iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Dre-027644

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Cbl proto-oncogene, E3 ubiquitin protein ligase

Genbank Nucleotide ID

BX571886

Gene Name

cbl

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSDARG00000009958.8	ENSDART00000006085.7	ENSDARP00000027963.7

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/RING	1.60e-07	32.6	365	404

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 1    CaiCledfkdgplvlpCgHvfhadClqkwpglknssskefrCPlCr 46
           C iC e  kd +++ pCgH+++++Cl +w    + +s  + CP Cr
   Q: 365  CKICAENDKD-VKIEPCGHLMCTSCLTAW----Q-ESEGQGCPFCR 404
           99********.******************....5.555555****8 PP

Organism

Danio rerio

Protein Sequence
(Fasta)

MAGNLKKGGG LIGMMKDAFQ PHHHLHHSHH QPGAVDKKTV EKCWKFMDKV VRLCQNPKLA 60
LKNSPPYILD LLPDTYQHLR TILSRYEGKM ETLGDNEYFR VFMENLTKKT KQTISLFKDG 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CGCACAGATA GAGAAAGAGA GCTGCAGGAA AAGGGAACAT CACGCACGGG GTGTCGATGT 60
GAAAGCAGTT GTTCTACCAC GTCCAGACAC CCATCAAAAC TTATTTTTAC GCGTTATTTT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR024162--Adaptor_Cbl
IPR014741--Adaptor_Cbl_EF_hand-like
IPR003153--Adaptor_Cbl_N_hlx
IPR014742--Adaptor_Cbl_SH2-like
IPR024159--Cbl_PTB
IPR011992--EF-hand-dom_pair
IPR000980--SH2
IPR015940--UBA
IPR009060--UBA-like
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS

PROSITE

PS51506--CBL_PTB
PS50030--UBA
PS00518--ZF_RING_1
PS50089--ZF_RING_2

Pfam

PF02262--Cbl_N
PF02761--Cbl_N2
PF02762--Cbl_N3
PF00627--UBA

SMART

SM00184--RING
SM00165--UBA

Gene Ontology

GO:0045121--C:membrane raft
GO:0005634--C:nucleus
GO:0005886--C:plasma membrane
GO:0005509--F:calcium ion binding
GO:0030971--F:receptor tyrosine kinase binding
GO:0017124--F:SH3 domain binding
GO:0004871--F:signal transducer activity
GO:0061630--F:ubiquitin protein ligase activity
GO:0008270--F:zinc ion binding
GO:0007173--P:epidermal growth factor receptor signaling pathway
GO:0007175--P:negative regulation of epidermal growth factor-activated receptor activity
GO:0006508--P:proteolysis

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002357	Ailuropoda melanoleuca	69.69	0.00e+00	1051.00
IUUC-Apl-004041	Anas platyrhynchos	71.71	0.00e+00	1105.00
IUUC-Aca-004899	Anolis carolinensis	69.51	0.00e+00	1053.00
IUUC-Ame-010746	Astyanax mexicanus	76.99	0.00e+00	805.00
IUUC-Bta-012759	Bos taurus	70.08	0.00e+00	1088.00
IUUC-Cja-019207	Callithrix jacchus	68.97	0.00e+00	1118.00
IUUC-Cfa-020897	Canis familiaris	69.50	0.00e+00	1118.00
IUUC-Cpo-021453	Cavia porcellus	68.49	0.00e+00	1067.00
IUUC-Csa-023136	Chlorocebus sabaeus	69.01	0.00e+00	1117.00
IUUC-Cho-024282	Choloepus hoffmanni	61.09	0.00e+00	903.00
IUUC-Cin-025574	Ciona intestinalis	70.48	2.00e-178	618.00
IUUC-Csv-025938	Ciona savignyi	68.86	1.00e-172	598.00
IUUC-Dno-030025	Dasypus novemcinctus	69.10	0.00e+00	1054.00
IUUC-Dme-032213	Drosophila melanogaster	73.98	0.00e+00	648.00
IUUC-Eca-033900	Equus caballus	69.75	0.00e+00	1057.00
IUUC-Eeu-035142	Erinaceus europaeus	71.94	0.00e+00	764.00
IUUC-Fca-035455	Felis catus	68.20	0.00e+00	1104.00
IUUC-Fal-037182	Ficedula albicollis	87.45	0.00e+00	848.00
IUUC-Gmo-038698	Gadus morhua	91.49	0.00e+00	915.00
IUUC-Gga-040438	Gallus gallus	72.00	0.00e+00	1122.00
IUUC-Gac-042166	Gasterosteus aculeatus	78.06	0.00e+00	1115.00
IUUC-Ggo-045618	Gorilla gorilla	69.08	0.00e+00	1118.00
IUUC-Hsa-046177	Homo sapiens	69.08	0.00e+00	1118.00
IUUC-Itr-048795	Ictidomys tridecemlineatus	77.21	0.00e+00	775.00
IUUC-Lch-050095	Latimeria chalumnae	72.26	0.00e+00	1131.00
IUUC-Loc-052570	Lepisosteus oculatus	80.09	0.00e+00	1222.00
IUUC-Laf-054008	Loxodonta africana	68.85	0.00e+00	1106.00
IUUC-Mcc-054676	Macaca mulatta	69.01	0.00e+00	1118.00
IUUC-Mga-059239	Meleagris gallopavo	71.97	0.00e+00	1145.00
IUUC-Mmr-060907	Microcebus murinus	67.23	0.00e+00	1085.00
IUUC-Mdo-062595	Monodelphis domestica	70.53	0.00e+00	1071.00
IUUC-Mmu-063725	Mus musculus	68.98	0.00e+00	1132.00
IUUC-Mpu-066771	Mustela putorius furo	68.65	0.00e+00	1104.00
IUUC-Mlu-067206	Myotis lucifugus	66.21	0.00e+00	914.00
IUUC-Nle-069285	Nomascus leucogenys	66.95	0.00e+00	1052.00
IUUC-Opr-071026	Ochotona princeps	68.57	0.00e+00	1062.00
IUUC-Ont-071954	Oreochromis niloticus	77.93	0.00e+00	1197.00
IUUC-Ocu-074657	Oryctolagus cuniculus	69.31	0.00e+00	1045.00
IUUC-Ola-087165	Oryzias latipes	76.99	0.00e+00	1233.00
IUUC-Oga-088198	Otolemur garnettii	73.20	0.00e+00	968.00
IUUC-Oar-090258	Ovis aries	70.18	0.00e+00	1040.00
IUUC-Ptr-090710	Pan troglodytes	69.08	0.00e+00	1118.00
IUUC-Pan-092785	Papio anubis	69.01	0.00e+00	1116.00
IUUC-Pfo-096990	Poecilia formosa	74.56	0.00e+00	1148.00
IUUC-Pab-098526	Pongo abelii	69.26	0.00e+00	1119.00
IUUC-Pva-102352	Pteropus vampyrus	85.54	0.00e+00	835.00
IUUC-Rno-105876	Rattus norvegicus	68.48	0.00e+00	1112.00
IUUC-Sha-107588	Sarcophilus harrisii	67.80	0.00e+00	925.00
IUUC-Sar-112959	Sorex araneus	68.05	0.00e+00	1049.00
IUUC-Ssc-115261	Sus scrofa	68.83	0.00e+00	1102.00
IUUC-Tgu-116580	Taeniopygia guttata	66.81	0.00e+00	1079.00
IUUC-Tru-118731	Takifugu rubripes	77.35	0.00e+00	1216.00
IUUC-Tni-120725	Tetraodon nigroviridis	75.39	0.00e+00	1159.00
IUUC-Tbe-128018	Tupaia belangeri	79.03	0.00e+00	923.00
IUUC-Ttr-128927	Tursiops truncatus	70.05	0.00e+00	1132.00
IUUC-Vpa-130369	Vicugna pacos	69.93	0.00e+00	1022.00
IUUC-Xtr-132474	Xenopus tropicalis	67.61	0.00e+00	1067.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence