iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Sha-107103

Ensembl Protein ID

ENSSHAP00000001735.1

UniProt Accession

G3VEY1; G3VEY1_SARHA

Genbank Protein ID

ENSSHAP00000001735

Protein Name

Tyrosine-protein kinase

Genbank Nucleotide ID

AEFK01144782

Gene Name

FGR

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSSHAG00000001546.1	ENSSHAT00000001752.1	ENSSHAP00000001735.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/SH3	8.10e-14	51.5	84	139

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 6    vqvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvekle 63
           + +ly y+a + d+Lt++kG++ +++  ++++++W+++ +  +g+ G +P+n+v+ ++
   Q: 84   FVALYGYDARTADDLTFTKGEKFHIL--NNTEGDWWEARSLSSGRTGYIPSNYVAPVN 139
           789***********************..8999**********************9997 PP

Organism

Sarcophilus harrisii

Protein Sequence
(Fasta)

MGCMPCKEKA GSDAKLEALH EDIAKGGQGY GDRYSPEPTR VTSSSSSHVP SISHFSQQML 60
SGPSFLTPIS PKPGGIAGTG VTLFVALYGY DARTADDLTF TKGEKFHILN NTEGDWWEAR 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GGAGCTGGCC CTTCCCTTCA GACATGCTGC TGTTCCCCTG ACCTCAGGGG CTCCGGACCT 60
GAAGGTAAGT ATCTGTGTGA GTAAAGAGTG GGGGTGGGGG AGGAAGCGGA GGACACGGCC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0418--Kinase
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0728--SH3 domain
KW-0808--Transferase
KW-0829--Tyrosine-protein kinase

Interpro

IPR011009--Kinase-like_dom
IPR000719--Prot_kinase_dom
IPR017441--Protein_kinase_ATP_BS
IPR001245--Ser-Thr/Tyr_kinase_cat_dom
IPR000980--SH2
IPR001452--SH3_domain
IPR008266--Tyr_kinase_AS
IPR020635--Tyr_kinase_cat_dom

PROSITE

PS00107--PROTEIN_KINASE_ATP
PS50011--PROTEIN_KINASE_DOM
PS00109--PROTEIN_KINASE_TYR
PS50001--SH2
PS50002--SH3

Pfam

PF07714--Pkinase_Tyr
PF00017--SH2
PF00018--SH3_1

PRINTS

PR00401--SH2DOMAIN
PR00452--SH3DOMAIN
PR00109--TYRKINASE

SMART

SM00252--SH2
SM00326--SH3
SM00219--TyrKc

Gene Ontology

GO:0015629--C:actin cytoskeleton
GO:0016235--C:aggresome
GO:0070062--C:extracellular exosome
GO:0032587--C:ruffle membrane
GO:0005524--F:ATP binding
GO:0004715--F:non-membrane spanning protein tyrosine kinase activity
GO:0050830--P:defense response to Gram-positive bacterium
GO:0007229--P:integrin-mediated signaling pathway
GO:0030335--P:positive regulation of cell migration
GO:0050715--P:positive regulation of cytokine secretion
GO:0043306--P:positive regulation of mast cell degranulation
GO:0043552--P:positive regulation of phosphatidylinositol 3-kinase activity
GO:0014068--P:positive regulation of phosphatidylinositol 3-kinase signaling
GO:0046777--P:protein autophosphorylation
GO:0008360--P:regulation of cell shape
GO:0045088--P:regulation of innate immune response
GO:0050764--P:regulation of phagocytosis
GO:0045859--P:regulation of protein kinase activity

KEGG

shr:100918989

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001938	Ailuropoda melanoleuca	77.21	0.00e+00	836.00
IUUC-Bta-012607	Bos taurus	76.64	0.00e+00	822.00
IUUC-Cja-018914	Callithrix jacchus	74.82	0.00e+00	816.00
IUUC-Cfa-020165	Canis familiaris	74.95	0.00e+00	815.00
IUUC-Cpo-021476	Cavia porcellus	76.69	0.00e+00	805.00
IUUC-Csa-023692	Chlorocebus sabaeus	76.03	0.00e+00	821.00
IUUC-Dno-028920	Dasypus novemcinctus	75.28	0.00e+00	813.00
IUUC-Eca-033581	Equus caballus	77.44	0.00e+00	830.00
IUUC-Fca-036499	Felis catus	77.63	0.00e+00	830.00
IUUC-Ggo-044640	Gorilla gorilla	75.42	0.00e+00	815.00
IUUC-Hsa-046751	Homo sapiens	75.42	0.00e+00	815.00
IUUC-Itr-048218	Ictidomys tridecemlineatus	76.16	0.00e+00	841.00
IUUC-Laf-054128	Loxodonta africana	75.89	0.00e+00	822.00
IUUC-Mcc-054715	Macaca mulatta	75.84	0.00e+00	818.00
IUUC-Meu-056155	Macropus eugenii	90.27	0.00e+00	855.00
IUUC-Mmr-060615	Microcebus murinus	83.02	0.00e+00	829.00
IUUC-Mmu-063286	Mus musculus	75.75	0.00e+00	815.00
IUUC-Mpu-066641	Mustela putorius furo	77.43	0.00e+00	839.00
IUUC-Oan-073486	Ornithorhynchus anatinus	75.80	0.00e+00	828.00
IUUC-Ocu-074552	Oryctolagus cuniculus	76.82	0.00e+00	807.00
IUUC-Oga-088731	Otolemur garnettii	75.89	0.00e+00	827.00
IUUC-Oar-090207	Ovis aries	76.88	0.00e+00	826.00
IUUC-Ptr-090979	Pan troglodytes	75.42	0.00e+00	815.00
IUUC-Pan-092188	Papio anubis	76.03	0.00e+00	819.00
IUUC-Pfo-096519	Poecilia formosa	82.29	0.00e+00	807.00
IUUC-Pab-098617	Pongo abelii	75.23	0.00e+00	816.00
IUUC-Rno-104945	Rattus norvegicus	84.21	0.00e+00	813.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence