iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMMUG00000010314.3	ENSMMUT00000057247.1	ENSMMUP00000054182.1
ENSMMUG00000010314.3	ENSMMUT00000014423.3	ENSMMUP00000013511.3
ENSMMUG00000010314.3	ENSMMUT00000073641.1	ENSMMUP00000056389.1
ENSMMUG00000010314.3	ENSMMUT00000014427.3	ENSMMUP00000013515.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	3.90e-90	303.8	721	1040

Active Site

Position(s)	Description	Evidence
1011	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 3    sdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlld 89
            d+ k+l vef +E   + gGv++ef++++++e+ +p++g+f+y e ++++++p++ +     e+ ++F ++G+l+g++l++ ++ +
   Q: 721  TDFCKVLVVEFIEEIRPESGGVSSEFFHCMFEEMTKPEYGMFMYPEMGSCMWFPAKPKL----EKKRYF-LFGMLCGLSLFNLNVAN 802
           688899**************************************************998....677888.55*************** PP
   S: 90   lplsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvkl 176
           lp++ ++yk+ll++k sledl+e+ p l ksl+e+++ + +di +  l+++fs++     ++++++L+p+G +ipV ++Nk++Yv++
   Q: 803  LPFPLALYKKLLDQKPSLEDLKELSPRLGKSLQEVLNDDADDIGDV-LCIRFSIH----WDQNDVDLIPNGISIPVDQTNKKDYVSK 884
           **************************************99999998.*****955....5779999********************* PP
   S: 177  vveyrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerka 263
           +++y+++ ++k  +e+f++Gf++v+++e+l+ F +eel + i G++++d+++++++ ky++gy++++p+i+ Fw+++++++ +e+k+
   Q: 885  YIDYIFNVSVKAVYEEFQRGFYRVCEKEILRHFYPEELMTAIIGNTDYDWKQFEQNSKYEQGYQKSHPTIRLFWKAFHKLTLDEKKK 971
           *************************************************************************************** PP
   S: 264  fLqFvTgssrlPlgGfaelkprlfvirkdasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgF 333
           fL F+Tg++rl ++G+++++  +f +++  s+++ P+s TC + L LP+Ys++e ++e L++Ai++++gF
   Q: 972  FLLFLTGRDRLHARGIQKME-IVFRCPETFSERDHPTSITCHHILYLPKYSTMERMEEALQVAINNNRGF 1040
           ********************.77888889****************************************9 PP

Organism

Macaca mulatta

Protein Sequence
(Fasta)

MYFCWGTDSR ELQRRRTERS PGAELLQAAS GERHSLLLLT NHRVLSCGDN SRGQLGRRRA 60
PRGELPGERG ALRNPNALDL VSCVEEHDSL PGCVPQRRVF AWGAGSEGQF KEISFTPKKI 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGTATTTCT GTTGGGGCAC CGACTCCAGG GAGCTGCAGC GCCGGAGGAC GGAGCGCAGC 60
CCCGGGGCTG AGCTACTGCA GGCGGCCAGC GGGGAGCGCC ACTCTCTGCT GCTGCTGACC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0677--Repeat
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000569--HECT_dom
IPR009091--RCC1/BLIP-II
IPR000408--Reg_chr_condens

PROSITE

PS50237--HECT
PS00626--RCC1_2
PS50012--RCC1_3

Pfam

PF00632--HECT
PF00415--RCC1

PRINTS

PR00633--RCCNDNSATION

SMART

SM00119--HECTc

Gene Ontology

GO:0004842--F:ubiquitin-protein transferase activity

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001374	Ailuropoda melanoleuca	69.77	0.00e+00	1345.00
IUUC-Aca-004663	Anolis carolinensis	45.04	0.00e+00	825.00
IUUC-Bta-013080	Bos taurus	69.84	0.00e+00	1394.00
IUUC-Cja-018891	Callithrix jacchus	83.48	0.00e+00	1723.00
IUUC-Cfa-020763	Canis familiaris	68.53	0.00e+00	1299.00
IUUC-Cpo-022346	Cavia porcellus	66.63	0.00e+00	1388.00
IUUC-Csa-023049	Chlorocebus sabaeus	93.72	0.00e+00	2011.00
IUUC-Dno-029093	Dasypus novemcinctus	72.69	0.00e+00	1492.00
IUUC-Eca-034098	Equus caballus	74.54	0.00e+00	1426.00
IUUC-Eeu-035028	Erinaceus europaeus	63.23	1.00e-150	527.00
IUUC-Fca-036283	Felis catus	70.15	0.00e+00	1369.00
IUUC-Ggo-045553	Gorilla gorilla	87.71	0.00e+00	1808.00
IUUC-Hsa-046396	Homo sapiens	90.77	0.00e+00	1897.00
IUUC-Loc-052700	Lepisosteus oculatus	39.64	0.00e+00	754.00
IUUC-Laf-054433	Loxodonta africana	68.30	0.00e+00	1445.00
IUUC-Mdo-061839	Monodelphis domestica	55.10	0.00e+00	1013.00
IUUC-Mmu-064378	Mus musculus	62.92	0.00e+00	1232.00
IUUC-Mpu-066293	Mustela putorius furo	68.00	0.00e+00	1305.00
IUUC-Mlu-067407	Myotis lucifugus	69.12	0.00e+00	1383.00
IUUC-Nle-069978	Nomascus leucogenys	90.48	0.00e+00	1941.00
IUUC-Opr-070190	Ochotona princeps	55.34	0.00e+00	645.00
IUUC-Ont-071328	Oreochromis niloticus	35.85	1.00e-175	610.00
IUUC-Ocu-074640	Oryctolagus cuniculus	67.72	0.00e+00	865.00
IUUC-Oga-088780	Otolemur garnettii	69.31	0.00e+00	1429.00
IUUC-Oar-090307	Ovis aries	70.07	0.00e+00	1394.00
IUUC-Ptr-091567	Pan troglodytes	90.49	0.00e+00	1890.00
IUUC-Pan-091802	Papio anubis	88.70	0.00e+00	1887.00
IUUC-Pab-098024	Pongo abelii	74.27	0.00e+00	1486.00
IUUC-Rno-105768	Rattus norvegicus	59.33	0.00e+00	1167.00
IUUC-Sha-106525	Sarcophilus harrisii	52.25	0.00e+00	1056.00
IUUC-Sar-113014	Sorex araneus	54.55	2.00e-143	503.00
IUUC-Tsy-119565	Tarsius syrichta	79.19	2.00e-179	623.00
IUUC-Vpa-130214	Vicugna pacos	68.31	0.00e+00	1268.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence