iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Afl-008644

Ensembl Protein ID

EED57893

UniProt Accession

B8MZV1; B8MZV1_ASPFN

Genbank Protein ID

EED57893.1

Protein Name

Coatomer subunit alpha

Genbank Nucleotide ID

EQ963472

Gene Name

AFLA_085910

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
AFLA_085910	EED57893	EED57893

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	8.70e-35	116.7	56	92
UBD/Beta-Prp	9.90e-77	257.5	8	334

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 2    Htdsvtclaf.sd.tllvsGsdDgtikvWDlrtgvll 36
           H ++v++++f ++ +l+vsG+dD +ikvW++ t ++l
   Q: 56   HDGPVRGIDFhPTqPLFVSGGDDYKIKVWNYQTRRCL 92
           99*********888*****************999987 PP

UBD/Beta-Prp

   S: 3    ktlkghhksvitcvkfspdksllatgsrdgtikvwdvttgkllrslsgheaevtavkfspdgkilvtgseDrtikvwdlstgkcvhtlkghedsvlslsfs 103
            t +++++s+ + ++f+p++++++++  ++ti++wd+++g+l+ ++++h+++v+ ++f+p+++++v+g++D+ ikvw+++t+ c+ tl+gh d+v+++ f+
   Q: 8    LTKFESKSSRAKGIAFHPKRPWILVSLHSSTIQLWDYRMGTLIDRFEEHDGPVRGIDFHPTQPLFVSGGDDYKIKVWNYQTRRCLFTLNGHLDYVRTVFFH 108
           67889999********************************************************************************************* PP
   S: 104  psgdklvsGshdrtirvwdletgqcleetlsghdgvvncvvvhpdgnllvsGslDrtvrlWdl...............................ktgkllr 173
           p+  +++s+s+d+tir+w++++++ +  t +gh++ v+c+++hp+++l++s+slD+ vr+Wd+                               +t+ +++
   Q: 109  PELPWILSASDDQTIRIWNWQNRSLIC-TMTGHNHYVMCAQFHPTEDLIASASLDQSVRIWDIsglrkkhsapttmsfedqmaranpsqadmfgNTDAVVK 208
           **************************9.***********************************************************99999977777777 PP
   S: 174  tltgghtdsvyslsfdsngkelvsgsldgtvklwdlqtgec..vrtlnghtdnvksvrfspnderlvsgssDgsiriWdlrsgdllktlqlhnssvisvav 272
              +gh++ v+++sf+++ + +vs+++d+ +klw ++ ++   v+t++gh +n +   f+p++++++s+++D++ir Wdl +++ ++++++  ++++ +a+
   Q: 209  FVLEGHDRGVNWVSFHPTLPLIVSAGDDRLIKLWRMSDTKAweVDTCRGHFQNASACLFHPHQDLILSVGEDKTIRAWDLNKRTSVQSFKRDLDRFWVIAA 309
           66777********************************777668********************************************************** PP
   S: 273  lsfgdnvlvlgsedskvniwklkknep 299
            +++ n +++g  d  v+++kl++++p
   Q: 310  -HPEINLFAAG-HDTGVMVFKLERERP 334
           .5555555444.589*******98775 PP

Organism

Aspergillus flavus

Functional Description
(View)

The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network.

Protein Sequence
(Fasta)

MQSSPNMLTK FESKSSRAKG IAFHPKRPWI LVSLHSSTIQ LWDYRMGTLI DRFEEHDGPV 60
RGIDFHPTQP LFVSGGDDYK IKVWNYQTRR CLFTLNGHLD YVRTVFFHPE LPWILSASDD 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGCAGTCCT CCCCAAACAT GCTCACTAAG GTATGTCCTC CCCTCCAATG CCCCCGGCGA 60
TCTGGCTCTG GAGTTTCAAG GGCAACTATT AAACATCATA TCCCACACAG TTCGAGTCGA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0931--ER-Golgi transport
KW-0333--Golgi apparatus
KW-0472--Membrane
KW-0653--Protein transport
KW-1185--Reference proteome
KW-0677--Repeat
KW-0813--Transport
KW-0853--WD repeat

Interpro

IPR011042--6-blade_b-propeller_TolB-like
IPR016391--Coatomer_asu
IPR010714--Coatomer_asu_C
IPR006692--Coatomer_WD-assoc_reg
IPR020472--G-protein_beta_WD-40_rep
IPR011048--Haem_d1
IPR011990--TPR-like_helical_dom
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF04053--Coatomer_WDAD
PF06957--COPI_C
PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM00320--WD40

Gene Ontology

GO:0030126--C:COPI vesicle coat
GO:0000139--C:Golgi membrane
GO:0005198--F:structural molecule activity
GO:0006888--P:ER to Golgi vesicle-mediated transport
GO:0006886--P:intracellular protein transport
GO:0006890--P:retrograde vesicle-mediated transport, Golgi to ER

KEGG

afv:AFLA_085910

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000064	Aegilops tauschii	55.91	0.00e+00	985.00
IUUC-Aml-001758	Ailuropoda melanoleuca	49.07	0.00e+00	1215.00
IUUC-Atr-002493	Amborella trichopoda	55.35	0.00e+00	964.00
IUUC-Apl-003385	Anas platyrhynchos	43.70	0.00e+00	915.00
IUUC-Aca-005154	Anolis carolinensis	71.84	2.00e-93	332.00
IUUC-Aly-006494	Arabidopsis lyrata	43.41	0.00e+00	1025.00
IUUC-Ath-007360	Arabidopsis thaliana	54.76	0.00e+00	969.00
IUUC-Ago-007992	Ashbya gossypii	53.32	0.00e+00	1276.00
IUUC-Acl-008027	Aspergillus clavatus	92.49	0.00e+00	2224.00
IUUC-Afu-008964	Aspergillus fumigatus	93.23	0.00e+00	2284.00
IUUC-Ani-009379	Aspergillus nidulans	90.79	0.00e+00	2232.00
IUUC-Ang-009756	Aspergillus niger	93.86	0.00e+00	2257.00
IUUC-Aor-010174	Aspergillus oryzae	99.83	0.00e+00	2350.00
IUUC-Ate-010302	Aspergillus terreus	91.63	0.00e+00	2264.00
IUUC-Ame-011229	Astyanax mexicanus	56.16	0.00e+00	1003.00
IUUC-Bgr-012300	Blumeria graminis	73.87	0.00e+00	1863.00
IUUC-Bta-012524	Bos taurus	49.43	0.00e+00	1208.00
IUUC-Bci-013781	Botrytis cinerea	77.46	0.00e+00	1978.00
IUUC-Bdi-014549	Brachypodium distachyon	47.14	0.00e+00	1144.00
IUUC-Bol-015925	Brassica oleracea	55.77	0.00e+00	963.00
IUUC-Bra-016978	Brassica rapa	55.29	0.00e+00	957.00
IUUC-Cel-018115	Caenorhabditis elegans	52.19	0.00e+00	904.00
IUUC-Cja-019107	Callithrix jacchus	47.95	0.00e+00	1190.00
IUUC-Cfa-020675	Canis familiaris	48.77	0.00e+00	1186.00
IUUC-Cpo-021813	Cavia porcellus	49.51	0.00e+00	1221.00
IUUC-Cre-022969	Chlamydomonas reinhardtii	56.26	0.00e+00	998.00
IUUC-Csa-023523	Chlorocebus sabaeus	49.43	0.00e+00	1225.00
IUUC-Cho-024704	Choloepus hoffmanni	36.62	3.00e-145	507.00
IUUC-Cin-025572	Ciona intestinalis	47.96	0.00e+00	1181.00
IUUC-Csv-025864	Ciona savignyi	54.53	0.00e+00	946.00
IUUC-Cgl-026510	Colletotrichum gloeosporioides	77.74	0.00e+00	1941.00
IUUC-Cne-027053	Cryptococcus neoformans	64.64	0.00e+00	1130.00
IUUC-Cme-027222	Cyanidioschyzon merolae	41.01	3.00e-141	494.00
IUUC-Dre-027421	Danio rerio	49.15	0.00e+00	1208.00
IUUC-Dno-029303	Dasypus novemcinctus	49.47	0.00e+00	1226.00
IUUC-Dor-030290	Dipodomys ordii	45.98	4.00e-144	503.00
IUUC-Dse-031543	Dothistroma septosporum	75.21	0.00e+00	1805.00
IUUC-Dme-031945	Drosophila melanogaster	55.78	0.00e+00	964.00
IUUC-Ete-032873	Echinops telfairi	54.14	0.00e+00	945.00
IUUC-Eca-033773	Equus caballus	48.67	0.00e+00	1179.00
IUUC-Eeu-034874	Erinaceus europaeus	37.49	5.00e-169	587.00
IUUC-Fca-035739	Felis catus	56.67	0.00e+00	1001.00
IUUC-Fal-037263	Ficedula albicollis	52.70	0.00e+00	884.00
IUUC-Fox-037738	Fusarium oxysporum	76.10	0.00e+00	1970.00
IUUC-Fso-038153	Fusarium solani	77.19	0.00e+00	1960.00
IUUC-Gmo-039602	Gadus morhua	45.61	0.00e+00	1116.00
IUUC-Ggr-039931	Gaeumannomyces graminis	75.37	0.00e+00	1874.00
IUUC-Gga-040590	Gallus gallus	48.57	0.00e+00	1229.00
IUUC-Gac-041318	Gasterosteus aculeatus	47.47	0.00e+00	1192.00
IUUC-Gma-043894	Glycine max	55.96	0.00e+00	980.00
IUUC-Ggo-045029	Gorilla gorilla	49.07	0.00e+00	1216.00
IUUC-Hsa-046078	Homo sapiens	49.16	0.00e+00	1219.00
IUUC-Hvu-047556	Hordeum vulgare	47.46	0.00e+00	1145.00
IUUC-Itr-048881	Ictidomys tridecemlineatus	41.15	0.00e+00	660.00
IUUC-Kpa-049256	Komagataella pastoris	55.43	0.00e+00	1382.00
IUUC-Lch-049706	Latimeria chalumnae	56.71	0.00e+00	1004.00
IUUC-Lpe-051316	Leersia perrieri	55.46	0.00e+00	977.00
IUUC-Loc-051867	Lepisosteus oculatus	39.12	0.00e+00	820.00
IUUC-Lma-053138	Leptosphaeria maculans	84.98	0.00e+00	1529.00
IUUC-Laf-053510	Loxodonta africana	49.96	0.00e+00	1228.00
IUUC-Mcc-055836	Macaca mulatta	49.15	0.00e+00	1221.00
IUUC-Meu-056238	Macropus eugenii	51.03	0.00e+00	700.00
IUUC-Mor-057172	Magnaporthe oryzae	76.70	0.00e+00	1940.00
IUUC-Mpo-057300	Magnaporthe poae	73.37	0.00e+00	1871.00
IUUC-Mtr-058248	Medicago truncatula	47.70	0.00e+00	1137.00
IUUC-Mla-059019	Melampsora laricipopulina	64.09	0.00e+00	1171.00
IUUC-Mga-059499	Meleagris gallopavo	48.57	0.00e+00	1225.00
IUUC-Mvi-060336	Microbotryum violaceum	64.75	0.00e+00	1169.00
IUUC-Mmr-061102	Microcebus murinus	49.07	0.00e+00	1216.00
IUUC-Mdo-062594	Monodelphis domestica	49.84	0.00e+00	1233.00
IUUC-Mmu-063736	Mus musculus	49.24	0.00e+00	1215.00
IUUC-Mac-065398	Musa acuminata	44.38	0.00e+00	1038.00
IUUC-Mpu-066701	Mustela putorius furo	57.11	0.00e+00	1016.00
IUUC-Mlu-067392	Myotis lucifugus	48.37	0.00e+00	1214.00
IUUC-Nfi-068270	Neosartorya fischeri	93.56	0.00e+00	2241.00
IUUC-Ncr-068892	Neurospora crassa	76.60	0.00e+00	1905.00
IUUC-Nle-069634	Nomascus leucogenys	59.52	0.00e+00	865.00
IUUC-Opr-070952	Ochotona princeps	37.92	4.00e-166	577.00
IUUC-Ont-072488	Oreochromis niloticus	47.89	0.00e+00	1188.00
IUUC-Ocu-074211	Oryctolagus cuniculus	49.27	0.00e+00	1218.00
IUUC-Oba-075761	Oryza barthii	55.22	0.00e+00	974.00
IUUC-Obr-076429	Oryza brachyantha	55.44	0.00e+00	978.00
IUUC-Ogl-077364	Oryza glaberrima	55.22	0.00e+00	975.00
IUUC-Ogu-078257	Oryza glumaepatula	55.22	0.00e+00	970.00
IUUC-Oin-080029	Oryza indica	55.22	0.00e+00	976.00
IUUC-Olo-080466	Oryza longistaminata	55.66	0.00e+00	972.00
IUUC-Ome-081993	Oryza meridionalis	57.68	0.00e+00	934.00
IUUC-Oni-082874	Oryza nivara	55.34	0.00e+00	972.00
IUUC-Opu-083885	Oryza punctata	55.22	0.00e+00	975.00
IUUC-Oru-084274	Oryza rufipogon	55.10	0.00e+00	973.00
IUUC-Osa-085841	Oryza sativa	55.46	0.00e+00	979.00
IUUC-Ola-086921	Oryzias latipes	48.55	0.00e+00	1186.00
IUUC-Olu-087639	Ostreococcus lucimarinus	48.66	0.00e+00	1187.00
IUUC-Oga-087991	Otolemur garnettii	46.86	0.00e+00	1144.00
IUUC-Oar-089590	Ovis aries	49.43	0.00e+00	1220.00
IUUC-Ptr-090808	Pan troglodytes	49.07	0.00e+00	1217.00
IUUC-Pan-092475	Papio anubis	49.23	0.00e+00	1214.00
IUUC-Psi-093044	Pelodiscus sinensis	51.33	0.00e+00	848.00
IUUC-Pno-094839	Phaeosphaeria nodorum	84.87	0.00e+00	1458.00
IUUC-Ppa-095254	Physcomitrella patens	58.47	0.00e+00	1038.00
IUUC-Pfo-097493	Poecilia formosa	56.71	0.00e+00	997.00
IUUC-Pab-098497	Pongo abelii	49.35	0.00e+00	1225.00
IUUC-Pop-099992	Populus trichocarpa	55.70	0.00e+00	962.00
IUUC-Pca-100413	Procavia capensis	53.23	4.00e-178	617.00
IUUC-Ppe-101899	Prunus persica	56.01	0.00e+00	981.00
IUUC-Pva-102126	Pteropus vampyrus	47.46	0.00e+00	1157.00
IUUC-Pgr-103376	Puccinia graminis	56.46	0.00e+00	1420.00
IUUC-Ptt-103978	Puccinia triticina	51.14	0.00e+00	1212.00
IUUC-Pte-104126	Pyrenophora teres	83.48	0.00e+00	1465.00
IUUC-Pyt-104778	Pyrenophora triticirepentis	74.64	0.00e+00	1053.00
IUUC-Rno-105428	Rattus norvegicus	49.51	0.00e+00	1223.00
IUUC-Sce-106464	Saccharomyces cerevisiae	53.47	0.00e+00	1264.00
IUUC-Sha-107301	Sarcophilus harrisii	49.18	0.00e+00	1203.00
IUUC-Sja-107961	Schizosaccharomyces japonicus	51.91	0.00e+00	1313.00
IUUC-Spo-108217	Schizosaccharomyces pombe	54.91	0.00e+00	1375.00
IUUC-Ssl-108643	Sclerotinia sclerotiorum	77.53	0.00e+00	1975.00
IUUC-Smo-109582	Selaginella moellendorffii	56.55	0.00e+00	1011.00
IUUC-Sit-109697	Setaria italica	55.46	0.00e+00	976.00
IUUC-Sly-111447	Solanum lycopersicum	54.93	0.00e+00	975.00
IUUC-Stu-112564	Solanum tuberosum	55.35	0.00e+00	973.00
IUUC-Sar-113313	Sorex araneus	40.68	9.00e-162	561.00
IUUC-Sbi-114388	Sorghum bicolor	55.34	0.00e+00	976.00
IUUC-Sre-115209	Sporisorium reilianum	62.69	0.00e+00	1120.00
IUUC-Ssc-115933	Sus scrofa	49.35	0.00e+00	1220.00
IUUC-Tgu-117109	Taeniopygia guttata	43.51	6.00e-91	325.00
IUUC-Tru-117772	Takifugu rubripes	47.54	0.00e+00	1172.00
IUUC-Tsy-119105	Tarsius syrichta	51.41	0.00e+00	882.00
IUUC-Tni-120556	Tetraodon nigroviridis	40.61	9.00e-167	579.00
IUUC-Tca-121046	Theobroma cacao	47.89	0.00e+00	1140.00
IUUC-Tre-121951	Trichoderma reesei	74.29	0.00e+00	1894.00
IUUC-Tvi-122359	Trichoderma virens	74.80	0.00e+00	1927.00
IUUC-Tae-123688	Triticum aestivum	47.73	0.00e+00	1152.00
IUUC-Tur-126754	Triticum urartu	55.79	0.00e+00	984.00
IUUC-Tme-127170	Tuber melanosporum	76.77	0.00e+00	1937.00
IUUC-Tbe-127882	Tupaia belangeri	62.18	2.00e-120	425.00
IUUC-Ttr-128217	Tursiops truncatus	47.38	0.00e+00	1150.00
IUUC-Uma-129337	Ustilago maydis	62.10	0.00e+00	1112.00
IUUC-Vda-129828	Verticillium dahliae	73.85	0.00e+00	1874.00
IUUC-Vpa-130537	Vicugna pacos	48.83	0.00e+00	1205.00
IUUC-Vvi-130958	Vitis vinifera	56.17	0.00e+00	982.00
IUUC-Xtr-132857	Xenopus tropicalis	48.12	0.00e+00	1137.00
IUUC-Xma-133138	Xiphophorus maculatus	56.71	0.00e+00	998.00
IUUC-Yli-134399	Yarrowia lipolytica	60.16	0.00e+00	1077.00
IUUC-Zma-135612	Zea mays	46.50	0.00e+00	1134.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence