iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

UUCD2 ID

IUUC-Mmu-063500

UUCD1 version

UUC-MuM-00296

Ensembl Protein ID

ENSMUSP00000108558.1

UniProt Accession

P0C090; A2AVP5; RC3H2_MOUSE

Genbank Protein ID

CAM25192.1

Protein Name

Roquin-2; Membrane-associated nucleic acid-binding protein; RING finger and CCCH-type zinc finger domain-containing protein 2; RING-type E3 ubiquitin transferase Roquin-2

Genbank Nucleotide ID

AL929572

Gene Name

Rc3h2; Mnab

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMUSG00000075376.10	ENSMUST00000112934.7	ENSMUSP00000108556.1
ENSMUSG00000075376.10	ENSMUST00000112936.3	ENSMUSP00000108558.1
ENSMUSG00000075376.10	ENSMUST00000125619.6	ENSMUSP00000145082.1

Annotation

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	GXD
DNA & RNA Element
AREsite	miRTarBase	microRNA	TRANSFAC
RepTar	RAID2
Protein-protein Interaction
IID	Mentha
Post-translational Modifications (PTMs)
dbPAF	PhosphositePlus
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
E3 activity/RING/RING	95.30	0.00e+00	2215.00	IUUC-Hsa-046662

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Organism

Mus musculus

Functional Description
(View)

Post-transcriptional repressor of mRNAs containing a conserved stem loop motif, called constitutive decay element (CDE), which is often located in the 3'-UTR, as in HMGXB3, ICOS, IER3, NFKBID, NFKBIZ, PPP1R10, TNF and in many more mRNAs. Binds to CDE and promotes mRNA deadenylation and degradation. This process does not involve miRNAs (PubMed:23663784). In follicular helper T (Tfh) cells, represses of ICOS and TNFRSF4/Ox40 expression, thus preventing spontaneous Tfh cell differentiation, germinal center B-cell differentiation in the absence of immunization and autoimmunity. In resting or LPS-stimulated macrophages, controls inflammation by suppressing TNF expression. Also recognizes CDE in its own mRNA and in that of paralogous RC3H2, possibly leading to feedback loop regulation (PubMed:23583643, PubMed:23583642). May act as ubiquitin E3 ligase. Involved in the ubiquitination of MAP3K5 (By similarity).

Protein Sequence
(Fasta)

MPVQAAQWTE FLSCPICYNE FDENVHKPIS LGCSHTVCKT CLNKLHRKAC PFDQTAINTD 60
IDVLPVNFAL LQLVGAQVPD HQSIKLSNLG ENKHYEVAKK CVEDLALYLK PLSGGKGVAS 120

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Nucleotide Sequence
(Fasta)

GTAGCTCCCG ATGGAGTTTG AGGCCCTGAA ACCGCCGCCG AGCTCTGCCC CGGCGAGACG 60
AGGCGCCTCC GTCGCCGAGC CGCGCCGTCG CGGGGCCCCC GGGAGCGGCC CTTAGCGACC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0479--Metal-binding
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0678--Repressor
KW-0694--RNA-binding
KW-0808--Transferase
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR032670--RC3H2
IPR027370--Znf-RING_LisH
IPR000571--Znf_CCCH
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS

PROSITE

PS50103--ZF_C3H1
PS00518--ZF_RING_1
PS50089--ZF_RING_2

Pfam

PF00642--zf-CCCH
PF13445--zf-RING_UBOX

SMART

SM00184--RING
SM00356--ZnF_C3H1

Gene Ontology

GO:0009986--C:cell surface
GO:0016020--C:membrane
GO:0000932--C:P-body
GO:0003677--F:DNA binding
GO:0003729--F:mRNA binding
GO:0003723--F:RNA binding
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0001782--P:B cell homeostasis
GO:0060173--P:limb development
GO:0048286--P:lung alveolus development
GO:0048535--P:lymph node development
GO:0035264--P:multicellular organism growth
GO:1901224--P:positive regulation of NIK/NF-kappaB signaling
GO:0009791--P:post-embryonic development
GO:0010608--P:posttranscriptional regulation of gene expression
GO:0000209--P:protein polyubiquitination
GO:0010468--P:regulation of gene expression
GO:0048536--P:spleen development
GO:0043029--P:T cell homeostasis
GO:0042098--P:T cell proliferation
GO:0061470--P:T follicular helper cell differentiation

KEGG

mmu:319817

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002394	Ailuropoda melanoleuca	95.63	0.00e+00	2199.00
IUUC-Apl-004222	Anas platyrhynchos	89.19	0.00e+00	2022.00
IUUC-Ang-009644	Aspergillus niger	27.78	2.00e-03	37.00
IUUC-Bta-012366	Bos taurus	94.79	0.00e+00	2156.00
IUUC-Cel-018474	Caenorhabditis elegans	48.72	2.00e-08	55.50
IUUC-Cja-019462	Callithrix jacchus	95.55	0.00e+00	2166.00
IUUC-Cpo-021406	Cavia porcellus	95.79	0.00e+00	2184.00
IUUC-Csa-023857	Chlorocebus sabaeus	95.10	0.00e+00	1892.00
IUUC-Cho-024281	Choloepus hoffmanni	84.65	0.00e+00	697.00
IUUC-Dre-028035	Danio rerio	54.96	0.00e+00	1047.00
IUUC-Dno-029311	Dasypus novemcinctus	94.28	0.00e+00	2174.00
IUUC-Dor-030104	Dipodomys ordii	91.33	0.00e+00	1747.00
IUUC-Ete-032926	Echinops telfairi	85.37	0.00e+00	1381.00
IUUC-Eca-034318	Equus caballus	95.79	0.00e+00	2202.00
IUUC-Fca-035557	Felis catus	95.47	0.00e+00	2193.00
IUUC-Fal-037375	Ficedula albicollis	89.94	0.00e+00	2058.00
IUUC-Gga-040314	Gallus gallus	89.19	0.00e+00	1983.00
IUUC-Ggo-045647	Gorilla gorilla	95.47	0.00e+00	2166.00
IUUC-Hsa-046662	Homo sapiens	95.30	0.00e+00	2160.00
IUUC-Itr-047974	Ictidomys tridecemlineatus	93.80	0.00e+00	1371.00
IUUC-Loc-052585	Lepisosteus oculatus	62.03	0.00e+00	1249.00
IUUC-Laf-054151	Loxodonta africana	94.20	0.00e+00	2157.00
IUUC-Mcc-055136	Macaca mulatta	95.63	0.00e+00	2167.00
IUUC-Meu-056747	Macropus eugenii	99.21	3.00e-143	503.00
IUUC-Mga-060133	Meleagris gallopavo	89.12	0.00e+00	1982.00
IUUC-Mmr-061559	Microcebus murinus	95.29	0.00e+00	2192.00
IUUC-Mdo-061870	Monodelphis domestica	92.60	0.00e+00	1993.00
IUUC-Mpu-066281	Mustela putorius furo	95.46	0.00e+00	2192.00
IUUC-Mlu-067576	Myotis lucifugus	93.36	0.00e+00	2200.00
IUUC-Nle-069921	Nomascus leucogenys	95.13	0.00e+00	2227.00
IUUC-Opr-070470	Ochotona princeps	90.87	0.00e+00	1375.00
IUUC-Ont-071268	Oreochromis niloticus	58.62	0.00e+00	1150.00
IUUC-Oan-073576	Ornithorhynchus anatinus	92.13	0.00e+00	1910.00
IUUC-Ocu-073971	Oryctolagus cuniculus	95.54	0.00e+00	2172.00
IUUC-Oga-088315	Otolemur garnettii	94.96	0.00e+00	2190.00
IUUC-Oar-090393	Ovis aries	94.88	0.00e+00	2182.00
IUUC-Ptr-091666	Pan troglodytes	95.38	0.00e+00	2162.00
IUUC-Pan-092630	Papio anubis	94.04	0.00e+00	2113.00
IUUC-Psi-093944	Pelodiscus sinensis	89.10	0.00e+00	2063.00
IUUC-Pfo-097469	Poecilia formosa	54.33	0.00e+00	1008.00
IUUC-Pab-098468	Pongo abelii	91.60	0.00e+00	2036.00
IUUC-Pca-100792	Procavia capensis	85.84	0.00e+00	1258.00
IUUC-Pva-103070	Pteropus vampyrus	93.62	0.00e+00	2157.00
IUUC-Rno-105194	Rattus norvegicus	98.48	0.00e+00	2283.00
IUUC-Sha-106725	Sarcophilus harrisii	91.89	0.00e+00	2111.00
IUUC-Sar-112923	Sorex araneus	93.53	0.00e+00	2184.00
IUUC-Ssc-115411	Sus scrofa	95.30	0.00e+00	2191.00
IUUC-Tgu-116794	Taeniopygia guttata	89.19	0.00e+00	2023.00
IUUC-Tru-118270	Takifugu rubripes	57.35	0.00e+00	951.00
IUUC-Tsy-119636	Tarsius syrichta	93.20	0.00e+00	2130.00
IUUC-Tni-120659	Tetraodon nigroviridis	59.10	0.00e+00	1028.00
IUUC-Tbe-127317	Tupaia belangeri	94.25	0.00e+00	1439.00
IUUC-Ttr-129141	Tursiops truncatus	96.40	0.00e+00	1351.00
IUUC-Vpa-130204	Vicugna pacos	95.05	0.00e+00	2240.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence