iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Bta-013080

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

DAAA02017014

Gene Name

HERC6

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSBTAG00000020536.5	ENSBTAT00000027362.5	ENSBTAP00000027362.5

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	9.10e-85	285.1	690	1009

Active Site

Position(s)	Description	Evidence
980	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 3    sdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlld 89
            dl+k l vef +E   + +Gv++ef++++++ + + ++g+f+y e+d+++++p + ++     +  +F ++G+l+g++l++ +++ 
   Q: 690  TDLQKILVVEFIKEIRSGGEGVKSEFFHCIFESMTKEEYGMFMYPEEDSYMWFPVKPKFE----KKMYF-LFGMLCGLSLYNFNVVY 771
           689999***************************************************984....44555.77*************** PP
   S: 90   lplsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvkl 176
           lp++ +++k+ll+++ sledl+e+ p + k l+e+++ + +di+e+ + l+fs+      ++++++L+p+G ++ V ++Nk++Yv++
   Q: 772  LPFPLALFKKLLDQEPSLEDLKELSPSFGKCLQEVLNDDVNDIKEE-FGLRFSI----HWDQNDVDLIPNGISVFVDQSNKKDYVSK 853
           ************************************9988899987.9999985....55789999********************* PP
   S: 177  vveyrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerka 263
            v+y l++++k  +e+f++Gf++++++e+l+ F++eel   i G++++d+e+++k+  y++gy+e++p+i +Fw+++++++ +e+++
   Q: 854  CVDYVLNTSVKAVYEEFQRGFYKLFDKEILKHFKPEELMRAIIGNTDYDWEQFEKNSIYEQGYHESHPTILMFWKAFHSLTLDEKRK 940
           *************************************************************************************** PP
   S: 264  fLqFvTgssrlPlgGfaelkprlfvirkdasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgF 333
           fL F+Tg++rl ++G+++   r f +++  s++++P+s TC n L+LPeYs+++++ke L+ Ai+++kgF
   Q: 941  FLFFLTGNDRLHVKGIQKPGIR-FRCPETCSESDFPKSLTCHNILELPEYSTMKKVKEALQRAINSNKGF 1009
           ******************9966.6777779***************************************9 PP

Organism

Bos taurus

Protein Sequence
(Fasta)

MYFCWRAGGR RPLRERQVCA GGNTLLQAAS GEHHSLLLLS DGTVQSCGDN SRGQLGRKGT 60
PRGEQPERIP ALETLNVALV SCGKEHSLAV CHKGRVFAWG AASEGQLGIG EFKETTFIPK 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AAGGCGCGGC TCACGCAGCC TCCGGTTTTC TGAGTAACAG CGCGCACTCG TCACTAGCCT 60
TAGGGTGCTG GGCTAGCAGA GCTCACAGAT TCGGGCAGGC GGCCGGAGCG CGGGAAGGCG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0677--Repeat
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000569--HECT_dom
IPR009091--RCC1/BLIP-II
IPR000408--Reg_chr_condens

PROSITE

PS50237--HECT
PS00626--RCC1_2
PS50012--RCC1_3

Pfam

PF00632--HECT
PF00415--RCC1

PRINTS

PR00633--RCCNDNSATION

SMART

SM00119--HECTc

Gene Ontology

GO:0005829--C:cytosol
GO:0005634--C:nucleus
GO:0004842--F:ubiquitin-protein transferase activity
GO:0002244--P:hematopoietic progenitor cell differentiation

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001374	Ailuropoda melanoleuca	71.86	0.00e+00	1338.00
IUUC-Aca-004663	Anolis carolinensis	46.90	0.00e+00	867.00
IUUC-Cja-018891	Callithrix jacchus	70.19	0.00e+00	1373.00
IUUC-Cfa-020763	Canis familiaris	71.62	0.00e+00	1308.00
IUUC-Cpo-022346	Cavia porcellus	67.67	0.00e+00	1342.00
IUUC-Csa-023049	Chlorocebus sabaeus	73.53	0.00e+00	1495.00
IUUC-Cho-025101	Choloepus hoffmanni	43.34	2.00e-167	582.00
IUUC-Dno-029093	Dasypus novemcinctus	70.60	0.00e+00	1393.00
IUUC-Eca-034098	Equus caballus	76.36	0.00e+00	1407.00
IUUC-Eeu-035028	Erinaceus europaeus	59.57	1.00e-160	560.00
IUUC-Fca-036283	Felis catus	74.73	0.00e+00	1389.00
IUUC-Ggo-045553	Gorilla gorilla	72.05	0.00e+00	1404.00
IUUC-Hsa-046396	Homo sapiens	73.73	0.00e+00	1460.00
IUUC-Itr-049004	Ictidomys tridecemlineatus	43.32	0.00e+00	766.00
IUUC-Loc-052700	Lepisosteus oculatus	40.59	0.00e+00	754.00
IUUC-Laf-054433	Loxodonta africana	68.77	0.00e+00	1409.00
IUUC-Mcc-055014	Macaca mulatta	69.84	0.00e+00	1421.00
IUUC-Mdo-061839	Monodelphis domestica	56.57	0.00e+00	976.00
IUUC-Mmu-064378	Mus musculus	62.76	0.00e+00	1191.00
IUUC-Mpu-066293	Mustela putorius furo	70.40	0.00e+00	1300.00
IUUC-Mlu-067407	Myotis lucifugus	71.43	0.00e+00	1386.00
IUUC-Nle-069978	Nomascus leucogenys	73.33	0.00e+00	1487.00
IUUC-Opr-070190	Ochotona princeps	57.10	0.00e+00	652.00
IUUC-Oga-088780	Otolemur garnettii	64.42	0.00e+00	1263.00
IUUC-Oar-090307	Ovis aries	89.96	0.00e+00	1771.00
IUUC-Ptr-091567	Pan troglodytes	73.63	0.00e+00	1454.00
IUUC-Pan-091802	Papio anubis	68.69	0.00e+00	1371.00
IUUC-Pab-098024	Pongo abelii	61.33	0.00e+00	1174.00
IUUC-Pca-100315	Procavia capensis	56.45	0.00e+00	781.00
IUUC-Pva-102382	Pteropus vampyrus	69.71	0.00e+00	1319.00
IUUC-Rno-105768	Rattus norvegicus	60.12	0.00e+00	1165.00
IUUC-Sha-106525	Sarcophilus harrisii	52.64	0.00e+00	1021.00
IUUC-Sar-113014	Sorex araneus	60.36	3.00e-156	545.00
IUUC-Tsy-119565	Tarsius syrichta	68.13	1.00e-148	520.00
IUUC-Tbe-127787	Tupaia belangeri	44.31	0.00e+00	740.00
IUUC-Vpa-130214	Vicugna pacos	72.19	0.00e+00	1287.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence