iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Mvi-060461

Ensembl Protein ID

MVLG_03643T0

UniProt Accession

U5H8U4; U5H8U4_USTV1

Genbank Protein ID

KDE05957.1

Protein Name

PAB-dependent poly(A)-specific ribonuclease subunit PAN2; PAB1P-dependent poly(A)-nuclease; PAN deadenylation complex catalytic subunit 2

Genbank Nucleotide ID

AEIJ01000353

Gene Name

PAN2; MVLG_03643

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
MVLG_03643	MVLG_03643T0	MVLG_03643T0

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	2.10e-14	52.1	587	955

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 2    GlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeelwkskkkavsprellkalkkeaeefs..gyeqqDaqEfl 96
           Gl+ +    Y NS+LQ+L+ ++++r l   +++ ++++e      ++ll++   lf+ l + k  + + +++ +a+++  +  s  g + +D +   
   Q: 587  GLETHITNSYTNSLLQALHYTTPVRTLAEAHTHTSCPKE------NCLLCEAGFLFRMLGDAKGMNCQASNFSRAFGASPQV-SalGLMDHDNETSS 676
           677777778*******************99888888765......69*****************************976654.44699999998877 PP
   S: 97   aflldqleeelkk.eknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikclecdnvssreepfldlslpvpgkeetkke....slq 188
           ++   +l +++++   ++   e++  ++  l + +   ++ + +s++ +l++++ k+   c +c+++s+r+  f ++ l  p++  +++     ++ 
   Q: 677  TVAYASLIQTFSRyLLEQMSAESNVGSNAPLYKAKTTADDASVPSPLAQLLRVEAKTVSACSQCGSQSKRDTGFSTVDLLYPRRALSNEVppasDFA 773
           66555555555443256666777777888999999********************************************999777554446666*** PP
   S: 189  dcLesftkeeelegenkyycekckkkqeaekklklkklPevLilhL.kRfsfseeqksrekinkkvefpleLdls...pfcts.............. 267
            +L++   +e++       c++ ++++  +   + + lP+vL+++   R s + e +++    +  +   +L      +f++s              
   Q: 774  TLLRNSIHRETIARMVCSTCRQPNHLRIRRVVAETTLLPPVLVVNAgVRTSDELEVWMDGSAATMGT-GSRLGSGgrkRFLESrfevrrkgevlsie 869
           ************9744444444455555667778899*******98467777777777755544444.33333322222333344444455555555 PP
   S: 268  .......peekqkekkkYeLiavvvHsG.slssGHYvayvknekgk......WllfdDskVtevkeeevleetg..staYvlfYkr 337
                  +  + ++ + YeL a+vv    + +  H va+++ ++++      W  f+D  V++++e+e l++ +  + + vlfY+r
   Q: 870  sppkevkERIEAENGVVYELRAMVVQIQsEGDAPHLVALARVSSEErnpgssWHVFNDFLVRPISEDEALSFPSswKIPAVLFYQR 955
           554444433333449*******99998879999********95555567888*******************999999999****98 PP

Organism

Microbotryum violaceum

Functional Description
(View)

Catalytic subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in mRNA turnover. PAN specifically shortens poly(A) tails of RNA when the poly(A) stretch is bound by poly(A)-binding protein PAB1, which is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping and subsequent 5'-3' exonucleolytic degradation by XRN1. May also be involved in post-transcriptional maturation of mRNA poly(A) tails.

Protein Sequence
(Fasta)

MATYVGVFDP HPNPFQPLLQ HQSYRVPRHA LAHHPISSSH LPGGSHLLQP QGGQPPRSGL 60
AQPSSSTMPS DPNDRSTWHP LPSMYLPTAA SSSLFDPAQP LLLAASALGT VSTYFCNPMT 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CTTCTCAGCG CTTTCTCTGG CTCATCCTCA ATTACCAACC TGGGGCGGGG GGAAGAGAGA 60
CGGGATCCGA CCCACTACAA GAGGCCGTGC CCGTTTGATG GCGACCTACG TCGGTGTATT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0269--Exonuclease
KW-0378--Hydrolase
KW-0507--mRNA processing
KW-0540--Nuclease
KW-1185--Reference proteome

Interpro

IPR013520--Exonuclease_RNaseT/DNA_pol3
IPR030843--PAN2
IPR028881--PAN2_dom
IPR011047--Quinoprotein_ADH-like_supfam
IPR012337--RNaseH-like_dom
IPR028889--USP_dom
IPR015943--WD40/YVTN_repeat-like_dom

PROSITE

PS50235--USP_3

Pfam

PF00929--RNase_T
PF13423--UCH_1

SMART

SM00479--EXOIII

Gene Ontology

GO:0031251--C:PAN complex
GO:0003676--F:nucleic acid binding
GO:0004535--F:poly(A)-specific ribonuclease activity
GO:0006397--P:mRNA processing
GO:0000289--P:nuclear-transcribed mRNA poly(A) tail shortening

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001273	Ailuropoda melanoleuca	34.41	3.00e-154	538.00
IUUC-Apl-003500	Anas platyrhynchos	32.83	3.00e-129	454.00
IUUC-Aca-004930	Anolis carolinensis	32.34	5.00e-156	543.00
IUUC-Acl-008214	Aspergillus clavatus	34.73	0.00e+00	647.00
IUUC-Afu-009112	Aspergillus fumigatus	34.09	8.00e-177	612.00
IUUC-Ang-009531	Aspergillus niger	34.29	3.00e-174	603.00
IUUC-Ame-011259	Astyanax mexicanus	44.94	1.00e-79	289.00
IUUC-Bta-012371	Bos taurus	34.41	3.00e-152	531.00
IUUC-Bci-013684	Botrytis cinerea	35.38	0.00e+00	635.00
IUUC-Cja-019297	Callithrix jacchus	34.59	5.00e-152	530.00
IUUC-Cfa-020489	Canis familiaris	34.39	7.00e-153	533.00
IUUC-Cpo-022392	Cavia porcellus	33.92	1.00e-151	529.00
IUUC-Csa-023220	Chlorocebus sabaeus	34.41	1.00e-153	535.00
IUUC-Csv-025841	Ciona savignyi	45.11	4.00e-73	268.00
IUUC-Cgl-026534	Colletotrichum gloeosporioides	36.33	0.00e+00	692.00
IUUC-Cne-026932	Cryptococcus neoformans	43.50	0.00e+00	830.00
IUUC-Dre-028482	Danio rerio	44.81	4.00e-82	298.00
IUUC-Dno-029398	Dasypus novemcinctus	34.29	2.00e-153	535.00
IUUC-Dor-030307	Dipodomys ordii	36.18	2.00e-110	392.00
IUUC-Dme-032111	Drosophila melanogaster	40.86	3.00e-80	292.00
IUUC-Eca-033985	Equus caballus	34.41	5.00e-152	530.00
IUUC-Eeu-034928	Erinaceus europaeus	27.06	2.00e-29	122.00
IUUC-Fca-035587	Felis catus	32.69	1.00e-154	538.00
IUUC-Fal-037587	Ficedula albicollis	31.84	3.00e-151	528.00
IUUC-Fso-038133	Fusarium solani	38.21	3.00e-116	411.00
IUUC-Gmo-039076	Gadus morhua	45.95	4.00e-77	281.00
IUUC-Ggr-039957	Gaeumannomyces graminis	35.44	0.00e+00	654.00
IUUC-Gga-040948	Gallus gallus	34.03	4.00e-150	524.00
IUUC-Gac-042396	Gasterosteus aculeatus	44.23	2.00e-79	289.00
IUUC-Ggo-045412	Gorilla gorilla	34.32	4.00e-153	533.00
IUUC-Hsa-046076	Homo sapiens	34.32	6.00e-153	533.00
IUUC-Itr-048143	Ictidomys tridecemlineatus	34.26	7.00e-135	473.00
IUUC-Kpa-049178	Komagataella pastoris	30.09	3.00e-143	501.00
IUUC-Lch-050279	Latimeria chalumnae	44.48	8.00e-83	300.00
IUUC-Loc-052872	Lepisosteus oculatus	32.25	4.00e-148	517.00
IUUC-Lma-052986	Leptosphaeria maculans	35.20	0.00e+00	649.00
IUUC-Laf-054181	Loxodonta africana	32.73	6.00e-152	530.00
IUUC-Mcc-054812	Macaca mulatta	34.32	9.00e-152	529.00
IUUC-Meu-056325	Macropus eugenii	34.03	2.00e-149	521.00
IUUC-Mor-057246	Magnaporthe oryzae	32.71	2.00e-155	541.00
IUUC-Mpo-057464	Magnaporthe poae	35.73	0.00e+00	657.00
IUUC-Mla-058911	Melampsora laricipopulina	40.93	0.00e+00	856.00
IUUC-Mga-059335	Meleagris gallopavo	34.27	8.00e-148	516.00
IUUC-Mmr-060636	Microcebus murinus	34.13	1.00e-149	522.00
IUUC-Mmu-063503	Mus musculus	32.60	3.00e-154	537.00
IUUC-Mpu-066670	Mustela putorius furo	34.32	4.00e-152	530.00
IUUC-Mlu-068119	Myotis lucifugus	32.75	2.00e-156	545.00
IUUC-Nfi-068398	Neosartorya fischeri	35.03	0.00e+00	644.00
IUUC-Ncr-068927	Neurospora crassa	30.94	3.00e-144	504.00
IUUC-Nle-069651	Nomascus leucogenys	32.60	4.00e-145	507.00
IUUC-Opr-070614	Ochotona princeps	34.78	5.00e-151	527.00
IUUC-Ont-072433	Oreochromis niloticus	32.03	1.00e-152	532.00
IUUC-Oan-073283	Ornithorhynchus anatinus	32.19	5.00e-125	440.00
IUUC-Ocu-074401	Oryctolagus cuniculus	34.46	3.00e-153	534.00
IUUC-Ola-087522	Oryzias latipes	31.19	2.00e-146	511.00
IUUC-Oga-088226	Otolemur garnettii	32.62	1.00e-154	539.00
IUUC-Oar-089241	Ovis aries	34.47	1.00e-156	545.00
IUUC-Pan-092297	Papio anubis	34.23	2.00e-151	528.00
IUUC-Psi-094043	Pelodiscus sinensis	31.98	8.00e-138	483.00
IUUC-Pma-094394	Petromyzon marinus	34.70	5.00e-146	510.00
IUUC-Pno-095053	Phaeosphaeria nodorum	36.86	0.00e+00	637.00
IUUC-Ppa-095188	Physcomitrella patens	43.96	2.00e-66	246.00
IUUC-Pfo-097517	Poecilia formosa	32.02	3.00e-153	534.00
IUUC-Pca-100471	Procavia capensis	34.27	4.00e-155	540.00
IUUC-Pva-102805	Pteropus vampyrus	38.10	3.00e-111	395.00
IUUC-Pte-104021	Pyrenophora teres	34.59	0.00e+00	647.00
IUUC-Pyt-104682	Pyrenophora triticirepentis	34.56	0.00e+00	644.00
IUUC-Rno-105471	Rattus norvegicus	32.62	2.00e-153	535.00
IUUC-Sce-106235	Saccharomyces cerevisiae	27.77	6.00e-108	384.00
IUUC-Sha-106883	Sarcophilus harrisii	33.96	2.00e-148	518.00
IUUC-Spo-108169	Schizosaccharomyces pombe	34.74	0.00e+00	647.00
IUUC-Sar-113323	Sorex araneus	36.93	2.00e-136	478.00
IUUC-Sre-115075	Sporisorium reilianum	39.54	8.00e-161	560.00
IUUC-Ssc-116363	Sus scrofa	34.16	7.00e-156	543.00
IUUC-Tru-118427	Takifugu rubripes	44.19	5.00e-81	294.00
IUUC-Tni-120218	Tetraodon nigroviridis	31.81	6.00e-150	523.00
IUUC-Tre-122177	Trichoderma reesei	36.41	0.00e+00	697.00
IUUC-Tme-127176	Tuber melanosporum	37.29	0.00e+00	653.00
IUUC-Tbe-127641	Tupaia belangeri	29.13	2.00e-19	90.10
IUUC-Ttr-128888	Tursiops truncatus	37.80	7.00e-126	443.00
IUUC-Uma-129361	Ustilago maydis	43.91	2.00e-87	316.00
IUUC-Xtr-132811	Xenopus tropicalis	31.36	2.00e-148	518.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence