iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMUSG00000000804.14	ENSMUST00000108075.8	ENSMUSP00000103710.2
ENSMUSG00000000804.14	ENSMUST00000000821.14	ENSMUSP00000000821.8
ENSMUSG00000000804.14	ENSMUST00000173156.1	ENSMUSP00000133531.1
ENSMUSG00000000804.14	ENSMUST00000174602.1	ENSMUSP00000134476.1
ENSMUSG00000000804.14	ENSMUST00000172515.1	ENSMUSP00000133781.1

Annotation

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	GXD
DNA & RNA Element
AREsite	circBase	miRTarBase	microRNA
TRANSFAC	RepTar	RAID2
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	PHOSIDA
mUbiSiDa
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	8.80e-107	358.3	734	1567

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrellle.kkkeklneenpkepkgellkslqklfeelwkskkkavsprellkalkkeaeefsg 86
           tGl+NlgNtC+mNS +Qc sn+++l++++ + ++  +ln++np ++kg+++k++ +l++elw++++k+v+p +l  +++k+a++f+g
   Q: 734  TGLSNLGNTCFMNSSIQCVSNTQPLTQYFISgRHLYELNRTNPIGMKGHMAKCYGDLVQELWSGTQKNVAPLKLRWTIAKYAPRFNG 820
           7******************************9******************************************************* PP
   S: 87   yeqqDaqEflaflldqleeelkkeknkpkeeeeeedkselsde.....aeekkkkknkslisdlFqgqlksqikclecdnvssreep 168
           ++qqD+qE+laflld+l+e+l++ ++kp+ e++++d   ++d+     a++++ ++n+s+++dlF+gql+sq+kc++c+++s+r++p
   Q: 821  FQQQDSQELLAFLLDGLHEDLNRVHEKPYVELKDSD--GRPDWevaaeAWDNHLRRNRSIVVDLFHGQLRSQVKCKTCGHISVRFDP 905
           ********************************9999..6666666777*************************************** PP
   S: 169  fldlslpvpgkeetkke...................................................................... 185
           f+ lslp+p+++ +++e                                                                      
   Q: 906  FNFLSLPLPMDSYMHLEitvikldgttpiryglrlnmdekytglkkqlsdlcglkseqilfaevhssniknfpqdnqkvrlsvsgfl 992
           *************9999********************************************************************** PP
   S: 186  ....................................................................................... 185
                                                                                                  
   Q: 993  cafeipipaspvsacspiqtdcssspstnglftlttngdlprpifipngmpntvvpcgteknvtngivnghmpplpddpftgyiiav 1079
           *************************************************************************************** PP
   S: 186  ....................................................................................... 185
                                                                                                  
   Q: 1080 hrkmmrtelyflssqknrpslfgmplivpctvhtrkkdlydavwiqvsrlasplppqeasnhaqdcddsmgyqypftlrvvqkdgns 1166
           *************************************************************************************** PP
   S: 186  ...................................................................slqdcLesftkeeelegenk 205
                                                                              +l++cL++ft+eeel ++++
   Q: 1167 cawcpwyrfcrgckidcgedrafignaciavdwdptalhlryqtsqervveehesveqsrraqaepiNLDSCLRAFTSEEELGENEM 1253
           *************************************************************************************** PP
   S: 206  yycekckkkqeaekklklkklPevLilhLkRfsfseeqksrekinkkvefple.Ldlspfcts........................ 267
           yyc+kck ++ a+kkl+l++lP++Li+hLkRf+f +   + +k +k v+fp+e +d s f++                         
   Q: 1254 YYCSKCKTHCLATKKLDLWRLPPILIIHLKRFQFVNG--RWIKSQKIVKFPREsFDPSAFLVPrdptlcqhkpltpqgddfselrip 1338
           ********************************99775..5569******************99999999999999999999999999 PP
   S: 268  ....................................................................................... 267
                                                                                                  
   Q: 1339 agdvkkvdiqssageedvllskspsslsanvtsspkgspsssrksgascpssknsspnssprtlgrnkgrlrlpqigsknklsnske 1425
           999999999999999999999999999999999999998888888888888888888888877777777777777777777777777 PP
   S: 268  ..........................................................................peekqke.....k 275
                                                                                     +     +     k
   Q: 1426 nldtskengagqiceladtlnrrhvlggsqpelvtpldheitlangflyeheacgngysngqlgnhseedstddQ-----ReethsK 1507
           766666666666666666666666666666666666666666666666666666666666666666555555542.....055555* PP
   S: 276  kkYeLiavvvHsGslssGHYvayvknekgkWllfdDskVtevkeeevleetgstaYvlfYkrr 338
            +Y+L+a+ +HsG l++GHYv+y+kn + kW++++Ds+++e++ +e+ +   ++aY+lfY+++
   Q: 1508 PIYNLYAISCHSGILGGGHYVTYAKNPNCKWYCYNDSSCKELHPDEIDT---DSAYILFYEQQ 1567
           *************************************************...********985 PP

Organism

Mus musculus

Protein Sequence
(Fasta)

MGAKESRIGF LSYEEALRRV TDVELKRLKD AFKRTCGLSY YMSQHCFIRE VLGDGVPPKV 60
AEVIYCSFGG TSKGLHFNNL IVGLVLLTRG KDEEKAKYIF SLFSSESGSY VVREEMERML 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GGGGTGGGGC GGAGCGTGGC CCCCCGGCGG CCATTACCCG GAACCGTCCC GGGCCTTGGG 60
TCAGGTGACC CGCGGCGGTG CTGGCGGGAG GGCGGGGTGG GGGCGGAAGG GAGGAGAGGA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0106--Calcium
KW-0181--Complete proteome
KW-1267--Proteomics identification
KW-1185--Reference proteome

Interpro

IPR011992--EF-hand-dom_pair
IPR018247--EF_Hand_1_Ca_BS
IPR002048--EF_hand_dom
IPR006615--Pept_C19_DUSP
IPR001394--Peptidase_C19_UCH
IPR028135--Ub_USP-typ
IPR018200--USP_CS
IPR028889--USP_dom

PROSITE

PS51283--DUSP
PS00018--EF_HAND_1
PS50222--EF_HAND_2
PS00972--USP_1
PS00973--USP_2
PS50235--USP_3

Pfam

PF06337--DUSP
PF13202--EF-hand_5
PF14836--Ubiquitin_3
PF00443--UCH

SMART

SM00695--DUSP
SM00054--EFh

Gene Ontology

GO:0005829--C:cytosol
GO:0005794--C:Golgi apparatus
GO:0005509--F:calcium ion binding
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0016579--P:protein deubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

mmu:237898

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001611	Ailuropoda melanoleuca	94.60	0.00e+00	2568.00
IUUC-Apl-003272	Anas platyrhynchos	83.24	0.00e+00	2638.00
IUUC-Aca-005057	Anolis carolinensis	83.44	0.00e+00	2295.00
IUUC-Ame-010781	Astyanax mexicanus	81.12	0.00e+00	2186.00
IUUC-Bta-013502	Bos taurus	90.86	0.00e+00	2767.00
IUUC-Cja-018754	Callithrix jacchus	95.14	0.00e+00	3042.00
IUUC-Cfa-020526	Canis familiaris	94.95	0.00e+00	2989.00
IUUC-Cpo-021568	Cavia porcellus	90.43	0.00e+00	2733.00
IUUC-Csa-023143	Chlorocebus sabaeus	95.32	0.00e+00	3009.00
IUUC-Cho-024603	Choloepus hoffmanni	61.00	0.00e+00	683.00
IUUC-Cin-025583	Ciona intestinalis	54.61	0.00e+00	860.00
IUUC-Csv-026344	Ciona savignyi	47.20	0.00e+00	1162.00
IUUC-Dre-028121	Danio rerio	75.25	0.00e+00	2353.00
IUUC-Dno-029911	Dasypus novemcinctus	93.81	0.00e+00	2932.00
IUUC-Dor-030608	Dipodomys ordii	59.96	0.00e+00	1096.00
IUUC-Dme-032094	Drosophila melanogaster	45.21	2.00e-123	437.00
IUUC-Ete-032639	Echinops telfairi	91.89	0.00e+00	1550.00
IUUC-Eca-034253	Equus caballus	94.69	0.00e+00	2954.00
IUUC-Eeu-035084	Erinaceus europaeus	79.94	0.00e+00	1570.00
IUUC-Fca-035474	Felis catus	93.99	0.00e+00	2434.00
IUUC-Fal-036985	Ficedula albicollis	84.11	0.00e+00	2591.00
IUUC-Gmo-039568	Gadus morhua	80.45	0.00e+00	2110.00
IUUC-Gga-040509	Gallus gallus	83.25	0.00e+00	2725.00
IUUC-Gac-041757	Gasterosteus aculeatus	80.41	0.00e+00	2163.00
IUUC-Ggo-044956	Gorilla gorilla	87.61	0.00e+00	1828.00
IUUC-Hsa-046107	Homo sapiens	95.76	0.00e+00	3046.00
IUUC-Itr-048865	Ictidomys tridecemlineatus	93.36	0.00e+00	1160.00
IUUC-Lch-050681	Latimeria chalumnae	77.53	0.00e+00	2377.00
IUUC-Loc-052474	Lepisosteus oculatus	77.63	0.00e+00	2466.00
IUUC-Laf-054273	Loxodonta africana	94.02	0.00e+00	2993.00
IUUC-Mcc-054718	Macaca mulatta	95.20	0.00e+00	3031.00
IUUC-Meu-056558	Macropus eugenii	71.94	0.00e+00	1394.00
IUUC-Mga-059892	Meleagris gallopavo	85.89	0.00e+00	2644.00
IUUC-Mmr-060866	Microcebus murinus	94.62	0.00e+00	3057.00
IUUC-Mdo-062607	Monodelphis domestica	91.03	0.00e+00	2913.00
IUUC-Mpu-066121	Mustela putorius furo	95.45	0.00e+00	3051.00
IUUC-Mlu-067581	Myotis lucifugus	93.40	0.00e+00	2998.00
IUUC-Nle-069916	Nomascus leucogenys	93.06	0.00e+00	2905.00
IUUC-Opr-071073	Ochotona princeps	84.14	0.00e+00	1185.00
IUUC-Ont-071310	Oreochromis niloticus	79.07	0.00e+00	2152.00
IUUC-Oan-073356	Ornithorhynchus anatinus	88.73	0.00e+00	2828.00
IUUC-Ocu-074216	Oryctolagus cuniculus	95.26	0.00e+00	3032.00
IUUC-Ola-087434	Oryzias latipes	79.00	0.00e+00	2081.00
IUUC-Oga-089034	Otolemur garnettii	93.67	0.00e+00	2916.00
IUUC-Oar-090369	Ovis aries	94.82	0.00e+00	2987.00
IUUC-Ptr-090605	Pan troglodytes	95.70	0.00e+00	3046.00
IUUC-Pan-092381	Papio anubis	95.08	0.00e+00	2950.00
IUUC-Psi-093819	Pelodiscus sinensis	86.31	0.00e+00	2724.00
IUUC-Pma-094480	Petromyzon marinus	63.64	0.00e+00	1469.00
IUUC-Pfo-096561	Poecilia formosa	80.38	0.00e+00	2121.00
IUUC-Pab-097643	Pongo abelii	92.89	0.00e+00	2926.00
IUUC-Pca-100944	Procavia capensis	76.76	0.00e+00	1007.00
IUUC-Pva-102732	Pteropus vampyrus	84.79	0.00e+00	2634.00
IUUC-Rno-105113	Rattus norvegicus	98.68	0.00e+00	3128.00
IUUC-Sha-107608	Sarcophilus harrisii	80.82	3.00e-163	567.00
IUUC-Sar-113201	Sorex araneus	82.49	0.00e+00	1662.00
IUUC-Ssc-115469	Sus scrofa	91.77	0.00e+00	632.00
IUUC-Tgu-117322	Taeniopygia guttata	85.50	0.00e+00	2735.00
IUUC-Tru-118705	Takifugu rubripes	59.69	0.00e+00	884.00
IUUC-Tsy-119433	Tarsius syrichta	80.83	0.00e+00	2090.00
IUUC-Tni-120631	Tetraodon nigroviridis	78.50	0.00e+00	2076.00
IUUC-Tbe-127553	Tupaia belangeri	88.80	0.00e+00	691.00
IUUC-Ttr-128260	Tursiops truncatus	93.50	0.00e+00	2980.00
IUUC-Vpa-130479	Vicugna pacos	89.84	0.00e+00	2794.00
IUUC-Xtr-132686	Xenopus tropicalis	82.52	0.00e+00	2585.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence