iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress
DNA & RNA Element
TRANSFAC	RAID2
Protein-protein Interaction
IID
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/PHD	4.00e-12	46.5	1182	1229

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/PHD

   S: 2    kvClvCgeggedekslveCekCrewfHpaClklsveeelpnsekwiCpkCr 52
           + C+vC+++ged+ +l+ C++C+++fH  Cl ++   e+p+ e w Cp C+
   Q: 1182 ARCKVCRKKGEDD-KLILCDECNKAFHLFCLRPA-LYEVPDGE-WQCPACQ 1229
           57*********98.6*******************.*******8.******6 PP

Organism

Rattus norvegicus

Protein Sequence
(Fasta)

MAPLLGRKPF PLVKPLPGEE PLFTIPHTQE AFRTREEYEA RLERYSERIW TCKSTGSSQL 60
THKEAWEEEQ EVAELLKEEF PNWYEKLVLE MVHHNTASLE KLVDSAWLEI MTKYAVGEEC 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GTGAGTGCCC GGATGTCGGT GTCGCCGTCG GTGACAGATG GCGCAATGTC TGTATCTATG 60
ACAGGGCTTT CTGCTCTGAC CTCTTTGAGT CTTCCGCTTT TCGTCCTCCC CCTCCCACTT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0103--Bromodomain
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0479--Metal-binding
KW-0539--Nucleus
KW-1267--Proteomics identification
KW-1185--Reference proteome
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR011989--ARM-like
IPR001487--Bromodomain
IPR018359--Bromodomain_CS
IPR018501--DDT_dom
IPR028942--WHIM1_dom
IPR028941--WHIM2_dom
IPR013136--WSTF_Acf1_Cbp146
IPR019786--Zinc_finger_PHD-type_CS
IPR011011--Znf_FYVE_PHD
IPR001965--Znf_PHD
IPR019787--Znf_PHD-finger
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS00633--BROMODOMAIN_1
PS50014--BROMODOMAIN_2
PS50827--DDT
PS51136--WAC
PS01359--ZF_PHD_1
PS50016--ZF_PHD_2
PS50089--ZF_RING_2

Pfam

PF00439--Bromodomain
PF00628--PHD
PF10537--WAC_Acf1_DNA_bd
PF15612--WHIM1
PF15613--WSD

PRINTS

PR00503--BROMODOMAIN

SMART

SM00297--BROMO
SM00571--DDT
SM00249--PHD

Gene Ontology

GO:0000793--C:condensed chromosome
GO:0016604--C:nuclear body
GO:0043596--C:nuclear replication fork
GO:0005721--C:pericentric heterochromatin
GO:0003682--F:chromatin binding
GO:0035173--F:histone kinase activity
GO:0004713--F:protein tyrosine kinase activity
GO:0071884--F:vitamin D receptor activator activity
GO:0008270--F:zinc ion binding
GO:0006333--P:chromatin assembly or disassembly
GO:0048096--P:chromatin-mediated maintenance of transcription
GO:0006302--P:double-strand break repair
GO:0003007--P:heart morphogenesis

KEGG

rno:368002

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002113	Ailuropoda melanoleuca	91.16	0.00e+00	2292.00
IUUC-Apl-003454	Anas platyrhynchos	78.71	0.00e+00	2102.00
IUUC-Ame-011469	Astyanax mexicanus	61.81	0.00e+00	1256.00
IUUC-Bta-012408	Bos taurus	90.70	0.00e+00	2381.00
IUUC-Cja-019194	Callithrix jacchus	90.03	0.00e+00	2363.00
IUUC-Cfa-021083	Canis familiaris	90.72	0.00e+00	2370.00
IUUC-Cpo-021422	Cavia porcellus	89.99	0.00e+00	2254.00
IUUC-Csa-023848	Chlorocebus sabaeus	91.71	0.00e+00	2417.00
IUUC-Dre-027895	Danio rerio	61.66	0.00e+00	1291.00
IUUC-Dno-029686	Dasypus novemcinctus	89.87	0.00e+00	2369.00
IUUC-Dor-030625	Dipodomys ordii	80.22	0.00e+00	1257.00
IUUC-Ete-032702	Echinops telfairi	90.05	0.00e+00	971.00
IUUC-Eca-033647	Equus caballus	91.44	0.00e+00	2353.00
IUUC-Eeu-034626	Erinaceus europaeus	85.05	0.00e+00	1930.00
IUUC-Fca-036092	Felis catus	90.78	0.00e+00	1962.00
IUUC-Fal-037127	Ficedula albicollis	78.13	0.00e+00	2103.00
IUUC-Gmo-039455	Gadus morhua	58.01	0.00e+00	1390.00
IUUC-Gga-041120	Gallus gallus	78.31	0.00e+00	2040.00
IUUC-Gac-041873	Gasterosteus aculeatus	58.83	0.00e+00	1431.00
IUUC-Ggo-045317	Gorilla gorilla	91.51	0.00e+00	2343.00
IUUC-Hsa-046773	Homo sapiens	91.58	0.00e+00	2403.00
IUUC-Itr-049026	Ictidomys tridecemlineatus	90.26	0.00e+00	2302.00
IUUC-Lch-050271	Latimeria chalumnae	68.65	0.00e+00	1608.00
IUUC-Loc-052699	Lepisosteus oculatus	63.76	0.00e+00	988.00
IUUC-Mcc-055171	Macaca mulatta	91.71	0.00e+00	2417.00
IUUC-Meu-055990	Macropus eugenii	82.31	0.00e+00	1930.00
IUUC-Mga-059913	Meleagris gallopavo	77.79	0.00e+00	1942.00
IUUC-Mmr-061681	Microcebus murinus	92.05	0.00e+00	2397.00
IUUC-Mdo-062486	Monodelphis domestica	84.59	0.00e+00	2157.00
IUUC-Mmu-063460	Mus musculus	97.57	0.00e+00	2427.00
IUUC-Mpu-066324	Mustela putorius furo	88.93	0.00e+00	1224.00
IUUC-Mlu-067334	Myotis lucifugus	90.37	0.00e+00	2427.00
IUUC-Nle-069983	Nomascus leucogenys	91.58	0.00e+00	2437.00
IUUC-Opr-070678	Ochotona princeps	79.13	0.00e+00	719.00
IUUC-Ont-071565	Oreochromis niloticus	59.50	0.00e+00	1362.00
IUUC-Ocu-074779	Oryctolagus cuniculus	89.18	0.00e+00	2277.00
IUUC-Obr-076214	Oryza brachyantha	35.45	1.00e-12	70.10
IUUC-Oin-079864	Oryza indica	35.04	2.00e-11	65.90
IUUC-Ola-086746	Oryzias latipes	59.96	0.00e+00	1336.00
IUUC-Oga-088475	Otolemur garnettii	88.16	0.00e+00	2314.00
IUUC-Oar-090191	Ovis aries	88.93	0.00e+00	2277.00
IUUC-Ptr-090963	Pan troglodytes	91.85	0.00e+00	2390.00
IUUC-Pan-091819	Papio anubis	90.47	0.00e+00	1863.00
IUUC-Psi-093967	Pelodiscus sinensis	80.03	0.00e+00	1979.00
IUUC-Pfo-096939	Poecilia formosa	57.77	0.00e+00	1382.00
IUUC-Pab-098679	Pongo abelii	91.36	0.00e+00	2237.00
IUUC-Pop-099061	Populus trichocarpa	65.52	5.00e-09	55.10
IUUC-Pva-102969	Pteropus vampyrus	91.44	0.00e+00	2209.00
IUUC-Sha-107021	Sarcophilus harrisii	82.07	0.00e+00	1991.00
IUUC-Ssc-116243	Sus scrofa	91.11	0.00e+00	2380.00
IUUC-Tgu-117073	Taeniopygia guttata	75.52	0.00e+00	1754.00
IUUC-Tru-118265	Takifugu rubripes	59.17	0.00e+00	1367.00
IUUC-Ttr-128885	Tursiops truncatus	88.17	0.00e+00	1952.00
IUUC-Xtr-131812	Xenopus tropicalis	63.26	0.00e+00	1528.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence