iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Ola-086981

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

BAAF04096775

Gene Name

HECW1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSORLG00000004224.1	ENSORLT00000005296.1	ENSORLP00000005295.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	1.20e-119	399.9	1220	1552

Active Site

Position(s)	Description	Evidence
1520	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 3    sdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlld 89
           + ++++l+v+f+gEegld++G++ref++ ls+el+np++glf+ys+nd++t+q++p s +  ++hl++F+f Gr+lg+al ++ lld
   Q: 1220 ELQRNKLYVTFLGEEGLDYSGPSREFFFFLSQELFNPYYGLFEYSANDTYTVQISPMSAFV-ENHLEWFRFSGRILGLALIHQYLLD 1305
           567899****************************************************985.6************************ PP
   S: 90   lplsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvkl 176
           ++++++fyk ll+ + +l+dle +d+e+++sl+++k+n   di+++ l+ltf+v+ee++g+++e+eLk+gG+n +Vt++Nk++Y+++
   Q: 1306 AFFTRPFYKALLRLPTDLSDLEYLDEEFHQSLQWMKDN---DITDI-LELTFTVNEEVFGQVTERELKSGGSNLQVTEKNKKDYIER 1388
           ************************************99...9***9.**************************************** PP
   S: 177  vveyrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerka 263
           ++++r+++g+ +q+ea+ +Gf+ev++ +l+s+F+++elel+i G+ eid++d++++t+y+ggy++ + +++wFw ++e+f++e+r +
   Q: 1389 MAKWRVERGVVQQTEALVRGFYEVVDSRLVSVFDARELELVIAGTVEIDLNDWRSNTEYRGGYHDGHIVMRWFWAAVERFNNEQRLR 1475
           *************************************************************************************** PP
   S: 264  fLqFvTgssrlPlgGfaelk....prlfvirkdasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFels 336
           +LqFvTg+s++P +Gfa+l+     r+f+i+k+++ + lP+++TCfn+L+LP+Y+s++il++kLl+A+eet+ F+l+
   Q: 1476 LLQFVTGTSSVPYEGFAALRgsngLRRFCIEKWGKVTALPRAHTCFNRLDLPPYPSYTILYDKLLIAVEETSTFGLE 1552
           ************************999***********************************************985 PP

Organism

Oryzias latipes

Protein Sequence
(Fasta)

VIMLMQLCSF KNLYQNRLLS LATMASPTRS GPTRQRCKDA VRHSYGAETY AVNGLNQEAF 60
VLGLSRSTSD TDLVSPDARS TLTVSTSHYT IGQSEDLVIS WDIKEEVDAG DWIGMYQVDE 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GTCATTATGC TGATGCAGCT CTGTAGTTTC AAGGTCAGTG CCCCCACTTC CCTGCTGTCC 60
AACCGTCTCC ATTCCCATTT CAACCCATAC AGCATGGTCA AAAATACATA GAACCTTAAA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000008--C2_dom
IPR000569--HECT_dom
IPR032348--HECW_N
IPR001202--WW_dom

PROSITE

PS50004--C2
PS50237--HECT
PS01159--WW_DOMAIN_1
PS50020--WW_DOMAIN_2

Pfam

PF00168--C2
PF00632--HECT
PF16562--HECW_N
PF00397--WW

SMART

SM00239--C2
SM00119--HECTc
SM00456--WW

Gene Ontology

GO:0004842--F:ubiquitin-protein transferase activity

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001636	Ailuropoda melanoleuca	73.00	0.00e+00	1415.00
IUUC-Apl-003299	Anas platyrhynchos	73.09	0.00e+00	1450.00
IUUC-Aca-005024	Anolis carolinensis	73.47	0.00e+00	1464.00
IUUC-Bta-012604	Bos taurus	66.05	0.00e+00	1924.00
IUUC-Cja-019880	Callithrix jacchus	63.52	0.00e+00	1625.00
IUUC-Cfa-021216	Canis familiaris	79.47	0.00e+00	1387.00
IUUC-Cpo-021466	Cavia porcellus	79.60	0.00e+00	1387.00
IUUC-Csa-023080	Chlorocebus sabaeus	67.24	0.00e+00	1955.00
IUUC-Cho-024740	Choloepus hoffmanni	84.28	0.00e+00	1041.00
IUUC-Dre-028750	Danio rerio	70.04	0.00e+00	1447.00
IUUC-Dno-030019	Dasypus novemcinctus	66.00	0.00e+00	1917.00
IUUC-Ete-032352	Echinops telfairi	84.77	0.00e+00	1142.00
IUUC-Eca-033948	Equus caballus	69.36	0.00e+00	1425.00
IUUC-Eeu-034474	Erinaceus europaeus	64.15	0.00e+00	766.00
IUUC-Fca-036148	Felis catus	73.33	0.00e+00	1435.00
IUUC-Fal-036957	Ficedula albicollis	73.19	0.00e+00	1468.00
IUUC-Gmo-038714	Gadus morhua	67.38	0.00e+00	1113.00
IUUC-Gga-041194	Gallus gallus	72.47	0.00e+00	1465.00
IUUC-Gac-041366	Gasterosteus aculeatus	77.11	0.00e+00	2309.00
IUUC-Ggo-045442	Gorilla gorilla	60.37	0.00e+00	1452.00
IUUC-Hsa-045730	Homo sapiens	67.00	0.00e+00	1949.00
IUUC-Itr-048439	Ictidomys tridecemlineatus	66.48	0.00e+00	1962.00
IUUC-Lch-050185	Latimeria chalumnae	68.48	0.00e+00	1229.00
IUUC-Loc-052744	Lepisosteus oculatus	68.02	0.00e+00	1980.00
IUUC-Laf-054368	Loxodonta africana	84.30	0.00e+00	1297.00
IUUC-Mcc-055487	Macaca mulatta	66.81	0.00e+00	1934.00
IUUC-Meu-056751	Macropus eugenii	86.88	0.00e+00	701.00
IUUC-Mga-059545	Meleagris gallopavo	72.47	0.00e+00	1468.00
IUUC-Mmr-061078	Microcebus murinus	71.22	0.00e+00	1394.00
IUUC-Mdo-062176	Monodelphis domestica	71.84	0.00e+00	1400.00
IUUC-Mmu-063513	Mus musculus	78.16	0.00e+00	1358.00
IUUC-Mpu-065786	Mustela putorius furo	73.99	0.00e+00	1458.00
IUUC-Mlu-067780	Myotis lucifugus	66.76	0.00e+00	1258.00
IUUC-Nle-069213	Nomascus leucogenys	73.13	0.00e+00	1462.00
IUUC-Opr-070208	Ochotona princeps	83.80	0.00e+00	1285.00
IUUC-Ont-072132	Oreochromis niloticus	79.71	0.00e+00	1673.00
IUUC-Oan-072807	Ornithorhynchus anatinus	79.65	0.00e+00	1379.00
IUUC-Ocu-074745	Oryctolagus cuniculus	72.12	0.00e+00	1457.00
IUUC-Oga-087965	Otolemur garnettii	72.48	0.00e+00	1426.00
IUUC-Oar-089749	Ovis aries	71.40	0.00e+00	1443.00
IUUC-Ptr-091243	Pan troglodytes	67.06	0.00e+00	1951.00
IUUC-Pan-092201	Papio anubis	67.41	0.00e+00	1924.00
IUUC-Psi-093511	Pelodiscus sinensis	78.54	0.00e+00	1372.00
IUUC-Pfo-097001	Poecilia formosa	76.62	0.00e+00	1868.00
IUUC-Pab-098728	Pongo abelii	65.29	0.00e+00	1854.00
IUUC-Pca-100129	Procavia capensis	67.56	0.00e+00	1018.00
IUUC-Pva-102250	Pteropus vampyrus	59.82	0.00e+00	1589.00
IUUC-Rno-105031	Rattus norvegicus	78.69	0.00e+00	1362.00
IUUC-Tgu-117515	Taeniopygia guttata	72.32	0.00e+00	1463.00
IUUC-Tru-117914	Takifugu rubripes	85.58	0.00e+00	1537.00
IUUC-Tsy-119379	Tarsius syrichta	83.94	2.00e-178	620.00
IUUC-Tni-120178	Tetraodon nigroviridis	78.07	0.00e+00	1686.00
IUUC-Tbe-127762	Tupaia belangeri	69.08	0.00e+00	1324.00
IUUC-Ttr-128806	Tursiops truncatus	78.52	0.00e+00	1361.00
IUUC-Xtr-132903	Xenopus tropicalis	78.79	0.00e+00	1400.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence