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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Mmu-063094
UUCD1 version UUC-MuM-00367
Ensembl Protein ID ENSMUSP00000101855.1
UniProt Accession Q1XH17; B2RWH7; Q6NX76; TRI72_MOUSE
Genbank Protein ID BAE93014.1; AAH67209.1; AAI47790.1; AAI58112.1; AAI58121.1
Protein Name Tripartite motif-containing protein 72; Mitsugumin-53
Genbank Nucleotide ID AB231474; BC067209; BC147789; BC158111; BC158120
Gene Name Trim72; Mg53
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000042828.12 ENSMUST00000106248.7 ENSMUSP00000101855.1
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressGXD
DNA & RNA Element
AREsitemiRTarBasemicroRNATRANSFAC
RepTarRAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
Mentha
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
mUbiSiDa
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
E3 activity/RING/U-box 4.20e-06 27.8 10 76
E3 activity/RING/RING 4.70e-06 28.2 14 57
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 activity/RING/U-box
   S: 4    eeflCpIslelMrdPvvlpsGitydrssIekwl...asggk....tcPvtrqplteedlvPnltlrrliq 66
           +e+ Cp+ l+l+  Pv++++G+++ r+++ +     a         cP +++p++++ l  nl l rl++
   Q: 10   QELSCPLCLQLFDAPVTAECGHSFCRACLIRVAgepA---AdgtvACPCCQAPTRPQALSTNLQLSRLVE 76
           6899*************************99665552...14557******************9988875 PP
   

   E3 activity/RING/RING
   S: 1    CaiCledfkdgplvlpCgHvfhadClqkwpglknssskefrCPlCr 46
           C++Cl+ f+  p++  CgH f++ Cl ++      + ++  CP C+
   Q: 14   CPLCLQLFDA-PVTAECGHSFCRACLIRV-AGEPAADGTVACPCCQ 57
           ********99.999************999.5555799999*****7 PP
   
Organism Mus musculus
Functional Description
(View)

Functional Description


     Muscle-specific protein that plays a central role in cell membrane repair by nucleating the assembly of the repair machinery at injury sites. Specifically binds phosphatidylserine. Acts as a sensor of oxidation: upon membrane damage, entry of extracellular oxidative environment results in disulfide bond formation and homooligomerization at the injury site. This oligomerization acts as a nucleation site for recruitment of TRIM72-containing vesicles to the injury site, leading to membrane patch formation. Probably acts upstream of the Ca(2+)-dependent membrane resealing process. Required for transport of DYSF to sites of cell injury during repair patch formation. Regulates membrane budding and exocytosis. May be involved in the regulation of the mobility of KCNB1-containing endocytic vesicles.
 Muscle-specific protein that plays a central role in cell membrane repair by nucleating the assembly of the repair machinery at injury sites. Specifically binds phosphatidylserine. Acts as a sensor of oxidation: upon membrane damage, entry of extracellular oxidative environment results in disulfide bond formation and homooligomerization at the injury site. This oligomerization acts as a nucleation site for recruitment of TRIM72-containing vesicles to the injury site, leading to membrane patch formation. Probably acts upstream of the Ca(2+)-dependent membrane resealing process. Required for transport of DYSF to sites of cell injury during repair patch formation. Regulates membrane budding and exocytosis. May be involved in the regulation of the mobility of KCNB1-containing endocytic vesicles.
Protein Sequence
(Fasta)
MSAAPGLLRQ ELSCPLCLQL FDAPVTAECG HSFCRACLIR VAGEPAADGT VACPCCQAPT 60
RPQALSTNLQ LSRLVEGLAQ VPQGHCEEHL DPLSIYCEQD RTLVCGVCAS LGSHRGHRLL 120
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Protein Fasta Sequence


>IUUC-Mmu-063094|E3,U-box;E3,RING|Mus musculus
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Nucleotide Sequence
(Fasta)
ATTGAGCCTG CTGCTTGCTT CTTGCTTGTC TTGGACACAA CTCCGATCAC CCTGCTGTTA 60
GACCTGAACC TGACTGGTCC TCCTGGGAGT CTTTTTTGGC CTAAGTTCTC CCACCAGACT 120
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Nucleotide Fasta Sequence


>IUUC-Mmu-063094|E3,U-box;E3,RING|Mus musculus
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Sequence Source Ensembl
Keyword

KW-1003--Cell membrane
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0968--Cytoplasmic vesicle
KW-1015--Disulfide bond
KW-0268--Exocytosis
KW-0472--Membrane
KW-0479--Metal-binding
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0702--S-nitrosylation
KW-0813--Transport
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR001870--B30.2/SPRY
IPR003879--Butyrophylin
IPR013320--ConA-like_dom
IPR006574--PRY
IPR003877--SPRY_dom
IPR000315--Znf_B-box
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS
PROSITE

PS50188--B302_SPRY
PS50119--ZF_BBOX
PS00518--ZF_RING_1
PS50089--ZF_RING_2
Pfam

PF13765--PRY
PF00622--SPRY
PF00643--zf-B_box
PRINTS

PR01407--BUTYPHLNCDUF
SMART

SM00336--BBOX
SM00589--PRY
SM00184--RING
SM00449--SPRY
Gene Ontology

GO:0030659--C:cytoplasmic vesicle membrane
GO:0042383--C:sarcolemma
GO:0001786--F:phosphatidylserine binding
GO:0031624--F:ubiquitin conjugating enzyme binding
GO:0061630--F:ubiquitin protein ligase activity
GO:0008270--F:zinc ion binding
GO:0006887--P:exocytosis
GO:0006900--P:membrane budding
GO:0006936--P:muscle contraction
GO:0007517--P:muscle organ development
GO:0003012--P:muscle system process
GO:0046627--P:negative regulation of insulin receptor signaling pathway
GO:0043569--P:negative regulation of insulin-like growth factor receptor signaling pathway
GO:0010832--P:negative regulation of myotube differentiation
GO:0001778--P:plasma membrane repair
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0051260--P:protein homooligomerization
KEGG mmu:434246
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-002377 Ailuropoda melanoleuca 73.03 0.00e+00 660.00
IUUC-Aca-004755 Anolis carolinensis 61.62 7.00e-169 586.00
IUUC-Bta-013476 Bos taurus 76.78 0.00e+00 704.00
IUUC-Cja-018969 Callithrix jacchus 79.96 0.00e+00 740.00
IUUC-Cfa-020155 Canis familiaris 89.94 0.00e+00 848.00
IUUC-Cpo-021646 Cavia porcellus 87.63 0.00e+00 827.00
IUUC-Csa-023855 Chlorocebus sabaeus 88.99 1.00e-169 589.00
IUUC-Dno-029142 Dasypus novemcinctus 87.21 0.00e+00 760.00
IUUC-Dor-030394 Dipodomys ordii 67.09 4.00e-86 311.00
IUUC-Ete-032801 Echinops telfairi 82.81 3.00e-62 232.00
IUUC-Eca-034378 Equus caballus 90.15 0.00e+00 852.00
IUUC-Eeu-034526 Erinaceus europaeus 82.18 0.00e+00 743.00
IUUC-Fca-036440 Felis catus 90.36 0.00e+00 880.00
IUUC-Ggo-045086 Gorilla gorilla 93.28 0.00e+00 676.00
IUUC-Hsa-046533 Homo sapiens 91.19 0.00e+00 833.00
IUUC-Itr-048959 Ictidomys tridecemlineatus 91.19 0.00e+00 865.00
IUUC-Laf-054479 Loxodonta africana 89.10 0.00e+00 841.00
IUUC-Mcc-055814 Macaca mulatta 89.35 0.00e+00 803.00
IUUC-Meu-056767 Macropus eugenii 71.55 0.00e+00 681.00
IUUC-Mmr-061616 Microcebus murinus 89.10 0.00e+00 845.00
IUUC-Mdo-062252 Monodelphis domestica 74.53 0.00e+00 717.00
IUUC-Mpu-065885 Mustela putorius furo 75.68 0.00e+00 657.00
IUUC-Mlu-068150 Myotis lucifugus 93.70 2.00e-66 245.00
IUUC-Nle-069476 Nomascus leucogenys 91.42 0.00e+00 832.00
IUUC-Opr-070871 Ochotona princeps 89.97 4.00e-142 498.00
IUUC-Oan-072738 Ornithorhynchus anatinus 73.58 0.00e+00 706.00
IUUC-Ocu-074132 Oryctolagus cuniculus 91.58 0.00e+00 651.00
IUUC-Olu-087666 Ostreococcus lucimarinus 41.89 2.00e-11 63.90
IUUC-Oga-088268 Otolemur garnettii 62.34 3.00e-146 511.00
IUUC-Oar-089555 Ovis aries 68.15 1.00e-168 586.00
IUUC-Ptr-090792 Pan troglodytes 91.19 0.00e+00 833.00
IUUC-Pan-092897 Papio anubis 91.19 0.00e+00 834.00
IUUC-Pab-098716 Pongo abelii 91.19 0.00e+00 833.00
IUUC-Pca-100618 Procavia capensis 81.34 0.00e+00 757.00
IUUC-Pva-102430 Pteropus vampyrus 80.71 0.00e+00 742.00
IUUC-Rno-105665 Rattus norvegicus 95.39 0.00e+00 929.00
IUUC-Sha-106854 Sarcophilus harrisii 62.86 6.00e-171 593.00
IUUC-Sar-113028 Sorex araneus 85.00 2.00e-144 504.00
IUUC-Ssc-116124 Sus scrofa 89.85 0.00e+00 820.00
IUUC-Tbe-127273 Tupaia belangeri 86.44 1.00e-120 426.00
Created Date 25-Jun-2017

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