iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSDARG00000060994.6	ENSDART00000148076.2	ENSDARP00000112746.1
ENSDARG00000060994.6	ENSDART00000086512.5	ENSDARP00000080947.5

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	3.30e-60	198.2	750	783
UBD/Beta-Prp	8.00e-96	321.6	501	783

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 2    HtdsvtclafsdtllvsGsdDgtikvWDlrtgvl 35
           H++ vtcl+f+ ++++++sdDgt+k+WDlrtg  
   Q: 750  HQSAVTCLQFNKNFVITSSDDGTVKLWDLRTGEF 783
           9*********449******************976 PP

UBD/Beta-Prp

   S: 3    ktlkghhksvitcvkfspdksllatgsrdgtikvwdvttgkllrslsgheaevtavkfspdgkilvtgseDrtikvwdlstgkcvhtlk 91
           k+lkgh+++vitc++f   ++ +++gs+d+t+kvw++ tgk+lr+l gh+++v++ ++ ++  i+++gs+Drt+kvw+ +tg+c+htl 
   Q: 501  KVLKGHDDHVITCLQF--CGNRIVSGSDDNTLKVWSAVTGKCLRTLVGHTGGVWSSQMRDN--IIISGSTDRTLKVWNAETGECIHTLY 585
           6799************..*******************************************..************************** PP
   S: 92   ghedsvlslsfspsgdklvsGshdrtirvwdletgqcleetlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkllrtltgght 180
           gh+++v+++++++  +++vsGs+d t+rvwd+etgqcl+ +l gh ++v+cv++++  + +vsG++D +v++Wd +t+++l+tl+g ht
   Q: 586  GHTSTVRCMHLHE--KRVVSGSRDATLRVWDIETGQCLH-VLMGHVAAVRCVQYDG--RRVVSGAYDFMVKVWDPETETCLHTLQG-HT 668
           *************..************************.****************..***************************9.** PP
   S: 181  dsvyslsfdsngkelvsgsldgtvklwdlqtgecvrtlnghtdnvksvrfspnderlvsgssDgsiriWdlrsgdllktlqlhnssvis 269
           ++vysl+fd    ++vsgsld+++++wd++tg+c++tl+gh++ ++ +++   d++lvsg++D +++iWd+++g++l+tlq+++++ ++
   Q: 669  NRVYSLQFDG--IHVVSGSLDTSIRVWDVETGNCIHTLTGHQSLTSGMELK--DNILVSGNADSTVKIWDIKTGQCLQTLQGPHKHQSA 753
           *********9..9**************************************..************************************ PP
   S: 270  vavlsfgdnvlvlgsedskvniwklkknep 299
           v++l+f++n +++ s+d++v++w+l++ e+
   Q: 754  VTCLQFNKNFVITSSDDGTVKLWDLRTGEF 783
           *************************98776 PP

Organism

Danio rerio

Protein Sequence
(Fasta)

MSRSMCGCGC SFISSLMKRL GRSACCSDLL SCSHTSEHLQ RLATGCPSQH KNAKSLSSSD 60
SLAKVQEVAS WLLEMNQDLL SGGSGSRAAQ QQRPRPGTAG AGNSISGRTP QPQPEHPDQV 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TCTTATTTAA GCGACGCGAG CAAGGGTGAC GTTATTGGAC GACACCGTGA CGCTATCATC 60
CGTGGACAGG GAGTCGTACA GGAATCGGTT GGATAAAGGC GATCGCGCTT TAACGGAGCA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat

Interpro

IPR001810--F-box_dom
IPR020472--G-protein_beta_WD-40_rep
IPR002469--Peptidase_S9B_N
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS50181--FBOX
PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF12937--F-box-like
PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM00256--FBOX
SM00320--WD40

Gene Ontology

GO:0001525--P:angiogenesis
GO:0031642--P:negative regulation of myelination
GO:0045746--P:negative regulation of Notch signaling pathway
GO:0031641--P:regulation of myelination
GO:0032006--P:regulation of TOR signaling

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002406	Ailuropoda melanoleuca	93.72	0.00e+00	1035.00
IUUC-Apl-003489	Anas platyrhynchos	90.62	0.00e+00	1038.00
IUUC-Aca-005318	Anolis carolinensis	93.72	0.00e+00	1033.00
IUUC-Ago-007794	Ashbya gossypii	31.48	7.00e-63	235.00
IUUC-Acl-008123	Aspergillus clavatus	32.80	2.00e-75	276.00
IUUC-Afl-008730	Aspergillus flavus	31.54	1.00e-73	271.00
IUUC-Afu-009014	Aspergillus fumigatus	32.53	4.00e-75	276.00
IUUC-Ani-009332	Aspergillus nidulans	33.66	1.00e-80	294.00
IUUC-Ang-009790	Aspergillus niger	31.57	2.00e-75	276.00
IUUC-Aor-010215	Aspergillus oryzae	31.10	2.00e-75	276.00
IUUC-Ate-010535	Aspergillus terreus	32.48	1.00e-76	280.00
IUUC-Ame-010898	Astyanax mexicanus	95.90	0.00e+00	1050.00
IUUC-Bgr-012075	Blumeria graminis	33.40	2.00e-79	290.00
IUUC-Bta-012391	Bos taurus	94.09	0.00e+00	1035.00
IUUC-Bci-013725	Botrytis cinerea	33.20	8.00e-78	285.00
IUUC-Cel-018495	Caenorhabditis elegans	49.02	2.00e-131	462.00
IUUC-Cja-018902	Callithrix jacchus	94.09	0.00e+00	1037.00
IUUC-Cfa-020237	Canis familiaris	94.09	0.00e+00	1037.00
IUUC-Cpo-022234	Cavia porcellus	94.09	0.00e+00	1035.00
IUUC-Cre-022837	Chlamydomonas reinhardtii	35.85	1.00e-48	187.00
IUUC-Csa-023532	Chlorocebus sabaeus	94.09	0.00e+00	1037.00
IUUC-Cho-025026	Choloepus hoffmanni	77.43	0.00e+00	676.00
IUUC-Cin-025516	Ciona intestinalis	69.42	3.00e-139	488.00
IUUC-Csv-026312	Ciona savignyi	74.21	0.00e+00	746.00
IUUC-Cgl-026492	Colletotrichum gloeosporioides	34.82	3.00e-85	309.00
IUUC-Cne-027018	Cryptococcus neoformans	32.95	2.00e-73	271.00
IUUC-Cme-027168	Cyanidioschyzon merolae	31.45	3.00e-31	130.00
IUUC-Dno-029576	Dasypus novemcinctus	92.05	0.00e+00	1018.00
IUUC-Dor-030196	Dipodomys ordii	92.79	0.00e+00	1016.00
IUUC-Dse-031558	Dothistroma septosporum	39.27	9.00e-71	261.00
IUUC-Dme-031702	Drosophila melanogaster	77.92	0.00e+00	792.00
IUUC-Ete-032791	Echinops telfairi	87.96	0.00e+00	967.00
IUUC-Eca-033424	Equus caballus	94.09	0.00e+00	1035.00
IUUC-Eeu-034996	Erinaceus europaeus	92.55	0.00e+00	1013.00
IUUC-Fca-036422	Felis catus	94.09	0.00e+00	1038.00
IUUC-Fal-037267	Ficedula albicollis	93.72	0.00e+00	1029.00
IUUC-Fox-037800	Fusarium oxysporum	34.07	1.00e-84	307.00
IUUC-Fso-038258	Fusarium solani	34.21	9.00e-84	305.00
IUUC-Gmo-039119	Gadus morhua	82.99	0.00e+00	870.00
IUUC-Ggr-039781	Gaeumannomyces graminis	34.66	7.00e-85	308.00
IUUC-Gga-040667	Gallus gallus	93.90	0.00e+00	1038.00
IUUC-Gac-042423	Gasterosteus aculeatus	74.30	0.00e+00	792.00
IUUC-Ggo-044422	Gorilla gorilla	94.09	0.00e+00	1036.00
IUUC-Hsa-045898	Homo sapiens	94.09	0.00e+00	1036.00
IUUC-Itr-048241	Ictidomys tridecemlineatus	98.29	0.00e+00	960.00
IUUC-Kpa-049097	Komagataella pastoris	31.92	2.00e-75	277.00
IUUC-Lch-050414	Latimeria chalumnae	90.86	0.00e+00	1049.00
IUUC-Loc-052348	Lepisosteus oculatus	95.56	0.00e+00	1048.00
IUUC-Lma-053185	Leptosphaeria maculans	32.40	1.00e-72	268.00
IUUC-Laf-054054	Loxodonta africana	93.90	0.00e+00	1037.00
IUUC-Mcc-055056	Macaca mulatta	94.09	0.00e+00	1037.00
IUUC-Meu-056778	Macropus eugenii	88.96	2.00e-161	563.00
IUUC-Mor-057133	Magnaporthe oryzae	39.13	1.00e-73	271.00
IUUC-Mpo-057423	Magnaporthe poae	39.60	2.00e-71	263.00
IUUC-Mla-059081	Melampsora laricipopulina	33.52	3.00e-77	283.00
IUUC-Mga-059255	Meleagris gallopavo	93.90	0.00e+00	1038.00
IUUC-Mvi-060490	Microbotryum violaceum	39.00	2.00e-67	251.00
IUUC-Mmr-061292	Microcebus murinus	94.09	0.00e+00	1035.00
IUUC-Mdo-062304	Monodelphis domestica	93.54	0.00e+00	1042.00
IUUC-Mmu-063610	Mus musculus	93.90	0.00e+00	1038.00
IUUC-Mpu-065931	Mustela putorius furo	94.09	0.00e+00	1037.00
IUUC-Mlu-066976	Myotis lucifugus	93.90	0.00e+00	1038.00
IUUC-Nfi-068428	Neosartorya fischeri	32.13	9.00e-76	278.00
IUUC-Ncr-068688	Neurospora crassa	36.17	6.00e-88	318.00
IUUC-Nle-070174	Nomascus leucogenys	94.09	0.00e+00	1037.00
IUUC-Opr-070851	Ochotona princeps	79.21	5.00e-170	591.00
IUUC-Ont-071997	Oreochromis niloticus	92.98	0.00e+00	1040.00
IUUC-Oan-072936	Ornithorhynchus anatinus	94.09	0.00e+00	1040.00
IUUC-Ocu-074742	Oryctolagus cuniculus	94.09	0.00e+00	1040.00
IUUC-Obr-076806	Oryza brachyantha	31.52	4.00e-29	124.00
IUUC-Oin-079809	Oryza indica	31.52	4.00e-29	124.00
IUUC-Ola-087098	Oryzias latipes	92.61	0.00e+00	1025.00
IUUC-Olu-087837	Ostreococcus lucimarinus	34.85	1.00e-38	152.00
IUUC-Oga-088884	Otolemur garnettii	98.94	0.00e+00	780.00
IUUC-Oar-090220	Ovis aries	90.54	0.00e+00	1033.00
IUUC-Ptr-090492	Pan troglodytes	94.09	0.00e+00	1036.00
IUUC-Pan-091770	Papio anubis	94.09	0.00e+00	1037.00
IUUC-Psi-093207	Pelodiscus sinensis	94.09	0.00e+00	1035.00
IUUC-Pma-094749	Petromyzon marinus	80.95	0.00e+00	909.00
IUUC-Pno-095026	Phaeosphaeria nodorum	38.67	1.00e-71	265.00
IUUC-Pfo-096493	Poecilia formosa	94.09	0.00e+00	1031.00
IUUC-Pab-098141	Pongo abelii	94.09	0.00e+00	1035.00
IUUC-Pca-100571	Procavia capensis	91.64	0.00e+00	717.00
IUUC-Pva-102988	Pteropus vampyrus	93.22	0.00e+00	1037.00
IUUC-Pgr-103612	Puccinia graminis	35.73	1.00e-61	231.00
IUUC-Pte-104275	Pyrenophora teres	31.78	2.00e-73	270.00
IUUC-Pyt-104438	Pyrenophora triticirepentis	31.74	1.00e-72	267.00
IUUC-Rno-105706	Rattus norvegicus	93.72	0.00e+00	1037.00
IUUC-Sce-106314	Saccharomyces cerevisiae	29.98	5.00e-63	236.00
IUUC-Sha-107653	Sarcophilus harrisii	93.54	0.00e+00	1038.00
IUUC-Sja-107840	Schizosaccharomyces japonicus	33.83	9.00e-80	291.00
IUUC-Spo-108115	Schizosaccharomyces pombe	32.08	1.00e-62	234.00
IUUC-Sar-113600	Sorex araneus	87.62	0.00e+00	946.00
IUUC-Sre-114901	Sporisorium reilianum	48.13	2.00e-67	251.00
IUUC-Ssc-115787	Sus scrofa	92.24	0.00e+00	1009.00
IUUC-Tgu-117510	Taeniopygia guttata	93.72	0.00e+00	1035.00
IUUC-Tru-117819	Takifugu rubripes	92.18	0.00e+00	1047.00
IUUC-Tsy-118828	Tarsius syrichta	93.91	0.00e+00	1036.00
IUUC-Tni-120468	Tetraodon nigroviridis	93.16	0.00e+00	1038.00
IUUC-Tre-122193	Trichoderma reesei	36.19	5.00e-85	308.00
IUUC-Tvi-122615	Trichoderma virens	34.83	1.00e-83	304.00
IUUC-Tme-127021	Tuber melanosporum	35.50	6.00e-85	308.00
IUUC-Tbe-127925	Tupaia belangeri	94.26	0.00e+00	1036.00
IUUC-Ttr-128899	Tursiops truncatus	93.72	0.00e+00	1034.00
IUUC-Uma-129449	Ustilago maydis	46.89	1.00e-66	248.00
IUUC-Vda-129802	Verticillium dahliae	36.61	1.00e-87	318.00
IUUC-Vpa-130082	Vicugna pacos	93.36	0.00e+00	860.00
IUUC-Xtr-132213	Xenopus tropicalis	91.65	0.00e+00	1031.00
IUUC-Xma-133646	Xiphophorus maculatus	93.91	0.00e+00	1027.00
IUUC-Yli-134429	Yarrowia lipolytica	34.68	4.00e-87	315.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence