iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Mdo-062595

UUCD1 version

UUC-MoD-00781

Ensembl Protein ID

ENSMODP00000016553.2

UniProt Accession

F7ECX4; F7ECX4_MONDO

Protein Name

Uncharacterized protein

Gene Name

CBL

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMODG00000013232.3	ENSMODT00000016858.2	ENSMODP00000016553.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/RING	7.20e-08	33.0	317	356

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 1    CaiCledfkdgplvlpCgHvfhadClqkwpglknssskefrCPlCr 46
           C iC e  kd +++ pCgH+++++Cl +w    + +s  + CP Cr
   Q: 317  CKICAENDKD-VKIEPCGHLMCTSCLTAW----Q-ESEGQGCPFCR 356
           99********.******************....5.555555****8 PP

Organism

Monodelphis domestica

Protein Sequence
(Fasta)

QVVRLCQNPK LALKNSPPYI LDLLPDTYQH LRTILSRYEG RMETLGENEY FRVFMENLMK 60
KTKQTISLFK EGKERMYEEN SQPRRNLTKL SLIFSHMLAE LKGIFPSGLF QGDTFRITKA 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CAGGTGGTGC GTTTATGTCA GAATCCAAAG CTGGCTCTAA AGAATAGTCC ACCTTACATA 60
TTAGACCTGC TACCAGATAC CTACCAGCAT CTTCGTACTA TCTTGTCAAG ATACGAAGGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR024162--Adaptor_Cbl
IPR014741--Adaptor_Cbl_EF_hand-like
IPR003153--Adaptor_Cbl_N_hlx
IPR014742--Adaptor_Cbl_SH2-like
IPR024159--Cbl_PTB
IPR011992--EF-hand-dom_pair
IPR000980--SH2
IPR015940--UBA
IPR009060--UBA-like
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS

PROSITE

PS51506--CBL_PTB
PS50030--UBA
PS00518--ZF_RING_1
PS50089--ZF_RING_2

Pfam

PF02262--Cbl_N
PF02761--Cbl_N2
PF02762--Cbl_N3
PF00627--UBA

SMART

SM00184--RING
SM00165--UBA

Gene Ontology

GO:0005829--C:cytosol
GO:0016600--C:flotillin complex
GO:0045121--C:membrane raft
GO:0005634--C:nucleus
GO:0005886--C:plasma membrane
GO:0005509--F:calcium ion binding
GO:0030971--F:receptor tyrosine kinase binding
GO:0017124--F:SH3 domain binding
GO:0004871--F:signal transducer activity
GO:0061630--F:ubiquitin protein ligase activity
GO:0008270--F:zinc ion binding
GO:0007173--P:epidermal growth factor receptor signaling pathway
GO:0043066--P:negative regulation of apoptotic process
GO:0007175--P:negative regulation of epidermal growth factor-activated receptor activity
GO:0014068--P:positive regulation of phosphatidylinositol 3-kinase signaling
GO:0048260--P:positive regulation of receptor-mediated endocytosis
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0006508--P:proteolysis

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002357	Ailuropoda melanoleuca	89.08	0.00e+00	1406.00
IUUC-Apl-004041	Anas platyrhynchos	86.55	0.00e+00	1392.00
IUUC-Aca-004899	Anolis carolinensis	83.16	0.00e+00	1297.00
IUUC-Ame-010746	Astyanax mexicanus	61.86	0.00e+00	634.00
IUUC-Bta-012759	Bos taurus	87.86	0.00e+00	1396.00
IUUC-Cja-019207	Callithrix jacchus	87.50	0.00e+00	1400.00
IUUC-Cfa-020897	Canis familiaris	88.54	0.00e+00	1380.00
IUUC-Cpo-021453	Cavia porcellus	87.28	0.00e+00	1431.00
IUUC-Csa-023136	Chlorocebus sabaeus	87.49	0.00e+00	1393.00
IUUC-Cho-024282	Choloepus hoffmanni	79.79	0.00e+00	1148.00
IUUC-Csv-025938	Ciona savignyi	69.74	4.00e-167	580.00
IUUC-Dre-027644	Danio rerio	69.27	0.00e+00	1006.00
IUUC-Dno-030025	Dasypus novemcinctus	88.81	0.00e+00	1407.00
IUUC-Ete-033118	Echinops telfairi	75.28	0.00e+00	754.00
IUUC-Eca-033900	Equus caballus	89.61	0.00e+00	1425.00
IUUC-Eeu-035142	Erinaceus europaeus	83.33	0.00e+00	902.00
IUUC-Fca-035455	Felis catus	88.19	0.00e+00	1388.00
IUUC-Fal-037182	Ficedula albicollis	97.31	0.00e+00	854.00
IUUC-Gmo-038698	Gadus morhua	87.92	0.00e+00	834.00
IUUC-Gga-040438	Gallus gallus	86.90	0.00e+00	1384.00
IUUC-Gac-042166	Gasterosteus aculeatus	77.95	0.00e+00	854.00
IUUC-Ggo-045618	Gorilla gorilla	88.42	0.00e+00	1412.00
IUUC-Hsa-046177	Homo sapiens	87.84	0.00e+00	1399.00
IUUC-Itr-048795	Ictidomys tridecemlineatus	93.69	0.00e+00	962.00
IUUC-Lch-050095	Latimeria chalumnae	74.48	0.00e+00	1163.00
IUUC-Loc-052570	Lepisosteus oculatus	72.99	0.00e+00	1107.00
IUUC-Laf-054008	Loxodonta africana	88.01	0.00e+00	1415.00
IUUC-Mcc-054676	Macaca mulatta	87.37	0.00e+00	1390.00
IUUC-Mga-059239	Meleagris gallopavo	86.43	0.00e+00	1393.00
IUUC-Mmr-060907	Microcebus murinus	86.40	0.00e+00	1371.00
IUUC-Mmu-063725	Mus musculus	88.21	0.00e+00	1454.00
IUUC-Mpu-066771	Mustela putorius furo	87.94	0.00e+00	1398.00
IUUC-Mlu-067206	Myotis lucifugus	74.88	0.00e+00	1055.00
IUUC-Nle-069285	Nomascus leucogenys	84.91	0.00e+00	1303.00
IUUC-Opr-071026	Ochotona princeps	87.50	0.00e+00	1412.00
IUUC-Ont-071954	Oreochromis niloticus	69.18	0.00e+00	1023.00
IUUC-Ocu-074657	Oryctolagus cuniculus	88.72	0.00e+00	1383.00
IUUC-Ola-087165	Oryzias latipes	67.04	0.00e+00	1011.00
IUUC-Oga-088198	Otolemur garnettii	76.82	0.00e+00	1203.00
IUUC-Oar-090258	Ovis aries	87.62	0.00e+00	1373.00
IUUC-Ptr-090710	Pan troglodytes	87.84	0.00e+00	1399.00
IUUC-Pan-092785	Papio anubis	87.49	0.00e+00	1393.00
IUUC-Psi-093431	Pelodiscus sinensis	80.88	0.00e+00	741.00
IUUC-Pfo-096990	Poecilia formosa	89.31	0.00e+00	775.00
IUUC-Pab-098526	Pongo abelii	87.60	0.00e+00	1395.00
IUUC-Pva-102352	Pteropus vampyrus	97.58	0.00e+00	816.00
IUUC-Rno-105876	Rattus norvegicus	87.51	0.00e+00	1420.00
IUUC-Sha-107588	Sarcophilus harrisii	95.73	0.00e+00	1379.00
IUUC-Sar-112959	Sorex araneus	84.86	0.00e+00	1362.00
IUUC-Ssc-115261	Sus scrofa	88.67	0.00e+00	1410.00
IUUC-Tgu-116580	Taeniopygia guttata	83.29	0.00e+00	1296.00
IUUC-Tru-118731	Takifugu rubripes	68.22	0.00e+00	1017.00
IUUC-Tsy-118982	Tarsius syrichta	78.87	0.00e+00	946.00
IUUC-Tni-120725	Tetraodon nigroviridis	68.37	0.00e+00	1015.00
IUUC-Tbe-128018	Tupaia belangeri	93.80	0.00e+00	1111.00
IUUC-Ttr-128927	Tursiops truncatus	89.33	0.00e+00	1441.00
IUUC-Vpa-130369	Vicugna pacos	88.15	0.00e+00	1347.00
IUUC-Xtr-132474	Xenopus tropicalis	75.20	0.00e+00	1130.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence