iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Mla-059183

Ensembl Protein ID

EGG02509

UniProt Accession

F4RYQ0; F4RYQ0_MELLP

Genbank Protein ID

EGG02509.1

Protein Name

NEDD8-activating enzyme E1 regulatory subunit

Genbank Nucleotide ID

GL883130

Gene Name

MELLADRAFT_91342

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
MELLADRAFT_91342	EGG02509	EGG02509

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E1	2.50e-66	224.3	30	557

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

   S: 1    YDRQirlwGeeaqeklksakvllvGagglGcEllKnLvlaGvgsitvvDmdtvevsnlnrqFLfraedvgksKAevaaealkelnpdvnveaheesitele 101
           YDRQ+rlw + +q++l++a+  +  a+++ + +lKnLvl G+gs+ + D + v+ s+l+ +F++++++ gk++A+ + + l+elnpdv+    e++++   
   Q: 30   YDRQLRLWASSGQAALERASLVIGPATATSAQILKNLVLPGIGSFSLYDSQSVSESDLGHNFFLEESSSGKNRAQEVSRLLAELNPDVKTNGIEDDLMSFV 130
           ********************99989*************************************************************************998 PP
   S: 102  eeiv.......FfkkfdvVvlaldnrearrkvnrlclnarvpliesgtlGllGqvrviikgltecyscsd..dppqktiPfctlketpn.........aae 184
            ++v       F +    + ++l+  ++   +++ c+++++pli ++t G+lG +rv +k+l  ++ ++d   +++++ Pf+tl e++           ++
   Q: 131  RQKVegseettFHSSSIAIGVGLEDNDEN-ELAEKCWENNIPLILVQTCGFLGSIRVQVKELGLIETHPDsyVDLRLDSPFPTLLEFVKsfdfqkldtHEH 230
           88888999999999999999999998888.9********************************************************88888888887889 PP
   S: 185  htiewavlfnklleeeageeevlekldseekeegkdkvkselksedeenfeeaieiavkafakttins.ikqllksfecdivtkskspfwv.......... 274
            +i+ +v++ ++le  ++ ++++ +++s+e ee k+ +++e +++de+nf+ea+ +  ka  +t  ++ i++l+ ++ c  ++ +++pfw+          
   Q: 231  THIPAVVIMIHFLELFKSTHDGKLPKTSAEREELKKMIQAEKRNADEDNFDEAVGMIWKACRPTRVPDsIQSLFLDPCCTTLSPNSTPFWIlvrtlrefvh 331
           999999*********************************************************************************************** PP
   S: 275  .....................................................................................sfcsnaealqvpekve 290
                                                                                                +  s+a+  + pe  +
   Q: 332  rkqndgslllpltgvlpdmkadtnsyvklqtiyrqkaqqdlldfknilkeildqhsqiipsinhenfsdevlhsfvkhsaflkliRGRSLAQERSGPEGLI 432
           **************************************************************999999999995555555555554444444444554444 PP
   S: 291  kdeevvkasap......lylllralerfekkkgrkpgelsfekddds.avdlvtaaanlra.....eslgiepkldddlikeiagniipaiattnavvgGl 379
           +  ++ +++++      +yl+lra  +f++k+ r+pg++  e ++d+ +++ ++            ++ g+++    d+i e+++ + +++  ++a +gG+
   Q: 433  SLLTAESEPSAeqipasWYLALRASALFRQKHHRYPGSIASEIKSDQtLMETIANEYLGSLgglklSEPGLPK-TLIDAIGEVVRAGGSELPQIAALIGGI 532
           44444444433445566*******************9998887766556666665554333443334555555.445566789****************** PP
   S: 380  aaqEviKvvsgkfeplknfflfdae 404
           +aqE+iK++s+++ pl  + +fd++
   Q: 533  VAQEAIKLISHQYIPLSGTCIFDGI 557
           *********************9986 PP

Organism

Melampsora laricipopulina

Functional Description
(View)

Regulatory subunit of the dimeric UBA3-ULA1 E1 enzyme.

Protein Sequence
(Fasta)

MSEPQVALED VAPILPVSSR DRPDAKTQRY DRQLRLWASS GQAALERASL VIGPATATSA 60
QILKNLVLPG IGSFSLYDSQ SVSESDLGHN FFLEESSSGK NRAQEVSRLL AELNPDVKTN 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGTCTGAAC CTCAGGTCGC TTTGGAAGAT GTCGCGCCTA TATTACCCGT CTCTAGTCGT 60
GATCGGTACG TGTTCATAAA TATCAAAAAT CGTCATCTGA GGTTTCATAG AGTGATATCG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway

Interpro

IPR030667--APP-BP1
IPR016040--NAD(P)-bd_dom
IPR000594--ThiF_NAD_FAD-bd

Pfam

PF00899--ThiF

Gene Ontology

GO:0005829--C:cytosol
GO:0005634--C:nucleus
GO:0019781--F:NEDD8 activating enzyme activity
GO:0045116--P:protein neddylation

KEGG

mlr:MELLADRAFT_91342

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000764	Aegilops tauschii	35.53	1.00e-86	311.00
IUUC-Aml-002333	Ailuropoda melanoleuca	36.35	7.00e-97	345.00
IUUC-Atr-002644	Amborella trichopoda	33.46	5.00e-78	283.00
IUUC-Apl-003446	Anas platyrhynchos	36.20	3.00e-92	330.00
IUUC-Aca-004450	Anolis carolinensis	37.43	1.00e-102	364.00
IUUC-Aly-005466	Arabidopsis lyrata	34.93	9.00e-87	312.00
IUUC-Ath-007600	Arabidopsis thaliana	35.73	2.00e-88	317.00
IUUC-Ago-007900	Ashbya gossypii	25.81	4.00e-31	127.00
IUUC-Acl-008333	Aspergillus clavatus	32.86	3.00e-75	273.00
IUUC-Afl-008529	Aspergillus flavus	34.90	2.00e-83	301.00
IUUC-Afu-009071	Aspergillus fumigatus	33.22	4.00e-75	273.00
IUUC-Ani-009443	Aspergillus nidulans	33.39	1.00e-73	268.00
IUUC-Ang-009669	Aspergillus niger	33.16	2.00e-80	291.00
IUUC-Aor-009914	Aspergillus oryzae	34.78	5.00e-82	296.00
IUUC-Ate-010450	Aspergillus terreus	32.92	1.00e-78	285.00
IUUC-Ame-011183	Astyanax mexicanus	35.33	6.00e-99	352.00
IUUC-Bgr-012111	Blumeria graminis	34.05	4.00e-67	246.00
IUUC-Bta-012583	Bos taurus	36.78	4.00e-98	350.00
IUUC-Bci-013892	Botrytis cinerea	35.29	4.00e-69	253.00
IUUC-Bdi-014592	Brachypodium distachyon	35.30	2.00e-85	307.00
IUUC-Bol-016399	Brassica oleracea	35.35	1.00e-88	318.00
IUUC-Bra-017506	Brassica rapa	33.46	1.00e-84	305.00
IUUC-Cel-018456	Caenorhabditis elegans	30.33	2.00e-73	268.00
IUUC-Cja-020007	Callithrix jacchus	36.48	1.00e-95	341.00
IUUC-Cfa-020324	Canis familiaris	37.18	6.00e-99	352.00
IUUC-Cpo-022248	Cavia porcellus	33.15	3.00e-55	207.00
IUUC-Csa-023149	Chlorocebus sabaeus	33.12	6.00e-70	256.00
IUUC-Cho-024537	Choloepus hoffmanni	29.30	4.00e-58	216.00
IUUC-Cin-025763	Ciona intestinalis	37.09	7.00e-104	369.00
IUUC-Csv-026113	Ciona savignyi	35.64	2.00e-100	357.00
IUUC-Cgl-026428	Colletotrichum gloeosporioides	33.85	5.00e-73	266.00
IUUC-Cne-026884	Cryptococcus neoformans	37.21	2.00e-84	304.00
IUUC-Cme-027210	Cyanidioschyzon merolae	29.87	2.00e-22	98.20
IUUC-Dre-028140	Danio rerio	34.76	5.00e-97	346.00
IUUC-Dno-030033	Dasypus novemcinctus	37.60	4.00e-87	313.00
IUUC-Dor-030513	Dipodomys ordii	56.86	1.00e-26	112.00
IUUC-Dse-031536	Dothistroma septosporum	34.25	5.00e-84	303.00
IUUC-Dme-031683	Drosophila melanogaster	35.05	1.00e-77	281.00
IUUC-Ete-032420	Echinops telfairi	31.78	1.00e-77	281.00
IUUC-Eca-033992	Equus caballus	32.13	3.00e-68	250.00
IUUC-Eeu-034713	Erinaceus europaeus	56.57	2.00e-27	114.00
IUUC-Fca-036548	Felis catus	37.34	5.00e-96	342.00
IUUC-Fal-037600	Ficedula albicollis	36.98	4.00e-92	330.00
IUUC-Fox-038037	Fusarium oxysporum	33.21	3.00e-74	270.00
IUUC-Fso-038387	Fusarium solani	33.45	9.00e-74	268.00
IUUC-Gmo-038562	Gadus morhua	35.99	1.00e-99	354.00
IUUC-Ggr-040005	Gaeumannomyces graminis	34.10	7.00e-78	282.00
IUUC-Gga-041129	Gallus gallus	36.27	1.00e-95	341.00
IUUC-Gac-042558	Gasterosteus aculeatus	36.30	1.00e-96	344.00
IUUC-Gma-043221	Glycine max	34.44	7.00e-82	295.00
IUUC-Ggo-045611	Gorilla gorilla	36.79	9.00e-96	342.00
IUUC-Hsa-046563	Homo sapiens	36.80	1.00e-96	344.00
IUUC-Hvu-047790	Hordeum vulgare	35.80	2.00e-61	227.00
IUUC-Itr-048066	Ictidomys tridecemlineatus	37.34	3.00e-98	350.00
IUUC-Kpa-049309	Komagataella pastoris	36.23	6.00e-81	292.00
IUUC-Lch-050038	Latimeria chalumnae	36.40	5.00e-96	342.00
IUUC-Lpe-051535	Leersia perrieri	32.49	3.00e-66	244.00
IUUC-Loc-051917	Lepisosteus oculatus	32.92	1.00e-84	305.00
IUUC-Lma-053112	Leptosphaeria maculans	32.94	1.00e-81	295.00
IUUC-Laf-053690	Loxodonta africana	37.18	1.00e-98	351.00
IUUC-Mcc-055117	Macaca mulatta	35.30	3.00e-91	327.00
IUUC-Meu-056761	Macropus eugenii	30.41	8.00e-64	236.00
IUUC-Mor-057230	Magnaporthe oryzae	34.75	5.00e-82	296.00
IUUC-Mpo-057514	Magnaporthe poae	35.49	8.00e-76	275.00
IUUC-Mtr-058551	Medicago truncatula	33.51	2.00e-78	284.00
IUUC-Mga-060144	Meleagris gallopavo	35.77	6.00e-91	325.00
IUUC-Mvi-060221	Microbotryum violaceum	42.06	6.00e-110	389.00
IUUC-Mmr-061325	Microcebus murinus	36.07	2.00e-93	334.00
IUUC-Mdo-062532	Monodelphis domestica	36.84	1.00e-96	345.00
IUUC-Mmu-063956	Mus musculus	37.16	2.00e-97	347.00
IUUC-Mac-064521	Musa acuminata	34.07	4.00e-82	296.00
IUUC-Mpu-066716	Mustela putorius furo	36.82	7.00e-89	319.00
IUUC-Mlu-067459	Myotis lucifugus	37.05	1.00e-97	348.00
IUUC-Nfi-068245	Neosartorya fischeri	33.04	2.00e-75	274.00
IUUC-Ncr-068910	Neurospora crassa	34.47	1.00e-78	285.00
IUUC-Nle-070034	Nomascus leucogenys	34.95	1.00e-87	315.00
IUUC-Opr-070552	Ochotona princeps	34.10	1.00e-73	268.00
IUUC-Ont-071426	Oreochromis niloticus	35.20	1.00e-100	358.00
IUUC-Oan-073389	Ornithorhynchus anatinus	33.97	3.00e-64	237.00
IUUC-Ocu-074911	Oryctolagus cuniculus	36.89	2.00e-98	350.00
IUUC-Oba-075437	Oryza barthii	34.38	7.00e-80	289.00
IUUC-Obr-076684	Oryza brachyantha	34.20	6.00e-71	259.00
IUUC-Ogl-077170	Oryza glaberrima	34.38	7.00e-80	289.00
IUUC-Ogu-078844	Oryza glumaepatula	33.85	3.00e-71	260.00
IUUC-Oin-079105	Oryza indica	34.38	3.00e-79	287.00
IUUC-Olo-080943	Oryza longistaminata	32.44	2.00e-65	241.00
IUUC-Oni-082891	Oryza nivara	33.09	2.00e-72	264.00
IUUC-Opu-083457	Oryza punctata	34.75	3.00e-80	290.00
IUUC-Oru-084960	Oryza rufipogon	32.44	2.00e-65	241.00
IUUC-Osa-085358	Oryza sativa	34.38	6.00e-79	286.00
IUUC-Ola-086420	Oryzias latipes	32.66	6.00e-63	232.00
IUUC-Olu-087625	Ostreococcus lucimarinus	28.03	1.00e-49	189.00
IUUC-Oga-088810	Otolemur garnettii	37.16	8.00e-98	348.00
IUUC-Oar-089196	Ovis aries	36.58	1.00e-96	345.00
IUUC-Ptr-090617	Pan troglodytes	36.98	4.00e-97	346.00
IUUC-Pan-092761	Papio anubis	36.98	2.00e-97	347.00
IUUC-Psi-093191	Pelodiscus sinensis	34.31	1.00e-88	318.00
IUUC-Pma-094380	Petromyzon marinus	39.69	3.00e-95	340.00
IUUC-Pno-095084	Phaeosphaeria nodorum	31.27	4.00e-69	254.00
IUUC-Ppa-095798	Physcomitrella patens	33.33	1.00e-81	295.00
IUUC-Pfo-096467	Poecilia formosa	35.73	2.00e-97	347.00
IUUC-Pab-098255	Pongo abelii	39.00	2.00e-86	310.00
IUUC-Pop-099871	Populus trichocarpa	34.01	4.00e-88	316.00
IUUC-Pca-100807	Procavia capensis	41.54	5.00e-37	146.00
IUUC-Ppe-101280	Prunus persica	34.99	3.00e-87	313.00
IUUC-Pva-102333	Pteropus vampyrus	35.84	2.00e-86	310.00
IUUC-Pgr-103401	Puccinia graminis	47.66	1.00e-149	521.00
IUUC-Ptt-103889	Puccinia triticina	42.44	5.00e-126	442.00
IUUC-Pte-104355	Pyrenophora teres	32.43	4.00e-79	286.00
IUUC-Pyt-104545	Pyrenophora triticirepentis	32.83	3.00e-78	283.00
IUUC-Rno-105810	Rattus norvegicus	36.10	2.00e-95	341.00
IUUC-Sce-106397	Saccharomyces cerevisiae	27.07	2.00e-27	115.00
IUUC-Sha-106770	Sarcophilus harrisii	41.73	7.00e-57	211.00
IUUC-Sja-107926	Schizosaccharomyces japonicus	30.97	2.00e-77	281.00
IUUC-Spo-108276	Schizosaccharomyces pombe	32.84	5.00e-80	289.00
IUUC-Ssl-108387	Sclerotinia sclerotiorum	35.20	6.00e-71	259.00
IUUC-Smo-109296	Selaginella moellendorffii	34.25	1.00e-81	295.00
IUUC-Sit-110157	Setaria italica	36.78	1.00e-92	331.00
IUUC-Sly-111105	Solanum lycopersicum	34.72	6.00e-89	319.00
IUUC-Stu-112469	Solanum tuberosum	34.85	3.00e-91	327.00
IUUC-Sar-113083	Sorex araneus	43.04	8.00e-29	119.00
IUUC-Sbi-113813	Sorghum bicolor	35.49	1.00e-88	318.00
IUUC-Sre-115058	Sporisorium reilianum	42.49	7.00e-93	332.00
IUUC-Tgu-116772	Taeniopygia guttata	38.04	8.00e-96	342.00
IUUC-Tru-118686	Takifugu rubripes	35.21	2.00e-97	347.00
IUUC-Tsy-119111	Tarsius syrichta	36.30	4.00e-45	174.00
IUUC-Tni-120231	Tetraodon nigroviridis	33.15	1.00e-83	301.00
IUUC-Tca-121491	Theobroma cacao	35.10	5.00e-82	296.00
IUUC-Tre-122103	Trichoderma reesei	35.08	4.00e-78	283.00
IUUC-Tvi-122672	Trichoderma virens	34.14	4.00e-78	283.00
IUUC-Tae-125316	Triticum aestivum	36.04	3.00e-88	317.00
IUUC-Tur-126487	Triticum urartu	34.94	1.00e-82	298.00
IUUC-Tme-127097	Tuber melanosporum	35.89	3.00e-84	303.00
IUUC-Ttr-128465	Tursiops truncatus	35.19	2.00e-86	311.00
IUUC-Uma-129645	Ustilago maydis	41.33	8.00e-92	329.00
IUUC-Vda-129989	Verticillium dahliae	31.55	3.00e-59	220.00
IUUC-Vpa-130529	Vicugna pacos	35.24	7.00e-88	315.00
IUUC-Vvi-131059	Vitis vinifera	35.17	3.00e-85	307.00
IUUC-Xtr-132002	Xenopus tropicalis	36.58	4.00e-97	346.00
IUUC-Xma-133930	Xiphophorus maculatus	36.28	2.00e-98	351.00
IUUC-Yli-134505	Yarrowia lipolytica	34.38	5.00e-81	292.00
IUUC-Zma-135895	Zea mays	35.12	3.00e-87	313.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence