2.30e-56	189.6	316	643

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclafsd.tllvsGsdDgtikvWDlrtgv 34
           gHtd++t+l+f d   lv+Gs D+++++WDlrt  
   Q: 527  GHTDGITSLKF-DsEKLVTGSMDNSVRIWDLRTSS 560
           8**********.5499***************9976 PP

UBD/Beta-Prp

   S: 7    ghhksvitcvkf.spdksllatgsrdgtikvwdvttgkllrslsgheaevtavkfspd.gkilvtgseDrtikvwdls...................tgkc 86
           g+h + it+++f +p ++l+ ++++d+ +kvwd+  g  + +l gh a+v++++++++ +++l+tgs+D+t+k+wdl+                     +c
   Q: 316  GEHGNSITALDFdTPWGTLCSSSYQDRIVKVWDLNHGIQVGELPGHLATVNCMQIDKKnYNMLITGSKDATLKLWDLNlsreiyldhsplkekteeiVTPC 416
           78999**************************************************876156**************99999***************99999* PP
   S: 87   vhtlkghedsvlslsfspsgdklvsGshdrtirvwdletgqclee.......................tlsghdgvvncvvvhpdgnllvsGslDrtvrlW 164
           +h ++ h+d++++lsf+   + lvsGs+d+ i  wdl tg+c+++                       +l g+ ++ ++ ++++ ++ l++G++D++vrlW
   Q: 417  IHNFELHKDEITALSFDS--EALVSGSRDKKIFHWDLTTGKCIQQldliftpthsdikmparslnngaCLLGT-EAPMIGALQCYNSALATGTKDGIVRLW 514
           ******************..*******************************************8888766554.5899999******************** PP
   S: 165  dlktgkllrtltgghtdsvyslsfdsngkelvsgsldgtvklwdlqtgecvrtlnghtdnvksvrfspnderlvsgssDgsiriWdlrsgdllktlqlhn. 264
           dl+ gk +r l+g htd ++sl+fds  + lv+gs+d++v++wdl+t++ +  +++++ +v+s++f+  ++++ +g+ +g +++++++ ++ + t + ++ 
   Q: 515  DLRVGKPVRLLEG-HTDGITSLKFDS--EKLVTGSMDNSVRIWDLRTSS-ILDVIAYDLPVSSLDFD--GKLITVGANEGGVNVFNMERDEHWMTPEPPHs 609
           ************9.************..68****************998.8889*************..******************************** PP
   S: 265  ....ssvisvavlsfgdnvlvlgsedskvniwkl 294
               + +  +a ++++d  l+ g +d+++n+w l
   Q: 610  ldgdELSRRIAIVKYKDGFLINGHNDGDINVWTL 643
           ***866677888999*****************86 PP

Organism

Saccharomyces cerevisiae

Functional Description
(View)

Involved in mitochondrial fission. Has a partially redundant function to MDV1 in acting as an adapter protein, binding to FIS1 on the mitochondrial outer membrane and recruiting the dynamin-like GTPase DNM1 to form mitochondrial fission complexes. Plays a key role in determining the polarized localization of those DNM1 clusters that are not immediately involved in the mitochondrial fission process.

Protein Sequence
(Fasta)

MGSGDTRGES SLVAKPIEII LNKLPHAILA QQQFQKYITS PIYRYLSKLL LFREVAWPES 60
TKDTQKGQVG IFSFQNNYAD SATTFRILAH LDEQRYPLPN GAAEKNLPSL FEGFKATVSI 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGGTTCGG GCGATACTAG AGGAGAAAGC TCTCTGGTAG CTAAACCAAT CGAAATTATA 60
CTTAATAAGC TACCACATGC CATACTAGCG CAACAACAAT TTCAAAAATA TATAACGAGC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0472--Membrane
KW-0496--Mitochondrion
KW-1000--Mitochondrion outer membrane
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat

Interpro

IPR021653--Caf4
IPR020472--G-protein_beta_WD-40_rep
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF11615--Caf4
PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM00320--WD40

Gene Ontology

GO:0030014--C:CCR4-NOT complex
GO:0005741--C:mitochondrial outer membrane
GO:0005739--C:mitochondrion
GO:0000266--P:mitochondrial fission
GO:0016559--P:peroxisome fission
GO:0006357--P:regulation of transcription from RNA polymerase II promoter

KEGG

sce:YKR036C

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Afl-008726	Aspergillus flavus	40.29	2.00e-66	243.00
IUUC-Cho-024531	Choloepus hoffmanni	31.20	4.00e-23	102.00
IUUC-Cme-027168	Cyanidioschyzon merolae	28.98	7.00e-27	113.00
IUUC-Dno-029972	Dasypus novemcinctus	31.37	5.00e-23	102.00
IUUC-Dor-030330	Dipodomys ordii	31.76	2.00e-24	106.00
IUUC-Meu-056080	Macropus eugenii	30.28	3.00e-21	96.30
IUUC-Mla-058916	Melampsora laricipopulina	35.86	2.00e-56	210.00
IUUC-Mvi-060499	Microbotryum violaceum	28.12	7.00e-49	186.00
IUUC-Mdo-062688	Monodelphis domestica	31.91	1.00e-24	107.00
IUUC-Pgr-103442	Puccinia graminis	27.83	2.00e-39	155.00
IUUC-Sre-115117	Sporisorium reilianum	30.77	5.00e-55	207.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence