iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000123154.11	ENST00000418543.7	ENSP00000402653.3
ENSG00000123154.11	ENST00000548381.5	ENSP00000448722.1
ENSG00000123154.11	ENST00000547481.5	ENSP00000448331.1
ENSG00000123154.11	ENST00000425834.7	ENSP00000396530.3
ENSG00000123154.11	ENST00000547797.1	ENSP00000449257.1

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	circBase	circRNADb	CircNet
microRNA	TRANSFAC	TargetScan	RepTar
SomamiR	miRcode	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha	InWeb_IM
Disease-associated Variation
OMIM
Post-translational Modifications (PTMs)
CPLM	PhosphositePlus	BioGRID
DNA Methylation
TCGA	ICGC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	2.00e-32	111.5	107	142
UBD/Beta-Prp	4.70e-51	175.4	15	189

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf.sd.tllvsGsdDgtikvWDlrtgv 34
           gH+++v+ ++f  + t ++sGs D +i++WD r+ +
   Q: 107  GHAGKVNTVQFnEEaTVILSGSIDSSIRCWDCRSRR 142
           8**********54489***************99866 PP

UBD/Beta-Prp

   S: 42   gkllrslsgheaevtavkfspdgkilvtgseDrtikvwdlstgkcvhtlkghedsvlslsfspsgdklvsGshdrtirvwdletgqcleetl 133
           +k l++l   +++v+av+f+ dg++ +t+++D+t+k+w++  g+ ++t++gh ++vl+ + s ++++l sG+ d+ + +wd+ +gq+++  +
   Q: 15   QKRLKTLDCGQGAVRAVRFNVDGNYCLTCGSDKTLKLWNPLRGTLLRTYSGHGYEVLDAAGSFDNSSLCSGGGDKAVVLWDVASGQVVR-KF 105
           56778888888999999999999999999999999999999999999999999999998888888999999999999999999999998.89 PP
   S: 134  sghdgvvncvvvhpdgnllvsGslDrtvrlWdl..ktgkllrtltgghtdsvyslsfdsngkelvsgsldgtvklwdlqtgecvrtl 218
           +gh g vn+v++++++ ++ sGs D+ +r Wd   ++ + ++tl +   d v s+++++   e+++gs dg+v+ +dl+ g+    +
   Q: 106  RGHAGKVNTVQFNEEATVILSGSIDSSIRCWDCrsRRPEPVQTLDE-ARDGVSSVKVSD--HEILAGSVDGRVRRYDLRMGQLFSDY 189
           9999999999999999999999999999999986667778899987.899999999988..68999999999999999888766655 PP

Organism

Homo sapiens

Functional Description
(View)

Molecular scaffold protein for various multimeric protein complexes. Acts as a module in the assembly of a multicomponent scaffold for the ERK pathway, linking ERK responses to specific agonists. At low concentrations it enhances ERK activation, whereas high concentrations lead to the inhibition of ERK activation. Also involved in response to hypoxia by acting as a negative regulator of HIF1A/HIF-1-alpha via its interaction with EGLN3/PHD3. May promote degradation of HIF1A. May act by recruiting signaling complexes to a specific upstream activator (By similarity). May also be involved in pre-mRNA splicing.

Protein Sequence
(Fasta)

MAFPEPKPRP PELPQKRLKT LDCGQGAVRA VRFNVDGNYC LTCGSDKTLK LWNPLRGTLL 60
RTYSGHGYEV LDAAGSFDNS SLCSGGGDKA VVLWDVASGQ VVRKFRGHAG KVNTVQFNEE 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CCAGGGCGCG GTCTGGAGGC TCACGGGAGA GAGGCTGTAG CCCTGGGCAA TCCCGGGGGT 60
CGTTACAGGA AGGTAGGAAA ATGCCACCCT CAGGGCACTG GTTGGGCTAA AGGTGACACT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0507--mRNA processing
KW-0508--mRNA splicing
KW-0539--Nucleus
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0747--Spliceosome
KW-0853--WD repeat

Interpro

IPR020472--G-protein_beta_WD-40_rep
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM00320--WD40

Gene Ontology

GO:0071013--C:catalytic step 2 spliceosome
GO:0010008--C:endosome membrane
GO:0005681--C:spliceosomal complex
GO:0000165--P:MAPK cascade
GO:0000398--P:mRNA splicing, via spliceosome
GO:0000375--P:RNA splicing, via transesterification reactions

KEGG

hsa:84292

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002160	Ailuropoda melanoleuca	96.82	0.00e+00	627.00
IUUC-Atr-002647	Amborella trichopoda	49.49	7.00e-90	323.00
IUUC-Aca-004948	Anolis carolinensis	80.25	5.00e-146	510.00
IUUC-Aly-006489	Arabidopsis lyrata	51.18	1.00e-82	299.00
IUUC-Ath-007099	Arabidopsis thaliana	50.84	2.00e-82	298.00
IUUC-Acl-008374	Aspergillus clavatus	37.67	9.00e-50	190.00
IUUC-Afl-008506	Aspergillus flavus	38.67	2.00e-51	196.00
IUUC-Afu-009098	Aspergillus fumigatus	34.14	2.00e-44	173.00
IUUC-Ang-009705	Aspergillus niger	34.84	1.00e-46	180.00
IUUC-Aor-010031	Aspergillus oryzae	38.67	1.00e-51	196.00
IUUC-Ame-011056	Astyanax mexicanus	72.67	3.00e-139	487.00
IUUC-Bgr-012109	Blumeria graminis	41.90	7.00e-57	214.00
IUUC-Bta-012476	Bos taurus	95.24	2.00e-179	621.00
IUUC-Bci-013860	Botrytis cinerea	36.49	2.00e-46	179.00
IUUC-Bdi-014565	Brachypodium distachyon	50.51	8.00e-88	317.00
IUUC-Bol-016204	Brassica oleracea	51.53	1.00e-82	299.00
IUUC-Bra-018093	Brassica rapa	51.53	2.00e-82	298.00
IUUC-Cel-018500	Caenorhabditis elegans	48.46	8.00e-85	306.00
IUUC-Cja-019279	Callithrix jacchus	99.05	1.00e-173	602.00
IUUC-Cfa-020516	Canis familiaris	96.51	0.00e+00	627.00
IUUC-Cpo-021427	Cavia porcellus	93.65	1.00e-167	582.00
IUUC-Cre-022775	Chlamydomonas reinhardtii	46.49	6.00e-75	274.00
IUUC-Csa-023449	Chlorocebus sabaeus	98.41	4.00e-173	600.00
IUUC-Cin-025637	Ciona intestinalis	57.58	2.00e-107	382.00
IUUC-Cgl-026458	Colletotrichum gloeosporioides	38.19	2.00e-51	196.00
IUUC-Cne-026994	Cryptococcus neoformans	35.83	2.00e-50	192.00
IUUC-Dre-028239	Danio rerio	73.57	2.00e-132	465.00
IUUC-Dno-029408	Dasypus novemcinctus	93.97	2.00e-177	614.00
IUUC-Dor-030684	Dipodomys ordii	95.12	4.00e-114	404.00
IUUC-Dse-031344	Dothistroma septosporum	46.18	3.00e-54	205.00
IUUC-Dme-031634	Drosophila melanogaster	47.92	3.00e-77	281.00
IUUC-Ete-033126	Echinops telfairi	86.35	3.00e-159	554.00
IUUC-Eca-034356	Equus caballus	88.25	2.00e-157	548.00
IUUC-Eeu-035196	Erinaceus europaeus	94.08	6.00e-80	290.00
IUUC-Fca-036231	Felis catus	96.19	5.00e-180	623.00
IUUC-Fox-038076	Fusarium oxysporum	37.07	3.00e-53	202.00
IUUC-Fso-038093	Fusarium solani	35.64	3.00e-45	175.00
IUUC-Gmo-039056	Gadus morhua	72.35	8.00e-133	466.00
IUUC-Ggr-039981	Gaeumannomyces graminis	34.04	1.00e-43	171.00
IUUC-Gga-041042	Gallus gallus	77.81	3.00e-149	521.00
IUUC-Gac-042638	Gasterosteus aculeatus	73.53	6.00e-136	476.00
IUUC-Gma-042689	Glycine max	50.68	7.00e-90	323.00
IUUC-Ggo-044720	Gorilla gorilla	99.37	1.00e-174	605.00
IUUC-Hvu-047675	Hordeum vulgare	47.22	3.00e-85	308.00
IUUC-Itr-048733	Ictidomys tridecemlineatus	93.75	1.00e-171	595.00
IUUC-Lch-050634	Latimeria chalumnae	78.95	6.00e-133	466.00
IUUC-Lpe-051470	Leersia perrieri	49.83	2.00e-87	315.00
IUUC-Loc-052452	Lepisosteus oculatus	77.89	2.00e-135	474.00
IUUC-Lma-053235	Leptosphaeria maculans	41.38	1.00e-27	117.00
IUUC-Laf-054315	Loxodonta africana	95.87	1.00e-170	592.00
IUUC-Mcc-054923	Macaca mulatta	98.41	2.00e-173	600.00
IUUC-Mor-056936	Magnaporthe oryzae	37.16	3.00e-46	179.00
IUUC-Mtr-058595	Medicago truncatula	52.46	1.00e-89	323.00
IUUC-Mla-058902	Melampsora laricipopulina	40.21	7.00e-61	227.00
IUUC-Mvi-060471	Microbotryum violaceum	43.29	3.00e-72	265.00
IUUC-Mmr-061665	Microcebus murinus	96.19	0.00e+00	625.00
IUUC-Mdo-062750	Monodelphis domestica	82.69	3.00e-135	474.00
IUUC-Mmu-063750	Mus musculus	93.97	5.00e-178	616.00
IUUC-Mac-065441	Musa acuminata	51.02	1.00e-89	322.00
IUUC-Mpu-066863	Mustela putorius furo	95.56	2.00e-179	621.00
IUUC-Mlu-067645	Myotis lucifugus	94.29	4.00e-177	613.00
IUUC-Nfi-068549	Neosartorya fischeri	37.01	7.00e-49	187.00
IUUC-Ncr-068816	Neurospora crassa	34.91	8.00e-42	164.00
IUUC-Nle-069457	Nomascus leucogenys	98.73	5.00e-174	603.00
IUUC-Opr-070874	Ochotona princeps	94.52	8.00e-78	283.00
IUUC-Ont-071674	Oreochromis niloticus	73.40	3.00e-122	431.00
IUUC-Oan-073391	Ornithorhynchus anatinus	80.00	2.00e-152	531.00
IUUC-Ocu-074186	Oryctolagus cuniculus	93.97	9.00e-172	595.00
IUUC-Oba-075414	Oryza barthii	51.25	5.00e-85	307.00
IUUC-Obr-076739	Oryza brachyantha	49.49	4.00e-86	311.00
IUUC-Ogl-076962	Oryza glaberrima	49.83	7.00e-87	313.00
IUUC-Ogu-078831	Oryza glumaepatula	49.83	6.00e-87	313.00
IUUC-Oin-079985	Oryza indica	49.49	7.00e-87	313.00
IUUC-Ome-081333	Oryza meridionalis	49.63	4.00e-79	288.00
IUUC-Oni-082558	Oryza nivara	49.49	7.00e-87	313.00
IUUC-Opu-084091	Oryza punctata	50.17	3.00e-88	318.00
IUUC-Oru-085253	Oryza rufipogon	49.82	2.00e-81	295.00
IUUC-Osa-086077	Oryza sativa	49.49	7.00e-87	313.00
IUUC-Ola-086946	Oryzias latipes	72.61	6.00e-137	479.00
IUUC-Olu-087604	Ostreococcus lucimarinus	40.65	6.00e-54	204.00
IUUC-Oga-088681	Otolemur garnettii	94.23	9.00e-176	608.00
IUUC-Oar-089913	Ovis aries	94.29	1.00e-176	612.00
IUUC-Ptr-091343	Pan troglodytes	99.37	3.00e-173	600.00
IUUC-Pan-092078	Papio anubis	98.41	4.00e-173	600.00
IUUC-Psi-093190	Pelodiscus sinensis	80.45	3.00e-152	530.00
IUUC-Pno-095078	Phaeosphaeria nodorum	39.49	2.00e-53	202.00
IUUC-Ppa-095777	Physcomitrella patens	50.17	4.00e-89	321.00
IUUC-Pfo-097153	Poecilia formosa	74.92	2.00e-129	455.00
IUUC-Pab-098307	Pongo abelii	98.10	2.00e-171	594.00
IUUC-Pop-099315	Populus trichocarpa	52.38	3.00e-84	305.00
IUUC-Pca-100538	Procavia capensis	95.17	1.00e-150	525.00
IUUC-Ppe-101632	Prunus persica	49.49	1.00e-89	322.00
IUUC-Pva-102484	Pteropus vampyrus	97.14	0.00e+00	630.00
IUUC-Pgr-103495	Puccinia graminis	39.01	4.00e-63	234.00
IUUC-Ptt-103975	Puccinia triticina	38.65	1.00e-61	229.00
IUUC-Pte-104354	Pyrenophora teres	37.32	5.00e-42	164.00
IUUC-Pyt-104692	Pyrenophora triticirepentis	38.04	8.00e-42	164.00
IUUC-Rno-105655	Rattus norvegicus	93.33	9.00e-177	612.00
IUUC-Sha-107130	Sarcophilus harrisii	83.97	5.00e-113	400.00
IUUC-Sja-107933	Schizosaccharomyces japonicus	39.93	1.00e-57	216.00
IUUC-Spo-108131	Schizosaccharomyces pombe	40.89	1.00e-57	216.00
IUUC-Ssl-108405	Sclerotinia sclerotiorum	36.49	9.00e-47	180.00
IUUC-Smo-108996	Selaginella moellendorffii	48.81	1.00e-80	292.00
IUUC-Sit-110508	Setaria italica	50.51	3.00e-88	318.00
IUUC-Sly-111093	Solanum lycopersicum	49.32	5.00e-81	294.00
IUUC-Stu-112380	Solanum tuberosum	49.32	8.00e-81	293.00
IUUC-Sar-113127	Sorex araneus	89.66	4.00e-73	268.00
IUUC-Sbi-114461	Sorghum bicolor	49.49	2.00e-86	312.00
IUUC-Sre-115020	Sporisorium reilianum	38.16	4.00e-42	166.00
IUUC-Ssc-115632	Sus scrofa	96.46	2.00e-179	620.00
IUUC-Tru-118039	Takifugu rubripes	71.24	9.00e-128	449.00
IUUC-Tsy-119239	Tarsius syrichta	98.22	3.00e-96	344.00
IUUC-Tni-120097	Tetraodon nigroviridis	68.97	7.00e-125	439.00
IUUC-Tca-121695	Theobroma cacao	52.38	1.00e-92	333.00
IUUC-Tre-122182	Trichoderma reesei	37.13	2.00e-49	189.00
IUUC-Tvi-122429	Trichoderma virens	37.04	2.00e-52	199.00
IUUC-Tae-125136	Triticum aestivum	51.19	1.00e-89	322.00
IUUC-Tur-126216	Triticum urartu	51.19	4.00e-90	324.00
IUUC-Tme-127030	Tuber melanosporum	43.38	2.00e-62	232.00
IUUC-Tbe-127686	Tupaia belangeri	93.12	3.00e-102	364.00
IUUC-Ttr-128770	Tursiops truncatus	94.60	5.00e-179	620.00
IUUC-Uma-129446	Ustilago maydis	35.37	3.00e-37	150.00
IUUC-Vda-129680	Verticillium dahliae	39.34	5.00e-42	164.00
IUUC-Vvi-131292	Vitis vinifera	51.88	4.00e-91	327.00
IUUC-Xtr-132204	Xenopus tropicalis	75.80	1.00e-145	509.00
IUUC-Xma-133727	Xiphophorus maculatus	73.72	5.00e-130	457.00
IUUC-Zma-135908	Zea mays	49.49	4.00e-81	294.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence