iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Cpo-022336

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AAKN02012904

Gene Name

UBA7

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSCPOG00000008926.3	ENSCPOT00000009007.2	ENSCPOP00000008020.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E1	1.70e-186	620.3	420	883

Active Site

Position(s)	Description	Evidence
602	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU10132}

Domain Profile

   S: 1    YDRQirlwGeeaqeklksakvllvGagglGcEllKnLvlaGv.....gsitvvDmdtvevsnlnrqFLfraedvgksKAevaaealkel 84
           YD+Qi+++G+  qe l+ +++llvGag++GcEllK ++l+G+     gs+tvvDmd++e+snl+rqFLfr++d+gksKAevaa+a ++l
   Q: 420  YDGQIAVFGAGFQETLSCQRYLLVGAGAIGCELLKGFALMGLgagtsGSVTVVDMDHIEYSNLSRQFLFRPWDIGKSKAEVAAAATQDL 508
           ***************************************************************************************** PP
   S: 85   npdvnveaheesiteleeeiv...FfkkfdvVvlaldnrearrkvnrlclnarvpliesgtlGllGqvrviikgltecyscsd.dppqk 169
           npd +v+a++  ++ ++e+i+   Ff+ +d+Vv+a+d ++ar ++  +c+++ +pl+e+gtlG++G ++v+++++te y+ +   ++  
   Q: 509  NPDLEVTAYTRILDHTTEDIYadnFFSHVDGVVAAVDTFKARYYLSARCIHYLKPLLEAGTLGTKGSASVFVPHVTEVYKGPVeASEGA 597
           ***********************************************************************************999*** PP
   S: 170  tiPfctlketpnaaehtiewa........vlfnklleeeageeevlekldseekeegkdkvkselksedeenfeeaieiavkafaktti 250
            +P+ctl+ +p + eht++wa        +l +++++ ++++ + le+++  ++++++++    l+  +++++++++e+a+ ++  ++ 
   Q: 598  PAPVCTLRYFPGTYEHTLQWAqnefeelfRLPAETINRYQQAATSLEDVSGLQMLTSLQLLLGVLRV-RPQTWQDCVEWALGHWRLRFC 685
           **************************9999999****************************888777.6******************** PP
   S: 251  nsikqllksfecdivtkskspfwv.........................................................sfcsnaea 282
            +i  ll+ f++ +v ++++pfw+                                                          + s   +
   Q: 686  DDIIRLLRLFPPYKVHEDGAPFWSgpkqcpqplefdisqdmhflyilaaanlyaqmhglpgsldqpalrvllklllqtdppHVASIFHR 774
           *************************************************************9999999999999999999988888888 PP
   S: 283  lqvpekvekdeevvkasaplylllralerfekkkgrkpgelsfekddds..avdlvtaaanlraeslgiepkldddlikeiagniipai 369
           +++ +k+ +  + ++++++l+ l ++le + k + +kp  l f k +ds  +vd+v+aaa+lr +++gi++++d+ + k+i+++iipai
   Q: 775  KNTGDKGHSASTPLTDPEQLKELQESLEVWTKGPALKP--LVFGKNEDShfHVDFVRAAASLRSQNYGISEPADYAQSKRIMSQIIPAI 861
           8899999*******************************..66666666666************************************** PP
   S: 370  attnavvgGlaaqEviKvvsgk 391
           att+a+v+Gl+ +E++Kvv  +
   Q: 862  ATTTAAVAGLLGLEMYKVVGSP 883
           ******************9874 PP

Organism

Cavia porcellus

Protein Sequence
(Fasta)

QLLSSPAFRM AVKESSQRLD RELYSRQLPV LGLPAMQRIQ EAKVLLSGLQ GLGAEVAKNL 60
VLMGVGSLTL HDPQPTCWSD LAAQFLLSEK DLGKSRAEAS QKHLAQLNEA VQVFVHASDI 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CAGCTGCTGT CGAGCCCGGC CTTCAGGATG GCAGTCAAGG AGTCTTCCCA GCGGCTGGAC 60
AGAGAGCTGT ACTCCAGGCA GCTGTGAGCC TTGTGGTGGG GGAGGAAGCC GGTGGTCTTC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0436--Ligase
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway

Interpro

IPR032420--E1_4HB
IPR032418--E1_FCCH
IPR016040--NAD(P)-bd_dom
IPR000594--ThiF_NAD_FAD-bd
IPR018965--Ub-activating_enz_E1_C
IPR019572--UBA_E1_Cys
IPR018075--UBQ-activ_enz_E1
IPR033127--UBQ-activ_enz_E1_Cys_AS
IPR000011--UBQ/SUMO-activ_enz_E1-like

PROSITE

PS00865--UBIQUITIN_ACTIVAT_2

Pfam

PF16191--E1_4HB
PF16190--E1_FCCH
PF09358--E1_UFD
PF00899--ThiF
PF10585--UBA_e1_thiolCys

PRINTS

PR01849--UBIQUITINACT

SMART

SM00985--UBA_e1_C

Gene Ontology

GO:0005524--F:ATP binding
GO:0019782--F:ISG15 activating enzyme activity
GO:0032020--P:ISG15-protein conjugation
GO:0019941--P:modification-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001816	Ailuropoda melanoleuca	69.84	0.00e+00	1264.00
IUUC-Bta-012665	Bos taurus	67.75	0.00e+00	1182.00
IUUC-Cja-019047	Callithrix jacchus	69.35	0.00e+00	1280.00
IUUC-Cfa-021225	Canis familiaris	69.92	0.00e+00	1314.00
IUUC-Csa-023462	Chlorocebus sabaeus	72.10	0.00e+00	1280.00
IUUC-Cho-024436	Choloepus hoffmanni	64.98	1.00e-80	295.00
IUUC-Dno-029347	Dasypus novemcinctus	70.04	0.00e+00	1280.00
IUUC-Dor-030997	Dipodomys ordii	69.23	0.00e+00	1263.00
IUUC-Ete-033124	Echinops telfairi	67.95	0.00e+00	859.00
IUUC-Eca-033929	Equus caballus	70.24	0.00e+00	1342.00
IUUC-Eeu-034717	Erinaceus europaeus	63.49	0.00e+00	855.00
IUUC-Fca-036564	Felis catus	70.00	0.00e+00	1256.00
IUUC-Ggo-044480	Gorilla gorilla	71.43	0.00e+00	1282.00
IUUC-Hsa-046498	Homo sapiens	71.02	0.00e+00	1265.00
IUUC-Itr-048657	Ictidomys tridecemlineatus	70.09	0.00e+00	1267.00
IUUC-Laf-054119	Loxodonta africana	70.41	0.00e+00	1328.00
IUUC-Mcc-055597	Macaca mulatta	70.10	0.00e+00	1211.00
IUUC-Mdo-063058	Monodelphis domestica	53.78	0.00e+00	949.00
IUUC-Mmu-063578	Mus musculus	66.43	0.00e+00	1244.00
IUUC-Mpu-066255	Mustela putorius furo	69.80	0.00e+00	1273.00
IUUC-Mlu-067814	Myotis lucifugus	65.86	0.00e+00	1128.00
IUUC-Nle-069193	Nomascus leucogenys	71.50	0.00e+00	1283.00
IUUC-Opr-070715	Ochotona princeps	66.57	0.00e+00	1211.00
IUUC-Ocu-074162	Oryctolagus cuniculus	68.72	0.00e+00	1240.00
IUUC-Oga-088895	Otolemur garnettii	69.90	0.00e+00	1250.00
IUUC-Oar-089579	Ovis aries	67.06	0.00e+00	1160.00
IUUC-Ptr-090581	Pan troglodytes	71.64	0.00e+00	1250.00
IUUC-Pan-092458	Papio anubis	72.20	0.00e+00	1277.00
IUUC-Pab-098653	Pongo abelii	67.19	0.00e+00	1201.00
IUUC-Pca-100578	Procavia capensis	65.99	0.00e+00	753.00
IUUC-Pva-102914	Pteropus vampyrus	66.63	0.00e+00	964.00
IUUC-Rno-106066	Rattus norvegicus	68.33	0.00e+00	1302.00
IUUC-Ssc-115743	Sus scrofa	69.25	0.00e+00	1255.00
IUUC-Tbe-127587	Tupaia belangeri	71.41	0.00e+00	971.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence