iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Mdo-062124

Ensembl Protein ID

ENSMODP00000008575.3

UniProt Accession

F6PS88; F6PS88_MONDO

Protein Name

Uncharacterized protein

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMODG00000025321.2	ENSMODT00000008745.3	ENSMODP00000008575.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	8.80e-32	108.0	287	324
E3 adaptor/Cullin RING/APC_C/CDC20	8.50e-142	472.0	151	455
UBD/Beta-Prp	9.60e-48	163.0	283	456

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf.sd.tllvsGsdDgtikvWDlrtgvll 36
           gH+ +v++l++ +d +ll+sG++D+ + +W+  + +++
   Q: 287  GHKQEVCGLKWsTDhRLLASGGNDNRLLLWNCYSLKPV 324
           8**********98889***************8776665 PP

E3 adaptor/Cullin RING/APC_C/CDC20

   S: 1    pekvldapelrddfylnLldWssknvlavaLgssvylwsaktgdvskladl.eekdlvtsvswieegtllavGtkkgeveiyDveekkk 88
           p+++l+apel ddfylnLldWs++n++av+Lgs+v+lwsa+t++v++l+dl +e+d vtsvsw+e+gtllavGt+kg+v+i+D++++k+
   Q: 151  PFRILEAPELSDDFYLNLLDWSRHNIVAVGLGSTVFLWSATTSQVTELCDLaQEDDAVTSVSWTERGTLLAVGTQKGVVQIWDADAEKR 239
           689************************************************999*********************************** PP
   S: 89   vrtltghsarvgaLsWnaevlssGsrdgeilhrdvrvkelkl.stlqahaqevCGlkwnedaklLasGGnDnsvsvwdasssePlkkfk 176
           v t++ghs rv++L+Wn  ++ssGsrd++i++rd+r+  l+  + lq+h+qevCGlkw++d++lLasGGnDn + +w+  s +P++k++
   Q: 240  VATMEGHSGRVSSLAWNGSQISSGSRDRRINQRDIRAYPLQSqRWLQGHKQEVCGLKWSTDHRLLASGGNDNRLLLWNCYSLKPVQKYT 328
           *****************************************97889******************************************* PP
   S: 177  ehkaavkaiawsPwqkslLasGGGtaDrcikfwntltgalleeidtgsqvcsllwskkskelvsthGfaenkitlwkypslskvaelkg 265
            hkaavkaiawsP+q+ lLasGGG+aDrci+fwntltg+ l+++dtgsqvc+l+wsk+ +elvsthG++en+i++wkyps+++va+l+g
   Q: 329  AHKAAVKAIAWSPHQHRLLASGGGSADRCIRFWNTLTGQPLQHVDTGSQVCNLAWSKQDNELVSTHGYSENQIVIWKYPSMTQVAKLTG 417
           ***************************************************************************************** PP
   S: 266  heaRvlslalspdgeaivtaagDetlrfwklfdkkkak 303
           h +Rvl+la+spdg++ivt+agD +lrfw++f k +a+
   Q: 418  HLYRVLYLAVSPDGQTIVTGAGDKSLRFWNVFRKACAQ 455
           ********************************999876 PP

UBD/Beta-Prp

   S: 46   rslsgheaevtavkfspdgkilvtgseDrtikvwdlstgkcvhtlkghedsvlslsfspsg.dklvs..Gshdrtirvwdletgqclee 131
           r l+gh++ev  +k+s d  +l++g++D+ + +w+  + k+v+++++h++ v ++++sp +   l+s  Gs+dr ir w++ tgq l++
   Q: 283  RWLQGHKQEVCGLKWSTDHRLLASGGNDNRLLLWNCYSLKPVQKYTAHKAAVKAIAWSPHQhRLLASggGSADRCIRFWNTLTGQPLQH 371
           4589*******************************************************6636677755699****************9 PP
   S: 132  tlsghdgvvncvvvhpdgnllvs..GslDrtvrlWdlktgkllrtltgghtdsvyslsfdsngkelvsgsldgtvklwdlqtgecvrt 217
           +++g +  v+ +++++++n lvs  G   +++ +W+ ++++ + +ltg h  +v  l+++++g+ +v+g+ d+++++w++ ++ c ++
   Q: 372  VDTGSQ--VCNLAWSKQDNELVSthGYSENQIVIWKYPSMTQVAKLTG-HLYRVLYLAVSPDGQTIVTGAGDKSLRFWNVFRKACAQK 456
           999988..777777777766665458899******************9.*******************************99999876 PP

Organism

Monodelphis domestica

Protein Sequence
(Fasta)

MSWSLALPPT APVPSASKYG DRYIPSRVAA NWEVHFHSKD ESELSSGPKQ KTEDSNSGKN 60
RSSLVYSTAL KNELLGARIQ KAPSLESEEN QSPQPCGPTK RNLFTYSPNT FRWRPEIGSE 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGAGCTGGA GCCTGGCGCT GCCGCCCACT GCTCCGGTGC CCTCTGCCAG CAAATACGGA 60
GACCGCTACA TTCCCTCTCG GGTGGCCGCC AACTGGGAAG TGCACTTCCA CAGCAAAGAT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat

Interpro

IPR024977--Apc4_WD40_dom
IPR033010--Cdc20/Fizzy
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF12894--ANAPC4_WD40
PF00400--WD40

SMART

SM00320--WD40

Gene Ontology

GO:0097027--F:ubiquitin-protein transferase activator activity
GO:1904668--P:positive regulation of ubiquitin protein ligase activity

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence