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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-046352
Ensembl Protein ID ENSP00000393099.2
UniProt Accession O60336; A6NM93; A8K8P9; Q14CB5; Q14CD8; Q49AJ8; Q5W9G9; MABP1_HUMAN
Genbank Protein ID BAD66828.1; BAA25522.2; BAF85103.1; EAW92516.1; AAH36660.1; AAI13984.1; AAI14494.1
Protein Name Mitogen-activated protein kinase-binding protein 1; JNK-binding protein 1
Genbank Nucleotide ID AB177850; AB011168; AK292414; AL833267; BC036660; BC113983; BC114493
Gene Name MAPKBP1; JNKBP1; KIAA0596
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000137802.13 ENST00000512970.5 ENSP00000427582.1
ENSG00000137802.13 ENST00000457542.6 ENSP00000397570.2
ENSG00000137802.13 ENST00000505373.5 ENSP00000421891.1
ENSG00000137802.13 ENST00000456763.6 ENSP00000393099.2
ENSG00000137802.13 ENST00000514566.5 ENSP00000426154.1
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbAREsitecircBasecircRNADb
CircNetmiRTarBasemicroRNATRANSFAC
RepTarSomamiRmiRcodeRAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
MenthaInWeb_IM
Disease-associated Variation
ClinVarGWASdbOMIM
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusUniProt
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
E3 adaptor/Cullin RING/DCX/DWD 1.60e-30 105.5 701 734
UBD/Beta-Prp 7.40e-73 247.0 482 740
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/DCX/DWD
   S: 1    gHtdsvtclaf.sd.tllvsGsdDgtikvWDlrt 32
           gH++ vt+++f +d ++l+s s+D  i vW+l++
   Q: 701  GHSEIVTGMKFsNDcKHLISVSGDSCIFVWRLSS 734
           8***********999****************865 PP
   

   UBD/Beta-Prp
   S: 13   itcvkfspdksllatgsrdgtikvwdvttgkllrslsgheaevtavkfspdgk...ilvtgseDrtikvwdls.tgkcvhtlkghedsvlsl 100
           i++v++sp++++la+g r gt++v+++++ + + +++ h++e+ ++++s+ +    +l+++s+Dr+i+v d    ++  +tl +h++s++++
   Q: 482  IRSVCVSPNGQHLASGDRMGTLRVHELQSLSEMLKVEAHDSEILCLEYSKPDTglkLLASASRDRLIHVLDAGrEYSLQQTLDEHSSSITAV 573
           6789********************************************98765688*************98765889999************ PP
   S: 101  sfsp.sg.dklvsGshdrtirvwdletgqclee...tlsghdgvvnc.....vvvhpdgnllvsGslDrtvrlWdlktgkllrtltgghtds 182
           +f + +g  +++s ++d+ i     +t q++ +   + + h +vv+      + v p+ ++ + G+ Dr +r++++++gk  + ++g + ++
   Q: 574  KFAAsDGqVRMISCGADKSIYF---RTAQKSGDgvqFTRTH-HVVRKttlydMDVEPSWKYTAIGCQDRNIRIFNISSGKQKKLFKGSQGED 661
           ****6556899*******9976...4444444444333333.33333011114566766************************997777777 PP
   S: 183  vysls..fdsngkelvsgsldgtvklwdlqtgecvrtlnghtdnvksvrfspnderlvsgssDgsiriWdlrsgdllkt 259
            + ++   d++g ++++   d+ + ++d+++gecv t+ gh++ v+ ++fs++ ++l+s+s D  i++W l s  ++++
   Q: 662  GTLIKvqTDPSGIYIATSCSDKNLSIFDFSSGECVATMFGHSEIVTGMKFSNDCKHLISVSGDSCIFVWRLSSEMTISM 740
           776665589999*********************************************************8888777665 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Involved in JNK signaling pathway.
 Involved in JNK signaling pathway.
Protein Sequence
(Fasta)
MAVEGSTITS RIKNLLRSPS IKLRRSKAGN RREDLSSKVT LEKVLGITVS GGRGLACDPR 60
SGLVAYPAGC VVVLFNPRKH KQHHILNSSR KTITALAFSP DGKYLVTGES GHMPAVRVWD 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-046352|E3,WD_repeat;UBD,Beta-Prp|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GGCTCCGCCC ACCCAGCCCG CGGCTTGGCC CAGGCGGTAG TTCGCGTTTT GAGCCGATCG 60
TGCCACCATA GCTCCTGCTG CTGCCTCTAC CGCTGCGGCT ACCGCGGCGG AGCTGAAATT 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046352|E3,WD_repeat;UBD,Beta-Prp|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0007--Acetylation
KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat
Interpro

IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR017986--WD40_repeat_dom
PROSITE

PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION
Pfam

PF00400--WD40
SMART

SM00320--WD40
Gene Ontology

GO:0071013--C:catalytic step 2 spliceosome
GO:0071011--C:precatalytic spliceosome
GO:0005682--C:U5 snRNP
GO:0008380--P:RNA splicing
KEGG hsa:23005
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001604 Ailuropoda melanoleuca 90.69 0.00e+00 2503.00
IUUC-Atr-003165 Amborella trichopoda 34.92 1.00e-124 441.00
IUUC-Apl-003236 Anas platyrhynchos 64.45 0.00e+00 1748.00
IUUC-Aca-004486 Anolis carolinensis 62.74 0.00e+00 1623.00
IUUC-Aly-006434 Arabidopsis lyrata 31.32 6.00e-58 219.00
IUUC-Ath-007624 Arabidopsis thaliana 31.59 9.00e-92 332.00
IUUC-Ago-007823 Ashbya gossypii 33.96 4.00e-16 80.50
IUUC-Acl-008257 Aspergillus clavatus 22.66 2.00e-28 122.00
IUUC-Afl-008426 Aspergillus flavus 23.45 4.00e-34 140.00
IUUC-Ang-009797 Aspergillus niger 26.47 6.00e-16 80.10
IUUC-Aor-009966 Aspergillus oryzae 23.45 4.00e-34 140.00
IUUC-Ate-010425 Aspergillus terreus 23.47 1.00e-29 125.00
IUUC-Ame-011306 Astyanax mexicanus 74.37 0.00e+00 1187.00
IUUC-Bgr-012083 Blumeria graminis 24.07 4.00e-33 137.00
IUUC-Bta-013041 Bos taurus 89.24 0.00e+00 2451.00
IUUC-Bci-013828 Botrytis cinerea 24.96 2.00e-39 158.00
IUUC-Bol-016347 Brassica oleracea 31.60 3.00e-90 327.00
IUUC-Bra-017959 Brassica rapa 31.33 3.00e-93 337.00
IUUC-Cja-018986 Callithrix jacchus 94.39 0.00e+00 2650.00
IUUC-Cfa-020896 Canis familiaris 90.30 0.00e+00 2496.00
IUUC-Cpo-021348 Cavia porcellus 85.83 0.00e+00 2414.00
IUUC-Csa-023118 Chlorocebus sabaeus 97.03 0.00e+00 2599.00
IUUC-Cin-025412 Ciona intestinalis 54.86 1.00e-58 219.00
IUUC-Csv-026079 Ciona savignyi 43.73 3.00e-82 298.00
IUUC-Dre-027495 Danio rerio 73.26 0.00e+00 1161.00
IUUC-Dno-029772 Dasypus novemcinctus 88.64 0.00e+00 2481.00
IUUC-Dor-030615 Dipodomys ordii 87.24 0.00e+00 2209.00
IUUC-Dme-032179 Drosophila melanogaster 51.10 0.00e+00 780.00
IUUC-Ete-033108 Echinops telfairi 89.57 0.00e+00 1662.00
IUUC-Eca-033836 Equus caballus 90.84 0.00e+00 2464.00
IUUC-Eeu-035189 Erinaceus europaeus 77.33 0.00e+00 2089.00
IUUC-Fca-036471 Felis catus 90.83 0.00e+00 2537.00
IUUC-Fal-037354 Ficedula albicollis 60.79 0.00e+00 1733.00
IUUC-Fox-037952 Fusarium oxysporum 23.10 4.00e-33 137.00
IUUC-Fso-038440 Fusarium solani 22.79 6.00e-35 143.00
IUUC-Gmo-039644 Gadus morhua 61.96 0.00e+00 870.00
IUUC-Ggr-039729 Gaeumannomyces graminis 24.02 2.00e-28 121.00
IUUC-Gga-040202 Gallus gallus 82.61 3.00e-160 557.00
IUUC-Gac-042491 Gasterosteus aculeatus 59.53 0.00e+00 996.00
IUUC-Ggo-045532 Gorilla gorilla 98.41 0.00e+00 2612.00
IUUC-Itr-048210 Ictidomys tridecemlineatus 89.26 0.00e+00 2463.00
IUUC-Kpa-049269 Komagataella pastoris 25.36 3.00e-17 84.70
IUUC-Lch-049450 Latimeria chalumnae 66.60 0.00e+00 1268.00
IUUC-Loc-052784 Lepisosteus oculatus 66.00 0.00e+00 1332.00
IUUC-Lma-053327 Leptosphaeria maculans 30.26 4.00e-21 97.40
IUUC-Laf-053885 Loxodonta africana 87.75 0.00e+00 2371.00
IUUC-Mcc-055747 Macaca mulatta 97.16 0.00e+00 2563.00
IUUC-Meu-056200 Macropus eugenii 76.05 0.00e+00 2029.00
IUUC-Mor-057027 Magnaporthe oryzae 22.00 5.00e-27 117.00
IUUC-Mga-059325 Meleagris gallopavo 75.24 0.00e+00 1543.00
IUUC-Mmr-061305 Microcebus murinus 91.49 0.00e+00 2428.00
IUUC-Mdo-063076 Monodelphis domestica 72.39 0.00e+00 1773.00
IUUC-Mmu-064319 Mus musculus 85.87 0.00e+00 2393.00
IUUC-Mpu-066443 Mustela putorius furo 89.45 0.00e+00 2494.00
IUUC-Mlu-068153 Myotis lucifugus 88.73 0.00e+00 2419.00
IUUC-Ncr-068758 Neurospora crassa 22.69 6.00e-31 130.00
IUUC-Nle-069578 Nomascus leucogenys 97.75 0.00e+00 2586.00
IUUC-Opr-070721 Ochotona princeps 89.57 0.00e+00 2347.00
IUUC-Ont-071411 Oreochromis niloticus 65.90 0.00e+00 1087.00
IUUC-Oan-073644 Ornithorhynchus anatinus 86.62 0.00e+00 1208.00
IUUC-Ocu-073900 Oryctolagus cuniculus 86.93 0.00e+00 2286.00
IUUC-Ola-087185 Oryzias latipes 60.27 0.00e+00 1158.00
IUUC-Oga-088733 Otolemur garnettii 89.34 0.00e+00 2394.00
IUUC-Oar-089569 Ovis aries 87.89 0.00e+00 2405.00
IUUC-Pan-092735 Papio anubis 97.23 0.00e+00 2675.00
IUUC-Psi-093457 Pelodiscus sinensis 74.18 0.00e+00 1600.00
IUUC-Pma-094285 Petromyzon marinus 64.91 0.00e+00 1023.00
IUUC-Pno-094837 Phaeosphaeria nodorum 30.88 2.00e-20 95.50
IUUC-Ppa-095596 Physcomitrella patens 37.56 3.00e-142 500.00
IUUC-Pfo-096375 Poecilia formosa 67.02 0.00e+00 996.00
IUUC-Pab-098737 Pongo abelii 98.08 0.00e+00 2620.00
IUUC-Pop-099155 Populus trichocarpa 31.57 2.00e-97 351.00
IUUC-Pca-100959 Procavia capensis 81.70 0.00e+00 1664.00
IUUC-Pva-102929 Pteropus vampyrus 86.01 0.00e+00 2358.00
IUUC-Pte-104373 Pyrenophora teres 28.29 3.00e-17 84.30
IUUC-Rno-105509 Rattus norvegicus 85.74 0.00e+00 2405.00
IUUC-Sha-106946 Sarcophilus harrisii 78.06 0.00e+00 2007.00
IUUC-Ssl-108471 Sclerotinia sclerotiorum 25.00 2.00e-33 138.00
IUUC-Sly-110969 Solanum lycopersicum 31.12 6.00e-92 332.00
IUUC-Stu-112838 Solanum tuberosum 32.48 7.00e-56 212.00
IUUC-Ssc-116302 Sus scrofa 89.26 0.00e+00 2496.00
IUUC-Tgu-117055 Taeniopygia guttata 73.57 0.00e+00 1488.00
IUUC-Tru-118066 Takifugu rubripes 53.99 0.00e+00 1125.00
IUUC-Tsy-119530 Tarsius syrichta 97.98 0.00e+00 701.00
IUUC-Tni-120316 Tetraodon nigroviridis 56.38 0.00e+00 781.00
IUUC-Tca-121475 Theobroma cacao 32.25 3.00e-95 343.00
IUUC-Tre-122008 Trichoderma reesei 23.18 9.00e-32 132.00
IUUC-Tbe-128005 Tupaia belangeri 87.03 0.00e+00 1769.00
IUUC-Ttr-128385 Tursiops truncatus 82.44 0.00e+00 2255.00
IUUC-Vvi-131035 Vitis vinifera 34.02 8.00e-104 372.00
IUUC-Xtr-132966 Xenopus tropicalis 58.85 0.00e+00 1521.00
Created Date 25-Jun-2017

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