iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Dre-028757

Ensembl Protein ID

ENSDARP00000039906.5

UniProt Accession

Q5TZE1; BTB6B_DANRE

Genbank Protein ID

CAH68989.1; CAK11390.1; AAI24115.1

Protein Name

BTB/POZ domain-containing protein 6-B

Genbank Nucleotide ID

BX255905; BX321888; BC124114

Gene Name

btbd6b; btbd6; si:dkey-11b8.2

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSDARG00000032369.10	ENSDART00000039907.6	ENSDARP00000039906.5
ENSDARG00000032369.10	ENSDART00000152415.1	ENSDARP00000126966.1
ENSDARG00000032369.10	ENSDART00000123909.2	ENSDARP00000124816.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/BCR/BTB_Other: BTB	4.50e-16	59.9	80	148

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/BCR/BTB_Other: BTB

   S: 1    aDvilvvg....geeffahkivLaasSsvFyalflmeleesksklmveikdvqpevfrallkFlYtgklde 67
           aDv +vvg     ++++ahk+vLa  SsvF a+f+++l e+  +++++i dv+p +f  llk++Y++++++
   Q: 80   ADVHFVVGppgaSQKVPAHKYVLAVGSSVFGAMFYGDLAEG--ESEIHIPDVEPAAFLILLKYMYSDEIEL 148
           79*****666689***************************9..6***********************9986 PP

Organism

Danio rerio

Functional Description
(View)

Adapter protein for the cul3 E3 ubiquitin-protein ligase complex. Promotes the export of zbtb16/plzf from the nucleus to the cytoplasm and targets zbtb16/plzf for ubiquitination and degradation. Up-regulates neurog1 expression and antagonizes zbtb16/plzf, to promote neurogenesis (By similarity).

Protein Sequence
(Fasta)

MAAELYPASI NTNLPNSNST AVTAASKKTI VQVTQTVTTP TTTATQQNIN NNNVETASWQ 60
STHPTLRERN ALMFNNELMA DVHFVVGPPG ASQKVPAHKY VLAVGSSVFG AMFYGDLAEG 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CTCTCTCATA GCACACACTG TAGATTTAAC ATGGCTCCTG GTTGCCAGCG AGCCTCCAAA 60
CATCAAACCT GAATGTATTT TTCCTGGCAG CTGCGCTTCG CTCGGCTCAA TAAGGTAAAG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0217--Developmental protein
KW-0221--Differentiation
KW-0524--Neurogenesis
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway

Interpro

IPR011705--BACK
IPR000210--BTB/POZ_dom
IPR012983--PHR
IPR011333--SKP1/BTB/POZ

PROSITE

PS50097--BTB

Pfam

PF07707--BACK
PF00651--BTB
PF08005--PHR

SMART

SM00875--BACK
SM00225--BTB

Gene Ontology

GO:0005829--C:cytosol
GO:0000932--C:P-body
GO:0019005--C:SCF ubiquitin ligase complex
GO:0031625--F:ubiquitin protein ligase binding
GO:0022008--P:neurogenesis
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0030162--P:regulation of proteolysis

KEGG

dre:553533

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001698	Ailuropoda melanoleuca	89.02	0.00e+00	763.00
IUUC-Apl-003687	Anas platyrhynchos	83.40	0.00e+00	803.00
IUUC-Aca-004837	Anolis carolinensis	89.74	0.00e+00	786.00
IUUC-Ame-010962	Astyanax mexicanus	95.44	0.00e+00	871.00
IUUC-Bta-013321	Bos taurus	90.00	0.00e+00	754.00
IUUC-Bci-013714	Botrytis cinerea	33.33	3.00e-05	42.70
IUUC-Cja-018819	Callithrix jacchus	86.67	0.00e+00	766.00
IUUC-Cfa-020312	Canis familiaris	87.80	0.00e+00	735.00
IUUC-Cpo-021713	Cavia porcellus	87.99	0.00e+00	785.00
IUUC-Csa-023707	Chlorocebus sabaeus	89.27	0.00e+00	751.00
IUUC-Eca-033474	Equus caballus	89.15	0.00e+00	793.00
IUUC-Fca-036108	Felis catus	89.02	0.00e+00	748.00
IUUC-Fal-037012	Ficedula albicollis	91.43	0.00e+00	783.00
IUUC-Gmo-038628	Gadus morhua	89.25	0.00e+00	775.00
IUUC-Gga-040672	Gallus gallus	91.36	0.00e+00	800.00
IUUC-Gac-041592	Gasterosteus aculeatus	85.27	0.00e+00	793.00
IUUC-Ggo-044914	Gorilla gorilla	87.10	0.00e+00	775.00
IUUC-Hsa-046005	Homo sapiens	87.33	0.00e+00	777.00
IUUC-Itr-048159	Ictidomys tridecemlineatus	87.85	0.00e+00	775.00
IUUC-Lch-049492	Latimeria chalumnae	82.99	0.00e+00	782.00
IUUC-Loc-052121	Lepisosteus oculatus	90.25	0.00e+00	862.00
IUUC-Laf-054023	Loxodonta africana	89.61	0.00e+00	758.00
IUUC-Mcc-055221	Macaca mulatta	89.27	0.00e+00	750.00
IUUC-Meu-056880	Macropus eugenii	87.56	0.00e+00	736.00
IUUC-Mga-059788	Meleagris gallopavo	91.12	0.00e+00	793.00
IUUC-Mmr-061333	Microcebus murinus	90.00	0.00e+00	755.00
IUUC-Mdo-062071	Monodelphis domestica	86.34	0.00e+00	771.00
IUUC-Mmu-064273	Mus musculus	87.07	0.00e+00	776.00
IUUC-Mpu-065966	Mustela putorius furo	88.29	0.00e+00	740.00
IUUC-Mlu-066940	Myotis lucifugus	86.78	0.00e+00	746.00
IUUC-Nle-070099	Nomascus leucogenys	89.02	0.00e+00	747.00
IUUC-Opr-070931	Ochotona princeps	88.29	0.00e+00	744.00
IUUC-Ont-071493	Oreochromis niloticus	90.44	0.00e+00	794.00
IUUC-Ocu-074781	Oryctolagus cuniculus	89.27	0.00e+00	751.00
IUUC-Ola-086691	Oryzias latipes	84.36	0.00e+00	813.00
IUUC-Oga-088166	Otolemur garnettii	88.79	0.00e+00	778.00
IUUC-Oar-090170	Ovis aries	87.29	0.00e+00	743.00
IUUC-Pan-092894	Papio anubis	83.30	0.00e+00	766.00
IUUC-Psi-093858	Pelodiscus sinensis	90.48	0.00e+00	775.00
IUUC-Pfo-096949	Poecilia formosa	82.35	0.00e+00	802.00
IUUC-Pca-100556	Procavia capensis	88.77	0.00e+00	691.00
IUUC-Rno-105298	Rattus norvegicus	86.84	0.00e+00	772.00
IUUC-Sha-107182	Sarcophilus harrisii	85.88	0.00e+00	764.00
IUUC-Tgu-117158	Taeniopygia guttata	91.43	0.00e+00	784.00
IUUC-Tru-118020	Takifugu rubripes	83.06	0.00e+00	775.00
IUUC-Tni-120155	Tetraodon nigroviridis	82.57	0.00e+00	798.00
IUUC-Tbe-127750	Tupaia belangeri	84.77	0.00e+00	694.00
IUUC-Ttr-128417	Tursiops truncatus	88.77	0.00e+00	686.00
IUUC-Xtr-132362	Xenopus tropicalis	89.98	0.00e+00	791.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence