iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMUSG00000000561.14	ENSMUST00000128005.1	ENSMUSP00000122465.1
ENSMUSG00000000561.14	ENSMUST00000130994.7	ENSMUSP00000120517.1
ENSMUSG00000000561.14	ENSMUST00000010278.11	ENSMUSP00000010278.5

Annotation

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	GXD
DNA & RNA Element
microRNA	TRANSFAC	RepTar	RAID2
Protein-protein Interaction
IID	Mentha
Post-translational Modifications (PTMs)
dbPAF	PhosphositePlus	dbPTM	UniProt
PHOSIDA
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	5.70e-15	55.9	124	160

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 2    Htdsvtclaf.sd.tllvsGsdDgtikvWDlrtgvll 36
           H d v+ +   s+ t  vsGs D+ ik+WDl ++v+l
   Q: 124  HDDIVSTVTVlSSgTQAVSGSKDCCIKIWDLAQQVSL 160
           88999999977555*****************999876 PP

Organism

Mus musculus

Functional Description
(View)

Non-catalytic component of the 20S PRMT5-containing methyltransferase complex, which modifies specific arginines to dimethylarginines in several spliceosomal Sm proteins and histones. This modification targets Sm proteins to the survival of motor neurons (SMN) complex for assembly into small nuclear ribonucleoprotein core particles. Might play a role in transcription regulation (By similarity). The 20S PRMT5-containing methyltransferase complex also methylates the Piwi proteins (PIWIL1, PIWIL2 and PIWIL4), methylation of Piwi proteins being required for the interaction with Tudor domain-containing proteins and subsequent localization to the meiotic nuage.

Protein Sequence
(Fasta)

MRKDTPPPLV PPAAREWNLP PNAPACMERQ LEAARYRSDG SLLLGVSSLS GRCWVGSLWF 60
FKDPSAAPNE GFCSAGVQTE AGVADLTWVG DKGILVASDS GAVELWELDE NETLIVSKFC 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GGTGGGGCTG AGGGAGGGAA ACAAACAAAA TCCCGCTGCG GGGACAGGAG ACGGAAAAGC 60
AGGCTGGAAG GGTAGACACA ATTCTCGCGA GAAGTAGAGC GAATTCCCTC GGAGAGGGGC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat

Interpro

IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF00400--WD40

SMART

SM00320--WD40

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0005794--C:Golgi apparatus
GO:0034709--C:methylosome
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0030374--F:ligand-dependent nuclear receptor transcription coactivator activity
GO:0008327--F:methyl-CpG binding
GO:0008285--P:negative regulation of cell proliferation
GO:0060770--P:negative regulation of epithelial cell proliferation involved in prostate gland development
GO:0008284--P:positive regulation of cell proliferation
GO:0006357--P:regulation of transcription from RNA polymerase II promoter
GO:0060528--P:secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development

KEGG

mmu:70465

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002192	Ailuropoda melanoleuca	87.46	1.00e-171	595.00
IUUC-Apl-003921	Anas platyrhynchos	60.32	2.00e-64	238.00
IUUC-Aca-004870	Anolis carolinensis	69.31	4.00e-121	427.00
IUUC-Ame-011872	Astyanax mexicanus	46.67	2.00e-37	148.00
IUUC-Bta-013325	Bos taurus	88.60	4.00e-175	607.00
IUUC-Cja-019059	Callithrix jacchus	90.06	7.00e-176	609.00
IUUC-Cfa-021036	Canis familiaris	87.63	2.00e-150	525.00
IUUC-Cpo-022369	Cavia porcellus	89.47	2.00e-176	611.00
IUUC-Csa-023585	Chlorocebus sabaeus	90.35	1.00e-176	612.00
IUUC-Cho-024470	Choloepus hoffmanni	80.91	8.00e-111	392.00
IUUC-Dno-029867	Dasypus novemcinctus	85.67	1.00e-169	588.00
IUUC-Dor-030834	Dipodomys ordii	65.01	3.00e-113	401.00
IUUC-Ete-032245	Echinops telfairi	81.79	5.00e-137	480.00
IUUC-Eca-033360	Equus caballus	88.30	2.00e-167	581.00
IUUC-Eeu-035353	Erinaceus europaeus	88.01	3.00e-172	597.00
IUUC-Fca-036277	Felis catus	88.89	2.00e-174	604.00
IUUC-Fal-037383	Ficedula albicollis	66.02	7.00e-103	366.00
IUUC-Gmo-038575	Gadus morhua	55.21	3.00e-98	351.00
IUUC-Gga-040658	Gallus gallus	66.87	1.00e-126	446.00
IUUC-Gac-041463	Gasterosteus aculeatus	50.76	4.00e-84	304.00
IUUC-Ggo-045120	Gorilla gorilla	88.89	4.00e-175	607.00
IUUC-Hsa-046247	Homo sapiens	89.77	6.00e-176	609.00
IUUC-Itr-048292	Ictidomys tridecemlineatus	90.35	1.00e-172	598.00
IUUC-Lch-049741	Latimeria chalumnae	64.44	6.00e-112	397.00
IUUC-Loc-052695	Lepisosteus oculatus	56.89	3.00e-103	368.00
IUUC-Laf-054535	Loxodonta africana	87.36	2.00e-172	598.00
IUUC-Mcc-054699	Macaca mulatta	90.35	1.00e-176	612.00
IUUC-Meu-056053	Macropus eugenii	75.44	3.00e-136	477.00
IUUC-Mga-059672	Meleagris gallopavo	61.86	3.00e-70	257.00
IUUC-Mmr-060963	Microcebus murinus	90.06	4.00e-178	617.00
IUUC-Mdo-062694	Monodelphis domestica	72.01	1.00e-128	452.00
IUUC-Mpu-066408	Mustela putorius furo	88.30	4.00e-174	603.00
IUUC-Mlu-068184	Myotis lucifugus	87.17	4.00e-170	590.00
IUUC-Nle-069251	Nomascus leucogenys	89.77	3.00e-176	610.00
IUUC-Opr-071156	Ochotona princeps	83.33	1.00e-161	562.00
IUUC-Ont-072683	Oreochromis niloticus	55.14	2.00e-94	338.00
IUUC-Oan-073042	Ornithorhynchus anatinus	74.31	1.00e-125	442.00
IUUC-Ocu-074843	Oryctolagus cuniculus	90.38	4.00e-172	597.00
IUUC-Ola-086929	Oryzias latipes	52.01	5.00e-88	317.00
IUUC-Oga-088237	Otolemur garnettii	89.47	1.00e-176	612.00
IUUC-Oar-089312	Ovis aries	88.29	2.00e-159	554.00
IUUC-Ptr-091625	Pan troglodytes	89.18	2.00e-175	608.00
IUUC-Pan-091902	Papio anubis	85.76	4.00e-165	573.00
IUUC-Psi-094035	Pelodiscus sinensis	69.83	1.00e-123	436.00
IUUC-Pma-094565	Petromyzon marinus	61.88	1.00e-50	192.00
IUUC-Pfo-097070	Poecilia formosa	53.21	5.00e-91	327.00
IUUC-Pab-098007	Pongo abelii	89.77	2.00e-176	611.00
IUUC-Pca-100513	Procavia capensis	70.30	2.00e-98	351.00
IUUC-Pva-102821	Pteropus vampyrus	83.04	1.00e-158	552.00
IUUC-Rno-105836	Rattus norvegicus	93.39	0.00e+00	637.00
IUUC-Sha-106847	Sarcophilus harrisii	69.51	7.00e-88	317.00
IUUC-Sar-113451	Sorex araneus	81.34	7.00e-161	559.00
IUUC-Ssc-115978	Sus scrofa	87.43	4.00e-168	583.00
IUUC-Tgu-116745	Taeniopygia guttata	66.81	9.00e-94	335.00
IUUC-Tru-117945	Takifugu rubripes	52.81	1.00e-79	290.00
IUUC-Tsy-119059	Tarsius syrichta	87.01	4.00e-88	316.00
IUUC-Tni-120414	Tetraodon nigroviridis	53.56	5.00e-94	337.00
IUUC-Tbe-127559	Tupaia belangeri	91.81	7.00e-180	622.00
IUUC-Ttr-128505	Tursiops truncatus	88.01	1.00e-170	592.00
IUUC-Vpa-130350	Vicugna pacos	89.56	1.00e-96	344.00
IUUC-Xtr-132939	Xenopus tropicalis	59.12	2.00e-107	382.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence