iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Eca-033799

Ensembl Protein ID

ENSECAP00000019672.1

UniProt Accession

F6YPV5; F6YPV5_HORSE

Protein Name

Non-specific serine/threonine protein kinase

Gene Name

MARK2

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSECAG00000021754.1	ENSECAT00000023728.1	ENSECAP00000019672.1

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
UBD/Alpha-Helix/UBA	98.69	0.00e+00	1515.00	IUUC-Hsa-046901

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Organism

Equus caballus

Protein Sequence
(Fasta)

SSKSNMLRGR NSATSADEQP HIGNYRLLKT IGKGNFAKVK LARHILTGKE VAVKIIDKTQ 60
LNSSSLQKLF REVRIMKVLN HPNIVKLFEV IETEKTLYLV MEYASGGEVF DYLVAHGRMK 120

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Nucleotide Sequence
(Fasta)

GCTGAACGAG AGGGACACGG AGCAGGTAAG GAGCCCCGAG GGCTCCCCGA TTCTCTGGCT 60
GGGCCCCTGC ACCTTGCGGA GCCTCCTCCC TCCTCTGCTC CCCTCGTGCC CCTGCTGCCT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0418--Kinase
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0723--Serine/threonine-protein kinase
KW-0808--Transferase

Interpro

IPR028375--KA1/Ssp2_C
IPR001772--KA1_dom
IPR011009--Kinase-like_dom
IPR033624--MARK/par1
IPR000719--Prot_kinase_dom
IPR017441--Protein_kinase_ATP_BS
IPR008271--Ser/Thr_kinase_AS
IPR015940--UBA

PROSITE

PS50032--KA1
PS00107--PROTEIN_KINASE_ATP
PS50011--PROTEIN_KINASE_DOM
PS00108--PROTEIN_KINASE_ST
PS50030--UBA

Pfam

PF02149--KA1
PF00069--Pkinase
PF00627--UBA

SMART

SM00220--S_TKc
SM00165--UBA

Gene Ontology

GO:0005884--C:actin filament
GO:0016328--C:lateral plasma membrane
GO:0097427--C:microtubule bundle
GO:0005654--C:nucleoplasm
GO:0005524--F:ATP binding
GO:0000287--F:magnesium ion binding
GO:0004674--F:protein serine/threonine kinase activity
GO:0003723--F:RNA binding
GO:0030010--P:establishment of cell polarity
GO:0045197--P:establishment or maintenance of epithelial cell apical/basal polarity
GO:0035556--P:intracellular signal transduction
GO:0000226--P:microtubule cytoskeleton organization
GO:0010976--P:positive regulation of neuron projection development
GO:0050770--P:regulation of axonogenesis

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aca-004803	Anolis carolinensis	86.89	0.00e+00	1296.00
IUUC-Ame-011854	Astyanax mexicanus	71.34	0.00e+00	1051.00
IUUC-Cel-018198	Caenorhabditis elegans	73.55	3.00e-160	559.00
IUUC-Cja-019475	Callithrix jacchus	96.85	0.00e+00	1476.00
IUUC-Cfa-020356	Canis familiaris	98.69	0.00e+00	1511.00
IUUC-Cgl-026480	Colletotrichum gloeosporioides	43.01	2.00e-69	257.00
IUUC-Dre-028467	Danio rerio	72.60	0.00e+00	1058.00
IUUC-Dno-029653	Dasypus novemcinctus	98.03	0.00e+00	1508.00
IUUC-Dor-030743	Dipodomys ordii	98.81	0.00e+00	1508.00
IUUC-Ete-032528	Echinops telfairi	97.07	0.00e+00	1257.00
IUUC-Eeu-034949	Erinaceus europaeus	97.24	0.00e+00	946.00
IUUC-Fca-035596	Felis catus	98.69	0.00e+00	1513.00
IUUC-Gac-042044	Gasterosteus aculeatus	72.88	0.00e+00	1021.00
IUUC-Hsa-046901	Homo sapiens	98.69	0.00e+00	1515.00
IUUC-Lch-049551	Latimeria chalumnae	82.44	0.00e+00	1220.00
IUUC-Loc-051934	Lepisosteus oculatus	68.59	0.00e+00	984.00
IUUC-Mcc-055104	Macaca mulatta	98.56	0.00e+00	1512.00
IUUC-Meu-056525	Macropus eugenii	96.30	0.00e+00	1472.00
IUUC-Mmr-060697	Microcebus murinus	98.43	0.00e+00	1509.00
IUUC-Mmu-063467	Mus musculus	97.37	0.00e+00	1462.00
IUUC-Mpu-066665	Mustela putorius furo	98.82	0.00e+00	1519.00
IUUC-Opr-070302	Ochotona princeps	96.33	0.00e+00	1466.00
IUUC-Ont-071386	Oreochromis niloticus	69.69	0.00e+00	977.00
IUUC-Pan-092847	Papio anubis	98.56	0.00e+00	1512.00
IUUC-Pva-103239	Pteropus vampyrus	98.41	0.00e+00	1492.00
IUUC-Pgr-103687	Puccinia graminis	46.18	9.00e-71	261.00
IUUC-Ptt-103944	Puccinia triticina	44.73	6.00e-67	249.00
IUUC-Ssc-116439	Sus scrofa	93.62	0.00e+00	979.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence