iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Mcc-055261

Ensembl Protein ID

ENSMMUP00000039174.1

UniProt Accession

F7BEE5; F7BEE5_MACMU

Genbank Protein ID

AFE66218.1; AFI35763.1; EHH15162.1

Protein Name

OTU domain-containing protein 7B

Genbank Nucleotide ID

JSUE03002348; JV045692; CM001253

Gene Name

OTUD7B; EGK_01217

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMMUG00000007244.3	ENSMMUT00000046131.2	ENSMMUP00000039174.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/OTU	4.40e-37	128.7	184	365
UBD/ZnF/ZnF_A20	2.00e-16	60.7	796	830

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/OTU

   S: 2    lilktkgDGnCLlrAvsqsllgvfddds.lsdalveaLreltseylqkesdffsefieek...........edekefcqklvepe.... 74
           l+l+t+gDGnCLl+A+s +++g++d+d+ l++al+  + + +++++ k+++++++++++k           ++e++++ kl+++e    
   Q: 184  LPLATTGDGNCLLHAASLGMWGFHDRDLmLRKALYALMEKGVEKEALKRRWRWQQTQQNKesglvytedewQKEWNELIKLASSEprmh 272
           6899********************************************************************************98887 PP
   S: 75   ...akg.................eeihifaLaqiLsrpiivvdvdsles.........kvggillpllfpeek.lkkpivLlYrsgHYd 133
                g                 ee+h+f+La++L+rpi+vv++++l++         ++ggi+lpl++p+++ +++p+vL+Y+++H++
   Q: 273  lgtN-GancggvesseepvyeslEEFHVFVLAHVLRRPIVVVADTMLRDsggeafapiPFGGIYLPLEVPASQcHRSPLVLAYDQAHFS 360
           7650.255579****************************************************************************** PP
   S: 134  aLval 138
           aLv++
   Q: 361  ALVSM 365
           **986 PP

UBD/ZnF/ZnF_A20

   S: 1    dpskllCkk.gCgfYGnpetngyCSkCyreelrrr 34
           +p++++Ck+ +C+fYG+petn++CS+Cyreelrrr
   Q: 796  PPTQTKCKQpNCSFYGHPETNNFCSCCYREELRRR 830
           59********************************9 PP

Organism

Macaca mulatta

Protein Sequence
(Fasta)

MTLDMDAVLS DFVRSTGAEP GLARDLLEGK NWDVSAALSD FEQLRQVHAG NLPPSFSEGI 60
GGSRTPEKGF SDREPSRPPR PILQRQDDIV QEKRLSRGIS HASSSIVSLA RSHVSSNGGG 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GTGGATGCCT GAATTTTGAT CTATGTTCTA CCTACATCCA GCTGGCTGAA AGTACTTGAT 60
GATCACATGA CCCTGGACAT GGATGCTGTT CTGTCGGATT TTGTCCGTTC CACAGGAGCA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR003323--OTU_dom
IPR002653--Znf_A20

PROSITE

PS50802--OTU
PS51036--ZF_A20

Pfam

PF02338--OTU
PF01754--zf-A20

SMART

SM00259--ZnF_A20

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005634--C:nucleus
GO:0003677--F:DNA binding
GO:1990380--F:Lys48-specific deubiquitinase activity
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0008270--F:zinc ion binding
GO:0002385--P:mucosal immune response
GO:0043124--P:negative regulation of I-kappaB kinase/NF-kappaB signaling
GO:0032717--P:negative regulation of interleukin-8 production
GO:1900181--P:negative regulation of protein localization to nucleus
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0035871--P:protein K11-linked deubiquitination
GO:0070536--P:protein K63-linked deubiquitination

KEGG

mcc:705774

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002119	Ailuropoda melanoleuca	93.32	0.00e+00	1419.00
IUUC-Apl-003567	Anas platyrhynchos	66.63	0.00e+00	970.00
IUUC-Bta-013398	Bos taurus	93.59	0.00e+00	1386.00
IUUC-Cel-018468	Caenorhabditis elegans	50.67	4.00e-85	308.00
IUUC-Cja-019965	Callithrix jacchus	95.86	0.00e+00	1428.00
IUUC-Cfa-020191	Canis familiaris	93.48	0.00e+00	1423.00
IUUC-Cpo-022232	Cavia porcellus	90.59	0.00e+00	1333.00
IUUC-Csa-023593	Chlorocebus sabaeus	99.53	0.00e+00	1564.00
IUUC-Cho-024729	Choloepus hoffmanni	83.60	5.00e-169	588.00
IUUC-Csv-026177	Ciona savignyi	30.56	3.00e-03	35.00
IUUC-Dno-029900	Dasypus novemcinctus	92.35	0.00e+00	1361.00
IUUC-Dor-031121	Dipodomys ordii	85.61	0.00e+00	699.00
IUUC-Ete-032473	Echinops telfairi	88.69	0.00e+00	1040.00
IUUC-Eca-033946	Equus caballus	94.85	0.00e+00	1051.00
IUUC-Eeu-034670	Erinaceus europaeus	91.22	0.00e+00	1362.00
IUUC-Fca-035871	Felis catus	93.48	0.00e+00	1351.00
IUUC-Fso-038203	Fusarium solani	29.90	5.50e-02	33.50
IUUC-Gmo-039373	Gadus morhua	77.25	0.00e+00	686.00
IUUC-Gga-041105	Gallus gallus	68.09	0.00e+00	994.00
IUUC-Gac-041806	Gasterosteus aculeatus	77.99	0.00e+00	733.00
IUUC-Ggo-045472	Gorilla gorilla	98.10	0.00e+00	1501.00
IUUC-Hsa-046473	Homo sapiens	98.10	0.00e+00	1509.00
IUUC-Itr-048841	Ictidomys tridecemlineatus	94.66	0.00e+00	1424.00
IUUC-Lch-050432	Latimeria chalumnae	63.70	0.00e+00	956.00
IUUC-Meu-056477	Macropus eugenii	79.71	0.00e+00	947.00
IUUC-Mga-059533	Meleagris gallopavo	69.76	0.00e+00	993.00
IUUC-Mdo-062847	Monodelphis domestica	82.71	0.00e+00	1172.00
IUUC-Mmu-064260	Mus musculus	88.86	0.00e+00	1322.00
IUUC-Mpu-066876	Mustela putorius furo	88.28	0.00e+00	1303.00
IUUC-Mlu-068039	Myotis lucifugus	93.84	0.00e+00	1402.00
IUUC-Nle-069260	Nomascus leucogenys	97.86	0.00e+00	1506.00
IUUC-Opr-070564	Ochotona princeps	91.61	0.00e+00	786.00
IUUC-Ont-071542	Oreochromis niloticus	80.09	0.00e+00	738.00
IUUC-Ocu-073824	Oryctolagus cuniculus	95.36	0.00e+00	961.00
IUUC-Opu-083273	Oryza punctata	24.68	7.50e-02	32.00
IUUC-Ola-086490	Oryzias latipes	76.23	0.00e+00	699.00
IUUC-Oga-088124	Otolemur garnettii	93.84	0.00e+00	1394.00
IUUC-Oar-090086	Ovis aries	94.07	0.00e+00	1390.00
IUUC-Ptr-091622	Pan troglodytes	98.43	0.00e+00	1140.00
IUUC-Pan-092724	Papio anubis	99.41	0.00e+00	1554.00
IUUC-Psi-093333	Pelodiscus sinensis	64.80	0.00e+00	959.00
IUUC-Pfo-096563	Poecilia formosa	78.06	0.00e+00	724.00
IUUC-Pab-098667	Pongo abelii	97.98	0.00e+00	1488.00
IUUC-Pca-100701	Procavia capensis	91.90	0.00e+00	736.00
IUUC-Pva-102136	Pteropus vampyrus	92.65	0.00e+00	1375.00
IUUC-Rno-105546	Rattus norvegicus	89.81	0.00e+00	1342.00
IUUC-Sha-106732	Sarcophilus harrisii	82.48	0.00e+00	1082.00
IUUC-Sar-113562	Sorex araneus	81.28	0.00e+00	1102.00
IUUC-Ssc-116191	Sus scrofa	94.42	0.00e+00	1411.00
IUUC-Tgu-116942	Taeniopygia guttata	75.55	0.00e+00	782.00
IUUC-Tru-117911	Takifugu rubripes	77.56	0.00e+00	724.00
IUUC-Tsy-119343	Tarsius syrichta	84.42	0.00e+00	1225.00
IUUC-Tur-126860	Triticum urartu	24.39	7.60e-02	32.00
IUUC-Tbe-127283	Tupaia belangeri	96.14	0.00e+00	756.00
IUUC-Ttr-128692	Tursiops truncatus	90.39	0.00e+00	1303.00
IUUC-Xtr-132888	Xenopus tropicalis	78.83	0.00e+00	751.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence