iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Mpu-066716

Ensembl Protein ID

ENSMPUP00000005226.1

UniProt Accession

M3Y1M5; M3Y1M5_MUSPF

Genbank Protein ID

ENSMPUP00000005226

Protein Name

NEDD8-activating enzyme E1 regulatory subunit

Genbank Nucleotide ID

AEYP01015789

Gene Name

NAE1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMPUG00000005264.1	ENSMPUT00000005314.1	ENSMPUP00000005226.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E1	1.20e-119	400.2	13	501

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

   S: 1    YDRQirlwGeeaqeklksakvllvGagglGcEllKnLvlaGvgsitvvDmdtvevsnlnrqFLfraedvgksKAevaaealkelnpdvn 89
           YDRQ+rlwG+++qe+l+sa+v+l++a+++G+E+lKnLvl G+gs+tv+D+++v+ ++ +++F+++++++gk++A++a+e+l+eln dv+
   Q: 13   YDRQLRLWGDHGQEALESAHVCLINATATGTEILKNLVLPGIGSFTVIDGNQVSGEDAGNNFFLQRSSIGKNRAQAAMEFLQELNNDVS 101
           ***************************************************************************************** PP
   S: 90   veaheesiteleeeiv.FfkkfdvVvlaldnrearrkvnrlclnarvpliesgtlGllGqvrviikgltecyscsd...dppqktiPfc 174
           ++++ees+++l ++++ Ff++f++Vv+++ ++++ ++++++++n ++pl++++t+Gl+G++r+iik++++++s++d   +++++++Pf+
   Q: 102  GSFVEESPENLLDNDPsFFCRFTIVVATQLPESTLLRLADVLWNSQIPLLICRTYGLVGYMRIIIKEHPVIESHPDnalEDLRLDKPFP 190
           ***************************************************************************************** PP
   S: 175  tlketpn.........aaehtiewavlfnklleeeageeevlekldseekeegkdkvkselks......edeenfeeaieiavkafakt 248
           +l+e+++         +++++++w+v+++k+l+++++e++++ +++++eke+++d++++++ +      edeenfeeai+++++a+++t
   Q: 191  ELREHFQsydldhmekKDHSHTPWIVIVAKYLAQWYSETNGRIPKTYKEKEDFRDLIRQGILKnengapEDEENFEEAIKNVNTALNTT 279
           *****99999999998***********************************************9************************* PP
   S: 249  tins.ikqllksfecdivtkskspfwv.............................................................. 274
           +i+s i++++++++c ++tk++++fw+                                                              
   Q: 280  QIPSsIEDIFNDDHCINITKQTPSFWIlaralkefvakegqgnlpvrgtipdmiadsskyiklqnvyrekakkdaaavgnhvakllqsi 368
           ***************************************************************************************** PP
   S: 275  .............sfcsnaealqvp...........ekvekdeevvkasap.....lylllralerfekkkgrkpgelsfekddds..a 332
                         +c+n++ l+v            ++++k+e+++++++p     lyl+lra++rf+k++gr+pg +++++++d+  +
   Q: 369  gqapesisekelkLLCTNSAFLRVVrcrslaeeyglDTINKEEIISSMDNPdneivLYLMLRAVDRFHKQHGRYPGISNYQVEEDIgkL 457
           *************999999999977777777778889999**9*9999999999********************************999 PP
   S: 333  vdlvtaaanlraeslgiepkldddlikeiagniipaiattnavvgGla 380
            +++t ++    +++g++ +++dd+++e++++++++ +t++a++g  a
   Q: 458  KSCLTGFL----QEYGLSVMVKDDYVHEFCRYGAAEPHTIAAFLGDTA 501
           ********....********************************9665 PP

Organism

Mustela putorius furo

Functional Description
(View)

Regulatory subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M.

Protein Sequence
(Fasta)

MAQPGKLLKE QKYDRQLRLW GDHGQEALES AHVCLINATA TGTEILKNLV LPGIGSFTVI 60
DGNQVSGEDA GNNFFLQRSS IGKNRAQAAM EFLQELNNDV SGSFVEESPE NLLDNDPSFF 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ACCAATCTGC CCGATTCCAG AGCCCGAGTG CCCTACCTAC GATTACCGCA CCTACAAAGT 60
CACGGACTGG CCGACTAGCC GGGACGCAGC CAGAGGGAAA GACCCGCCTC AGTCCGGGTT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway

Interpro

IPR030667--APP-BP1
IPR016040--NAD(P)-bd_dom
IPR000594--ThiF_NAD_FAD-bd

Pfam

PF00899--ThiF

Gene Ontology

GO:0019781--F:NEDD8 activating enzyme activity
GO:0033314--P:mitotic DNA replication checkpoint
GO:0051402--P:neuron apoptotic process
GO:0045116--P:protein neddylation
GO:0043523--P:regulation of neuron apoptotic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000764	Aegilops tauschii	42.45	2.00e-116	412.00
IUUC-Aml-002333	Ailuropoda melanoleuca	97.82	0.00e+00	1032.00
IUUC-Atr-002644	Amborella trichopoda	40.95	1.00e-106	380.00
IUUC-Apl-003446	Anas platyrhynchos	83.40	0.00e+00	864.00
IUUC-Aca-004450	Anolis carolinensis	79.88	0.00e+00	866.00
IUUC-Aly-006187	Arabidopsis lyrata	39.17	2.00e-115	409.00
IUUC-Ath-007600	Arabidopsis thaliana	39.96	2.00e-117	416.00
IUUC-Ago-007900	Ashbya gossypii	28.50	5.00e-31	128.00
IUUC-Acl-008333	Aspergillus clavatus	34.03	1.00e-71	263.00
IUUC-Afl-008529	Aspergillus flavus	35.82	4.00e-77	281.00
IUUC-Afu-009071	Aspergillus fumigatus	32.95	6.00e-72	265.00
IUUC-Ani-009443	Aspergillus nidulans	34.78	7.00e-69	254.00
IUUC-Ang-009669	Aspergillus niger	35.28	4.00e-73	269.00
IUUC-Aor-009914	Aspergillus oryzae	37.03	8.00e-74	271.00
IUUC-Ate-010450	Aspergillus terreus	34.42	4.00e-75	275.00
IUUC-Ame-011183	Astyanax mexicanus	70.42	0.00e+00	771.00
IUUC-Bgr-012111	Blumeria graminis	35.43	1.00e-57	217.00
IUUC-Bta-012583	Bos taurus	97.21	0.00e+00	1025.00
IUUC-Bci-013892	Botrytis cinerea	36.75	2.00e-59	223.00
IUUC-Bdi-014592	Brachypodium distachyon	43.70	3.00e-120	425.00
IUUC-Bol-016399	Brassica oleracea	39.84	9.00e-115	407.00
IUUC-Bra-017506	Brassica rapa	38.29	3.00e-110	392.00
IUUC-Cel-018456	Caenorhabditis elegans	34.90	3.00e-82	298.00
IUUC-Cja-020007	Callithrix jacchus	96.44	0.00e+00	1022.00
IUUC-Cfa-020324	Canis familiaris	98.01	0.00e+00	1033.00
IUUC-Cpo-022248	Cavia porcellus	83.80	2.00e-174	605.00
IUUC-Csa-023149	Chlorocebus sabaeus	93.62	0.00e+00	858.00
IUUC-Cho-024537	Choloepus hoffmanni	84.15	0.00e+00	743.00
IUUC-Cin-025763	Ciona intestinalis	49.09	8.00e-145	506.00
IUUC-Csv-026113	Ciona savignyi	45.06	8.00e-136	477.00
IUUC-Cgl-026428	Colletotrichum gloeosporioides	34.82	2.00e-59	223.00
IUUC-Cne-026884	Cryptococcus neoformans	30.04	2.00e-64	240.00
IUUC-Cme-027210	Cyanidioschyzon merolae	27.56	2.00e-19	90.90
IUUC-Dre-028140	Danio rerio	72.11	0.00e+00	796.00
IUUC-Dno-030033	Dasypus novemcinctus	97.89	0.00e+00	965.00
IUUC-Dor-030513	Dipodomys ordii	68.69	3.00e-116	411.00
IUUC-Dse-031536	Dothistroma septosporum	34.10	4.00e-74	272.00
IUUC-Dme-031683	Drosophila melanogaster	43.95	1.00e-115	409.00
IUUC-Ete-032420	Echinops telfairi	82.23	0.00e+00	825.00
IUUC-Eca-033992	Equus caballus	97.34	0.00e+00	847.00
IUUC-Eeu-034713	Erinaceus europaeus	74.32	2.00e-95	342.00
IUUC-Fca-036548	Felis catus	98.21	0.00e+00	1034.00
IUUC-Fal-037600	Ficedula albicollis	80.38	0.00e+00	835.00
IUUC-Fox-038037	Fusarium oxysporum	37.31	1.00e-69	256.00
IUUC-Fso-038387	Fusarium solani	38.50	2.00e-70	260.00
IUUC-Gmo-038562	Gadus morhua	70.16	0.00e+00	766.00
IUUC-Ggr-040005	Gaeumannomyces graminis	37.91	3.00e-66	245.00
IUUC-Gga-041129	Gallus gallus	84.15	0.00e+00	889.00
IUUC-Gac-042558	Gasterosteus aculeatus	71.94	0.00e+00	780.00
IUUC-Gma-043610	Glycine max	40.59	3.00e-111	395.00
IUUC-Ggo-045611	Gorilla gorilla	96.24	0.00e+00	1016.00
IUUC-Hsa-046563	Homo sapiens	96.81	0.00e+00	1021.00
IUUC-Hvu-047790	Hordeum vulgare	37.05	2.00e-66	246.00
IUUC-Itr-048066	Ictidomys tridecemlineatus	96.61	0.00e+00	1021.00
IUUC-Kpa-049309	Komagataella pastoris	36.46	9.00e-76	277.00
IUUC-Lch-050038	Latimeria chalumnae	75.55	0.00e+00	800.00
IUUC-Lpe-051535	Leersia perrieri	40.85	5.00e-109	388.00
IUUC-Loc-051917	Lepisosteus oculatus	68.43	0.00e+00	737.00
IUUC-Lma-053112	Leptosphaeria maculans	34.90	1.00e-78	287.00
IUUC-Laf-053690	Loxodonta africana	95.22	0.00e+00	1012.00
IUUC-Mcc-055117	Macaca mulatta	94.86	0.00e+00	1003.00
IUUC-Meu-056761	Macropus eugenii	74.95	0.00e+00	761.00
IUUC-Mor-057230	Magnaporthe oryzae	37.28	3.00e-68	252.00
IUUC-Mpo-057514	Magnaporthe poae	37.31	3.00e-64	239.00
IUUC-Mtr-058551	Medicago truncatula	39.69	4.00e-108	385.00
IUUC-Mla-059183	Melampsora laricipopulina	36.82	3.00e-88	319.00
IUUC-Mga-060144	Meleagris gallopavo	82.27	0.00e+00	860.00
IUUC-Mvi-060221	Microbotryum violaceum	38.16	5.00e-77	281.00
IUUC-Mmr-061325	Microcebus murinus	94.85	0.00e+00	1000.00
IUUC-Mdo-062532	Monodelphis domestica	89.82	0.00e+00	959.00
IUUC-Mmu-063956	Mus musculus	95.82	0.00e+00	1017.00
IUUC-Mac-064521	Musa acuminata	41.15	1.00e-114	406.00
IUUC-Mlu-067459	Myotis lucifugus	94.44	0.00e+00	995.00
IUUC-Nfi-068245	Neosartorya fischeri	33.59	2.00e-72	266.00
IUUC-Ncr-068910	Neurospora crassa	38.10	4.00e-68	252.00
IUUC-Nle-070034	Nomascus leucogenys	93.91	0.00e+00	973.00
IUUC-Opr-070552	Ochotona princeps	86.63	0.00e+00	882.00
IUUC-Ont-071426	Oreochromis niloticus	72.84	0.00e+00	799.00
IUUC-Oan-073389	Ornithorhynchus anatinus	83.42	0.00e+00	731.00
IUUC-Ocu-074911	Oryctolagus cuniculus	95.22	0.00e+00	1015.00
IUUC-Oba-075437	Oryza barthii	43.09	8.00e-110	390.00
IUUC-Obr-076684	Oryza brachyantha	42.91	3.00e-105	375.00
IUUC-Ogl-077170	Oryza glaberrima	43.09	8.00e-110	390.00
IUUC-Ogu-078844	Oryza glumaepatula	43.52	4.00e-109	388.00
IUUC-Oin-079105	Oryza indica	43.09	4.00e-109	388.00
IUUC-Olo-080943	Oryza longistaminata	40.04	3.00e-104	372.00
IUUC-Oni-082891	Oryza nivara	39.84	4.00e-103	368.00
IUUC-Opu-083457	Oryza punctata	43.09	3.00e-109	388.00
IUUC-Oru-084960	Oryza rufipogon	40.04	3.00e-104	372.00
IUUC-Osa-085358	Oryza sativa	43.29	4.00e-110	391.00
IUUC-Ola-086420	Oryzias latipes	69.79	2.00e-151	528.00
IUUC-Olu-087625	Ostreococcus lucimarinus	29.83	1.00e-51	197.00
IUUC-Oga-088810	Otolemur garnettii	95.82	0.00e+00	1015.00
IUUC-Oar-089196	Ovis aries	96.63	0.00e+00	1021.00
IUUC-Ptr-090617	Pan troglodytes	97.01	0.00e+00	1023.00
IUUC-Pan-092761	Papio anubis	97.01	0.00e+00	1026.00
IUUC-Psi-093191	Pelodiscus sinensis	85.57	0.00e+00	897.00
IUUC-Pma-094380	Petromyzon marinus	61.51	0.00e+00	659.00
IUUC-Pno-095084	Phaeosphaeria nodorum	36.18	4.00e-66	246.00
IUUC-Ppa-095875	Physcomitrella patens	40.00	4.00e-111	395.00
IUUC-Pfo-096467	Poecilia formosa	71.83	0.00e+00	779.00
IUUC-Pab-098255	Pongo abelii	97.75	0.00e+00	909.00
IUUC-Pop-099722	Populus trichocarpa	40.16	1.00e-115	410.00
IUUC-Pca-100807	Procavia capensis	79.25	1.00e-119	423.00
IUUC-Ppe-101280	Prunus persica	40.00	7.00e-114	404.00
IUUC-Pva-102333	Pteropus vampyrus	92.08	0.00e+00	959.00
IUUC-Pgr-103401	Puccinia graminis	32.45	4.00e-73	268.00
IUUC-Ptt-103889	Puccinia triticina	27.36	2.00e-52	200.00
IUUC-Pte-104355	Pyrenophora teres	35.73	2.00e-81	296.00
IUUC-Pyt-104545	Pyrenophora triticirepentis	36.11	8.00e-83	301.00
IUUC-Rno-105810	Rattus norvegicus	95.22	0.00e+00	1008.00
IUUC-Sce-106397	Saccharomyces cerevisiae	28.04	9.00e-31	127.00
IUUC-Sha-106770	Sarcophilus harrisii	90.46	2.00e-155	541.00
IUUC-Sja-107926	Schizosaccharomyces japonicus	32.86	4.00e-71	261.00
IUUC-Spo-108276	Schizosaccharomyces pombe	34.61	4.00e-73	268.00
IUUC-Ssl-108387	Sclerotinia sclerotiorum	34.26	5.00e-60	225.00
IUUC-Smo-109296	Selaginella moellendorffii	41.60	2.00e-114	406.00
IUUC-Sit-110157	Setaria italica	44.64	2.00e-126	446.00
IUUC-Sly-111660	Solanum lycopersicum	40.40	1.00e-115	410.00
IUUC-Stu-112469	Solanum tuberosum	40.43	4.00e-115	408.00
IUUC-Sar-113083	Sorex araneus	70.66	0.00e+00	683.00
IUUC-Sbi-113813	Sorghum bicolor	44.25	2.00e-125	442.00
IUUC-Sre-115058	Sporisorium reilianum	39.33	6.00e-86	311.00
IUUC-Tgu-116772	Taeniopygia guttata	79.96	0.00e+00	831.00
IUUC-Tru-118686	Takifugu rubripes	70.62	0.00e+00	781.00
IUUC-Tsy-119111	Tarsius syrichta	90.11	6.00e-151	527.00
IUUC-Tni-120231	Tetraodon nigroviridis	65.47	0.00e+00	699.00
IUUC-Tca-121491	Theobroma cacao	39.80	3.00e-107	382.00
IUUC-Tre-122103	Trichoderma reesei	40.50	6.00e-74	271.00
IUUC-Tvi-122672	Trichoderma virens	40.51	1.00e-69	257.00
IUUC-Tae-125679	Triticum aestivum	43.09	7.00e-119	421.00
IUUC-Tur-126487	Triticum urartu	41.67	2.00e-112	399.00
IUUC-Tme-127097	Tuber melanosporum	37.94	2.00e-83	303.00
IUUC-Ttr-128465	Tursiops truncatus	88.91	0.00e+00	930.00
IUUC-Uma-129645	Ustilago maydis	38.05	5.00e-85	308.00
IUUC-Vda-129989	Verticillium dahliae	32.79	5.00e-49	188.00
IUUC-Vpa-130529	Vicugna pacos	92.28	0.00e+00	966.00
IUUC-Vvi-131059	Vitis vinifera	40.79	3.00e-113	402.00
IUUC-Xtr-132002	Xenopus tropicalis	78.18	0.00e+00	846.00
IUUC-Xma-133930	Xiphophorus maculatus	72.27	0.00e+00	784.00
IUUC-Yli-134505	Yarrowia lipolytica	34.86	4.00e-78	285.00
IUUC-Zma-135895	Zea mays	44.72	6.00e-125	441.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence