iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Oan-073495

Ensembl Protein ID

ENSOANP00000006710.1

UniProt Accession

F7BKT0; F7BKT0_ORNAN

Protein Name

Tyrosine-protein kinase

Gene Name

BTK

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSOANG00000004224.2	ENSOANT00000006712.2	ENSOANP00000006710.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/SH3	2.80e-12	46.7	214	271

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 3    kekvqvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvekle 63
           ++kv +lydy++ +  +L+l+kG+  +++  ee +  W+++ ++ +g++G +P+n+v+++e
   Q: 214  LKKVVALYDYTPMKPHDLQLQKGEEYFIL--EESNLPWWRA-RDKNGQEGYIPNNYVTEAE 271
           789*************************9..9999******.6***************987 PP

Organism

Ornithorhynchus anatinus

Protein Sequence
(Fasta)

MAGVILESIF LKRSQQKKKT SPLNFKKRLF LLTTNKLSYY EYDFERGRRG SKKGSVDIEK 60
ITCVETVVPE NNPPPERQIP RKGEEYGEME QISIIERFPY PFQVVYDEGP LYVFSPTEEL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGCCGGTG TGATCCTGGA GAGCATCTTT CTGAAGCGGT CCCAGCAGAA GAAGAAGACT 60
TCCCCTCTGA ACTTCAAGAA GCGACTCTTC CTCCTGACCA CGAACAAACT GTCCTACTAT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0418--Kinase
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0728--SH3 domain
KW-0808--Transferase
KW-0829--Tyrosine-protein kinase

Interpro

IPR011009--Kinase-like_dom
IPR011993--PH_dom-like
IPR001849--PH_domain
IPR000719--Prot_kinase_dom
IPR017441--Protein_kinase_ATP_BS
IPR001245--Ser-Thr/Tyr_kinase_cat_dom
IPR000980--SH2
IPR001452--SH3_domain
IPR008266--Tyr_kinase_AS
IPR020635--Tyr_kinase_cat_dom
IPR001562--Znf_Btk_motif

PROSITE

PS50003--PH_DOMAIN
PS00107--PROTEIN_KINASE_ATP
PS50011--PROTEIN_KINASE_DOM
PS00109--PROTEIN_KINASE_TYR
PS50001--SH2
PS50002--SH3
PS51113--ZF_BTK

Pfam

PF00779--BTK
PF00169--PH
PF07714--Pkinase_Tyr
PF00017--SH2
PF00018--SH3_1

PRINTS

PR00401--SH2DOMAIN
PR00452--SH3DOMAIN
PR00402--TECBTKDOMAIN
PR00109--TYRKINASE

SMART

SM00107--BTK
SM00233--PH
SM00252--SH2
SM00326--SH3
SM00219--TyrKc

Gene Ontology

GO:0031410--C:cytoplasmic vesicle
GO:0005829--C:cytosol
GO:0031234--C:extrinsic component of cytoplasmic side of plasma membrane
GO:0045121--C:membrane raft
GO:0005634--C:nucleus
GO:0005524--F:ATP binding
GO:0004715--F:non-membrane spanning protein tyrosine kinase activity
GO:0005547--F:phosphatidylinositol-3,4,5-trisphosphate binding
GO:0005102--F:receptor binding
GO:0002344--P:B cell affinity maturation
GO:0030154--P:cell differentiation
GO:0048469--P:cell maturation
GO:0098761--P:cellular response to interleukin-7
GO:0007249--P:I-kappaB kinase/NF-kappaB signaling
GO:0045087--P:innate immune response
GO:0030889--P:negative regulation of B cell proliferation
GO:0001818--P:negative regulation of cytokine production
GO:0038083--P:peptidyl-tyrosine autophosphorylation
GO:0042127--P:regulation of cell proliferation
GO:0007169--P:transmembrane receptor protein tyrosine kinase signaling pathway

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001365	Ailuropoda melanoleuca	92.87	0.00e+00	1239.00
IUUC-Apl-003907	Anas platyrhynchos	86.52	0.00e+00	1148.00
IUUC-Aca-004978	Anolis carolinensis	76.33	0.00e+00	1058.00
IUUC-Ame-010694	Astyanax mexicanus	57.34	3.00e-154	537.00
IUUC-Bta-012467	Bos taurus	93.02	0.00e+00	1243.00
IUUC-Cja-018841	Callithrix jacchus	92.26	0.00e+00	1231.00
IUUC-Cfa-020983	Canis familiaris	92.72	0.00e+00	1205.00
IUUC-Cpo-021307	Cavia porcellus	93.17	0.00e+00	1243.00
IUUC-Csa-023508	Chlorocebus sabaeus	92.76	0.00e+00	920.00
IUUC-Dre-028544	Danio rerio	58.46	6.00e-148	516.00
IUUC-Dno-029828	Dasypus novemcinctus	91.79	0.00e+00	1220.00
IUUC-Dor-030102	Dipodomys ordii	85.46	0.00e+00	1026.00
IUUC-Ete-032981	Echinops telfairi	84.98	0.00e+00	1110.00
IUUC-Eca-033594	Equus caballus	93.17	0.00e+00	1244.00
IUUC-Eeu-035281	Erinaceus europaeus	88.21	0.00e+00	971.00
IUUC-Fca-035495	Felis catus	92.41	0.00e+00	1202.00
IUUC-Fal-036719	Ficedula albicollis	86.15	0.00e+00	1181.00
IUUC-Gga-041193	Gallus gallus	86.15	0.00e+00	1153.00
IUUC-Gac-042383	Gasterosteus aculeatus	46.85	7.00e-129	453.00
IUUC-Hsa-045931	Homo sapiens	93.02	0.00e+00	1211.00
IUUC-Itr-048061	Ictidomys tridecemlineatus	93.47	0.00e+00	1246.00
IUUC-Lch-049868	Latimeria chalumnae	74.79	0.00e+00	988.00
IUUC-Loc-052730	Lepisosteus oculatus	56.98	8.00e-160	556.00
IUUC-Laf-053516	Loxodonta africana	92.74	0.00e+00	1263.00
IUUC-Mcc-054795	Macaca mulatta	93.02	0.00e+00	1213.00
IUUC-Meu-056157	Macropus eugenii	82.70	0.00e+00	1064.00
IUUC-Mga-059529	Meleagris gallopavo	85.22	0.00e+00	979.00
IUUC-Mmr-060824	Microcebus murinus	88.77	0.00e+00	1134.00
IUUC-Mdo-063036	Monodelphis domestica	92.64	0.00e+00	1223.00
IUUC-Mmu-064047	Mus musculus	92.56	0.00e+00	1240.00
IUUC-Mpu-066810	Mustela putorius furo	92.72	0.00e+00	1237.00
IUUC-Mlu-067671	Myotis lucifugus	92.61	0.00e+00	1237.00
IUUC-Nle-069108	Nomascus leucogenys	93.02	0.00e+00	1214.00
IUUC-Opr-070505	Ochotona princeps	74.26	0.00e+00	655.00
IUUC-Ont-072585	Oreochromis niloticus	58.37	1.00e-160	559.00
IUUC-Ocu-074416	Oryctolagus cuniculus	92.87	0.00e+00	1240.00
IUUC-Ola-086938	Oryzias latipes	57.91	5.00e-154	536.00
IUUC-Oga-088995	Otolemur garnettii	92.15	0.00e+00	1203.00
IUUC-Oar-089632	Ovis aries	91.96	0.00e+00	1219.00
IUUC-Ptr-090941	Pan troglodytes	92.87	0.00e+00	1212.00
IUUC-Pan-091900	Papio anubis	90.29	0.00e+00	1166.00
IUUC-Psi-093048	Pelodiscus sinensis	85.13	0.00e+00	1115.00
IUUC-Pfo-096955	Poecilia formosa	58.89	4.00e-161	560.00
IUUC-Pab-097587	Pongo abelii	93.02	0.00e+00	1214.00
IUUC-Pca-100374	Procavia capensis	84.23	4.00e-141	494.00
IUUC-Pva-102583	Pteropus vampyrus	92.87	0.00e+00	1216.00
IUUC-Rno-104868	Rattus norvegicus	87.92	0.00e+00	1157.00
IUUC-Sha-106744	Sarcophilus harrisii	92.11	0.00e+00	1251.00
IUUC-Sar-113041	Sorex araneus	91.85	0.00e+00	1066.00
IUUC-Ssc-115294	Sus scrofa	92.72	0.00e+00	1240.00
IUUC-Tgu-116458	Taeniopygia guttata	53.26	0.00e+00	713.00
IUUC-Tsy-118945	Tarsius syrichta	91.98	0.00e+00	824.00
IUUC-Ttr-128769	Tursiops truncatus	83.61	0.00e+00	1105.00
IUUC-Vpa-130517	Vicugna pacos	87.24	0.00e+00	689.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence