iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Details
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

iUUCD ID

IUUC-Sce-106394

UUCD1 version

UUC-SaC-00252

Ensembl Protein ID

YDR177W

UniProt Accession

P21734; D6VSF9; UBC1_YEAST

Genbank Protein ID

CAA39812.1; CAA86682.1; AAS56001.1; DAA12019.1

Protein Name

Ubiquitin-conjugating enzyme E2 1; E2 ubiquitin-conjugating enzyme 1; Ubiquitin carrier protein; Ubiquitin-conjugating enzyme E2-24 kDa; Ubiquitin-protein ligase

Genbank Nucleotide ID

X56402; Z46727; AY557675; BK006938

Gene Name

UBC1; YDR177W; YD9395.10

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
YDR177W	YDR177W	YDR177W

Annotation

mRNA Expression
GEO	FFGED
Protein-protein Interaction
IID	iRefIndex	HINT	Mentha
Protein 3D Structure
PDB	MMDB
Post-translational Modifications (PTMs)
CPLM	dbPAF	BioGRID
Protein Expression/Proteomics
GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E2/UBC	E2_UBC	15328341; 19951915; 19759160; 16687735
UBD/Alpha-Helix/UBA	UBA	15328341

Classification

Family	E-value	Score	Start	End
E2/UBC	1.40e-46	156.1	6	141
UBD/Alpha-Helix/UBA	6.50e-08	31.0	169	214

Active Site

Position(s)	Description	Evidence
88	Glycyl thioester intermediate	N/A

Domain Profile

E2/UBC

   S: 1    RlkkelkelekdppegisakpvdesdltewevlilGpedtpYeggvFkleiefpedYPfkPPkvkfltkifhPnvyen.GkvClsilkeeekWspalsvesv 101
           R++ke++++++dp ++i++++v+esd+++++ ++lGp++tpYegg+F ++ie+p +YPfkPPk++f tk++hPn+++  G++Cl+ilk  ++Wsp+++++s 
   Q: 6    RIMKEIQAVKDDPAAHITLEFVSESDIHHLKGTFLGPPGTPYEGGKFVVDIEVPMEYPFKPPKMQFDTKVYHPNISSVtGAICLDILK--NAWSPVITLKSA 105
           9****************************************************************************99********9..************ PP
   S: 102  llsiqsllaepnpesplneeaaellkknreeykkkv 137
           l+s+q+ll++p+p++p+++e+a+++ ++re+++k++
   Q: 106  LISLQALLQSPEPNDPQDAEVAQHYLRDRESFNKTA 141
           *********************************987 PP

UBD/Alpha-Helix/UBA

   S: 3    dedkleqlveMGFdreealqaLra........a.nnnleaAveyLl 39
           d+d++++++++GF+++++++ Lr+        + nn++++ +e Ll
   Q: 169  DHDLIDEFESQGFEKDKIVEVLRRlgvksldpNdNNTANRIIEELL 214
           89******************************99**********98 PP

Organism

Saccharomyces cerevisiae

Functional Description
(View)

Catalyzes the covalent attachment of ubiquitin to other proteins. Functions in degradation of misfolded or regulated proteins localized in the endoplasmic reticulum (ER) lumen or membrane via the ubiquitin-proteasome system. Cognate E2 conjugating enzyme for the HRD1 ubiquitin ligase complex, which is part of the ERAD-L and ERAD-M pathways responsible for the rapid degradation of soluble lumenal and membrane proteins with misfolded lumenal domains (ERAD-L), or ER-membrane proteins with misfolded transmembrane domains (ERAD-M).

Protein Sequence
(Fasta)

MSRAKRIMKE IQAVKDDPAA HITLEFVSES DIHHLKGTFL GPPGTPYEGG KFVVDIEVPM 60
EYPFKPPKMQ FDTKVYHPNI SSVTGAICLD ILKNAWSPVI TLKSALISLQ ALLQSPEPND 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGTCTAGGG CTAAGAGAAT TATGAAAGAA ATCCAAGCTG TGAAGGATGA TCCTGCAGCT 60
CACATTACTC TTGAATTTGT GAGTGAATCT GATATCCACC ATTTAAAAGG CACATTTTTG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0067--ATP-binding
KW-0181--Complete proteome
KW-1017--Isopeptide bond
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0346--Stress response
KW-0808--Transferase
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway

Interpro

IPR009060--UBA-like
IPR015368--UBA_C_fun
IPR000608--UBQ-conjugat_E2
IPR023313--UBQ-conjugating_AS
IPR016135--UBQ-conjugating_enzyme/RWD

PROSITE

PS00183--UBIQUITIN_CONJUGAT_1
PS50127--UBIQUITIN_CONJUGAT_2

Pfam

PF09288--UBA_3
PF00179--UQ_con

Gene Ontology

GO:0005634--C:nucleus
GO:0000502--C:proteasome complex
GO:0005524--F:ATP binding
GO:0061630--F:ubiquitin protein ligase activity
GO:0031625--F:ubiquitin protein ligase binding
GO:0004842--F:ubiquitin-protein transferase activity
GO:0000209--P:protein polyubiquitination
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0030433--P:ubiquitin-dependent ERAD pathway
GO:0016050--P:vesicle organization

KEGG

sce:YDR177W

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000621	Aegilops tauschii	53.12	1.00e-24	104.00
IUUC-Aml-001286	Ailuropoda melanoleuca	43.01	1.00e-37	147.00
IUUC-Atr-003063	Amborella trichopoda	54.94	2.00e-34	136.00
IUUC-Apl-004122	Anas platyrhynchos	45.09	2.00e-35	140.00
IUUC-Aca-004565	Anolis carolinensis	45.09	1.00e-35	140.00
IUUC-Aly-006390	Arabidopsis lyrata	52.70	2.00e-44	169.00
IUUC-Ath-006637	Arabidopsis thaliana	49.69	8.00e-42	160.00
IUUC-Ago-007714	Ashbya gossypii	76.28	2.00e-99	352.00
IUUC-Acl-008189	Aspergillus clavatus	42.17	2.00e-35	140.00
IUUC-Afl-008489	Aspergillus flavus	49.55	2.00e-40	157.00
IUUC-Afu-008850	Aspergillus fumigatus	47.98	2.00e-41	160.00
IUUC-Ani-009361	Aspergillus nidulans	42.86	9.00e-35	137.00
IUUC-Ang-009548	Aspergillus niger	45.54	2.00e-36	143.00
IUUC-Aor-010105	Aspergillus oryzae	49.55	2.00e-40	157.00
IUUC-Ate-010389	Aspergillus terreus	45.98	2.00e-38	150.00
IUUC-Ame-011454	Astyanax mexicanus	43.16	3.00e-38	149.00
IUUC-Bgr-012255	Blumeria graminis	42.86	2.00e-40	157.00
IUUC-Bta-012992	Bos taurus	43.01	1.00e-37	147.00
IUUC-Bci-013806	Botrytis cinerea	44.60	5.00e-43	165.00
IUUC-Bdi-015024	Brachypodium distachyon	51.43	2.00e-36	142.00
IUUC-Bol-015985	Brassica oleracea	52.70	6.00e-45	171.00
IUUC-Bra-016805	Brassica rapa	52.70	4.00e-45	171.00
IUUC-Cel-018353	Caenorhabditis elegans	40.53	8.00e-40	154.00
IUUC-Cja-019051	Callithrix jacchus	43.01	1.00e-37	147.00
IUUC-Cfa-020016	Canis familiaris	43.01	1.00e-37	147.00
IUUC-Cpo-022026	Cavia porcellus	43.01	1.00e-37	147.00
IUUC-Cre-022987	Chlamydomonas reinhardtii	45.99	2.00e-31	126.00
IUUC-Csa-023059	Chlorocebus sabaeus	43.01	1.00e-37	147.00
IUUC-Cin-025598	Ciona intestinalis	50.68	5.00e-36	141.00
IUUC-Csv-025831	Ciona savignyi	43.14	4.00e-36	142.00
IUUC-Cgl-026449	Colletotrichum gloeosporioides	44.21	2.00e-43	166.00
IUUC-Cne-027068	Cryptococcus neoformans	50.00	6.00e-58	214.00
IUUC-Dre-028139	Danio rerio	42.63	6.00e-38	148.00
IUUC-Dno-029169	Dasypus novemcinctus	45.09	1.00e-35	140.00
IUUC-Dse-031335	Dothistroma septosporum	43.48	1.00e-46	177.00
IUUC-Dme-032003	Drosophila melanogaster	52.00	4.00e-36	142.00
IUUC-Eca-033428	Equus caballus	43.01	1.00e-37	147.00
IUUC-Fca-035366	Felis catus	43.01	1.00e-37	147.00
IUUC-Fal-037016	Ficedula albicollis	43.01	1.00e-37	147.00
IUUC-Fox-037969	Fusarium oxysporum	42.03	2.00e-44	170.00
IUUC-Fso-038296	Fusarium solani	42.04	1.00e-45	174.00
IUUC-Gmo-039135	Gadus morhua	43.68	3.00e-38	149.00
IUUC-Ggr-039768	Gaeumannomyces graminis	44.71	1.00e-38	150.00
IUUC-Gga-041018	Gallus gallus	43.01	1.00e-37	146.00
IUUC-Gac-041503	Gasterosteus aculeatus	43.68	1.00e-38	150.00
IUUC-Gma-043630	Glycine max	53.80	4.00e-45	172.00
IUUC-Ggo-045032	Gorilla gorilla	43.01	1.00e-37	147.00
IUUC-Hsa-046490	Homo sapiens	43.01	1.00e-37	147.00
IUUC-Itr-048373	Ictidomys tridecemlineatus	43.01	1.00e-37	147.00
IUUC-Kpa-049297	Komagataella pastoris	52.52	5.00e-61	225.00
IUUC-Lch-050588	Latimeria chalumnae	55.04	3.00e-40	155.00
IUUC-Lpe-051070	Leersia perrieri	52.00	3.00e-32	129.00
IUUC-Loc-052549	Lepisosteus oculatus	42.63	8.00e-38	147.00
IUUC-Lma-052949	Leptosphaeria maculans	42.86	8.00e-51	191.00
IUUC-Laf-053688	Loxodonta africana	45.09	1.00e-35	140.00
IUUC-Mcc-055606	Macaca mulatta	43.01	1.00e-37	147.00
IUUC-Mor-056946	Magnaporthe oryzae	45.93	8.00e-41	158.00
IUUC-Mpo-057441	Magnaporthe poae	46.15	1.00e-39	154.00
IUUC-Mtr-058002	Medicago truncatula	50.96	5.00e-45	171.00
IUUC-Mla-059007	Melampsora laricipopulina	53.57	4.00e-58	215.00
IUUC-Mga-059254	Meleagris gallopavo	45.09	1.00e-35	140.00
IUUC-Mvi-060346	Microbotryum violaceum	47.27	1.00e-55	206.00
IUUC-Mmr-061211	Microcebus murinus	43.01	1.00e-37	147.00
IUUC-Mdo-062458	Monodelphis domestica	43.01	1.00e-35	140.00
IUUC-Mmu-063648	Mus musculus	43.01	1.00e-37	147.00
IUUC-Mac-065447	Musa acuminata	49.22	2.00e-40	156.00
IUUC-Mpu-066407	Mustela putorius furo	43.01	3.00e-37	146.00
IUUC-Mlu-067682	Myotis lucifugus	45.09	1.00e-35	140.00
IUUC-Nfi-068517	Neosartorya fischeri	47.98	2.00e-41	160.00
IUUC-Ncr-068749	Neurospora crassa	42.23	9.00e-48	181.00
IUUC-Nle-069712	Nomascus leucogenys	45.09	3.00e-35	139.00
IUUC-Opr-070651	Ochotona princeps	43.01	1.00e-37	147.00
IUUC-Ont-071595	Oreochromis niloticus	43.68	1.00e-38	150.00
IUUC-Ocu-074939	Oryctolagus cuniculus	43.01	1.00e-37	147.00
IUUC-Oba-075530	Oryza barthii	52.30	2.00e-33	133.00
IUUC-Obr-076838	Oryza brachyantha	52.87	7.00e-34	134.00
IUUC-Ogl-077606	Oryza glaberrima	52.30	2.00e-33	133.00
IUUC-Ogu-078238	Oryza glumaepatula	52.30	2.00e-33	133.00
IUUC-Oin-079643	Oryza indica	52.30	2.00e-33	133.00
IUUC-Ome-081274	Oryza meridionalis	52.30	2.00e-33	133.00
IUUC-Oni-082651	Oryza nivara	52.30	2.00e-33	133.00
IUUC-Opu-083933	Oryza punctata	52.30	3.00e-33	132.00
IUUC-Oru-085054	Oryza rufipogon	52.30	2.00e-33	133.00
IUUC-Osa-085716	Oryza sativa	52.30	2.00e-33	133.00
IUUC-Ola-087043	Oryzias latipes	43.68	1.00e-38	150.00
IUUC-Olu-087846	Ostreococcus lucimarinus	44.39	1.00e-48	183.00
IUUC-Oga-088897	Otolemur garnettii	43.48	5.00e-36	141.00
IUUC-Oar-089673	Ovis aries	41.97	1.00e-36	143.00
IUUC-Ptr-091295	Pan troglodytes	43.01	1.00e-37	147.00
IUUC-Pan-092034	Papio anubis	45.09	3.00e-35	139.00
IUUC-Psi-093498	Pelodiscus sinensis	43.01	1.00e-37	147.00
IUUC-Pma-094115	Petromyzon marinus	43.01	3.00e-38	149.00
IUUC-Pno-095102	Phaeosphaeria nodorum	43.75	2.00e-51	193.00
IUUC-Ppa-095326	Physcomitrella patens	56.96	3.00e-40	155.00
IUUC-Pfo-096174	Poecilia formosa	43.68	8.00e-39	150.00
IUUC-Pab-098279	Pongo abelii	43.01	1.00e-37	147.00
IUUC-Pop-099543	Populus trichocarpa	50.27	2.00e-47	179.00
IUUC-Pca-100782	Procavia capensis	43.01	3.00e-36	142.00
IUUC-Ppe-101789	Prunus persica	52.53	7.00e-40	154.00
IUUC-Pgr-103643	Puccinia graminis	58.75	7.00e-52	195.00
IUUC-Ptt-103772	Puccinia triticina	60.81	4.00e-50	189.00
IUUC-Pte-104370	Pyrenophora teres	41.96	4.00e-49	185.00
IUUC-Pyt-104592	Pyrenophora triticirepentis	41.52	2.00e-48	183.00
IUUC-Rno-104984	Rattus norvegicus	43.01	1.00e-37	147.00
IUUC-Sha-106721	Sarcophilus harrisii	43.52	9.00e-39	150.00
IUUC-Sja-107866	Schizosaccharomyces japonicus	53.74	2.00e-60	223.00
IUUC-Spo-108209	Schizosaccharomyces pombe	52.56	3.00e-60	222.00
IUUC-Ssl-108609	Sclerotinia sclerotiorum	43.40	2.00e-43	167.00
IUUC-Smo-109233	Selaginella moellendorffii	48.90	3.00e-37	145.00
IUUC-Sit-110639	Setaria italica	51.15	4.00e-37	145.00
IUUC-Sly-110978	Solanum lycopersicum	45.31	2.00e-44	169.00
IUUC-Stu-112088	Solanum tuberosum	45.83	6.00e-45	171.00
IUUC-Sbi-113986	Sorghum bicolor	51.72	1.00e-37	147.00
IUUC-Sre-115046	Sporisorium reilianum	49.56	6.00e-58	214.00
IUUC-Ssc-116314	Sus scrofa	43.01	1.00e-37	147.00
IUUC-Tgu-117427	Taeniopygia guttata	45.09	1.00e-35	140.00
IUUC-Tru-118196	Takifugu rubripes	46.77	7.00e-39	151.00
IUUC-Tsy-119208	Tarsius syrichta	42.49	4.00e-37	145.00
IUUC-Tni-119667	Tetraodon nigroviridis	43.16	2.00e-38	149.00
IUUC-Tca-121446	Theobroma cacao	45.55	3.00e-44	169.00
IUUC-Tre-122053	Trichoderma reesei	44.13	3.00e-47	179.00
IUUC-Tvi-122533	Trichoderma virens	43.63	6.00e-45	171.00
IUUC-Tae-124726	Triticum aestivum	51.45	9.00e-30	120.00
IUUC-Tme-127024	Tuber melanosporum	38.49	7.00e-48	181.00
IUUC-Tbe-127752	Tupaia belangeri	43.01	3.00e-37	145.00
IUUC-Ttr-128287	Tursiops truncatus	45.09	1.00e-35	140.00
IUUC-Uma-129512	Ustilago maydis	49.56	2.00e-57	213.00
IUUC-Vda-129947	Verticillium dahliae	42.86	3.00e-45	172.00
IUUC-Vpa-130481	Vicugna pacos	43.01	2.00e-37	146.00
IUUC-Vvi-131429	Vitis vinifera	54.97	6.00e-44	167.00
IUUC-Xma-134165	Xiphophorus maculatus	43.68	1.00e-38	150.00
IUUC-Yli-134523	Yarrowia lipolytica	57.48	7.00e-65	237.00
IUUC-Zma-135733	Zea mays	43.50	1.00e-35	140.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence