iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Aca-004336

UUCD1 version

UUC-AnC-00405

Ensembl Protein ID

ENSACAP00000010343.3

UniProt Accession

H9GGH7; H9GGH7_ANOCA

Protein Name

Uncharacterized protein

Gene Name

HERC4

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSACAG00000010493.3	ENSACAT00000010557.3	ENSACAP00000010343.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	2.70e-102	342.5	728	1051

Active Site

Position(s)	Description	Evidence
1020	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 4    dlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldl 90
           d kk l+v fvgEe++d+gGv +ef+ l+++el +p++g+f+y e+++  ++ +++      e  +lF+++G+++g+a+++  +++l
   Q: 728  DYKKPLKVIFVGEEAVDAGGVRKEFFLLIMRELLDPKYGMFRYYEDSRLIWFSDKTF-----EDSDLFHLIGVVCGLAIYNFTIVEL 809
           78999***********************************************88877.....689********************** PP
   S: 91   plsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklv 177
           +++ ++yk+ll+kk sledl+e++p++ +s+++++++ e+die++ ++l+f+++ +++g t+++eL+p+G++ipV ++N++e+v+++
   Q: 810  HFPLALYKKLLNKKPSLEDLKELMPDVGRSMQQLLDYPEDDIEDT-FCLNFTITVDNFGATEVKELIPNGADIPVVKQNRQEFVDAY 895
           ********************************************8.***************************************** PP
   S: 178  veyrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkaf 264
           v+y+++e++++ ++af++Gf++v+  ++l+lF+++el+ ++ G++++d+++l+k+t+ykg+y +++ +i+ Fwev++e+  e++k+f
   Q: 896  VNYIFNESVASLFDAFHAGFHKVCGGKVLQLFQPSELQAMVIGNANYDWKELEKNTQYKGDYWAEHTTIKLFWEVFHELPLEKKKQF 982
           *************************************************************************************** PP
   S: 265  LqFvTgssrlPlgGfaelkprlfvirk.dasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFel 335
           L F+Tgs+r+P+ G+++l+    vi+   + d+ lP ++TCfn+L+LP+Y+ keilk+kL+ Ai++ +gF+l
   Q: 983  LLFLTGSDRIPILGMKSLS---LVIQPtGGGDEYLPVAHTCFNLLDLPKYTDKEILKSKLIQAIDHYEGFNL 1051
           *******************...6666659999**************************************87 PP

Organism

Anolis carolinensis

Protein Sequence
(Fasta)

MLCWGNASFG QLGLGGIDEE VVLEPRRCNF FLNKTVRDVG CGLRHTVFVL DDGTVYTCGC 60
NDLGQLGHEK SRKRPEQVGA LDAQNIVAVS CGEAHTLTLN DKGQVYAWGF AADGQLGLPG 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CCTCAAAGGT GCTCAGCCAG GCTATGGCTT CTTGTGGACC TCTCCCCCGT CAGAATAACG 60
GGCCTCGAAG TTTCGCGGCC TTTCGCCTCA GGGGAGGAAC GGAGGCCTGG CCTGAGCGAG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0677--Repeat
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000569--HECT_dom
IPR009091--RCC1/BLIP-II
IPR000408--Reg_chr_condens

PROSITE

PS50237--HECT
PS00626--RCC1_2
PS50012--RCC1_3

Pfam

PF00632--HECT
PF00415--RCC1

PRINTS

PR00633--RCCNDNSATION

SMART

SM00119--HECTc

Gene Ontology

GO:0005829--C:cytosol
GO:0001650--C:fibrillar center
GO:0004842--F:ubiquitin-protein transferase activity
GO:0007283--P:spermatogenesis

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001666	Ailuropoda melanoleuca	86.04	0.00e+00	1784.00
IUUC-Apl-003295	Anas platyrhynchos	86.15	0.00e+00	1861.00
IUUC-Ame-010768	Astyanax mexicanus	72.68	0.00e+00	1578.00
IUUC-Bta-013279	Bos taurus	86.42	0.00e+00	1785.00
IUUC-Cel-018150	Caenorhabditis elegans	34.16	2.00e-158	552.00
IUUC-Cja-019023	Callithrix jacchus	86.13	0.00e+00	1779.00
IUUC-Cfa-021074	Canis familiaris	85.94	0.00e+00	1780.00
IUUC-Cpo-021461	Cavia porcellus	83.90	0.00e+00	1732.00
IUUC-Csa-024261	Chlorocebus sabaeus	86.23	0.00e+00	1784.00
IUUC-Cho-024513	Choloepus hoffmanni	68.26	0.00e+00	751.00
IUUC-Cin-025232	Ciona intestinalis	43.64	0.00e+00	844.00
IUUC-Dre-028829	Danio rerio	74.69	0.00e+00	1543.00
IUUC-Dno-029445	Dasypus novemcinctus	83.48	0.00e+00	1437.00
IUUC-Dor-030158	Dipodomys ordii	85.93	0.00e+00	801.00
IUUC-Dme-032103	Drosophila melanogaster	45.69	0.00e+00	900.00
IUUC-Ete-033072	Echinops telfairi	77.95	0.00e+00	1588.00
IUUC-Eca-033317	Equus caballus	85.09	0.00e+00	1763.00
IUUC-Fca-035682	Felis catus	86.79	0.00e+00	1791.00
IUUC-Fal-036969	Ficedula albicollis	85.66	0.00e+00	1845.00
IUUC-Gmo-038671	Gadus morhua	73.38	0.00e+00	1570.00
IUUC-Gga-041174	Gallus gallus	85.85	0.00e+00	1855.00
IUUC-Gac-042600	Gasterosteus aculeatus	73.03	0.00e+00	1510.00
IUUC-Gma-043616	Glycine max	37.79	2.00e-52	199.00
IUUC-Ggo-044589	Gorilla gorilla	85.94	0.00e+00	1798.00
IUUC-Hsa-046772	Homo sapiens	86.13	0.00e+00	1799.00
IUUC-Lch-050147	Latimeria chalumnae	80.02	0.00e+00	1415.00
IUUC-Loc-052684	Lepisosteus oculatus	78.85	0.00e+00	1665.00
IUUC-Laf-053844	Loxodonta africana	85.66	0.00e+00	1774.00
IUUC-Mcc-055531	Macaca mulatta	84.23	0.00e+00	1767.00
IUUC-Mga-060151	Meleagris gallopavo	85.14	0.00e+00	1543.00
IUUC-Mmr-060954	Microcebus murinus	85.85	0.00e+00	1775.00
IUUC-Mdo-062246	Monodelphis domestica	85.36	0.00e+00	1656.00
IUUC-Mmu-063369	Mus musculus	85.93	0.00e+00	1817.00
IUUC-Mpu-065936	Mustela putorius furo	85.79	0.00e+00	1640.00
IUUC-Mlu-067326	Myotis lucifugus	85.66	0.00e+00	1742.00
IUUC-Nle-069453	Nomascus leucogenys	86.69	0.00e+00	1786.00
IUUC-Ont-071720	Oreochromis niloticus	74.05	0.00e+00	1545.00
IUUC-Oan-073464	Ornithorhynchus anatinus	85.48	0.00e+00	1649.00
IUUC-Ocu-074207	Oryctolagus cuniculus	83.74	0.00e+00	1626.00
IUUC-Ola-086762	Oryzias latipes	73.55	0.00e+00	1506.00
IUUC-Oga-088435	Otolemur garnettii	85.66	0.00e+00	1773.00
IUUC-Oar-089233	Ovis aries	86.51	0.00e+00	1785.00
IUUC-Ptr-091368	Pan troglodytes	86.23	0.00e+00	1801.00
IUUC-Pan-092300	Papio anubis	86.23	0.00e+00	1784.00
IUUC-Psi-093406	Pelodiscus sinensis	87.55	0.00e+00	1887.00
IUUC-Pma-094113	Petromyzon marinus	68.51	0.00e+00	1107.00
IUUC-Ppa-095354	Physcomitrella patens	32.66	2.00e-154	540.00
IUUC-Pfo-097021	Poecilia formosa	73.69	0.00e+00	1603.00
IUUC-Pab-098327	Pongo abelii	86.13	0.00e+00	1801.00
IUUC-Pca-101075	Procavia capensis	81.94	0.00e+00	726.00
IUUC-Pva-102909	Pteropus vampyrus	75.94	0.00e+00	1497.00
IUUC-Rno-105457	Rattus norvegicus	85.47	0.00e+00	1814.00
IUUC-Sha-106632	Sarcophilus harrisii	86.12	0.00e+00	1814.00
IUUC-Sar-113679	Sorex araneus	77.76	0.00e+00	1007.00
IUUC-Tgu-116849	Taeniopygia guttata	81.79	0.00e+00	1740.00
IUUC-Tru-118206	Takifugu rubripes	71.98	0.00e+00	1453.00
IUUC-Tsy-119521	Tarsius syrichta	72.55	0.00e+00	1416.00
IUUC-Tni-120233	Tetraodon nigroviridis	72.01	0.00e+00	1461.00
IUUC-Vpa-130448	Vicugna pacos	86.23	0.00e+00	1786.00
IUUC-Xtr-132719	Xenopus tropicalis	70.55	0.00e+00	1395.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence