iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSOCUG00000006595.3	ENSOCUT00000033488.1	ENSOCUP00000026535.1
ENSOCUG00000006595.3	ENSOCUT00000006600.2	ENSOCUP00000005704.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E1	1.50e-198	660.1	419	889

Active Site

Position(s)	Description	Evidence
600	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU10132}

Domain Profile

   S: 1    YDRQirlwGeeaqeklksakvllvGagglGcEllKnLvlaGv.....gsitvvDmdtvevsnlnrqFLfraedvgksKAevaaealkel 84
           YD+Qi+++G+  qekl+++++llvGag++GcEllK ++l+G+     gs+tv Dmd+ve snl+rqFLfr++d+g++KAevaa a+++l
   Q: 419  YDGQIAVFGAGFQEKLSRQHYLLVGAGAIGCELLKGFALVGLgagggGSVTVADMDHVERSNLSRQFLFRPQDIGRPKAEVAAVAAQRL 507
           ***************************************************************************************** PP
   S: 85   npdvnveaheesiteleeeiv...FfkkfdvVvlaldnrearrkvnrlclnarvpliesgtlGllGqvrviikgltecyscsddppqkt 170
           npd +v++ ++++++++e+++   Ff+++++V++ald+++ar +v+ +c+++ +pl+e+gt+G++G + v+++ +te y++s   ++++
   Q: 508  NPDLQVTPLTYPLDPTTEHVYgdhFFSRVNGVAAALDSFQARHYVAARCTHYLKPLLEAGTEGTKGSAAVFVPDVTEGYKASGLAEDTS 596
           ***************************************************************************************** PP
   S: 171  iPfctlketpnaaehtiewa........vlfnklleeeageeevlekldseekeegkdkvkselksedeenfeeaieiavkafakttin 251
           +P+ct++++p++aeht++wa        +l +++++  +++++ l+++d  ++++ +++v     +++++n+e+++ +a  +++ ++++
   Q: 597  YPVCTVRHFPSTAEHTLQWArdefeglfRLSAETINRARQAHTSLADMDGPQTLALLRPVLGV-LKARPQNWEDCVVWAHGHWQLRFHY 684
           ************************************************************655.6668********************* PP
   S: 252  sikqllksfecdivtkskspfwv.................................................sfcsnaealqvpekvek 291
           +i qll+++++d+v ++++ fw+                                                 +  ++++ ++  +  + 
   Q: 685  GIIQLLSHIPPDRVLEDGTLFWSglkqcpqplefdmdqenhllfvlaaanlyarmhglpgslglaalkglllKSLPQTDPQRLAPILTR 773
           *99999999************************************************************99977777777776666666 PP
   S: 292  deevvkasap.....lylllralerfekkkgrkpgelsfekddds..avdlvtaaanlraeslgiepkldddlikeiagniipaiattn 373
             e ++asa+     l+ l ++l  +++ + ++p  l+fekddds  ++d+v aaanlr +++gi+p +++ + k+i+g+iipaiatt+
   Q: 774  APERDQASAEfgpelLKELQEVLGVWSEHPALNP--LMFEKDDDSnfHMDFVVAAANLRSQNYGIPP-VTRAQGKQIVGRIIPAIATTT 859
           6666666666799*9*****************99..*******************************.********************* PP
   S: 374  avvgGlaaqEviKvvsg..kfeplknfflf 401
           a+v+Gl+ +E++Kvv g     ++++ +l+
   Q: 860  AAVAGLVGLELYKVVGGsrTLGAYRHSYLH 889
           ***************994444456666555 PP

Organism

Oryctolagus cuniculus

Protein Sequence
(Fasta)

SSPRLRMRAP GPSQLLDEEL YSRQLYVLGP PAMQRMREAK VLLSGLQGLG AEVAKNLVLM 60
GVGSLTLHDP CPTCWSDLAA QFLLSERDLG RSRAEASREL LAQLNEAVQV SVHLGDITEA 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CAGAGTCTAG TTTCAGTTTT GTTTCCCCTG TGGTGACAGA GGTGAGAGAG CTGTCGGGAG 60
AGGCGGCCTC CACTCCTTCC GCATTGGTGC CTGACTGCAC TGCTGTAGCT GAGCAGCACC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0436--Ligase
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway

Interpro

IPR032420--E1_4HB
IPR032418--E1_FCCH
IPR016040--NAD(P)-bd_dom
IPR000594--ThiF_NAD_FAD-bd
IPR018965--Ub-activating_enz_E1_C
IPR019572--UBA_E1_Cys
IPR018075--UBQ-activ_enz_E1
IPR033127--UBQ-activ_enz_E1_Cys_AS
IPR000011--UBQ/SUMO-activ_enz_E1-like

PROSITE

PS00865--UBIQUITIN_ACTIVAT_2

Pfam

PF16191--E1_4HB
PF16190--E1_FCCH
PF09358--E1_UFD
PF00899--ThiF
PF10585--UBA_e1_thiolCys

PRINTS

PR01849--UBIQUITINACT

SMART

SM00985--UBA_e1_C

Gene Ontology

GO:0005524--F:ATP binding
GO:0019782--F:ISG15 activating enzyme activity
GO:0032020--P:ISG15-protein conjugation
GO:0019941--P:modification-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001816	Ailuropoda melanoleuca	76.09	0.00e+00	1405.00
IUUC-Bta-012665	Bos taurus	72.64	0.00e+00	1267.00
IUUC-Cja-019047	Callithrix jacchus	75.91	0.00e+00	1415.00
IUUC-Cfa-021225	Canis familiaris	77.06	0.00e+00	1426.00
IUUC-Cpo-022336	Cavia porcellus	69.40	0.00e+00	1251.00
IUUC-Csa-023462	Chlorocebus sabaeus	79.37	0.00e+00	1428.00
IUUC-Cho-024436	Choloepus hoffmanni	74.26	9.00e-91	328.00
IUUC-Dno-029347	Dasypus novemcinctus	75.32	0.00e+00	1380.00
IUUC-Dor-030997	Dipodomys ordii	71.27	0.00e+00	1310.00
IUUC-Ete-033124	Echinops telfairi	72.82	0.00e+00	930.00
IUUC-Eca-033929	Equus caballus	76.17	0.00e+00	1447.00
IUUC-Eeu-034717	Erinaceus europaeus	67.15	0.00e+00	936.00
IUUC-Fca-036564	Felis catus	76.55	0.00e+00	1402.00
IUUC-Ggo-044480	Gorilla gorilla	78.07	0.00e+00	1400.00
IUUC-Hsa-046498	Homo sapiens	78.18	0.00e+00	1402.00
IUUC-Itr-048657	Ictidomys tridecemlineatus	73.81	0.00e+00	1353.00
IUUC-Laf-054119	Loxodonta africana	73.09	0.00e+00	1379.00
IUUC-Mcc-055597	Macaca mulatta	77.14	0.00e+00	1357.00
IUUC-Meu-056534	Macropus eugenii	48.99	0.00e+00	868.00
IUUC-Mdo-063058	Monodelphis domestica	56.21	0.00e+00	981.00
IUUC-Mmu-063578	Mus musculus	69.77	0.00e+00	1316.00
IUUC-Mpu-066255	Mustela putorius furo	76.81	0.00e+00	1416.00
IUUC-Mlu-067814	Myotis lucifugus	71.55	0.00e+00	1242.00
IUUC-Nle-069193	Nomascus leucogenys	77.20	0.00e+00	1397.00
IUUC-Opr-070715	Ochotona princeps	76.67	0.00e+00	1429.00
IUUC-Oan-073306	Ornithorhynchus anatinus	52.68	0.00e+00	725.00
IUUC-Oga-088895	Otolemur garnettii	74.60	0.00e+00	1350.00
IUUC-Oar-089579	Ovis aries	72.07	0.00e+00	1256.00
IUUC-Ptr-090581	Pan troglodytes	78.47	0.00e+00	1384.00
IUUC-Pan-092458	Papio anubis	79.17	0.00e+00	1418.00
IUUC-Pab-098653	Pongo abelii	73.74	0.00e+00	1312.00
IUUC-Pca-100578	Procavia capensis	70.11	0.00e+00	805.00
IUUC-Pva-102914	Pteropus vampyrus	74.04	0.00e+00	1107.00
IUUC-Rno-106066	Rattus norvegicus	71.44	0.00e+00	1355.00
IUUC-Sha-107368	Sarcophilus harrisii	58.05	0.00e+00	1065.00
IUUC-Ssc-115743	Sus scrofa	77.86	0.00e+00	1432.00
IUUC-Tbe-127587	Tupaia belangeri	79.06	0.00e+00	1077.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence