iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Sha-106944

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AEFK01072271

Gene Name

HECTD4

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSSHAG00000008265.1	ENSSHAT00000009636.1	ENSSHAP00000009553.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	7.90e-79	265.6	3637	3997

Active Site

Position(s)	Description	Evidence
3971	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 4    dlkkrlevefvgEegldlgGvtreflallskelqnpdlglf.......lysendketlqpnpdsglknpehlklFeflGrllgkalq 83
           d ++ ++++f+gEe+++++G++r+fl++++kelq+++l+l+       ++++++k+ l+p+p ++     +++l +f+G+llg+a++
   Q: 3637 DPTYAFNIRFTGEEVHGTSGSFRHFLWQVCKELQSSSLSLLllcpssaVNKNKGKYILTPSPITY----GEEQLLHFFGQLLGIAIR 3719
           5667788*********************************9999999888888***********9....789*************** PP
   S: 84   dgrlldlplsksfyklllgkklsl.edleevdpelyks.lkeikenaesdieelgldltfs..vseei...............lget 151
            + +l+l+l +sf+k+l+g++l+   dl+e d  +y++ +k+ + n+e+++e+l+++++++  +  ++                 + 
   Q: 3720 ADVPLPLDLLPSFWKTLVGEPLDPdVDLQEADILTYNYvKKFENINDETELEALCAEIASQhlA--TEspdspnrpcckftylTMTG 3804
           ************************99************44555566688999999999998532..33468999*******655555 PP
   S: 152  keeeLkpgGenipVtneNkeeYvklvveyrlke.gikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykg 237
           +e+eL+++G++ipV +eNk+ Y  ++ ++rl+e + + +v a+r+G+ ++ipl+ll+ +t+ e+el +cG ++i++e lk++t+y+ 
   Q: 3805 EEVELCSRGRHIPVGWENKDVYATAIRNLRLRElQNHDCVMAVRAGLGSIIPLQLLTTLTPLEMELRTCGLPYINLEFLKAHTMYQV 3891
           6667*****************************9***************************************************** PP
   S: 238  gytedspaiqwFwevleefsseerkafLqFvTgssrlPl......gGfaelk....prlfvirk...dasddrlPssnTCfnyLkLP 311
           g++e++++i++Fw +le+f +ee ++f++F+++++r+P+      gG ++ +    p+++  ++    + d+r+++++TC++++kLP
   Q: 3892 GLMETDQHIEFFWGALEMFAQEELCKFIKFACNQERIPFtcpckdGGPDTAHvppyPMKIAPPDgtaGSPDSRYIRVETCMFMIKLP 3978
           *********************************************99999999988888888889955555**************** PP
   S: 312  eYsskeilkekLlyAieet 330
           +Yss ei+ ekL++Ai+++
   Q: 3979 QYSSLEIMLEKLRCAIHYR 3997
           ****************986 PP

Organism

Sarcophilus harrisii

Protein Sequence
(Fasta)

MPANHFPIGS TMSTVHLSSD GTYFYWIWSP ASLNEKTPKG HSVFMDIFEL IVENGMCVAS 60
PLQERIILMR KEGESAKSIN EMLLSRLSRY RASPSATLAA LTGSTISNTL KEDQAAANTS 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGCCAGCAA ACCATTTTCC TATTGGCAGC ACCATGAGCA CTGTGCATCT TTCTTCAGAT 60
GGTACTTATT TCTATTGGAT TTGGTCTCCT GCAAGTTTAA ATGAGAAAAC ACCAAAAGGA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000569--HECT_dom

PROSITE

PS50237--HECT

Pfam

PF00632--HECT

SMART

SM00119--HECTc

Gene Ontology

GO:0004842--F:ubiquitin-protein transferase activity

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002256	Ailuropoda melanoleuca	93.78	0.00e+00	7019.00
IUUC-Apl-004161	Anas platyrhynchos	92.74	0.00e+00	5220.00
IUUC-Aca-005341	Anolis carolinensis	89.15	0.00e+00	6653.00
IUUC-Ame-011574	Astyanax mexicanus	80.54	0.00e+00	4466.00
IUUC-Bta-012514	Bos taurus	90.18	0.00e+00	1822.00
IUUC-Cja-019148	Callithrix jacchus	92.73	0.00e+00	5063.00
IUUC-Cfa-020499	Canis familiaris	92.50	0.00e+00	6984.00
IUUC-Cpo-021894	Cavia porcellus	94.72	0.00e+00	2687.00
IUUC-Csa-023079	Chlorocebus sabaeus	92.65	0.00e+00	6956.00
IUUC-Cho-024415	Choloepus hoffmanni	91.40	0.00e+00	4935.00
IUUC-Dre-027452	Danio rerio	78.41	0.00e+00	4488.00
IUUC-Dno-029595	Dasypus novemcinctus	92.17	0.00e+00	6962.00
IUUC-Dor-030849	Dipodomys ordii	94.03	0.00e+00	1751.00
IUUC-Ete-032563	Echinops telfairi	84.33	0.00e+00	1545.00
IUUC-Eca-034202	Equus caballus	94.04	0.00e+00	6973.00
IUUC-Eeu-035175	Erinaceus europaeus	94.39	0.00e+00	1030.00
IUUC-Fca-036295	Felis catus	92.26	0.00e+00	6775.00
IUUC-Fal-037003	Ficedula albicollis	91.32	0.00e+00	6212.00
IUUC-Gmo-038579	Gadus morhua	83.89	0.00e+00	2825.00
IUUC-Gga-040961	Gallus gallus	91.84	0.00e+00	7024.00
IUUC-Gac-041899	Gasterosteus aculeatus	84.08	0.00e+00	2865.00
IUUC-Ggo-045099	Gorilla gorilla	93.52	0.00e+00	6150.00
IUUC-Hsa-046331	Homo sapiens	92.75	0.00e+00	7016.00
IUUC-Itr-048190	Ictidomys tridecemlineatus	90.08	0.00e+00	2034.00
IUUC-Lch-049923	Latimeria chalumnae	85.70	0.00e+00	2663.00
IUUC-Loc-052630	Lepisosteus oculatus	83.16	0.00e+00	3988.00
IUUC-Laf-053394	Loxodonta africana	92.26	0.00e+00	7031.00
IUUC-Mcc-055763	Macaca mulatta	92.63	0.00e+00	6947.00
IUUC-Meu-056039	Macropus eugenii	92.28	0.00e+00	5250.00
IUUC-Mga-059500	Meleagris gallopavo	92.57	0.00e+00	7026.00
IUUC-Mmr-060868	Microcebus murinus	88.99	0.00e+00	6706.00
IUUC-Mdo-062772	Monodelphis domestica	96.46	0.00e+00	7320.00
IUUC-Mmu-063606	Mus musculus	91.46	0.00e+00	6941.00
IUUC-Mpu-065860	Mustela putorius furo	92.09	0.00e+00	6878.00
IUUC-Mlu-067376	Myotis lucifugus	94.79	0.00e+00	5239.00
IUUC-Nle-069693	Nomascus leucogenys	92.42	0.00e+00	6906.00
IUUC-Opr-071065	Ochotona princeps	91.25	0.00e+00	1175.00
IUUC-Ont-072470	Oreochromis niloticus	83.22	0.00e+00	4627.00
IUUC-Oan-073693	Ornithorhynchus anatinus	92.40	0.00e+00	5213.00
IUUC-Ocu-074032	Oryctolagus cuniculus	91.48	0.00e+00	6950.00
IUUC-Ola-087433	Oryzias latipes	82.67	0.00e+00	1578.00
IUUC-Oga-088546	Otolemur garnettii	93.61	0.00e+00	6693.00
IUUC-Oar-089643	Ovis aries	88.94	0.00e+00	724.00
IUUC-Ptr-090504	Pan troglodytes	93.83	0.00e+00	7040.00
IUUC-Pan-092543	Papio anubis	92.68	0.00e+00	6935.00
IUUC-Psi-093952	Pelodiscus sinensis	91.04	0.00e+00	6915.00
IUUC-Pfo-096356	Poecilia formosa	81.21	0.00e+00	4552.00
IUUC-Pab-098240	Pongo abelii	92.68	0.00e+00	6942.00
IUUC-Pca-100994	Procavia capensis	94.77	0.00e+00	2949.00
IUUC-Pva-102263	Pteropus vampyrus	92.71	0.00e+00	6924.00
IUUC-Rno-104888	Rattus norvegicus	91.34	0.00e+00	6899.00
IUUC-Sar-113556	Sorex araneus	84.27	0.00e+00	919.00
IUUC-Ssc-116187	Sus scrofa	93.33	0.00e+00	4967.00
IUUC-Tgu-116655	Taeniopygia guttata	92.20	0.00e+00	5148.00
IUUC-Tru-118093	Takifugu rubripes	83.13	0.00e+00	2972.00
IUUC-Tni-119739	Tetraodon nigroviridis	82.98	0.00e+00	1594.00
IUUC-Tbe-127962	Tupaia belangeri	83.86	0.00e+00	1119.00
IUUC-Ttr-128819	Tursiops truncatus	87.59	0.00e+00	2716.00
IUUC-Vpa-130482	Vicugna pacos	93.23	0.00e+00	4355.00
IUUC-Xtr-132222	Xenopus tropicalis	86.72	0.00e+00	6546.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence