iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Laf-053598

UUCD1 version

UUC-LoA-00627

Ensembl Protein ID

ENSLAFP00000015367.3

UniProt Accession

G3TKK8; G3TKK8_LOXAF

Protein Name

Uncharacterized protein

Gene Name

NLE1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSLAFG00000018338.3	ENSLAFT00000018338.3	ENSLAFP00000015367.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	4.40e-68	222.5	197	240
UBD/Beta-Prp	6.80e-80	268.8	106	302

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf......sd.tllvsGsdDgtikvWDlrtgvllk 37
           gH+ ++t+l++      ++ ++++s+s Dg+++vWD++ g++++
   Q: 197  GHSKWITGLSWeplhanPEcRYVASSSKDGSVRVWDTTAGRCER 240
           8***************9889**********************86 PP

UBD/Beta-Prp

   S: 44   llrslsgheaevtavkfspdgkilvtgseDrtikvwdlstgkcvhtlkghedsvlslsfspsgdklvsGshdrtirvwdletgqcleet 132
           + +sl+gh+++v +v fsp+gk+l++gs D t++ wdlst ++  t kgh + vls+s+sp+g+kl+sG +   i +wd +tg+    t
   Q: 106  CTSSLEGHSEAVISVAFSPTGKYLASGSGDTTVRFWDLSTETPHFTCKGHRHWVLSISWSPDGKKLASGCKNGQILLWDPSTGKQEGRT 194
           5899**********************************************************************************99* PP
   S: 133  lsghdgvvncvvv.....hpdgnllvsGslDrtvrlWdlktgkllrtltgghtdsvyslsfdsngkelvsgsldgtvklwdlqtgecvr 216
           l+gh+++++++++     +p++++++s+s+D+ vr+Wd   g++ r ltg ht+sv++l +  +g  l s+s+d+t+k+w  + g   r
   Q: 195  LAGHSKWITGLSWeplhaNPECRYVASSSKDGSVRVWDTTAGRCERILTG-HTQSVTCLRWGGDG-LLYSASQDRTIKVWRAHDGVLCR 281
           **********9873332257889**************************9.************98.*********************** PP
   S: 217  tlnghtdnvksvrfspnderlv 238
           tl+gh  +v+ +++s  d  l 
   Q: 282  TLQGHGHWVNTMALS-TDYALR 302
           **************9.444444 PP

Organism

Loxodonta africana

Protein Sequence
(Fasta)

PRVSVQGEEA ARDVQRLLVQ FQDEGGQLLG APFDVPVDIT PDKLQLVCNA LLAQEDPLPL 60
AFYIHDAEIV SSLGKTLESQ AVETEKVLDI IYQPQAVFRV RAVTRCTSSL EGHSEAVISV 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CCGCGCGTGT CTGTGCAGGG CGAGGAGGCG GCTCGCGACG TGCAGCGGCT GCTGGTGCAG 60
TTCCAGGATG AGGGGGGGCA GCTGCTGGGC GCCCCGTTCG ACGTGCCCGT GGACATCACC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat

Interpro

IPR020472--G-protein_beta_WD-40_rep
IPR001632--Gprotein_B
IPR012972--NLE
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF08154--NLE
PF00400--WD40

PRINTS

PR00319--GPROTEINB
PR00320--GPROTEINBRPT

SMART

SM00320--WD40

Gene Ontology

GO:0005730--C:nucleolus
GO:0061484--P:hematopoietic stem cell homeostasis
GO:0001826--P:inner cell mass cell differentiation
GO:0001822--P:kidney development
GO:2001268--P:negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway
GO:0045930--P:negative regulation of mitotic cell cycle
GO:0007219--P:Notch signaling pathway
GO:0090263--P:positive regulation of canonical Wnt signaling pathway
GO:0042273--P:ribosomal large subunit biogenesis
GO:0048705--P:skeletal system morphogenesis
GO:0001756--P:somitogenesis

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000437	Aegilops tauschii	58.80	4.00e-170	590.00
IUUC-Aml-001793	Ailuropoda melanoleuca	96.83	0.00e+00	947.00
IUUC-Atr-002507	Amborella trichopoda	58.42	8.00e-169	586.00
IUUC-Apl-003964	Anas platyrhynchos	84.80	0.00e+00	811.00
IUUC-Aly-006396	Arabidopsis lyrata	54.89	2.00e-162	565.00
IUUC-Ath-007278	Arabidopsis thaliana	55.11	4.00e-162	564.00
IUUC-Ago-007951	Ashbya gossypii	48.25	1.00e-128	453.00
IUUC-Acl-008298	Aspergillus clavatus	46.48	4.00e-120	424.00
IUUC-Afl-008581	Aspergillus flavus	52.50	3.00e-109	388.00
IUUC-Afu-008906	Aspergillus fumigatus	45.51	4.00e-120	424.00
IUUC-Ani-009189	Aspergillus nidulans	44.62	4.00e-116	411.00
IUUC-Ang-009630	Aspergillus niger	50.24	7.00e-123	434.00
IUUC-Aor-010038	Aspergillus oryzae	46.60	1.00e-127	449.00
IUUC-Ate-010278	Aspergillus terreus	46.18	1.00e-122	433.00
IUUC-Ame-011890	Astyanax mexicanus	80.97	0.00e+00	823.00
IUUC-Bgr-012011	Blumeria graminis	47.98	7.00e-131	460.00
IUUC-Bta-012964	Bos taurus	97.05	0.00e+00	950.00
IUUC-Bci-013592	Botrytis cinerea	45.29	3.00e-121	428.00
IUUC-Bdi-015035	Brachypodium distachyon	59.31	1.00e-171	595.00
IUUC-Bol-015501	Brassica oleracea	54.36	1.00e-162	565.00
IUUC-Bra-017642	Brassica rapa	54.15	5.00e-162	563.00
IUUC-Cel-018430	Caenorhabditis elegans	58.37	4.00e-167	580.00
IUUC-Cja-019125	Callithrix jacchus	96.41	0.00e+00	944.00
IUUC-Cfa-021013	Canis familiaris	95.84	0.00e+00	858.00
IUUC-Cpo-021743	Cavia porcellus	95.35	0.00e+00	940.00
IUUC-Cre-022973	Chlamydomonas reinhardtii	47.71	2.00e-122	432.00
IUUC-Csa-024270	Chlorocebus sabaeus	96.08	0.00e+00	959.00
IUUC-Cin-025795	Ciona intestinalis	67.38	0.00e+00	688.00
IUUC-Csv-025953	Ciona savignyi	67.57	0.00e+00	687.00
IUUC-Cgl-026517	Colletotrichum gloeosporioides	51.99	1.00e-108	386.00
IUUC-Cne-026901	Cryptococcus neoformans	49.70	5.00e-141	494.00
IUUC-Cme-027281	Cyanidioschyzon merolae	47.25	3.00e-115	408.00
IUUC-Dre-028515	Danio rerio	78.22	0.00e+00	801.00
IUUC-Dno-029596	Dasypus novemcinctus	97.10	0.00e+00	959.00
IUUC-Dor-030494	Dipodomys ordii	94.65	0.00e+00	941.00
IUUC-Dse-031538	Dothistroma septosporum	48.28	4.00e-130	458.00
IUUC-Dme-031974	Drosophila melanogaster	58.16	3.00e-169	587.00
IUUC-Ete-032948	Echinops telfairi	98.56	1.00e-119	422.00
IUUC-Eca-033399	Equus caballus	97.88	0.00e+00	952.00
IUUC-Eeu-035013	Erinaceus europaeus	95.22	1.00e-116	413.00
IUUC-Fca-035860	Felis catus	96.84	0.00e+00	946.00
IUUC-Fal-037069	Ficedula albicollis	88.00	3.00e-132	464.00
IUUC-Fox-038059	Fusarium oxysporum	46.97	6.00e-125	440.00
IUUC-Fso-038445	Fusarium solani	47.18	3.00e-125	442.00
IUUC-Gmo-039319	Gadus morhua	76.81	0.00e+00	736.00
IUUC-Ggr-040095	Gaeumannomyces graminis	48.23	3.00e-123	435.00
IUUC-Gga-040303	Gallus gallus	85.60	6.00e-130	456.00
IUUC-Gac-042267	Gasterosteus aculeatus	78.83	0.00e+00	768.00
IUUC-Gma-043974	Glycine max	57.26	1.00e-170	592.00
IUUC-Ggo-044637	Gorilla gorilla	96.60	0.00e+00	938.00
IUUC-Hsa-046128	Homo sapiens	96.06	0.00e+00	956.00
IUUC-Hvu-047373	Hordeum vulgare	58.24	2.00e-169	588.00
IUUC-Itr-048070	Ictidomys tridecemlineatus	95.28	0.00e+00	952.00
IUUC-Kpa-049274	Komagataella pastoris	44.00	9.00e-127	447.00
IUUC-Lch-049907	Latimeria chalumnae	81.48	0.00e+00	825.00
IUUC-Lpe-050778	Leersia perrieri	54.49	3.00e-153	535.00
IUUC-Loc-051889	Lepisosteus oculatus	80.97	0.00e+00	827.00
IUUC-Lma-053041	Leptosphaeria maculans	50.12	2.00e-116	413.00
IUUC-Mcc-055660	Macaca mulatta	95.88	0.00e+00	958.00
IUUC-Meu-056197	Macropus eugenii	80.00	0.00e+00	788.00
IUUC-Mor-056949	Magnaporthe oryzae	46.79	4.00e-120	424.00
IUUC-Mpo-057571	Magnaporthe poae	45.76	3.00e-64	239.00
IUUC-Mtr-058530	Medicago truncatula	58.61	6.00e-168	583.00
IUUC-Mla-059133	Melampsora laricipopulina	45.88	6.00e-124	437.00
IUUC-Mga-059252	Meleagris gallopavo	84.38	0.00e+00	657.00
IUUC-Mvi-060522	Microbotryum violaceum	50.41	2.00e-136	478.00
IUUC-Mmr-061117	Microcebus murinus	95.26	0.00e+00	946.00
IUUC-Mdo-062892	Monodelphis domestica	89.98	0.00e+00	898.00
IUUC-Mmu-064108	Mus musculus	96.41	0.00e+00	917.00
IUUC-Mac-064430	Musa acuminata	59.96	2.00e-174	605.00
IUUC-Mpu-065882	Mustela putorius furo	96.19	0.00e+00	939.00
IUUC-Mlu-068123	Myotis lucifugus	96.41	0.00e+00	949.00
IUUC-Nfi-068484	Neosartorya fischeri	46.57	3.00e-120	425.00
IUUC-Ncr-068649	Neurospora crassa	43.88	7.00e-116	410.00
IUUC-Nle-069140	Nomascus leucogenys	96.60	0.00e+00	940.00
IUUC-Opr-070220	Ochotona princeps	88.63	0.00e+00	828.00
IUUC-Ont-072643	Oreochromis niloticus	79.87	0.00e+00	817.00
IUUC-Ocu-074007	Oryctolagus cuniculus	96.62	0.00e+00	915.00
IUUC-Oba-075904	Oryza barthii	59.74	3.00e-173	600.00
IUUC-Obr-076280	Oryza brachyantha	59.31	4.00e-172	597.00
IUUC-Ogl-077425	Oryza glaberrima	59.74	4.00e-173	600.00
IUUC-Ogu-078586	Oryza glumaepatula	59.74	5.00e-173	600.00
IUUC-Oin-079489	Oryza indica	57.60	6.00e-164	570.00
IUUC-Olo-080766	Oryza longistaminata	59.62	7.00e-173	600.00
IUUC-Ome-081905	Oryza meridionalis	59.74	3.00e-173	601.00
IUUC-Oni-083022	Oryza nivara	59.74	2.00e-173	602.00
IUUC-Opu-083615	Oryza punctata	59.74	3.00e-173	601.00
IUUC-Oru-085076	Oryza rufipogon	59.74	2.00e-173	602.00
IUUC-Osa-085516	Oryza sativa	59.74	2.00e-173	602.00
IUUC-Ola-087290	Oryzias latipes	78.36	0.00e+00	803.00
IUUC-Olu-087898	Ostreococcus lucimarinus	53.14	8.00e-145	506.00
IUUC-Oga-088980	Otolemur garnettii	95.75	0.00e+00	936.00
IUUC-Oar-089580	Ovis aries	96.83	0.00e+00	825.00
IUUC-Ptr-090845	Pan troglodytes	96.18	0.00e+00	935.00
IUUC-Pan-092836	Papio anubis	95.85	0.00e+00	953.00
IUUC-Psi-093965	Pelodiscus sinensis	83.33	2.00e-56	210.00
IUUC-Pno-095052	Phaeosphaeria nodorum	47.43	8.00e-122	430.00
IUUC-Ppa-095432	Physcomitrella patens	58.77	8.00e-171	593.00
IUUC-Pfo-096963	Poecilia formosa	71.43	0.00e+00	699.00
IUUC-Pab-097716	Pongo abelii	92.78	0.00e+00	894.00
IUUC-Pop-099224	Populus trichocarpa	58.94	2.00e-172	598.00
IUUC-Pca-100682	Procavia capensis	94.37	0.00e+00	688.00
IUUC-Ppe-101819	Prunus persica	58.21	2.00e-170	591.00
IUUC-Pva-102338	Pteropus vampyrus	96.48	0.00e+00	737.00
IUUC-Pgr-103583	Puccinia graminis	54.74	6.00e-132	464.00
IUUC-Ptt-103737	Puccinia triticina	44.57	4.00e-99	355.00
IUUC-Pte-104150	Pyrenophora teres	50.23	3.00e-121	428.00
IUUC-Pyt-104606	Pyrenophora triticirepentis	50.00	6.00e-121	427.00
IUUC-Rno-105987	Rattus norvegicus	95.97	0.00e+00	939.00
IUUC-Sce-106315	Saccharomyces cerevisiae	47.26	8.00e-130	456.00
IUUC-Sha-107273	Sarcophilus harrisii	90.17	0.00e+00	905.00
IUUC-Sja-107677	Schizosaccharomyces japonicus	45.59	6.00e-119	421.00
IUUC-Spo-108092	Schizosaccharomyces pombe	48.97	9.00e-123	433.00
IUUC-Ssl-108442	Sclerotinia sclerotiorum	44.31	1.00e-116	413.00
IUUC-Smo-108855	Selaginella moellendorffii	56.67	3.00e-164	571.00
IUUC-Sit-110329	Setaria italica	59.96	5.00e-173	600.00
IUUC-Sly-111830	Solanum lycopersicum	60.60	5.00e-175	607.00
IUUC-Stu-112603	Solanum tuberosum	60.60	5.00e-175	607.00
IUUC-Sar-113504	Sorex araneus	86.27	2.00e-74	273.00
IUUC-Sbi-114560	Sorghum bicolor	58.46	2.00e-169	588.00
IUUC-Sre-115133	Sporisorium reilianum	41.62	2.00e-124	439.00
IUUC-Ssc-115903	Sus scrofa	97.68	0.00e+00	950.00
IUUC-Tgu-116798	Taeniopygia guttata	85.20	0.00e+00	855.00
IUUC-Tru-118361	Takifugu rubripes	78.74	0.00e+00	803.00
IUUC-Tsy-118849	Tarsius syrichta	96.26	0.00e+00	954.00
IUUC-Tni-120094	Tetraodon nigroviridis	77.53	0.00e+00	804.00
IUUC-Tca-121634	Theobroma cacao	57.98	5.00e-169	587.00
IUUC-Tre-122051	Trichoderma reesei	47.08	1.00e-120	426.00
IUUC-Tvi-122322	Trichoderma virens	48.54	9.00e-125	440.00
IUUC-Tae-125822	Triticum aestivum	58.67	2.00e-170	591.00
IUUC-Tur-126766	Triticum urartu	52.38	5.00e-162	564.00
IUUC-Tme-127175	Tuber melanosporum	52.42	2.00e-132	466.00
IUUC-Tbe-127779	Tupaia belangeri	96.02	0.00e+00	836.00
IUUC-Ttr-128224	Tursiops truncatus	92.76	0.00e+00	817.00
IUUC-Uma-129537	Ustilago maydis	41.99	2.00e-124	439.00
IUUC-Vda-129927	Verticillium dahliae	45.61	1.00e-111	396.00
IUUC-Vpa-130658	Vicugna pacos	84.02	0.00e+00	809.00
IUUC-Vvi-131659	Vitis vinifera	57.80	1.00e-172	599.00
IUUC-Xtr-132918	Xenopus tropicalis	76.24	0.00e+00	788.00
IUUC-Xma-133700	Xiphophorus maculatus	80.04	0.00e+00	814.00
IUUC-Yli-134478	Yarrowia lipolytica	50.20	4.00e-139	488.00
IUUC-Zma-135835	Zea mays	55.58	7.00e-166	576.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence