iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Sha-107588

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AEFK01114288

Gene Name

CBL

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSSHAG00000008028.1	ENSSHAT00000009356.1	ENSSHAP00000009276.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/RING	8.10e-08	32.8	276	315

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 1    CaiCledfkdgplvlpCgHvfhadClqkwpglknssskefrCPlCr 46
           C iC e  kd +++ pCgH+++++Cl +w    + +s  + CP Cr
   Q: 276  CKICAENDKD-VKIEPCGHLMCTSCLTAW----Q-ESEGQGCPFCR 315
           99********.******************....5.555555****8 PP

Organism

Sarcophilus harrisii

Protein Sequence
(Fasta)

METLGENEYF RVFMENLMKK TKQTISLFKE GKERMYEENS QPRRNLTKLS LIFSHMLAEL 60
KGIFPSGLFQ GDTFRITKAD AAEFWRKAFG EKTIVPWKSF RQALHEVHPI SSGLEAMALK 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GTGGTGCGTT TGTGTCAGAA TCCAAAGCTG GCTCTAAAGA ATAGTCCTCC TTATATATTA 60
GACCTGCTAC CAGATACCTA CCAGCATCTT CGTACAATTT TGTCAAGATA CGAGGGGAGA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR024162--Adaptor_Cbl
IPR014741--Adaptor_Cbl_EF_hand-like
IPR003153--Adaptor_Cbl_N_hlx
IPR014742--Adaptor_Cbl_SH2-like
IPR024159--Cbl_PTB
IPR011992--EF-hand-dom_pair
IPR000980--SH2
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS

PROSITE

PS51506--CBL_PTB
PS00518--ZF_RING_1
PS50089--ZF_RING_2

Pfam

PF02262--Cbl_N
PF02761--Cbl_N2
PF02762--Cbl_N3

SMART

SM00184--RING

Gene Ontology

GO:0005829--C:cytosol
GO:0016600--C:flotillin complex
GO:0005634--C:nucleus
GO:0005509--F:calcium ion binding
GO:0004871--F:signal transducer activity
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0007166--P:cell surface receptor signaling pathway
GO:0043066--P:negative regulation of apoptotic process
GO:0042059--P:negative regulation of epidermal growth factor receptor signaling pathway
GO:0014068--P:positive regulation of phosphatidylinositol 3-kinase signaling
GO:0048260--P:positive regulation of receptor-mediated endocytosis
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002357	Ailuropoda melanoleuca	87.06	0.00e+00	1231.00
IUUC-Apl-004041	Anas platyrhynchos	84.92	0.00e+00	1222.00
IUUC-Aca-004899	Anolis carolinensis	81.23	0.00e+00	1136.00
IUUC-Ame-010746	Astyanax mexicanus	60.00	3.00e-163	568.00
IUUC-Bta-012759	Bos taurus	87.03	0.00e+00	1234.00
IUUC-Cja-019207	Callithrix jacchus	85.73	0.00e+00	1226.00
IUUC-Cfa-020897	Canis familiaris	86.47	0.00e+00	1206.00
IUUC-Cpo-021453	Cavia porcellus	85.75	0.00e+00	1259.00
IUUC-Csa-023136	Chlorocebus sabaeus	85.71	0.00e+00	1220.00
IUUC-Cho-024282	Choloepus hoffmanni	77.38	0.00e+00	978.00
IUUC-Dre-027644	Danio rerio	66.88	0.00e+00	858.00
IUUC-Dno-030025	Dasypus novemcinctus	86.92	0.00e+00	1228.00
IUUC-Ete-033118	Echinops telfairi	72.49	0.00e+00	662.00
IUUC-Eca-033900	Equus caballus	87.53	0.00e+00	1254.00
IUUC-Eeu-035142	Erinaceus europaeus	81.92	0.00e+00	817.00
IUUC-Fca-035455	Felis catus	86.34	0.00e+00	1217.00
IUUC-Fal-037182	Ficedula albicollis	97.28	0.00e+00	768.00
IUUC-Gmo-038698	Gadus morhua	87.01	0.00e+00	751.00
IUUC-Gga-040438	Gallus gallus	85.05	0.00e+00	1213.00
IUUC-Gac-042166	Gasterosteus aculeatus	72.11	0.00e+00	773.00
IUUC-Ggo-045618	Gorilla gorilla	86.74	0.00e+00	1239.00
IUUC-Hsa-046177	Homo sapiens	86.10	0.00e+00	1226.00
IUUC-Itr-048795	Ictidomys tridecemlineatus	92.95	0.00e+00	951.00
IUUC-Lch-050095	Latimeria chalumnae	73.31	0.00e+00	1014.00
IUUC-Loc-052570	Lepisosteus oculatus	70.80	0.00e+00	956.00
IUUC-Laf-054008	Loxodonta africana	86.16	0.00e+00	1239.00
IUUC-Mcc-054676	Macaca mulatta	85.59	0.00e+00	1217.00
IUUC-Mga-059239	Meleagris gallopavo	84.41	0.00e+00	1219.00
IUUC-Mmr-060907	Microcebus murinus	84.53	0.00e+00	1208.00
IUUC-Mdo-062595	Monodelphis domestica	96.25	0.00e+00	1392.00
IUUC-Mmu-063725	Mus musculus	86.91	0.00e+00	1281.00
IUUC-Mpu-066771	Mustela putorius furo	85.68	0.00e+00	1221.00
IUUC-Mlu-067206	Myotis lucifugus	83.28	0.00e+00	895.00
IUUC-Nle-069285	Nomascus leucogenys	83.14	0.00e+00	1141.00
IUUC-Opr-071026	Ochotona princeps	86.52	0.00e+00	1248.00
IUUC-Ont-071954	Oreochromis niloticus	66.91	0.00e+00	877.00
IUUC-Ocu-074657	Oryctolagus cuniculus	88.59	0.00e+00	1226.00
IUUC-Ola-087165	Oryzias latipes	65.44	0.00e+00	868.00
IUUC-Oga-088198	Otolemur garnettii	74.49	0.00e+00	1035.00
IUUC-Oar-090258	Ovis aries	86.90	0.00e+00	1214.00
IUUC-Ptr-090710	Pan troglodytes	86.10	0.00e+00	1226.00
IUUC-Pan-092785	Papio anubis	85.71	0.00e+00	1220.00
IUUC-Psi-093431	Pelodiscus sinensis	79.64	0.00e+00	672.00
IUUC-Pab-098526	Pongo abelii	85.84	0.00e+00	1222.00
IUUC-Pca-100984	Procavia capensis	71.37	2.00e-140	493.00
IUUC-Pva-102352	Pteropus vampyrus	97.85	0.00e+00	733.00
IUUC-Rno-105876	Rattus norvegicus	86.01	0.00e+00	1250.00
IUUC-Sar-112959	Sorex araneus	83.07	0.00e+00	1202.00
IUUC-Ssc-115261	Sus scrofa	86.23	0.00e+00	1232.00
IUUC-Tgu-116580	Taeniopygia guttata	81.75	0.00e+00	1128.00
IUUC-Tru-118731	Takifugu rubripes	65.98	0.00e+00	870.00
IUUC-Tsy-118982	Tarsius syrichta	77.29	0.00e+00	869.00
IUUC-Tni-120725	Tetraodon nigroviridis	66.37	0.00e+00	870.00
IUUC-Tbe-128018	Tupaia belangeri	93.02	0.00e+00	1019.00
IUUC-Ttr-128927	Tursiops truncatus	87.34	0.00e+00	1264.00
IUUC-Vpa-130369	Vicugna pacos	87.27	0.00e+00	1187.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence