iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSPTRG00000014967.5	ENSPTRT00000028014.3	ENSPTRP00000025840.3
ENSPTRG00000014967.5	ENSPTRT00000075684.1	ENSPTRP00000060580.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/ECS/SOCS_VHL_BC-box	3.70e-15	55.5	227	274

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/ECS/SOCS_VHL_BC-box

   S: 1    lsklwllrseprSLqhLCRlaIrrclgsqrlkaidkLPLPksLkdYLlyedyq 53
           l++++++rs+ rSLqhLCRl+I+r++ +     +d+LPLP+++ dYL+++++q
   Q: 227  LVQPFVRRSSARSLQHLCRLVINRLVAD-----VDCLPLPRRMADYLRQYPFQ 274
           57999***********************.....8****************986 PP

Organism

Pan troglodytes

Protein Sequence
(Fasta)

MYLEHTSHCP HHDDDTAMDT PLPRPRPLLA VERTGQRPLW APSLELPKPV MQPLPAGAFP 60
EEVAEGTPAQ TESEPKVLDP EEDLLCIAKT FSYLRESGWY WGSITASEAR QHLQKMPEGT 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CCCGCTCGTC TGGCCCGCCC CCCTCGCCCT CGCAGGCGGT CCGCGCCACT GCCTCTCAGT 60
CCCTGTCCTG CGCCCGCGCG CCCCGGGAGC CTACCCAGCA CGCGCTCCGC GCCCACTGGT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR028425--CIS
IPR000980--SH2
IPR001496--SOCS_box

PROSITE

PS50001--SH2
PS50225--SOCS

Pfam

PF00017--SH2
PF07525--SOCS_box

PRINTS

PR00401--SH2DOMAIN

SMART

SM00252--SH2
SM00253--SOCS
SM00969--SOCS_box

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005886--C:plasma membrane
GO:0004860--F:protein kinase inhibitor activity
GO:0019221--P:cytokine-mediated signaling pathway
GO:0035556--P:intracellular signal transduction
GO:0046627--P:negative regulation of insulin receptor signaling pathway
GO:0046426--P:negative regulation of JAK-STAT cascade
GO:0006469--P:negative regulation of protein kinase activity
GO:0007205--P:protein kinase C-activating G-protein coupled receptor signaling pathway
GO:0016567--P:protein ubiquitination

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001189	Ailuropoda melanoleuca	87.23	2.00e-118	418.00
IUUC-Aca-004372	Anolis carolinensis	63.89	2.00e-83	301.00
IUUC-Ame-010787	Astyanax mexicanus	47.68	5.00e-49	187.00
IUUC-Bta-012826	Bos taurus	87.55	3.00e-115	407.00
IUUC-Cja-020004	Callithrix jacchus	94.57	2.00e-132	464.00
IUUC-Cfa-020150	Canis familiaris	88.89	2.00e-107	381.00
IUUC-Csa-023173	Chlorocebus sabaeus	95.28	8.00e-120	422.00
IUUC-Dre-028606	Danio rerio	45.98	1.00e-32	132.00
IUUC-Dno-028956	Dasypus novemcinctus	86.96	2.00e-112	398.00
IUUC-Dor-030148	Dipodomys ordii	73.90	1.00e-94	338.00
IUUC-Ete-032313	Echinops telfairi	82.88	3.00e-100	357.00
IUUC-Eca-033422	Equus caballus	89.64	3.00e-117	414.00
IUUC-Eeu-034806	Erinaceus europaeus	88.42	7.00e-111	392.00
IUUC-Fca-036374	Felis catus	89.24	5.00e-117	413.00
IUUC-Fal-036801	Ficedula albicollis	65.22	1.00e-82	299.00
IUUC-Gmo-038483	Gadus morhua	39.00	2.00e-34	139.00
IUUC-Gga-040891	Gallus gallus	66.02	2.00e-79	288.00
IUUC-Gac-042147	Gasterosteus aculeatus	39.43	5.00e-32	130.00
IUUC-Ggo-045511	Gorilla gorilla	98.18	5.00e-134	469.00
IUUC-Hsa-046678	Homo sapiens	99.60	4.00e-121	426.00
IUUC-Itr-048397	Ictidomys tridecemlineatus	83.59	1.00e-117	415.00
IUUC-Lch-050555	Latimeria chalumnae	57.64	3.00e-69	254.00
IUUC-Laf-054141	Loxodonta africana	86.11	1.00e-110	392.00
IUUC-Mcc-055401	Macaca mulatta	95.67	2.00e-119	421.00
IUUC-Meu-056592	Macropus eugenii	69.44	6.00e-93	333.00
IUUC-Mga-059515	Meleagris gallopavo	66.14	3.00e-78	284.00
IUUC-Mmr-060848	Microcebus murinus	90.55	1.00e-130	458.00
IUUC-Mdo-062720	Monodelphis domestica	68.13	8.00e-90	322.00
IUUC-Mmu-063348	Mus musculus	89.16	1.00e-123	435.00
IUUC-Mpu-065834	Mustela putorius furo	89.64	5.00e-110	390.00
IUUC-Mlu-067687	Myotis lucifugus	77.48	2.00e-92	331.00
IUUC-Nle-069277	Nomascus leucogenys	97.61	2.00e-120	424.00
IUUC-Ont-071890	Oreochromis niloticus	45.83	2.00e-35	141.00
IUUC-Oan-073672	Ornithorhynchus anatinus	69.10	2.00e-83	301.00
IUUC-Ocu-073875	Oryctolagus cuniculus	87.64	9.00e-124	435.00
IUUC-Ola-087140	Oryzias latipes	55.29	8.00e-24	102.00
IUUC-Oga-087943	Otolemur garnettii	88.45	7.00e-110	389.00
IUUC-Oar-090194	Ovis aries	87.11	6.00e-117	413.00
IUUC-Pan-092121	Papio anubis	96.02	4.00e-119	420.00
IUUC-Psi-093733	Pelodiscus sinensis	62.07	3.00e-84	304.00
IUUC-Pfo-096313	Poecilia formosa	47.52	2.00e-42	164.00
IUUC-Pab-098439	Pongo abelii	98.41	2.00e-119	421.00
IUUC-Pca-101010	Procavia capensis	86.51	5.00e-109	386.00
IUUC-Pva-103112	Pteropus vampyrus	87.95	4.00e-120	423.00
IUUC-Rno-105917	Rattus norvegicus	83.21	3.00e-110	390.00
IUUC-Sha-106954	Sarcophilus harrisii	67.73	3.00e-91	327.00
IUUC-Smo-109292	Selaginella moellendorffii	31.15	2.50e-01	30.40
IUUC-Sar-113001	Sorex araneus	88.89	4.00e-109	387.00
IUUC-Ssc-115922	Sus scrofa	90.30	2.00e-60	223.00
IUUC-Tgu-117338	Taeniopygia guttata	65.22	2.00e-83	301.00
IUUC-Tru-118511	Takifugu rubripes	43.48	1.00e-31	129.00
IUUC-Tsy-119434	Tarsius syrichta	89.24	2.00e-114	404.00
IUUC-Tni-119837	Tetraodon nigroviridis	42.13	2.00e-28	118.00
IUUC-Tca-120923	Theobroma cacao	32.43	4.30e-01	27.30
IUUC-Ttr-128340	Tursiops truncatus	74.10	9.00e-74	269.00
IUUC-Vpa-130443	Vicugna pacos	88.84	4.00e-123	433.00
IUUC-Xtr-131784	Xenopus tropicalis	57.98	8.00e-65	239.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence