iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Mpu-066616

Ensembl Protein ID

ENSMPUP00000012771.1

UniProt Accession

M3YN64; M3YN64_MUSPF

Genbank Protein ID

ENSMPUP00000012771

Protein Name

Ubiquitinyl hydrolase 1

Genbank Nucleotide ID

AEYP01042520

Gene Name

USP20

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMPUG00000012869.1	ENSMPUT00000012978.1	ENSMPUP00000012771.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	4.30e-109	364.8	145	685

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeelw.kskkkavsprellkalkkeaeefsgye 88
           tG+kNlgN+CYm ++LQ+Lsn+p+l++++le     +    ++++k +l+ks+qkl++e+w  ++ ++v p+ l + +k ++++f+gy+
   Q: 145  TGMKNLGNSCYMSAALQALSNCPPLTQFFLE-----CGGLVRTDKKPALCKSYQKLVSEVWhRRRPSYVVPTGLSHGIKLVNPMFRGYA 228
           7******************************.....999999*******************889999********************** PP
   S: 89   qqDaqEflaflldqleeelkk..............eknkpkeeeeeedkselsde.................................. 129
           qqD+qEfl++l+dql+eelk+              +++++++e++e d+s ++de                                  
   Q: 229  QQDTQEFLRCLMDQLHEELKEpevaaatvlaeaqdSDSSDTDEKREGDRSPSEDEflscdsssdrgegdgqvrsgassqaeaellipde 317
           *******************998776666665555544445555555555555555********************************** PP
   S: 130  ......................................................................................... 129
                                                                                                    
   Q: 318  agraisekermkdrkfswgqqrasseqvdedadvdtamaalddqpseaqpplpgssspfrtpepdneahmhsssrpcspahhheghakl 406
           ***************************************************************************************** PP
   S: 130  ...........................aeekkkkknkslisdlFqgqlksqikclecdnvssreepfldlslpvpgkeetkke...... 185
                                      ++++k++ ++s+isd+F+g++ s ++cl+cd+vs++ e+f+dlslp+pgke+ +k+      
   Q: 407  agspprsspvrmgpsyvlkkaqvlsagSRRRKEQPYRSVISDIFNGSILSLVQCLTCDRVSTTVETFQDLSLPIPGKEDLAKLhsaiyq 495
           ***************************999************************************************99888****** PP
   S: 186  ...........................................slqdcLesftkeeelegenkyycekckkkqeaekklklkklPevLi 231
                                                      +l+dcL++f++++el+g+n+y+ce+ckk+++ +k +k+ +lPe+L+
   Q: 496  nvpakpgacgdsyaaqgwlafiveyirrfvvsctpswfwgpvvTLEDCLAAFFAADELKGDNMYSCERCKKLRNGVKYCKVLRLPEILC 584
           ***************************************************************************************** PP
   S: 232  lhLkRfsfseeqksrekinkkvefple.LdlspfctspeekqkekkkYeLiavvvHsGslssGHYvayvkn.ekgkWllfdDskVtevk 318
           +hLkRf  ++e + + ki+++v+fple Ldl+pf+++++++q   ++Y+L++v++H+G+++sGHY+ay++n  +g+W++fdD++Vtev+
   Q: 585  IHLKRF--RHEVMYSFKISSHVTFPLEgLDLRPFLAKECKSQ--ITTYDLLSVICHHGTAGSGHYIAYCQNvINGQWYEFDDQYVTEVH 669
           ******..9999***************************998..9**************************78999************* PP
   S: 319  eeevleetgstaYvlfYkr 337
           e+ v++   ++aYvlfY++
   Q: 670  ETVVQN---AEAYVLFYRK 685
           ******...********98 PP

Organism

Mustela putorius furo

Protein Sequence
(Fasta)

MGDSRDLCPH LDSIGEVTKE DLVFKSKGVC QSCGVAGPNL WACLQVSCPY VGCGESFADH 60
STIHAQAKNH NLTVNLTTFR VWCYACEKEV FLEQRPAAQP AGPSPRFSEQ DSPLPSHLLK 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GCTCGCCTGG CCCCGCCCCC GGCCTGCACT GCCCGCCTAG CCCCGCCCAC ACCCGTGGCG 60
TCCCCCTCTC CTGATTGGGC TGCCAGGGGG AGGAGGCGGG GCGCGGCCCG CCGATCCCAC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR006615--Pept_C19_DUSP
IPR001394--Peptidase_C19_UCH
IPR018200--USP_CS
IPR028889--USP_dom
IPR013083--Znf_RING/FYVE/PHD
IPR001607--Znf_UBP

PROSITE

PS51283--DUSP
PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
PS50271--ZF_UBP

Pfam

PF06337--DUSP
PF00443--UCH
PF02148--zf-UBP

SMART

SM00695--DUSP
SM00290--ZnF_UBP

Gene Ontology

GO:0005813--C:centrosome
GO:0004197--F:cysteine-type endopeptidase activity
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0008270--F:zinc ion binding
GO:0071108--P:protein K48-linked deubiquitination
GO:0070536--P:protein K63-linked deubiquitination
GO:0008277--P:regulation of G-protein coupled receptor protein signaling pathway
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002209	Ailuropoda melanoleuca	93.68	0.00e+00	1698.00
IUUC-Apl-003351	Anas platyrhynchos	84.38	0.00e+00	1569.00
IUUC-Aca-005077	Anolis carolinensis	75.89	0.00e+00	1115.00
IUUC-Ame-011777	Astyanax mexicanus	75.03	0.00e+00	1336.00
IUUC-Bta-013063	Bos taurus	92.58	0.00e+00	1659.00
IUUC-Cja-019868	Callithrix jacchus	91.72	0.00e+00	1695.00
IUUC-Cfa-020761	Canis familiaris	94.00	0.00e+00	1711.00
IUUC-Cpo-022267	Cavia porcellus	84.86	0.00e+00	1544.00
IUUC-Csa-024251	Chlorocebus sabaeus	92.58	0.00e+00	1705.00
IUUC-Cho-024483	Choloepus hoffmanni	96.70	9.00e-125	441.00
IUUC-Dre-028061	Danio rerio	73.99	0.00e+00	1214.00
IUUC-Dno-029423	Dasypus novemcinctus	92.91	0.00e+00	1688.00
IUUC-Dor-030877	Dipodomys ordii	89.70	0.00e+00	1076.00
IUUC-Dme-031837	Drosophila melanogaster	49.67	6.00e-137	481.00
IUUC-Ete-032802	Echinops telfairi	77.78	4.00e-140	492.00
IUUC-Eca-034283	Equus caballus	91.49	0.00e+00	1662.00
IUUC-Eeu-034620	Erinaceus europaeus	89.04	0.00e+00	1174.00
IUUC-Fca-036357	Felis catus	94.22	0.00e+00	1684.00
IUUC-Fal-037411	Ficedula albicollis	84.47	0.00e+00	1558.00
IUUC-Gmo-038944	Gadus morhua	58.83	0.00e+00	1036.00
IUUC-Gga-041101	Gallus gallus	83.75	0.00e+00	1545.00
IUUC-Gac-041315	Gasterosteus aculeatus	73.08	0.00e+00	1311.00
IUUC-Ggo-045600	Gorilla gorilla	92.19	0.00e+00	1655.00
IUUC-Hsa-045825	Homo sapiens	92.80	0.00e+00	1670.00
IUUC-Itr-048549	Ictidomys tridecemlineatus	79.42	0.00e+00	1385.00
IUUC-Lch-050002	Latimeria chalumnae	73.71	0.00e+00	1311.00
IUUC-Loc-052574	Lepisosteus oculatus	76.69	0.00e+00	1400.00
IUUC-Laf-054428	Loxodonta africana	91.40	0.00e+00	1648.00
IUUC-Mcc-055736	Macaca mulatta	92.37	0.00e+00	1700.00
IUUC-Mga-059781	Meleagris gallopavo	83.12	0.00e+00	1543.00
IUUC-Mdo-063048	Monodelphis domestica	85.87	0.00e+00	1515.00
IUUC-Mmu-064079	Mus musculus	89.98	0.00e+00	1633.00
IUUC-Mlu-067294	Myotis lucifugus	90.95	0.00e+00	1595.00
IUUC-Nle-070015	Nomascus leucogenys	92.26	0.00e+00	1630.00
IUUC-Opr-070328	Ochotona princeps	89.88	0.00e+00	1651.00
IUUC-Ont-071464	Oreochromis niloticus	74.05	0.00e+00	1293.00
IUUC-Oan-073259	Ornithorhynchus anatinus	78.20	0.00e+00	1320.00
IUUC-Ocu-074630	Oryctolagus cuniculus	88.00	0.00e+00	1583.00
IUUC-Ola-087240	Oryzias latipes	72.73	0.00e+00	1284.00
IUUC-Oga-088761	Otolemur garnettii	91.06	0.00e+00	1675.00
IUUC-Oar-089490	Ovis aries	87.35	0.00e+00	1499.00
IUUC-Ptr-091662	Pan troglodytes	92.80	0.00e+00	1668.00
IUUC-Pan-092199	Papio anubis	92.17	0.00e+00	1693.00
IUUC-Psi-093726	Pelodiscus sinensis	84.98	0.00e+00	1563.00
IUUC-Pma-094389	Petromyzon marinus	62.75	4.00e-97	347.00
IUUC-Pfo-097415	Poecilia formosa	60.00	0.00e+00	1072.00
IUUC-Pab-098632	Pongo abelii	92.58	0.00e+00	1661.00
IUUC-Pca-100614	Procavia capensis	84.18	0.00e+00	1276.00
IUUC-Pva-102922	Pteropus vampyrus	89.16	0.00e+00	962.00
IUUC-Rno-105215	Rattus norvegicus	89.64	0.00e+00	1630.00
IUUC-Sce-106176	Saccharomyces cerevisiae	32.97	3.00e-26	114.00
IUUC-Sha-106601	Sarcophilus harrisii	84.25	0.00e+00	1496.00
IUUC-Ssc-115533	Sus scrofa	91.27	0.00e+00	1639.00
IUUC-Tgu-117364	Taeniopygia guttata	84.64	0.00e+00	1526.00
IUUC-Tru-117770	Takifugu rubripes	70.51	0.00e+00	1268.00
IUUC-Tni-120001	Tetraodon nigroviridis	71.95	0.00e+00	1258.00
IUUC-Ttr-128732	Tursiops truncatus	92.58	0.00e+00	1670.00
IUUC-Xtr-132157	Xenopus tropicalis	75.27	0.00e+00	1350.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence