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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Sce-106132
UUCD1 version UUC-SaC-00117
Ensembl Protein ID YBR103W
UniProt Accession P38262; D6VQA2; SIF2_YEAST
Genbank Protein ID CAA55606.1; CAA85058.1; AAT93072.1; DAA07222.1
Protein Name SIR4-interacting protein SIF2
Genbank Nucleotide ID X78993; Z35972; AY693053; BK006936
Gene Name SIF2; EMB1; YBR103W; YBR0832
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
YBR103W YBR103W YBR103W
Annotation
mRNA Expression
GEOFFGED
Protein-protein Interaction
IIDiRefIndexHINTMentha
Protein 3D Structure
PDBMMDB
Post-translational Modifications (PTMs)
dbPAFdbPTMUniProtPHOSIDA
BioGRID
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
E3 adaptor/Cullin RING/DCX/DWD 7.10e-22 75.1 399 434
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/DCX/DWD
   S: 1    gHtdsvtclaf.sdtllvsGsdDgtikvWDlrtgvl 35
           gH+ s+ + ++  d+ ++s+s Dg++++W+l++++l
   Q: 399  GHSQSIVSASWvGDDKVISCSMDGSVRLWSLKQNTL 434
           8**********97799**************988765 PP
   
Organism Saccharomyces cerevisiae
Functional Description
(View)

Functional Description


     Homotetramer. Interacts with SIR4 N-terminal domain. Interacts with a complex composed of SIN3 and RPD3. Identified in the Set3C complex with HOS2, HST1, SNT1, CPR1, HOS4/YIL112W and SET3.
 Homotetramer. Interacts with SIR4 N-terminal domain. Interacts with a complex composed of SIN3 and RPD3. Identified in the Set3C complex with HOS2, HST1, SNT1, CPR1, HOS4/YIL112W and SET3.
Protein Sequence
(Fasta)
MSITSEELNY LIWRYCQEMG HEVSALALQD ETRVLEFDEK YKEHIPLGTL VNLVQRGILY 60
TESELMVDSK GDISALNEHH LSEDFNLVQA LQIDKEKFPE ISSEGRFTLE TNSESNKAGE 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Sce-106132|E3,WD_repeat|Saccharomyces cerevisiae
Please wait for a moment...
Nucleotide Sequence
(Fasta)
ATGAGTATAA CAAGTGAAGA ACTAAACTAC TTGATATGGA GGTATTGTCA AGAGATGGGA 60
CACGAGGTGA GTGCATTAGC ATTGCAGGAT GAAACAAGAG TATTGGAATT TGATGAGAAG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Sce-106132|E3,WD_repeat|Saccharomyces cerevisiae
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0156--Chromatin regulator
KW-0181--Complete proteome
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat
Interpro

IPR006594--LisH
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR017986--WD40_repeat_dom
PROSITE

PS50896--LISH
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION
Pfam

PF08513--LisH
PF00400--WD40
SMART

SM00667--LisH
SM00320--WD40
Gene Ontology

GO:0005634--C:nucleus
GO:0034967--C:Set3 complex
GO:0003714--F:transcription corepressor activity
GO:0016575--P:histone deacetylation
GO:0031939--P:negative regulation of chromatin silencing at telomere
GO:0045835--P:negative regulation of meiotic nuclear division
GO:0032874--P:positive regulation of stress-activated MAPK cascade
GO:0006357--P:regulation of transcription from RNA polymerase II promoter
GO:0006355--P:regulation of transcription, DNA-templated
KEGG sce:YBR103W
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001717 Ailuropoda melanoleuca 24.78 3.00e-40 157.00
IUUC-Atr-002514 Amborella trichopoda 25.99 8.00e-33 132.00
IUUC-Apl-003232 Anas platyrhynchos 24.30 7.00e-41 159.00
IUUC-Aca-004611 Anolis carolinensis 24.46 6.00e-42 163.00
IUUC-Aly-005622 Arabidopsis lyrata 25.55 4.00e-30 124.00
IUUC-Ath-007137 Arabidopsis thaliana 24.92 1.00e-29 122.00
IUUC-Ago-007869 Ashbya gossypii 46.83 1.00e-137 481.00
IUUC-Ame-011601 Astyanax mexicanus 23.30 6.00e-39 153.00
IUUC-Bta-012418 Bos taurus 24.42 3.00e-41 160.00
IUUC-Bdi-014315 Brachypodium distachyon 24.70 4.00e-29 120.00
IUUC-Cja-018832 Callithrix jacchus 24.78 7.00e-41 159.00
IUUC-Cfa-020029 Canis familiaris 24.96 7.00e-41 159.00
IUUC-Cpo-022080 Cavia porcellus 23.87 4.00e-37 147.00
IUUC-Csa-024075 Chlorocebus sabaeus 24.78 7.00e-41 159.00
IUUC-Cho-024872 Choloepus hoffmanni 29.79 3.00e-08 51.20
IUUC-Cin-025704 Ciona intestinalis 24.07 1.00e-40 158.00
IUUC-Csv-026257 Ciona savignyi 24.21 3.00e-40 157.00
IUUC-Cne-026946 Cryptococcus neoformans 23.05 1.00e-13 69.30
IUUC-Cme-027258 Cyanidioschyzon merolae 23.83 5.00e-35 140.00
IUUC-Dre-028075 Danio rerio 23.93 1.00e-39 155.00
IUUC-Dno-029196 Dasypus novemcinctus 24.42 1.00e-41 162.00
IUUC-Dor-030732 Dipodomys ordii 26.19 8.00e-33 132.00
IUUC-Dme-031939 Drosophila melanogaster 24.93 5.00e-30 124.00
IUUC-Ete-033150 Echinops telfairi 26.41 6.00e-30 123.00
IUUC-Eca-033897 Equus caballus 24.17 2.00e-40 157.00
IUUC-Eeu-034952 Erinaceus europaeus 25.90 1.00e-25 109.00
IUUC-Fca-035734 Felis catus 24.42 2.00e-41 161.00
IUUC-Fal-037185 Ficedula albicollis 24.29 5.00e-41 160.00
IUUC-Gmo-038870 Gadus morhua 23.88 1.00e-38 152.00
IUUC-Gga-041161 Gallus gallus 24.29 3.00e-41 160.00
IUUC-Gac-041770 Gasterosteus aculeatus 25.04 5.00e-42 163.00
IUUC-Gma-042796 Glycine max 25.67 2.00e-33 135.00
IUUC-Ggo-044882 Gorilla gorilla 24.78 7.00e-41 159.00
IUUC-Hsa-046488 Homo sapiens 24.78 7.00e-41 159.00
IUUC-Itr-047958 Ictidomys tridecemlineatus 25.98 3.00e-33 133.00
IUUC-Kpa-049338 Komagataella pastoris 32.85 3.00e-68 250.00
IUUC-Lch-050672 Latimeria chalumnae 24.56 4.00e-42 163.00
IUUC-Lpe-051084 Leersia perrieri 24.47 8.00e-29 119.00
IUUC-Loc-052030 Lepisosteus oculatus 23.36 5.00e-38 150.00
IUUC-Laf-054280 Loxodonta africana 24.24 7.00e-41 159.00
IUUC-Mcc-055203 Macaca mulatta 24.78 1.00e-40 159.00
IUUC-Meu-056563 Macropus eugenii 25.79 1.00e-24 105.00
IUUC-Mor-056992 Magnaporthe oryzae 23.73 2.00e-15 75.10
IUUC-Mtr-058624 Medicago truncatula 25.68 1.00e-28 119.00
IUUC-Mga-059660 Meleagris gallopavo 24.29 3.00e-41 160.00
IUUC-Mmr-061286 Microcebus murinus 24.31 2.00e-39 155.00
IUUC-Mdo-062200 Monodelphis domestica 24.20 4.00e-41 160.00
IUUC-Mmu-063603 Mus musculus 24.42 5.00e-42 163.00
IUUC-Mac-065508 Musa acuminata 30.39 2.00e-25 107.00
IUUC-Mpu-066741 Mustela putorius furo 24.96 7.00e-41 159.00
IUUC-Mlu-068152 Myotis lucifugus 24.42 2.00e-41 161.00
IUUC-Ncr-068945 Neurospora crassa 21.32 8.00e-11 60.10
IUUC-Nle-069229 Nomascus leucogenys 24.78 7.00e-41 159.00
IUUC-Opr-070277 Ochotona princeps 20.97 8.00e-22 96.30
IUUC-Ont-072252 Oreochromis niloticus 24.73 3.00e-43 167.00
IUUC-Oan-073562 Ornithorhynchus anatinus 23.96 8.00e-40 156.00
IUUC-Ocu-074280 Oryctolagus cuniculus 23.86 6.00e-41 159.00
IUUC-Oba-075618 Oryza barthii 24.54 1.00e-25 109.00
IUUC-Obr-076718 Oryza brachyantha 24.47 8.00e-29 119.00
IUUC-Ogl-077302 Oryza glaberrima 24.77 1.00e-29 122.00
IUUC-Ogu-078718 Oryza glumaepatula 24.77 1.00e-29 122.00
IUUC-Oin-079515 Oryza indica 28.65 2.00e-20 92.80
IUUC-Olo-080427 Oryza longistaminata 24.77 3.00e-29 121.00
IUUC-Ome-081696 Oryza meridionalis 24.77 3.00e-27 114.00
IUUC-Oni-082137 Oryza nivara 24.77 1.00e-29 122.00
IUUC-Opu-083505 Oryza punctata 24.85 4.00e-26 110.00
IUUC-Oru-085276 Oryza rufipogon 24.77 2.00e-29 121.00
IUUC-Osa-085791 Oryza sativa 24.77 1.00e-29 122.00
IUUC-Ola-087365 Oryzias latipes 23.84 1.00e-38 152.00
IUUC-Olu-087589 Ostreococcus lucimarinus 24.73 2.00e-39 155.00
IUUC-Oga-088357 Otolemur garnettii 24.10 3.00e-36 144.00
IUUC-Oar-089214 Ovis aries 24.42 1.00e-41 162.00
IUUC-Ptr-091532 Pan troglodytes 24.78 7.00e-41 159.00
IUUC-Pan-091927 Papio anubis 24.78 7.00e-41 159.00
IUUC-Psi-093941 Pelodiscus sinensis 24.39 3.00e-40 157.00
IUUC-Pma-094105 Petromyzon marinus 25.25 6.00e-21 92.40
IUUC-Ppa-095868 Physcomitrella patens 26.49 8.00e-31 126.00
IUUC-Pfo-096158 Poecilia formosa 23.84 1.00e-39 155.00
IUUC-Pab-098705 Pongo abelii 24.78 7.00e-41 159.00
IUUC-Pca-100256 Procavia capensis 25.40 1.00e-40 159.00
IUUC-Ppe-101572 Prunus persica 27.05 9.00e-29 119.00
IUUC-Pva-102616 Pteropus vampyrus 25.00 8.00e-42 162.00
IUUC-Rno-105411 Rattus norvegicus 24.42 4.00e-42 163.00
IUUC-Sha-107326 Sarcophilus harrisii 25.27 4.00e-44 170.00
IUUC-Sja-107844 Schizosaccharomyces japonicus 23.53 3.00e-19 87.80
IUUC-Spo-108242 Schizosaccharomyces pombe 23.17 3.00e-15 74.70
IUUC-Smo-109301 Selaginella moellendorffii 27.32 1.00e-32 132.00
IUUC-Sit-110710 Setaria italica 24.40 5.00e-32 130.00
IUUC-Sly-111042 Solanum lycopersicum 25.60 1.00e-41 162.00
IUUC-Stu-112786 Solanum tuberosum 23.96 5.00e-42 163.00
IUUC-Sar-112971 Sorex araneus 22.78 4.00e-31 127.00
IUUC-Sbi-114420 Sorghum bicolor 24.14 9.00e-31 126.00
IUUC-Sre-115175 Sporisorium reilianum 24.91 1.00e-19 89.70
IUUC-Ssc-115646 Sus scrofa 24.53 5.00e-40 157.00
IUUC-Tgu-117009 Taeniopygia guttata 24.32 7.00e-41 159.00
IUUC-Tru-118581 Takifugu rubripes 24.38 1.00e-39 155.00
IUUC-Tni-119656 Tetraodon nigroviridis 24.73 6.00e-41 159.00
IUUC-Tre-122052 Trichoderma reesei 26.85 7.00e-17 80.50
IUUC-Tae-125368 Triticum aestivum 24.77 2.00e-29 121.00
IUUC-Tur-126856 Triticum urartu 27.27 2.00e-15 75.10
IUUC-Tme-127126 Tuber melanosporum 22.78 7.00e-24 103.00
IUUC-Tbe-127665 Tupaia belangeri 25.71 2.00e-34 138.00
IUUC-Ttr-128826 Tursiops truncatus 24.56 7.00e-39 152.00
IUUC-Uma-129469 Ustilago maydis 26.05 2.00e-18 85.50
IUUC-Vpa-130768 Vicugna pacos 25.09 1.00e-40 158.00
IUUC-Vvi-131193 Vitis vinifera 25.08 7.00e-30 123.00
IUUC-Xtr-132842 Xenopus tropicalis 25.38 4.00e-29 120.00
IUUC-Xma-134168 Xiphophorus maculatus 24.29 2.00e-42 165.00
Created Date 25-Jun-2017

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